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1.发明授权Substrates of N-end rule ubiquitylation and methods for measuring the ubiquitylation of these substrate 有权N端规则泛素化的底物和测量这些底物的泛素化的方法公开(公告)号：US08530408B2
公开(公告)日：2013-09-10
申请号：US12606787
申请日：2009-10-27
申请人： Ilia Davydov , John H. Kenten , Hans Biebuyck , Pankaj Oberoi
发明人： Ilia Davydov , John H. Kenten , Hans Biebuyck , Pankaj Oberoi
IPC分类号： C07K14/00
CPC分类号： G01N33/573 , C07K14/00 , C07K14/47 , C07K14/4702 , C07K14/4703 , C07K14/4711 , C07K14/4716 , C07K14/4738 , C07K14/705 , C12Q1/25 , C12Q1/37 , G01N2500/04
摘要： The present invention relates to methods, compositions, compounds and kits for detecting, measuring and modulating protein ubiquitylation via the N-end rule pathway and for identifying novel substrates, enzymes and modulators of N-end rule ubiquitylation. The present invention also relates to specific substrates of N-end rule ubiquitylation as well as activated fragments of these substrates, proteases that expose N-degrons in these substrates, ubiquitin ligases that ubiquitylate these substrates and inhibitors of the ubiquitylation of these substrates.
摘要翻译： 本发明涉及用于通过N端规则途径检测，测量和调节蛋白质泛素化的方法，组合物，化合物和试剂盒，并用于鉴定N端规则泛素化的新基质，酶和调节剂。 本发明还涉及N端规则泛素化的特异性底物以及这些底物的活化片段，暴露这些底物中的N-脱落蛋白的蛋白酶，泛素化这些底物的泛素连接酶和这些底物泛素化的抑制剂。
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2.发明申请SUBSTRATES OF N-END RULE UBIQUITYLATION AND METHODS FOR MEASURING THE UBIQUITYLATION OF THESE SUBSTRATE 有权用于测量这些基板的非均匀性的N端规则UBIQUITYLATION的基板和方法公开(公告)号：US20100048485A1
公开(公告)日：2010-02-25
申请号：US12606787
申请日：2009-10-27
申请人： Ilia DAVYDOV , John H. Kenten , Hans Biebuyck , Pankaj Oberoi
发明人： Ilia DAVYDOV , John H. Kenten , Hans Biebuyck , Pankaj Oberoi
IPC分类号： A61K38/16 , C07K14/00 , C12Q1/37 , C40B30/04 , G01N33/53 , C12P21/00 , C12N15/00 , A61P43/00
CPC分类号： G01N33/573 , C07K14/00 , C07K14/47 , C07K14/4702 , C07K14/4703 , C07K14/4711 , C07K14/4716 , C07K14/4738 , C07K14/705 , C12Q1/25 , C12Q1/37 , G01N2500/04
摘要： The present invention relates to methods, compositions, compounds and kits for detecting, measuring and modulating protein ubiquitylation via the N-end rule pathway and for identifying novel substrates, enzymes and modulators of N-end rule ubiquitylation. The present invention also relates to specific substrates of N-end rule ubiquitylation as well as activated fragments of these substrates, proteases that expose N-degrons in these substrates, ubiquitin ligases that ubiquitylate these substrates and inhibitors of the ubiquitylation of these substrates.
