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公开(公告)号：US10918474B2
公开(公告)日：2021-02-16
申请号：US16122438
申请日：2018-09-05
Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Inventor： Yu-Bing Liou , Ming-Chia Yang , Hsin-Yi Hsu , Yun-Han Lin , Wei-Hong Chang , I-Jong Wang , Hsin-Hsin Shen
Abstract: An implanting device is used for implanting a membrane in a biological tissue. The implanting device includes a sleeve, a membrane storage element, an injection element and a bubble generating element. The membrane storage element is fixed at the sleeve. The injection element is inserted in the sleeve and the membrane storage element, and includes a capturing end and connecting end. The capturing end is for capturing the membrane and has a hole. The bubble generating element is connected to the connecting end, and is for providing a gas that is then outputted via the hole. By the rotation of the injection element, the capturing end extends straight out of the membrane storage element or retracts straight into the membrane storage element.
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公开(公告)号：US20190203165A1
公开(公告)日：2019-07-04
申请号：US16226647
申请日：2018-12-20
Applicant: Industrial Technology Research Institute
Inventor： Ing-Kae Wang , Ying-Wen Shen , Yea-Tzy Deng , Den-Tai Lin , Yu-Bing Liou , Sing-Ying Hsieh , Wei-Zhou Yeh , Meng-Hua Yang , Hsiang-Chun Hsu , Ying-Chun Chien
Abstract: A cell culture module, a cell culture system and a cell culture method are provided. The cell culture module includes a casing, a first fixer, a second fixer and a sheet-shaped carrier member. The casing has a chamber and at least one inlet/outlet. The inlet/outlet communicates with the chamber. The first fixer is fixed to the casing and located in the chamber. The second fixer is disposed in the chamber and is movable relative to the first fixer. The sheet-shaped carrier member is formed by arranging a plurality of cell culture carriers, and two opposite ends of the sheet-shaped carrier member are respectively fixed to the first fixer and the second fixer. The sheet-shaped carrier member is in an open state or a folded state according to a variation in a distance between the first fixer and the second fixer due to a movement of the second fixer.
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公开(公告)号：US20210206064A1
公开(公告)日：2021-07-08
申请号：US17129920
申请日：2020-12-22
Applicant: Industrial Technology Research Institute
Inventor： Hsin-Hsin Shen , Chang-Chou Li , Li-Wen Lai , Yu-Bing Liou , Ying-Wen Shen
IPC: B29C64/209 , B29C64/112 , B29C64/245 , B29C64/364
Abstract: A three-dimensional printing apparatus having electrostatic auxiliary, including a printing platform, a feeding device, a nozzle, and a high voltage power supply, is provided. The feeding device and the nozzle are disposed above the printing platform. The nozzle is connected to the feeding device and is located between the feeding device and the printing platform. A distance between the nozzle and the printing platform is less than or equal to 1 cm. The high voltage power supply has an output end electrically connected to the nozzle and a ground end electrically connected to the printing platform.
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公开(公告)号：US20200170838A1
公开(公告)日：2020-06-04
申请号：US16683277
申请日：2019-11-14
Applicant: Industrial Technology Research Institute
Inventor： Yun-Chung Teng , Yu-Bing Liou , Hsin-Yi Hsu , Ying-Wen Shen , Sen-Lu Chen , Yu-Chi Wang , Hsin-Hsin Shen
IPC: A61F9/00
Abstract: An eye wearing device is provided, including a body, at least one reservoir and at least one microchannel. The body has a first surface, a second surface, a center, a first outer edge of the first surface and a second outer edge of the second surface. The reservoir is disposed in the body to load the drug. The microchannel is disposed near the first outer edge of the first surface and the second outer edge of the second surface. One end of the microchannel is connected to the reservoir for filling the drug into the reservoir. The other end of the microchannel is an opening facing an edge of the eye wearing device for contacting the cornea and/or the sclera, and the opening is connected to the first outer edge of the first surface and the second outer edge of the second surface.
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公开(公告)号：US10143530B2
公开(公告)日：2018-12-04
申请号：US15211141
申请日：2016-07-15
Inventor： Yu-Bing Liou , Hsiu-Ying Wang , Hsin-Yi Hsu , Wei-Li Chen , Chin-Tsung Huang , Hsin-Hsin Shen
Abstract: According to embodiments, a membrane with a flat or curved surface is provided for protection of intraocular tissues. The membrane can be used to cover the cornea for protecting corneal endothelial cells, to cover the anterior and posterior surface of the iris, or to cover the surface of the posterior capsule for separating the intraocular tissues. The membrane has a layered structure, which is composed of a collagen and a hydrophilic biopolymer or an organic polymer material. In particular, the membrane has high transparency and high water retention in a wet state.
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Patent Agency Ranking
公开(公告)号：US20180223238A1
公开(公告)日：2018-08-09
申请号：US15854789
申请日：2017-12-27
Applicant: Industrial Technology Research Institute
Inventor： Ying-Wen Shen , Ing-Kae Wang , Chia-Jung Lu , Yea-Tzy Deng , Yu-Bing Liou , Sing-Ying Hsieh , Hsin-Hsin Shen , Hsiu-Ying Wang
CPC classification number: C12M23/52 , C12M3/04 , C12M23/08 , C12M23/26 , C12M23/40 , C12M23/46 , C12M25/00 , C12M35/04 , C12M35/06 , C12M41/40
Abstract: A cell culture carrier module and a cell culture system having the same are provided. A cell tank and a culture medium module respectively communicate with the carrier module. The carrier module includes a reactor, a first fixer, a second fixer and a plurality of cell culture carriers. The reactor has a chamber and at least one inlet/outlet. The inlet/outlet communicates with the chamber. The first fixer is fixed to the reactor and located in the chamber. The second fixer is disposed in the chamber and is movable relative to the first fixer. Two ends of each cell culture carrier are fixed to the first fixer and the second fixer, respectively. The cell culture carriers are in an untwisted state or a twisted state according to a variation in a distance between the first fixer and the second fixer due to a movement of the second fixer.
