公开(公告)号：US08114955B2

公开(公告)日：2012-02-14

申请号：US12440484

申请日：2006-09-26

Applicant: Jackie Y. Ying ,  Hsiao-Hua Yu ,  Emril Mohamed Ali ,  Eric Assen B Kantchev

Inventor： Jackie Y. Ying ,  Hsiao-Hua Yu ,  Emril Mohamed Ali ,  Eric Assen B Kantchev

IPC: C08G75/00

CPC classification number: C08G61/123 ,  C08G61/124 ,  C08G61/125 ,  C08G61/126 ,  H01B1/127 ,  H01L51/0037

Abstract: The present invention provides a polymer for use in detecting or quantifying an analyte Exposure of the polymer to the analyte is capable of causing a shift in the onset potential for conductivity or semiconductivity of the polymer. A sensor for an analyte comprising the polymer is also described.

Abstract translation: 本发明提供用于检测或定量分析物的聚合物聚合物对分析物的暴露能够导致聚合物的导电性或半导电性的起始电位的偏移。 还描述了用于包含聚合物的分析物的传感器。

公开(公告)号：US07658868B2

公开(公告)日：2010-02-09

申请号：US11603314

申请日：2006-11-21

Applicant: Patrick A Anquetil ,  Ian W Hunter ,  John D Madden ,  Peter G Madden ,  Anthony E Pullen ,  Timothy M Swager ,  Bing Xu ,  Hsiao-Hua Yu

Inventor： Patrick A Anquetil ,  Ian W Hunter ,  John D Madden ,  Peter G Madden ,  Anthony E Pullen ,  Timothy M Swager ,  Bing Xu ,  Hsiao-Hua Yu

IPC: H01B1/00 ,  C07D495/00

CPC classification number: H01B1/127 ,  C08G61/122 ,  H01B1/128

Abstract: The synthesis of thiophene based conducting polymer molecular actuators, exhibiting electrically triggered molecular conformational transitions is reported. Actuation is believed to be the result of conformational rearrangement of the polymer backbone at the molecular level, not simply ion intercalation in the bulk polymer chain upon electrochemical activation. Molecular actuation results from π-π stacking of thiophene oligomers upon oxidation, producing a reversible molecular displacement that leads to surprising material properties, such as electrically controllable porosity and large strains. The existence of active molecular conformational changes is supported by in situ electrochemical data. Single molecule techniques have been used to characterize the molecular actuators.

Abstract translation: 报道了噻吩基导电聚合物分子致动器的合成，显示出电触发的分子构象转变。 认为激发是聚合物骨架在分子水平上的构象重排的结果，而不是简单地在电化学活化时主体聚合物链中的离子嵌入。 分子致动由氧化后噻吩低聚物的pi-pi堆叠产生，产生可逆的分子位移，导致令人惊奇的材料性质，例如电可控孔隙率和大应变。 活性分子构象变化的存在由原位电化学数据支持。 已经使用单分子技术来表征分子致动器。

公开(公告)号：US20070215839A1

公开(公告)日：2007-09-20

申请号：US11603314

申请日：2006-11-21

Applicant: Patrick Anquetil ,  Ian Hunter ,  John Madden ,  Peter Madden ,  Anthony Pullen ,  Timothy Swager ,  Bing Xu ,  Hsiao-hua Yu

Inventor： Patrick Anquetil ,  Ian Hunter ,  John Madden ,  Peter Madden ,  Anthony Pullen ,  Timothy Swager ,  Bing Xu ,  Hsiao-hua Yu

IPC: H01B1/00 ,  C07D495/00

CPC classification number: H01B1/127 ,  C08G61/122 ,  H01B1/128

Abstract: The synthesis of thiophene based conducting polymer molecular actuators, exhibiting electrically triggered molecular conformational transitions is reported. Actuation is believed to be the result of conformational rearrangement of the polymer backbone at the molecular level, not simply ion intercalation in the bulk polymer chain upon electrochemical activation. Molecular actuation results from π-π stacking of thiophene oligomers upon oxidation, producing a reversible molecular displacement that leads to surprising material properties, such as electrically controllable porosity and large strains. The existence of active molecular conformational changes is supported by in situ electrochemical data. Single molecule techniques have been used to characterize the molecular actuators.