摘要翻译： 本发明涉及用于通过N端规则途径检测，测量和调节蛋白质泛素化的方法，组合物，化合物和试剂盒，并用于鉴定N端规则泛素化的新基质，酶和调节剂。 本发明还涉及N端规则泛素化的特异性底物以及这些底物的活化片段，暴露这些底物中的N-脱落蛋白的蛋白酶，泛素化这些底物的泛素连接酶和这些底物泛素化的抑制剂。
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3.发明授权Substrates of N-end rule ubiquitylation and methods for measuring the ubiquitylation of these substrates 有权N端规则泛素化的底物和测量这些底物的泛素化的方法公开(公告)号：US07608682B2
公开(公告)日：2009-10-27
申请号：US10693999
申请日：2003-10-28
申请人： Ilia Davydov , John H. Kenten , Hans Biebuyck , Pankaj Oberoi
发明人： Ilia Davydov , John H. Kenten , Hans Biebuyck , Pankaj Oberoi
CPC分类号： G01N33/573 , C07K14/00 , C07K14/47 , C07K14/4702 , C07K14/4703 , C07K14/4711 , C07K14/4716 , C07K14/4738 , C07K14/705 , C12Q1/25 , C12Q1/37 , G01N2500/04
摘要： The present invention relates to methods, compositions, compounds and kits for detecting, measuring and modulating protein ubiquitylation via the N-end rule pathway and for identifying novel substrates, enzymes and modulators of N-end rule ubiquitylation. The present invention also relates to specific substrates of N-end rule ubiquitylation as well as activated fragments of these substrates, proteases that expose N-degrons in these substrates, ubiquitin ligases that ubiquitylate these substrates and inhibitors of the ubiquitylation of these substrates.
摘要翻译： 本发明涉及用于通过N端规则途径检测，测量和调节蛋白质泛素化的方法，组合物，化合物和试剂盒，并用于鉴定N端规则泛素化的新基质，酶和调节剂。 本发明还涉及N端规则泛素化的特异性底物以及这些底物的活化片段，暴露这些底物中的N-脱落蛋白的蛋白酶，泛素化这些底物的泛素连接酶和这些底物泛素化的抑制剂。
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公开(公告)号：US20100048593A1
公开(公告)日：2010-02-25
申请号：US12390692
申请日：2009-02-23
申请人： Allan M. Weissman , Karen H. Vousden , Jane P. Jensen , Yili Yang , Shengyun Fang , Douglas Woods , John H. Kenten , Ilia Davydov , Yassamin J. Safiran , Pankaj Oberoi
发明人： Allan M. Weissman , Karen H. Vousden , Jane P. Jensen , Yili Yang , Shengyun Fang , Douglas Woods , John H. Kenten , Ilia Davydov , Yassamin J. Safiran , Pankaj Oberoi
IPC分类号： A61K31/519 , C07D239/70 , A61P35/00
CPC分类号： C07D471/04
摘要： The present invention features 5-deazaflavin compounds, pharmaceutical compositions of 5-deazaflavin compounds and methods of treating a patient suffering from cancer, the method comprising administering to a patient one or more 5-deazaflavin compounds of the invention.
摘要翻译： 本发明的特征在于5-脱氮黄素化合物，5-脱氮黄素化合物的药物组合物和治疗患有癌症的患者的方法，所述方法包括向患者施用本发明的一种或多种5-脱氮嘌呤化合物。
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公开(公告)号：US07498336B2
公开(公告)日：2009-03-03
申请号：US10545547
申请日：2004-02-12
申请人： Allan M. Weissman , Karen H. Vousden , Jane P. Jensen , Yili Yang , Shengyun Fang , Douglas Woods , John H. Kenten , Ilia Davydov , Yassamin J. Safiran , Pankaj Oberoi
发明人： Allan M. Weissman , Karen H. Vousden , Jane P. Jensen , Yili Yang , Shengyun Fang , Douglas Woods , John H. Kenten , Ilia Davydov , Yassamin J. Safiran , Pankaj Oberoi
IPC分类号： A01N43/54 , A61K31/505 , C07D239/00 , C07D471/00 , C07D487/00 , C07D491/00
CPC分类号： C07D471/04
摘要： The present invention features 5-deazaflavin compounds, pharmaceutical compositions of 5-deazaflavin compounds and methods of treating a patient suffering from cancer, the method comprising administering to a patient one or more 5-deazaflavin compounds of the invention.
