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    Method of fabricating nanostructure array and device including nanostructure array
    1.
    发明授权
    Method of fabricating nanostructure array and device including nanostructure array 有权
    制造纳米结构阵列的方法和包括纳米结构阵列的器件

    公开(公告)号：US08758985B2

    公开(公告)日：2014-06-24

    申请号：US13198892

    申请日：2011-08-05

    申请人： Kyeong Seok Lee ,  Won Mok Kim ,  In Ho Kim

    发明人： Kyeong Seok Lee ,  Won Mok Kim ,  In Ho Kim

    IPC分类号： G03F7/26

    CPC分类号： G03F7/2016 ,  G03F7/201

    摘要： Provided are a method of fabricating a nanostructure array and a device including the nanostructure array. Nanoscale patterning is caused at an interface of a resist layer by light passed through a focusing layer. By such nanoscale patterning, a nanostructure array is fabricated on a substrate in various ways. As the focusing layer, an array of beads or lenses is used, and a pattern of the resist layer may include a nanoscale pore-opening and an undercut structure connected to a lower portion of the opening. The method facilitates adjustment of the size and shape of nanostructures and the interval between the nanostructures. Also, performance of the device including the nanostructure array can be improved. In particular, the method and device result in a sensor having improved sensitivity and reliability optimized for an environment and purpose to be used.

    摘要翻译： 提供制造纳米结构阵列的方法和包括纳米结构阵列的器件。 通过穿过聚焦层的光在抗蚀剂层的界面处引起纳米级图案化。 通过这种纳米尺度的图案化，以各种方式在衬底上制造纳米结构阵列。 作为聚焦层，使用珠或透镜的阵列，并且抗蚀剂层的图案可以包括连接到开口的下部的纳米级孔隙和底切结构。 该方法有助于调整纳米结构的尺寸和形状以及纳米结构之间的间隔。 此外，可以提高包括纳米结构阵列的器件的性能。 特别地，该方法和装置导致传感器具有针对要使用的环境和目的优化的改进的灵敏度和可靠性。

    QUINOLONE CARBOXYLIC ACID-SUBSTITUTED RIFAMYCIN DERIVATIVES
    2.
    发明申请
    QUINOLONE CARBOXYLIC ACID-SUBSTITUTED RIFAMYCIN DERIVATIVES 有权
    喹诺酮羧酸取代的赖氨明衍生物

    公开(公告)号：US20090143373A1

    公开(公告)日：2009-06-04

    申请号：US12269652

    申请日：2008-11-12

    申请人： Charles Z. Ding ,  Yafei Jin ,  Keith Combrink ,  In Ho Kim

    发明人： Charles Z. Ding ,  Yafei Jin ,  Keith Combrink ,  In Ho Kim

    IPC分类号： A61K31/4709 ,  C07D498/04 ,  C07D471/20 ,  A61K31/5383 ,  A61P31/04

    CPC分类号： C07D491/20 ,  C07D498/16

    摘要： The compounds include substituted rifamycin derivatives in which a quinolone carboxylic acid pharmacophore is covalently bonded to a benzoxazinorifamycin or a spiropiperidinorifamycin. The rifamycin derivatives are useful as antimicrobial agents and are effective against a number of human and veterinary Gram positive and Gram negative pathogens. The advantage of the inventive compounds is that both the rifamycin and quinolone antibacterial pharmacophores are co-delivered with matched pharmacokinetics to the targeted pathogens of interests. Delivery of multiple antibacterial pharmacophores simultaneously to the targeted pathogens has the maximum chance of achieving synergy and minimizing the development of resistance to the antibiotics given.

    摘要翻译： 化合物包括取代的利福霉素衍生物，其中喹诺酮羧酸药效团与苯并恶嗪利福霉素或螺哌啶利多霉素共价键合。 利福霉素衍生物可用作抗微生物剂，并且对许多人和兽医革兰氏阳性和革兰氏阴性病原体有效。 本发明化合物的优点在于利福霉素和喹诺酮类抗菌药代动力剂与匹配的药代动力学共同输送到感兴趣的靶向病原体。 同时向目标病原体递送多个抗菌药代动力，最大限度地实现协同作用，并最大限度地减少给予抗生素的耐药性。

    Spiro-rifamycin derivatives targeting RNA polymerase
    3.
    发明授权
    Spiro-rifamycin derivatives targeting RNA polymerase 有权
    螺 - 利福霉素衍生物靶向RNA聚合酶

    公开(公告)号：US07202246B2

    公开(公告)日：2007-04-10

    申请号：US11147520

    申请日：2005-06-08

    申请人： Zhenkun Ma ,  In Ho Kim ,  Jing Li

    发明人： Zhenkun Ma ,  In Ho Kim ,  Jing Li

    IPC分类号： C07D225/04 ,  A61K31/495 ,  A61P31/04

    CPC分类号： C07D491/22

    摘要： Compounds of the current invention relate to rifamycin derivatives having antimicrobial activities, including activities against drug-resistant microorganisms. More specifically, compounds of the current invention relate to a series of novel spiro rifamycin derivatives which have demonstrated potent antimicrobial activity.

