公开(公告)号：US20080117416A1

公开(公告)日：2008-05-22

申请号：US11927557

申请日：2007-10-29

申请人： Ian W. Hunter ,  Shyamal Somaroo ,  Serge Lafontaine ,  Patrick A. Anquetil ,  Ching-Hua Tseng

发明人： Ian W. Hunter ,  Shyamal Somaroo ,  Serge Lafontaine ,  Patrick A. Anquetil ,  Ching-Hua Tseng

IPC分类号： G01J3/44

CPC分类号： G01N21/65 ,  A61B5/0059 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/14546 ,  A61B5/412 ,  A61B5/415 ,  A61B5/418 ,  A61B5/444 ,  A61B5/445 ,  G01N21/276 ,  G01N2021/653

摘要： System and methods are provided to perform non-invasive, real-time, continuous molecular detection and quantification of molecular species in a sample or animal subject using Raman spectroscopy. Such systems and methods may be applied to identify and quantify molecular species found in the body, which may be useful for prenatal diagnosis, detecting deep skin infections, performing cerebral spinal fluid assessment, measuring arterial blood gases, blood glucose, cardiac biomarkers, creatinine flow rates. The non-invasive, quantification of such molecular species continuously in real time enables a significantly more attractive course of therapy than existing protocols.

摘要翻译： 提供系统和方法以使用拉曼光谱法来对样品或动物受试者中的分子物质进行非侵入性，实时的，连续的分子检测和定量。 这样的系统和方法可以用于鉴定和定量在体内发现的分子种类，其可用于产前诊断，检测深层皮肤感染，进行脑脊髓液评估，测量动脉血气，血糖，心脏生物标志物，肌酐流 价格。 这种分子物质的非侵入性定量实时连续地实现了比现有方案显着更有吸引力的治疗过程。

公开(公告)号：US20110028676A1

公开(公告)日：2011-02-03

申请号：US12701986

申请日：2010-02-08

申请人： Patrick A. Anquetil ,  Ian W. Hunter ,  John D. Madden ,  Peter G. Madden ,  Anthony E. Pullen ,  Timothy M. Swager ,  Bing Xu ,  Hsiao-hua Yu

发明人： Patrick A. Anquetil ,  Ian W. Hunter ,  John D. Madden ,  Peter G. Madden ,  Anthony E. Pullen ,  Timothy M. Swager ,  Bing Xu ,  Hsiao-hua Yu

IPC分类号： C08G65/38

CPC分类号： H01B1/127 ,  C08G61/122 ,  H01B1/128

摘要： The synthesis of thiophene based conducting polymer molecular actuators, exhibiting electrically triggered molecular conformational transitions is reported. Actuation is believed to be the result of conformational rearrangement of the polymer backbone at the molecular level, not simply ion intercalation in the bulk polymer chain upon electrochemical activation. Molecular actuation results from π-π stacking of thiophene oligomers upon oxidation, producing a reversible molecular displacement that leads to surprising material properties, such as electrically controllable porosity and large strains. The existence of active molecular conformational changes is supported by in situ electrochemical data. Single molecule techniques have been used to characterize the molecular actuators.

摘要翻译： 报道了噻吩基导电聚合物分子致动器的合成，显示出电触发的分子构象转变。 认为激发是聚合物骨架在分子水平上的构象重排的结果，而不是简单地在电化学活化时主体聚合物链中的离子嵌入。 分子致动结果来自＆pgr; - ＆pgr; 在氧化时堆叠噻吩低聚物，产生可逆的分子位移，导致令人惊奇的材料性质，例如电可控孔隙率和大应变。 活性分子构象变化的存在由原位电化学数据支持。 已经使用单分子技术来表征分子致动器。

公开(公告)号：US07138075B2

公开(公告)日：2006-11-21

申请号：US10392354

申请日：2003-03-19

申请人： Patrick A. Anquetil ,  Ian W. Hunter ,  John D. Madden ,  Peter G. Madden ,  Anthony E. Pullen ,  Timothy M. Swager ,  Bing Xu ,  Hsiao-hua Yu

发明人： Patrick A. Anquetil ,  Ian W. Hunter ,  John D. Madden ,  Peter G. Madden ,  Anthony E. Pullen ,  Timothy M. Swager ,  Bing Xu ,  Hsiao-hua Yu

IPC分类号： H01B1/00 ,  C07D495/00

CPC分类号： H01B1/127 ,  C08G61/122 ,  H01B1/128

摘要： The synthesis of thiophene based conducting polymer molecular actuators, exhibiting electrically triggered molecular conformational transitions is reported. Actuation is believed to be the result of conformational rearrangement of the polymer backbone at the molecular level, not simply ion intercalation in the bulk polymer chain upon electrochemical activation. Molecular actuation results from π—π stacking of thiophene oligomers upon oxidation, producing a reversible molecular displacement that leads to surprising material properties, such as electrically controllable porosity and large strains. The existence of active molecular conformational changes is supported by in situ electrochemical data. Single molecule techniques have been used to characterize the molecular actuators.

摘要翻译： 报道了噻吩基导电聚合物分子致动器的合成，显示出电触发的分子构象转变。 认为激发是聚合物骨架在分子水平上的构象重排的结果，而不是简单地在电化学活化时主体聚合物链中的离子嵌入。 分子致动由氧化后噻吩低聚物的pi-pi堆叠产生，产生可逆的分子位移，导致令人惊奇的材料性质，例如电可控孔隙率和大应变。 活性分子构象变化的存在由原位电化学数据支持。 已经使用单分子技术来表征分子致动器。