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公开(公告)号：US12054612B2
公开(公告)日：2024-08-06
申请号：US17561133
申请日：2021-12-23
Applicant: Industrial Technology Research Institute
Inventor： Yun-Chung Teng , Jen-Huang Huang , Ying-Wen Shen , Yu-Bing Liou , Hsin-Yi Hsu , Li-Hsin Lin , Yuchi Wang , Hsin-Hsin Shen
CPC classification number: C08L89/06 , A61L27/26 , A61L27/52 , B33Y80/00 , C08J3/24 , C12N5/0018 , C08J2389/06 , C08J2489/06 , C08L2203/02 , C08L2205/02 , C08L2205/16 , C08L2312/00 , C12N2500/34
Abstract: A bioprintable material is provided. The bioprintable material includes a hydrogel and microfilaments mixed in the hydrogel. The hydrogel includes a first collagen. The microfilament includes a second collagen. The diameter of the microfilament is ranging from 5 microns to 200 microns. The weight ratio of the microfilaments to the first collagen is ranging from 0.01:1 to 10:1.
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公开(公告)号：US11904581B2
公开(公告)日：2024-02-20
申请号：US17885874
申请日：2022-08-11
Applicant: Industrial Technology Research Institute
Inventor： Hsin-Hsin Shen , Yu-Chi Wang , Ming-Chia Yang , Yu-Bing Liou , Wei-Hong Chang , Yun-Han Lin , Hsin-Yi Hsu , Yun-Chung Teng , Chia-Jung Lu , Yi-Hsuan Lee , Jian-Wei Lin , Kun-Mao Kuo , Ching-Mei Chen
IPC: B32B27/36 , B32B27/24 , B32B27/30 , B05D7/00 , B05D5/08 , B32B38/00 , B32B37/02 , B32B38/16 , B32B37/26
CPC classification number: B32B27/36 , B05D5/08 , B05D7/544 , B05D7/584 , B32B27/24 , B32B27/306 , B32B37/02 , B32B37/26 , B32B38/164 , B32B2038/168 , B32B2307/728 , B32B2307/73 , B32B2535/00
Abstract: A method for preparing a bifunctional film, including: (a) drying a first polymer solution to form a film to form an anti-adhesion layer, and (b) drying a second polymer solution over the anti-adhesion layer to form a film to form an attachment layer. The first polymer solution includes a first hydrophobic solution and a first hydrophilic solution, and in the first polymer solution, the weight ratio of the solute of the first hydrophobic solution to the solute of the first hydrophilic solution is 1:0.01-1. Moreover, the second polymer solution is composed of a second hydrophilic solution.
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公开(公告)号：US11103446B2
公开(公告)日：2021-08-31
申请号：US16731966
申请日：2019-12-31
Applicant: Industrial Technology Research Institute
Inventor： Yu-Bing Liou , Hsin-Yi Hsu , Ying-Wen Shen , Yun-Chung Teng , Yuchi Wang , Hsin-Hsin Shen
Abstract: An ophthalmic drug delivery device and a method for fabricating the same are provided. The ophthalmic drug delivery device includes a shield element and a drug release element. The shield element has a light transmittance more than or equal to 80%. The drug release element is an annular body so that the drug release element surrounds the shield element. The drug release element is neutral and includes a cross-linked neutral collagen, a first hydrophilic biodegradable polymer and a drug. The shield element is acidic and includes a cross-linked acidic collagen and a second hydrophilic biodegradable polymer.
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公开(公告)号：US09107979B2
公开(公告)日：2015-08-18
申请号：US13870178
申请日：2013-04-25
Applicant: Industrial Technology Research Institute
Inventor： Li-Hsin Lin , Hsin-Hsin Shen , Ying-Hsueh Chao , Hsiu-Hua Huang , Yu-Bing Liou , Chih-Bing Hung , Chin-Fu Chen
CPC classification number: A61L27/26 , A61K9/006 , A61K9/70 , A61K9/7007 , A61L27/54 , A61L27/56 , A61L27/58 , C08L67/04 , C08L71/02
Abstract: A bioresorbable porous film, including a blend mixture of polylactic acid and at least two kinds of polyethylene glycol, wherein the at least two kinds of polyethylene glycol include a first polyethylene glycol, which is in a solid form under ambient temperature and atmospheric pressure, and a second polyethylene glycol, which is in a liquid form under ambient temperature and atmospheric pressure is provided. The film has a porosity of 10%-90%.
Abstract translation: 一种生物可吸收多孔膜，其包括聚乳酸和至少两种聚乙二醇的混合物，其中所述至少两种聚乙二醇包括在环境温度和大气压下为固体形式的第一聚乙二醇，以及 提供在环境温度和大气压下为液体形式的第二聚乙二醇。 该膜的孔隙率为10％-90％。
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