摘要翻译： 本发明的特征在于5-脱氮黄素化合物，5-脱氮黄素化合物的药物组合物和治疗患有癌症的患者的方法，所述方法包括向患者施用本发明的一种或多种5-脱氮嘌呤化合物。
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公开(公告)号：US07063946B2
公开(公告)日：2006-06-20
申请号：US10238960
申请日：2002-09-10
申请人： John H. Kenten , Hans Biebuyck , Ilia Davydov , Nisar Pampori , Steven Yan Cheng , Stefanie Nelson
发明人： John H. Kenten , Hans Biebuyck , Ilia Davydov , Nisar Pampori , Steven Yan Cheng , Stefanie Nelson
IPC分类号： C12Q1/68
CPC分类号： G01N33/5304 , C12Q1/485 , G01N33/54366 , G01N33/54373 , G01N33/5438 , G01N33/54386 , G01N33/56944 , G01N33/56983 , G01N33/56988 , G01N33/573 , G01N33/68 , G01N33/6803 , G01N33/6842 , G01N33/6845 , G01N2333/11 , G01N2333/135 , G01N2333/16 , G01N2333/525 , G01N2333/5412 , G01N2333/545 , G01N2333/57 , G01N2333/71 , G01N2333/9121 , Y10S436/807
摘要： Apparatus, systems, system components, methods, compositions, and reagents for determining the function and activity of peptides and proteins and for identifying and characterizing molecules that affect these functions and activities. More specifically, methods and reagents used to determine the various activities of peptides and proteins including their binding specificity, binding activity, their enzymatic activity and their ability to act as substrates for enzymes. The disclosed methods are especially suited for the analysis of peptide and protein function where large numbers of peptides and proteins need to be analyzed.
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公开(公告)号：US20110105354A1
公开(公告)日：2011-05-05
申请号：US12977271
申请日：2010-12-23
申请人： Eli N. Glezer , Kent Johnson , Michael Tsionsky , John H. Kenten , Jeff D. Debad , Robert M. Umek , Paula Denney Eason , Hans Biebuyck , Jacob N. Wohlstadter , James Wilbur , George Sigal , Niranjan Y. Sardesai
发明人： Eli N. Glezer , Kent Johnson , Michael Tsionsky , John H. Kenten , Jeff D. Debad , Robert M. Umek , Paula Denney Eason , Hans Biebuyck , Jacob N. Wohlstadter , James Wilbur , George Sigal , Niranjan Y. Sardesai
CPC分类号： G01N33/5304 , C12Q1/485 , G01N33/54366 , G01N33/54373 , G01N33/5438 , G01N33/54386 , G01N33/56944 , G01N33/56983 , G01N33/56988 , G01N33/573 , G01N33/68 , G01N33/6803 , G01N33/6842 , G01N33/6845 , G01N2333/11 , G01N2333/135 , G01N2333/16 , G01N2333/525 , G01N2333/5412 , G01N2333/545 , G01N2333/57 , G01N2333/71 , G01N2333/9121 , Y10S436/807
摘要： Multiplexed test measurements are conducted using an assay module having a plurality of assay domains. In preferred embodiments, these measurements are conducted in assay modules having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
摘要翻译： 使用具有多个测定域的测定模块进行多重测试测量。 在优选实施方案中，这些测量在具有集成电极的测定模块中进行，所述测量模块具有适于接收测定模块的读取器装置，在测定模块的孔或测定区域中诱导发光，优选电极诱导的发光并测量诱导的发光。
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公开(公告)号：US07858321B2
公开(公告)日：2010-12-28
申请号：US10238391
申请日：2002-09-10
申请人： Eli N. Glezer , Kent Johnson , Michael Tsionsky , John H. Kenten , Jeff D. Debad , Robert M. Umek , Paula Denney Eason , Hans Biebuyck , Jacob N. Wohlstadter , James Wilbur , George Sigal , Niranjan Y. Sardesai
