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公开(公告)号：US20190203165A1
公开(公告)日：2019-07-04
申请号：US16226647
申请日：2018-12-20
Applicant: Industrial Technology Research Institute
Inventor： Ing-Kae Wang , Ying-Wen Shen , Yea-Tzy Deng , Den-Tai Lin , Yu-Bing Liou , Sing-Ying Hsieh , Wei-Zhou Yeh , Meng-Hua Yang , Hsiang-Chun Hsu , Ying-Chun Chien
Abstract: A cell culture module, a cell culture system and a cell culture method are provided. The cell culture module includes a casing, a first fixer, a second fixer and a sheet-shaped carrier member. The casing has a chamber and at least one inlet/outlet. The inlet/outlet communicates with the chamber. The first fixer is fixed to the casing and located in the chamber. The second fixer is disposed in the chamber and is movable relative to the first fixer. The sheet-shaped carrier member is formed by arranging a plurality of cell culture carriers, and two opposite ends of the sheet-shaped carrier member are respectively fixed to the first fixer and the second fixer. The sheet-shaped carrier member is in an open state or a folded state according to a variation in a distance between the first fixer and the second fixer due to a movement of the second fixer.
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公开(公告)号：US20210206064A1
公开(公告)日：2021-07-08
申请号：US17129920
申请日：2020-12-22
Applicant: Industrial Technology Research Institute
Inventor： Hsin-Hsin Shen , Chang-Chou Li , Li-Wen Lai , Yu-Bing Liou , Ying-Wen Shen
IPC: B29C64/209 , B29C64/112 , B29C64/245 , B29C64/364
Abstract: A three-dimensional printing apparatus having electrostatic auxiliary, including a printing platform, a feeding device, a nozzle, and a high voltage power supply, is provided. The feeding device and the nozzle are disposed above the printing platform. The nozzle is connected to the feeding device and is located between the feeding device and the printing platform. A distance between the nozzle and the printing platform is less than or equal to 1 cm. The high voltage power supply has an output end electrically connected to the nozzle and a ground end electrically connected to the printing platform.
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公开(公告)号：US20200170838A1
公开(公告)日：2020-06-04
申请号：US16683277
申请日：2019-11-14
Applicant: Industrial Technology Research Institute
Inventor： Yun-Chung Teng , Yu-Bing Liou , Hsin-Yi Hsu , Ying-Wen Shen , Sen-Lu Chen , Yu-Chi Wang , Hsin-Hsin Shen
IPC: A61F9/00
Abstract: An eye wearing device is provided, including a body, at least one reservoir and at least one microchannel. The body has a first surface, a second surface, a center, a first outer edge of the first surface and a second outer edge of the second surface. The reservoir is disposed in the body to load the drug. The microchannel is disposed near the first outer edge of the first surface and the second outer edge of the second surface. One end of the microchannel is connected to the reservoir for filling the drug into the reservoir. The other end of the microchannel is an opening facing an edge of the eye wearing device for contacting the cornea and/or the sclera, and the opening is connected to the first outer edge of the first surface and the second outer edge of the second surface.
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公开(公告)号：US20180223238A1
公开(公告)日：2018-08-09
申请号：US15854789
申请日：2017-12-27
Applicant: Industrial Technology Research Institute
Inventor： Ying-Wen Shen , Ing-Kae Wang , Chia-Jung Lu , Yea-Tzy Deng , Yu-Bing Liou , Sing-Ying Hsieh , Hsin-Hsin Shen , Hsiu-Ying Wang
CPC classification number: C12M23/52 , C12M3/04 , C12M23/08 , C12M23/26 , C12M23/40 , C12M23/46 , C12M25/00 , C12M35/04 , C12M35/06 , C12M41/40
Abstract: A cell culture carrier module and a cell culture system having the same are provided. A cell tank and a culture medium module respectively communicate with the carrier module. The carrier module includes a reactor, a first fixer, a second fixer and a plurality of cell culture carriers. The reactor has a chamber and at least one inlet/outlet. The inlet/outlet communicates with the chamber. The first fixer is fixed to the reactor and located in the chamber. The second fixer is disposed in the chamber and is movable relative to the first fixer. Two ends of each cell culture carrier are fixed to the first fixer and the second fixer, respectively. The cell culture carriers are in an untwisted state or a twisted state according to a variation in a distance between the first fixer and the second fixer due to a movement of the second fixer.
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公开(公告)号：US11254902B2
公开(公告)日：2022-02-22
申请号：US16226647
申请日：2018-12-20
Applicant: Industrial Technology Research Institute
Inventor： Ing-Kae Wang , Ying-Wen Shen , Yea-Tzy Deng , Den-Tai Lin , Yu-Bing Liou , Sing-Ying Hsieh , Wei-Zhou Yeh , Meng-Hua Yang , Hsiang-Chun Hsu , Ying-Chun Chien
Abstract: A cell culture module, a cell culture system and a cell culture method are provided. The cell culture module includes a casing, a first fixer, a second fixer and a sheet-shaped carrier member. The casing has a chamber and at least one inlet/outlet. The inlet/outlet communicates with the chamber. The first fixer is fixed to the casing and located in the chamber. The second fixer is disposed in the chamber and is movable relative to the first fixer. The sheet-shaped carrier member is formed by arranging a plurality of cell culture carriers, and two opposite ends of the sheet-shaped carrier member are respectively fixed to the first fixer and the second fixer. The sheet-shaped carrier member is in an open state or a folded state according to a variation in a distance between the first fixer and the second fixer due to a movement of the second fixer.