Abstract translation: 报道了噻吩基导电聚合物分子致动器的合成，显示出电触发的分子构象转变。 认为激发是聚合物骨架在分子水平上的构象重排的结果，而不是简单地在电化学活化时主体聚合物链中的离子嵌入。 分子致动由氧化后噻吩低聚物的pi-pi堆叠产生，产生可逆的分子位移，导致令人惊奇的材料性质，例如电可控孔隙率和大应变。 活性分子构象变化的存在由原位电化学数据支持。 已经使用单分子技术来表征分子致动器。

公开(公告)号：US07138075B2

公开(公告)日：2006-11-21

申请号：US10392354

申请日：2003-03-19

Applicant: Patrick A. Anquetil ,  Ian W. Hunter ,  John D. Madden ,  Peter G. Madden ,  Anthony E. Pullen ,  Timothy M. Swager ,  Bing Xu ,  Hsiao-hua Yu

Inventor： Patrick A. Anquetil ,  Ian W. Hunter ,  John D. Madden ,  Peter G. Madden ,  Anthony E. Pullen ,  Timothy M. Swager ,  Bing Xu ,  Hsiao-hua Yu

IPC: H01B1/00 ,  C07D495/00

CPC classification number: H01B1/127 ,  C08G61/122 ,  H01B1/128

Abstract: The synthesis of thiophene based conducting polymer molecular actuators, exhibiting electrically triggered molecular conformational transitions is reported. Actuation is believed to be the result of conformational rearrangement of the polymer backbone at the molecular level, not simply ion intercalation in the bulk polymer chain upon electrochemical activation. Molecular actuation results from π—π stacking of thiophene oligomers upon oxidation, producing a reversible molecular displacement that leads to surprising material properties, such as electrically controllable porosity and large strains. The existence of active molecular conformational changes is supported by in situ electrochemical data. Single molecule techniques have been used to characterize the molecular actuators.

Abstract translation: 报道了噻吩基导电聚合物分子致动器的合成，显示出电触发的分子构象转变。 认为激发是聚合物骨架在分子水平上的构象重排的结果，而不是简单地在电化学活化时主体聚合物链中的离子嵌入。 分子致动由氧化后噻吩低聚物的pi-pi堆叠产生，产生可逆的分子位移，导致令人惊奇的材料性质，例如电可控孔隙率和大应变。 活性分子构象变化的存在由原位电化学数据支持。 已经使用单分子技术来表征分子致动器。

公开(公告)号：US20110028676A1

公开(公告)日：2011-02-03

申请号：US12701986

申请日：2010-02-08

Applicant: Patrick A. Anquetil ,  Ian W. Hunter ,  John D. Madden ,  Peter G. Madden ,  Anthony E. Pullen ,  Timothy M. Swager ,  Bing Xu ,  Hsiao-hua Yu

Inventor： Patrick A. Anquetil ,  Ian W. Hunter ,  John D. Madden ,  Peter G. Madden ,  Anthony E. Pullen ,  Timothy M. Swager ,  Bing Xu ,  Hsiao-hua Yu

IPC: C08G65/38

CPC classification number: H01B1/127 ,  C08G61/122 ,  H01B1/128

Abstract: The synthesis of thiophene based conducting polymer molecular actuators, exhibiting electrically triggered molecular conformational transitions is reported. Actuation is believed to be the result of conformational rearrangement of the polymer backbone at the molecular level, not simply ion intercalation in the bulk polymer chain upon electrochemical activation. Molecular actuation results from π-π stacking of thiophene oligomers upon oxidation, producing a reversible molecular displacement that leads to surprising material properties, such as electrically controllable porosity and large strains. The existence of active molecular conformational changes is supported by in situ electrochemical data. Single molecule techniques have been used to characterize the molecular actuators.

