公开(公告)号：US20240218443A1

公开(公告)日：2024-07-04

申请号：US18393291

申请日：2023-12-21

申请人： Illumina, Inc.

发明人： Angelica Mariani ,  Antoine Francais ,  Frederick James Topping ,  Christopher Winnard ,  Philip Balding ,  Chol Steven Yun ,  Patrizia Iavicoli ,  Kathryn Hattingh ,  Xiaolin Wu ,  Xiaohai Liu

IPC分类号： C12Q1/6874 ,  B01J23/44 ,  C12Q1/48 ,  C12Q1/6806 ,  G01N21/64

CPC分类号： C12Q1/6874 ,  B01J23/44 ,  C12Q1/485 ,  C12Q1/6806 ,  G01N21/6486 ,  G01N2333/9126

摘要： The present application relates to palladium compositions, methods for sequencing by synthesis using nucleotides with 3′ blocking groups, and sequencing kits, where one or more palladium scavengers were used to improve sequencing metrics such phasing and prephasing values.

公开(公告)号：US20220396832A1

公开(公告)日：2022-12-15

申请号：US17748498

申请日：2022-05-19

申请人： Illumina Cambridge Limited ,  Illumina, Inc.

发明人： Angelica Mariani ,  Antoine Francais ,  Frederick James Topping ,  Christopher Winnard ,  Philip Balding ,  Chol Steven Yun ,  Patrizia Iavicoli

IPC分类号： C12Q1/6869

摘要： The present application relates to compositions and methods for sequencing by synthesis, where one or more palladium scavengers were used to improve sequencing metrics such phasing and prephasing values.

公开(公告)号：US20230314322A1

公开(公告)日：2023-10-05

申请号：US18190809

申请日：2023-03-27

申请人： Illumina, Inc. ,  Illumina Cambridge Limited

发明人： Michael James Callingham ,  Michael John Burek ,  Christopher Winnard ,  Oliver Jon Miller

IPC分类号： G01N21/64 ,  C12Q1/6874

CPC分类号： G01N21/6428 ,  C12Q1/6874

摘要： The application relates to DNA sequencing systems and methods. Systems and methods for determining the nucleotide sequence of a polynucleotide include attaching three different fluorescent dyes to three different nucleotides during incorporation. In particular, long Stokes shifted dyes may be used to determine the sequence of polynucleotides in a sequencing by synthesis system.