发明人： Eli N. Glezer , Kent Johnson , Michael Tsionsky , John H. Kenten , Jeff D. Debad , Robert M. Umek , Paula Denney Eason , Hans Biebuyck , Jacob N. Wohlstadter , James Wilbur , George Sigal , Niranjan Y. Sardesai
IPC分类号： G01N33/53
CPC分类号： G01N33/5304 , C12Q1/485 , G01N33/54366 , G01N33/54373 , G01N33/5438 , G01N33/54386 , G01N33/56944 , G01N33/56983 , G01N33/56988 , G01N33/573 , G01N33/68 , G01N33/6803 , G01N33/6842 , G01N33/6845 , G01N2333/11 , G01N2333/135 , G01N2333/16 , G01N2333/525 , G01N2333/5412 , G01N2333/545 , G01N2333/57 , G01N2333/71 , G01N2333/9121 , Y10S436/807
摘要： Multiplexed test measurements are conducted using an assay module having a plurality of assay domains. In preferred embodiments, these measurements are conducted in assay modules having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
摘要翻译： 使用具有多个测定域的测定模块进行多重测试测量。 在优选实施方案中，这些测量在具有集成电极的测定模块中进行，所述测量模块具有适于接收测定模块的读取器装置，在测定模块的孔或测定区域中诱导发光，优选电极诱导的发光并测量诱导的发光。
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公开(公告)号：US09354230B2
公开(公告)日：2016-05-31
申请号：US12977271
申请日：2010-12-23
申请人： Eli N. Glezer , Kent Johnson , Michael Tsionsky , John H. Kenten , Jeff D. Debad , Robert M. Umek , Paula Denney Eason , Hans Biebuyck , Jacob N. Wohlstadter , James Wilbur , George Sigal , Niranjan Y. Sardesai
发明人： Eli N. Glezer , Kent Johnson , Michael Tsionsky , John H. Kenten , Jeff D. Debad , Robert M. Umek , Paula Denney Eason , Hans Biebuyck , Jacob N. Wohlstadter , James Wilbur , George Sigal , Niranjan Y. Sardesai
IPC分类号： G01N33/543 , C12Q1/48 , G01N33/68
CPC分类号： G01N33/5304 , C12Q1/485 , G01N33/54366 , G01N33/54373 , G01N33/5438 , G01N33/54386 , G01N33/56944 , G01N33/56983 , G01N33/56988 , G01N33/573 , G01N33/68 , G01N33/6803 , G01N33/6842 , G01N33/6845 , G01N2333/11 , G01N2333/135 , G01N2333/16 , G01N2333/525 , G01N2333/5412 , G01N2333/545 , G01N2333/57 , G01N2333/71 , G01N2333/9121 , Y10S436/807
摘要： Multiplexed test measurements are conducted using an assay module having a plurality of assay domains. In preferred embodiments, these measurements are conducted in assay modules having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
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10.发明授权公开(公告)号：US07662642B2
公开(公告)日：2010-02-16
申请号：US10681388
申请日：2003-10-07
IPC分类号： G01N33/567 , G01N33/53 , A61K39/00
CPC分类号： C07K14/61 , A61K39/00 , C07K14/00 , C07K2319/00 , C07K2319/35 , C07K2319/40 , C07K2319/75 , C07K2319/95 , C12N15/62
摘要： Disclosed are epitope-containing heat shock fusion proteins, DNA constructs encoding such fusion proteins, and methods of use. More specifically, disclosed are ubiquitin fusion proteins comprising ubiquitin fused to a plurality of identical or non-identical epitopes at specified locations.
摘要翻译： 公开了含表位的热休克融合蛋白，编码这种融合蛋白的DNA构建体和使用方法。 更具体地，公开了包含在指定位置融合到多个相同或不相同表位的泛素的泛素融合蛋白。
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