公开(公告)号：US20200170838A1

公开(公告)日：2020-06-04

申请号：US16683277

申请日：2019-11-14

Applicant: Industrial Technology Research Institute

Inventor： Yun-Chung Teng ,  Yu-Bing Liou ,  Hsin-Yi Hsu ,  Ying-Wen Shen ,  Sen-Lu Chen ,  Yu-Chi Wang ,  Hsin-Hsin Shen

IPC: A61F9/00

Abstract: An eye wearing device is provided, including a body, at least one reservoir and at least one microchannel. The body has a first surface, a second surface, a center, a first outer edge of the first surface and a second outer edge of the second surface. The reservoir is disposed in the body to load the drug. The microchannel is disposed near the first outer edge of the first surface and the second outer edge of the second surface. One end of the microchannel is connected to the reservoir for filling the drug into the reservoir. The other end of the microchannel is an opening facing an edge of the eye wearing device for contacting the cornea and/or the sclera, and the opening is connected to the first outer edge of the first surface and the second outer edge of the second surface.

公开(公告)号：US11904581B2

公开(公告)日：2024-02-20

申请号：US17885874

申请日：2022-08-11

Applicant: Industrial Technology Research Institute

Inventor： Hsin-Hsin Shen ,  Yu-Chi Wang ,  Ming-Chia Yang ,  Yu-Bing Liou ,  Wei-Hong Chang ,  Yun-Han Lin ,  Hsin-Yi Hsu ,  Yun-Chung Teng ,  Chia-Jung Lu ,  Yi-Hsuan Lee ,  Jian-Wei Lin ,  Kun-Mao Kuo ,  Ching-Mei Chen

IPC: B32B27/36 ,  B32B27/24 ,  B32B27/30 ,  B05D7/00 ,  B05D5/08 ,  B32B38/00 ,  B32B37/02 ,  B32B38/16 ,  B32B37/26

CPC classification number: B32B27/36 ,  B05D5/08 ,  B05D7/544 ,  B05D7/584 ,  B32B27/24 ,  B32B27/306 ,  B32B37/02 ,  B32B37/26 ,  B32B38/164 ,  B32B2038/168 ,  B32B2307/728 ,  B32B2307/73 ,  B32B2535/00

Abstract: A method for preparing a bifunctional film, including: (a) drying a first polymer solution to form a film to form an anti-adhesion layer, and (b) drying a second polymer solution over the anti-adhesion layer to form a film to form an attachment layer. The first polymer solution includes a first hydrophobic solution and a first hydrophilic solution, and in the first polymer solution, the weight ratio of the solute of the first hydrophobic solution to the solute of the first hydrophilic solution is 1:0.01-1. Moreover, the second polymer solution is composed of a second hydrophilic solution.

公开(公告)号：US12258546B2

公开(公告)日：2025-03-25

申请号：US17561117

申请日：2021-12-23

Applicant: Industrial Technology Research Institute

Inventor： Hsin-Yi Hsu ,  Yang-Cheng Lin ,  Chao-Hong Hsu ,  Yu-Bing Liou ,  Li-Hsin Lin ,  Hsin-Hsin Shen ,  Yu-Chi Wang ,  Chang-Chou Li ,  Chih-Hung Huang

IPC: B01L3/00 ,  C12M1/00 ,  C12M1/42 ,  C12M3/00

Abstract: A cell and tissue sheet forming package includes a container body, a membrane, a sliding door plate and a sealing film. The sliding door plate is disposed slidably on a top of the container body to cover or expose the membrane. The sliding door plate has a hole and a passive magnetic assembly. The cell injection equipment includes a carrier, an injection mechanism and a drive mechanism. The carrier carries the package, and the drive mechanism moves the carrier and the injection mechanism to have the injection mechanism to inject a solution, through the hole, into the package. A heating element of the carrier is introduced to heat the membrane and the solution to transform the solution into a colloid sheet on the membrane. Then, the positive magnetic assembly engages magnetically the passive magnetic assembly to slide the sliding door plate to expose the colloid sheet on the membrane.

公开(公告)号：US11458715B2

公开(公告)日：2022-10-04

申请号：US16675838

申请日：2019-11-06

Applicant: Industrial Technology Research Institute

Inventor： Hsin-Hsin Shen ,  Yu-Chi Wang ,  Ming-Chia Yang ,  Yu-Bing Liou ,  Wei-Hong Chang ,  Yun-Han Lin ,  Hsin-Yi Hsu ,  Yun-Chung Teng ,  Chia-Jung Lu ,  Yi-Hsuan Lee ,  Jian-Wei Lin ,  Kun-Mao Kuo ,  Ching-Mei Chen

IPC: B32B27/36 ,  B05D7/00 ,  B05D5/08 ,  B32B27/24 ,  B32B27/30 ,  B32B38/00 ,  B32B37/02 ,  B32B38/16 ,  B32B37/26

Abstract: A method for preparing a bifunctional film, including: (a) drying a first polymer solution to form a film to form an anti-adhesion layer; and (b) drying a second polymer solution over the anti-adhesion layer to form a film to form an attachment layer. The first polymer solution includes a first hydrophobic solution and a first hydrophilic solution, and in the first polymer solution, the weight ratio of the solute of the first hydrophobic solution to the solute of the first hydrophilic solution is 1:0.01-1. Moreover, the second polymer solution consists of a second hydrophilic solution.

公开(公告)号：US11154637B2

公开(公告)日：2021-10-26

申请号：US16675860

申请日：2019-11-06

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Hsin-Hsin Shen ,  Yu-Chi Wang ,  Sen-Lu Chen ,  Yu-Bing Liou ,  Jian-Wei Lin ,  Yi-Hsuan Lee ,  Ming-Chia Yang ,  Ying-Wen Shen ,  Wei-Lin Yu

IPC: A61L24/06 ,  A61L24/00

Abstract: A biodegradable sealant includes: a polyethylene glycol derivative; a photoinitiator; and a solvent, wherein the content of the polyethylene glycol derivative is about 10-75 wt % in the biodegradable sealant. The polyethylene glycol derivative is obtained by a substitution reaction, and in the substitution reaction, the polyethylene glycol is modified with methacrylic anhydride.

公开(公告)号：US10449272B2

公开(公告)日：2019-10-22

申请号：US15294047

申请日：2016-10-14

Applicant: Industrial Technology Research Institute

Inventor： Yu-Chi Wang ,  Hsin-Hsin Shen ,  Chin-Fu Chen ,  Meng-Yow Hsieh ,  Sen-Lu Chen ,  Yu-Bing Liou ,  Tsai-Yu Lin ,  Pei-Shan Li ,  Wei-Lin Yu

IPC: A61L31/04 ,  A61L31/14

Abstract: The present disclosure provides a hydrogel composition including: a hydrogel having a structure represented by Formula (I) or Formula (II) shown as follows: A-B-BOX-B-A, Formula (I); B-A-B-(BOX-BAB)n-BOX-B-A-B, Formula (II), wherein, A is a hydrophilic polyethylene glycol polymer, B is a hydrophobic polyester polymer, BOX is a bifunctional group monomer of 2,2′-Bis(2-oxazoline) for coupling di-block of A-B or tri-block of B-A-B, and n is an integer greater than or equal to 0; and an anti-adhesion additive, wherein the anti-adhesion additive comprises a carbohydrate, a nitrogen-containing cyclic compound, a polymer or a combination thereof.