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    FIBER-OPTIC SURFACE PLASMON RESONANCE SENSOR AND SENSING METHOD USING THE SAME
    7.
    发明申请
    FIBER-OPTIC SURFACE PLASMON RESONANCE SENSOR AND SENSING METHOD USING THE SAME 有权
    光纤表面等离子体共振传感器和使用该传感器的感光方法

    公开(公告)号：US20130120752A1

    公开(公告)日：2013-05-16

    申请号：US13357837

    申请日：2012-01-25

    申请人： Kyeong Seok LEE ,  Won Mok Kim ,  Taek Sung Lee ,  In Ho Kim

    发明人： Kyeong Seok LEE ,  Won Mok Kim ,  Taek Sung Lee ,  In Ho Kim

    IPC分类号： G01N21/55

    CPC分类号： G02B6/02 ,  G01N21/553 ,  G02B5/008 ,  G02B6/1226

    摘要： A fiber-optic surface plasmon resonance sensor may include an optical fiber and a surface plasmon excitation layer. The optical fiber may include a core, a cladding surrounding the core, and a depression. The surface plasmon excitation layer may include a first excitation layer, a second excitation layer and an optical waveguide layer between the first excitation layer and the second excitation layer. Incident light incident through the core may be coupled to the surface plasmon excitation layer at a specific angle of incidence and wavelength satisfying the surface plasmon resonance condition. Depending on the polarizing direction of the incident light, an s-polarized component may be coupled to the guided-wave mode in the optical waveguide layer constituting the surface plasmon excitation layer.

    摘要翻译： 光纤表面等离子体共振传感器可以包括光纤和表面等离子体激元层。 光纤可以包括芯，围绕芯的包层和凹陷。 表面等离子激元激发层可以包括在第一激发层和第二激发层之间的第一激发层，第二激发层和光波导层。 通过芯入射的入射光可以以满足表面等离子体共振条件的特定入射角和波长耦合到表面等离子体激发层。 根据入射光的偏振方向，可以在构成表面等离子体激发层的光波导层中将s偏振分量耦合到导波模式。

    Fiber-optic surface plasmon resonance sensor and sensing method using the same
    8.
    发明授权
    Fiber-optic surface plasmon resonance sensor and sensing method using the same 有权
    光纤表面等离子体共振传感器和感测方法使用相同

    公开(公告)号：US09285534B2

    公开(公告)日：2016-03-15

    申请号：US13357837

    申请日：2012-01-25

    申请人： Kyeong Seok Lee ,  Won Mok Kim ,  Taek Sung Lee ,  In Ho Kim

    发明人： Kyeong Seok Lee ,  Won Mok Kim ,  Taek Sung Lee ,  In Ho Kim

    IPC分类号： G02B6/00 ,  G02F1/035 ,  G02B6/02 ,  G02B5/00 ,  G01N21/552 ,  G02B6/122

    CPC分类号： G02B6/02 ,  G01N21/553 ,  G02B5/008 ,  G02B6/1226

    摘要： A fiber-optic surface plasmon resonance sensor may include an optical fiber and a surface plasmon excitation layer. The optical fiber may include a core, a cladding surrounding the core, and a depression. The surface plasmon excitation layer may include a first excitation layer, a second excitation layer and an optical waveguide layer between the first excitation layer and the second excitation layer. Incident light incident through the core may be coupled to the surface plasmon excitation layer at a specific angle of incidence and wavelength satisfying the surface plasmon resonance condition. Depending on the polarizing direction of the incident light, an s-polarized component may be coupled to the guided-wave mode in the optical waveguide layer constituting the surface plasmon excitation layer.