Abstract translation: 报道了噻吩基导电聚合物分子致动器的合成，显示出电触发的分子构象转变。 认为激发是聚合物骨架在分子水平上的构象重排的结果，而不是简单地在电化学活化时主体聚合物链中的离子嵌入。 分子致动结果来自＆pgr; - ＆pgr; 在氧化时堆叠噻吩低聚物，产生可逆的分子位移，导致令人惊奇的材料性质，例如电可控孔隙率和大应变。 活性分子构象变化的存在由原位电化学数据支持。 已经使用单分子技术来表征分子致动器。

公开(公告)号：US20070141726A1

公开(公告)日：2007-06-21

申请号：US11313218

申请日：2005-12-19

Applicant: Jackie Ying ,  Hsiao-Hua Yu ,  Emril Ali ,  Nikhil Jana

Inventor： Jackie Ying ,  Hsiao-Hua Yu ,  Emril Ali ,  Nikhil Jana

IPC: G01N33/553

CPC classification number: G01N21/6489 ,  B82Y15/00 ,  B82Y20/00 ,  B82Y30/00 ,  G01N21/6408 ,  G01N21/77 ,  G01N2021/7786

Abstract: The present invention relates to methods for determination of an analyte. The invention provides various methods involving exposure of a luminescent material to an analyte wherein, upon interaction with the analyte, a change in luminescence may be observed as a function of the duration of exposure to electromagnetic radiation, thereby determining the analyte. Some embodiments of the invention include the use of highly emissive semiconductor nanocrystals.

Abstract translation: 本发明涉及测定分析物的方法。 本发明提供了将发光材料暴露于分析物的各种方法，其中在与分析物相互作用时，可以观察到发光变化作为暴露于电磁辐射的持续时间的函数，从而确定分析物。 本发明的一些实施方案包括使用高发射半导体纳米晶体。

公开(公告)号：US20100126880A1

公开(公告)日：2010-05-27

申请号：US12514299

申请日：2007-11-09

Applicant: Hsiao-Hua Yu ,  Jackie Y. Ying ,  Natalia C. Tansil ,  Eric Assen B. Kantchev

Inventor： Hsiao-Hua Yu ,  Jackie Y. Ying ,  Natalia C. Tansil ,  Eric Assen B. Kantchev

IPC: C07D471/04 ,  C07F15/00 ,  C08F26/06 ,  G01N27/00 ,  G01N27/26

CPC classification number: C07F15/0026 ,  C07D519/00

Abstract: The invention provides a compound of structure (I): wherein X is S, O or NRN, where RN is H or alkyl; L is a linker group; Q is a group capable of binding with dsDNA; G and G′ are, independently, absent or have between 1 and 20 main chain atoms; FG is a functional moiety comprising at least one O or N atom or a transition metal complex; and R is selected from the group consisting of H, alkyl, alkoxy or OCRaRb coupled to an atom in L so as to form a six-membered ring. Ra and Rb are independently H or optionally substituted alkyl.

Abstract translation: 本发明提供结构（I）的化合物：其中X是S，O或NRN，其中RN是H或烷基; L是连接基团; Q是能够与dsDNA结合的基团; G和G'独立地不存在或具有1至20个主链原子; FG是包含至少一个O或N原子或过渡金属络合物的官能部分; 并且R选自与L中的原子偶联的H，烷基，烷氧基或OCRaRb，以形成六元环。 Ra和Rb独立地为H或任选取代的烷基。