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Patent Agency Ranking
公开(公告)号：US11154637B2
公开(公告)日：2021-10-26
申请号：US16675860
申请日：2019-11-06
Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Inventor： Hsin-Hsin Shen , Yu-Chi Wang , Sen-Lu Chen , Yu-Bing Liou , Jian-Wei Lin , Yi-Hsuan Lee , Ming-Chia Yang , Ying-Wen Shen , Wei-Lin Yu
Abstract: A biodegradable sealant includes: a polyethylene glycol derivative; a photoinitiator; and a solvent, wherein the content of the polyethylene glycol derivative is about 10-75 wt % in the biodegradable sealant. The polyethylene glycol derivative is obtained by a substitution reaction, and in the substitution reaction, the polyethylene glycol is modified with methacrylic anhydride.
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公开(公告)号：US10704017B2
公开(公告)日：2020-07-07
申请号：US15854789
申请日：2017-12-27
Applicant: Industrial Technology Research Institute
Inventor： Ying-Wen Shen , Ing-Kae Wang , Chia-Jung Lu , Yea-Tzy Deng , Yu-Bing Liou , Sing-Ying Hsieh , Hsin-Hsin Shen , Hsiu-Ying Wang
Abstract: A cell culture carrier module and a cell culture system having the same are provided. A cell tank and a culture medium module respectively communicate with the carrier module. The carrier module includes a reactor, a first fixer, a second fixer and a plurality of cell culture carriers. The reactor has a chamber and at least one inlet/outlet. The inlet/outlet communicates with the chamber. The first fixer is fixed to the reactor and located in the chamber. The second fixer is disposed in the chamber and is movable relative to the first fixer. Two ends of each cell culture carrier are fixed to the first fixer and the second fixer, respectively. The cell culture carriers are in an untwisted state or a twisted state according to a variation in a distance between the first fixer and the second fixer due to a movement of the second fixer.
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公开(公告)号：US20170166859A1
公开(公告)日：2017-06-15
申请号：US14985308
申请日：2015-12-30
Applicant: Industrial Technology Research Institute
Inventor： Hsiu-Ying Wang , Ying-Wen Shen , Ing-Kae Wang , Shu-Fen Yeh , Wei-Zhou Yeh
Abstract: A cell culture carrier module, a bioreactor and a cell recovery method are provided. The cell culture carrier module includes at least one cell culture carrier capable of transforming between a two dimensional structure and a three dimensional structure. The cell culture carrier exhibits the two dimensional structure in a loosened state and exhibits the three dimensional structure in a compressed state.
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公开(公告)号：US12054612B2
公开(公告)日：2024-08-06
申请号：US17561133
申请日：2021-12-23
Applicant: Industrial Technology Research Institute
Inventor： Yun-Chung Teng , Jen-Huang Huang , Ying-Wen Shen , Yu-Bing Liou , Hsin-Yi Hsu , Li-Hsin Lin , Yuchi Wang , Hsin-Hsin Shen
CPC classification number: C08L89/06 , A61L27/26 , A61L27/52 , B33Y80/00 , C08J3/24 , C12N5/0018 , C08J2389/06 , C08J2489/06 , C08L2203/02 , C08L2205/02 , C08L2205/16 , C08L2312/00 , C12N2500/34
Abstract: A bioprintable material is provided. The bioprintable material includes a hydrogel and microfilaments mixed in the hydrogel. The hydrogel includes a first collagen. The microfilament includes a second collagen. The diameter of the microfilament is ranging from 5 microns to 200 microns. The weight ratio of the microfilaments to the first collagen is ranging from 0.01:1 to 10:1.
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公开(公告)号：US11103446B2
公开(公告)日：2021-08-31
申请号：US16731966
申请日：2019-12-31
Applicant: Industrial Technology Research Institute
Inventor： Yu-Bing Liou , Hsin-Yi Hsu , Ying-Wen Shen , Yun-Chung Teng , Yuchi Wang , Hsin-Hsin Shen
Abstract: An ophthalmic drug delivery device and a method for fabricating the same are provided. The ophthalmic drug delivery device includes a shield element and a drug release element. The shield element has a light transmittance more than or equal to 80%. The drug release element is an annular body so that the drug release element surrounds the shield element. The drug release element is neutral and includes a cross-linked neutral collagen, a first hydrophilic biodegradable polymer and a drug. The shield element is acidic and includes a cross-linked acidic collagen and a second hydrophilic biodegradable polymer.
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