    摘要翻译： 光纤表面等离子体共振传感器可以包括光纤和表面等离子体激元层。 光纤可以包括芯，围绕芯的包层和凹陷。 表面等离子激元激发层可以包括在第一激发层和第二激发层之间的第一激发层，第二激发层和光波导层。 通过芯入射的入射光可以以满足表面等离子体共振条件的特定入射角和波长耦合到表面等离子体激发层。 根据入射光的偏振方向，可以在构成表面等离子体激发层的光波导层中将s偏振分量耦合到导波模式。

    Method of fabricating nanostructure array and device including nanostructure array
    9.
    发明授权
    Method of fabricating nanostructure array and device including nanostructure array 有权
    制造纳米结构阵列的方法和包括纳米结构阵列的器件

    公开(公告)号：US08758985B2

    公开(公告)日：2014-06-24

    申请号：US13198892

    申请日：2011-08-05

    申请人： Kyeong Seok Lee ,  Won Mok Kim ,  In Ho Kim

    发明人： Kyeong Seok Lee ,  Won Mok Kim ,  In Ho Kim

    IPC分类号： G03F7/26

    CPC分类号： G03F7/2016 ,  G03F7/201

    摘要： Provided are a method of fabricating a nanostructure array and a device including the nanostructure array. Nanoscale patterning is caused at an interface of a resist layer by light passed through a focusing layer. By such nanoscale patterning, a nanostructure array is fabricated on a substrate in various ways. As the focusing layer, an array of beads or lenses is used, and a pattern of the resist layer may include a nanoscale pore-opening and an undercut structure connected to a lower portion of the opening. The method facilitates adjustment of the size and shape of nanostructures and the interval between the nanostructures. Also, performance of the device including the nanostructure array can be improved. In particular, the method and device result in a sensor having improved sensitivity and reliability optimized for an environment and purpose to be used.

    摘要翻译： 提供制造纳米结构阵列的方法和包括纳米结构阵列的器件。 通过穿过聚焦层的光在抗蚀剂层的界面处引起纳米级图案化。 通过这种纳米尺度的图案化，以各种方式在衬底上制造纳米结构阵列。 作为聚焦层，使用珠或透镜的阵列，并且抗蚀剂层的图案可以包括连接到开口的下部的纳米级孔隙和底切结构。 该方法有助于调整纳米结构的尺寸和形状以及纳米结构之间的间隔。 此外，可以提高包括纳米结构阵列的器件的性能。 特别地，该方法和装置导致传感器具有针对要使用的环境和目的优化的改进的灵敏度和可靠性。

    QUINOLONE CARBOXYLIC ACID-SUBSTITUTED RIFAMYCIN DERIVATIVES
    10.
    发明申请
    QUINOLONE CARBOXYLIC ACID-SUBSTITUTED RIFAMYCIN DERIVATIVES 有权
    喹诺酮羧酸取代的赖氨明衍生物

    公开(公告)号：US20090143373A1

    公开(公告)日：2009-06-04

    申请号：US12269652

    申请日：2008-11-12

    申请人： Charles Z. Ding ,  Yafei Jin ,  Keith Combrink ,  In Ho Kim

    发明人： Charles Z. Ding ,  Yafei Jin ,  Keith Combrink ,  In Ho Kim

    IPC分类号： A61K31/4709 ,  C07D498/04 ,  C07D471/20 ,  A61K31/5383 ,  A61P31/04

    CPC分类号： C07D491/20 ,  C07D498/16

    摘要： The compounds include substituted rifamycin derivatives in which a quinolone carboxylic acid pharmacophore is covalently bonded to a benzoxazinorifamycin or a spiropiperidinorifamycin. The rifamycin derivatives are useful as antimicrobial agents and are effective against a number of human and veterinary Gram positive and Gram negative pathogens. The advantage of the inventive compounds is that both the rifamycin and quinolone antibacterial pharmacophores are co-delivered with matched pharmacokinetics to the targeted pathogens of interests. Delivery of multiple antibacterial pharmacophores simultaneously to the targeted pathogens has the maximum chance of achieving synergy and minimizing the development of resistance to the antibiotics given.

    摘要翻译： 化合物包括取代的利福霉素衍生物，其中喹诺酮羧酸药效团与苯并恶嗪利福霉素或螺哌啶利多霉素共价键合。 利福霉素衍生物可用作抗微生物剂，并且对许多人和兽医革兰氏阳性和革兰氏阴性病原体有效。 本发明化合物的优点在于利福霉素和喹诺酮类抗菌药代动力剂与匹配的药代动力学共同输送到感兴趣的靶向病原体。 同时向目标病原体递送多个抗菌药代动力，最大限度地实现协同作用，并最大限度地减少给予抗生素的耐药性。