公开(公告)号：US20100116682A1

公开(公告)日：2010-05-13

申请号：US12310957

申请日：2007-09-13

Applicant: Pavel Neuzil ,  Hsiao-Hua Yu ,  Jackie Y. Ying

Inventor： Pavel Neuzil ,  Hsiao-Hua Yu ,  Jackie Y. Ying

IPC: G01N27/26 ,  C25B3/00 ,  G01N27/403

CPC classification number: H01L51/0006 ,  G01N27/403 ,  H01L51/0035 ,  H01L51/0036

Abstract: The present invention generally relates to electronic devices and methods. In some cases, the invention provides a sensor device comprising a pair of interdigitated microelectrodes (60), coated with an electrically conducting polymer material (70). The microelectrodes (60) may be surrounded by a first electrode (22), a second electrode (40), and a hydrophobic wall (50).

Abstract translation: 本发明一般涉及电子设备和方法。 在一些情况下，本发明提供一种传感器装置，其包括涂覆有导电聚合物材料（70）的一对叉指式微电极（60）。 微电极（60）可以被第一电极（22），第二电极（40）和疏水壁（50）围绕。

公开(公告)号：US20100048815A1

公开(公告)日：2010-02-25

申请号：US12440484

申请日：2006-09-26

Applicant: Jackie Y. Ying ,  Hsiao-Hua Yu ,  Emril Mohamed Ali ,  Eric Assen B. Kantchev

Inventor： Jackie Y. Ying ,  Hsiao-Hua Yu ,  Emril Mohamed Ali ,  Eric Assen B. Kantchev

IPC: C08G61/12 ,  C08F2/58 ,  C08F2/52 ,  C08G73/06 ,  C08G75/00

CPC classification number: C08G61/123 ,  C08G61/124 ,  C08G61/125 ,  C08G61/126 ,  H01B1/127 ,  H01L51/0037

Abstract: The present invention provides a polymer for use in detecting or quantifying an analyte Exposure of the polymer to the analyte is capable of causing a shift in the onset potential for conductivity or semiconductivity of the polymer. A sensor for an analyte comprising the polymer is also described.

Abstract translation: 本发明提供用于检测或定量分析物的聚合物聚合物对分析物的暴露能够导致聚合物的导电性或半导电性的起始电位的偏移。 还描述了用于包含聚合物的分析物的传感器。

公开(公告)号：US20090186419A1

公开(公告)日：2009-07-23

申请号：US12086716

申请日：2006-01-20

Applicant: Jackie Y. Ying ,  Hsiao-Hua Yu ,  Emril Mohamed Ali

Inventor： Jackie Y. Ying ,  Hsiao-Hua Yu ,  Emril Mohamed Ali

IPC: G01N33/551 ,  B05D5/12 ,  G01N33/50

CPC classification number: G01N33/542 ,  B82Y5/00 ,  C09K11/54 ,  G01N33/533 ,  G01N33/551 ,  Y10T436/147777 ,  Y10T436/16 ,  Y10T436/173845 ,  Y10T436/18 ,  Y10T436/19 ,  Y10T436/20 ,  Y10T436/201666 ,  Y10T436/203332

Abstract: The present invention relates to articles and methods involving luminescent films which may be useful in various applications. Luminescent films of the present invention may comprise a layer of metal oxide nanoparticles and, in some cases, may interact with an analyte to generate a detectable signal, whereby the presence and/or amount of analyte can be determined. In some embodiments, fluorescence resonance energy transfer (FRET) may occur between the luminescent film and the analyte. Such articles and methods may be useful in, for example, biological assays or in sensors.

Abstract translation: 本发明涉及可用于各种应用的涉及发光膜的制品和方法。 本发明的发光膜可以包括一层金属氧化物纳米颗粒，并且在一些情况下可以与分析物相互作用以产生可检测的信号，从而可以确定分析物的存在和/或量。 在一些实施方案中，荧光共振能量转移（FRET）可发生在发光膜和分析物之间。 这样的制品和方法可用于例如生物测定或传感器。