    摘要翻译： 本发明的化合物涉及具有抗微生物活性的利福霉素衍生物，包括抗耐药微生物的活性。 更具体地，本发明的化合物涉及一系列已经证明有效的抗微生物活性的新型螺利福霉素衍生物。

    FIBER-OPTIC SURFACE PLASMON RESONANCE SENSOR AND SENSING METHOD USING THE SAME
    4.
    发明申请
    FIBER-OPTIC SURFACE PLASMON RESONANCE SENSOR AND SENSING METHOD USING THE SAME 有权
    光纤表面等离子体共振传感器和使用该传感器的感光方法

    公开(公告)号：US20130120752A1

    公开(公告)日：2013-05-16

    申请号：US13357837

    申请日：2012-01-25

    申请人： Kyeong Seok LEE ,  Won Mok Kim ,  Taek Sung Lee ,  In Ho Kim

    发明人： Kyeong Seok LEE ,  Won Mok Kim ,  Taek Sung Lee ,  In Ho Kim

    IPC分类号： G01N21/55

    CPC分类号： G02B6/02 ,  G01N21/553 ,  G02B5/008 ,  G02B6/1226

    摘要： A fiber-optic surface plasmon resonance sensor may include an optical fiber and a surface plasmon excitation layer. The optical fiber may include a core, a cladding surrounding the core, and a depression. The surface plasmon excitation layer may include a first excitation layer, a second excitation layer and an optical waveguide layer between the first excitation layer and the second excitation layer. Incident light incident through the core may be coupled to the surface plasmon excitation layer at a specific angle of incidence and wavelength satisfying the surface plasmon resonance condition. Depending on the polarizing direction of the incident light, an s-polarized component may be coupled to the guided-wave mode in the optical waveguide layer constituting the surface plasmon excitation layer.

    摘要翻译： 光纤表面等离子体共振传感器可以包括光纤和表面等离子体激元层。 光纤可以包括芯，围绕芯的包层和凹陷。 表面等离子激元激发层可以包括在第一激发层和第二激发层之间的第一激发层，第二激发层和光波导层。 通过芯入射的入射光可以以满足表面等离子体共振条件的特定入射角和波长耦合到表面等离子体激发层。 根据入射光的偏振方向，可以在构成表面等离子体激发层的光波导层中将s偏振分量耦合到导波模式。

    IMAGE PHOTOGRAPHING APPARATUS AND METHOD OF CONTROLLING THE SAME
    7.
    发明申请
    IMAGE PHOTOGRAPHING APPARATUS AND METHOD OF CONTROLLING THE SAME 有权
    图像摄影装置及其控制方法

    公开(公告)号：US20100271485A1

    公开(公告)日：2010-10-28

    申请号：US12760697

    申请日：2010-04-15

    申请人： In Ho Kim

    发明人： In Ho Kim

    IPC分类号： H04N5/225

    CPC分类号： H04N5/232 ,  G06K9/32 ,  H04N5/23245 ,  H04N5/23254

    摘要： A method of controlling an image photographing apparatus to track a subject using a non-viewable pixel region of an image sensor includes detecting a motion vector of a subject when a moving image is photographed, determining whether a non-viewable pixel region of an image sensor is present in the direction of the detected motion vector of the subject, and moving a photographing region to the non-viewable pixel region so as to track the motion of the subject. Accordingly, the moving subject may be tracked within a range of a predetermined Field of View (FOV) of the image photographing apparatus without an additional hardware system.

    摘要翻译： 使用图像传感器的不可见像素区域来控制图像拍摄设备跟踪对象的方法包括：当拍摄运动图像时检测被摄体的运动矢量，确定图像传感器的不可见像素区域 存在于检测到的对象的运动矢量的方向上，并且将拍摄区域移动到不可见像素区域，以便跟踪被摄体的运动。 因此，可以在没有附加硬件系统的图像拍摄装置的预定视场（FOV）的范围内跟踪移动的被摄体。

    Rifamycin imino derivatives effective against drug-resistant microbes
    9.
    发明授权
    Rifamycin imino derivatives effective against drug-resistant microbes 有权
    对抗耐药性微生物有效的利福霉素亚氨基衍生物

    公开(公告)号：US07238694B2

    公开(公告)日：2007-07-03

    申请号：US11034279

    申请日：2005-01-12

    申请人： Charles Z. Ding ,  Yafei Jin ,  Jamie C. Longgood ,  Zhenkun Ma ,  Jing Li ,  In Ho Kim ,  Keith P. Minor ,  Susan Harran

    发明人： Charles Z. Ding ,  Yafei Jin ,  Jamie C. Longgood ,  Zhenkun Ma ,  Jing Li ,  In Ho Kim ,  Keith P. Minor ,  Susan Harran

    IPC分类号： C07D498/08 ,  C07D519/00 ,  A61K31/4709 ,  A61K31/496 ,  A61P31/04

    CPC分类号： C07D498/08 ,  C07D519/00

    摘要： The present invention relates to rifamycin 3-iminomethylenyl (—CH═N—) derivatives having antimicrobial activities, including activities against drug-resistant microorganisms. The claimed rifamycin derivative has a rifamycin moiety covalently linked to a linker through an iminomethylenyl (—CH═N—) group at the C-3 carbon of the rifamycin moiety and the linker is, in turn, covalently linked to a quinolone structure or its pharmacophore within the DNA gyrase and topoisomerase IV inhibitor family. The inventive rifamycins are novel and exhibit activity against both rifampin and ciprofloxacin-resistant microorganisms.

    摘要翻译： 本发明涉及具有抗菌活性的利福霉素3-亚氨基亚甲基（-CH-N-）衍生物，其包括抗药性微生物的活性。 所要求的利福霉素衍生物具有通过利莫霉素部分的C-3碳上的亚氨基亚甲基（-CH-N-）基团与连接体共价连接的利福霉素部分，并且连接体又与喹诺酮结构共价连接或其 DNA促旋酶和拓扑异构酶IV抑制剂家族内的药效团。 本发明的利福霉素是新颖的，并且表现出抵抗利福平和环丙沙星抗性微生物的活性。