公开(公告)号：US10006913B2

公开(公告)日：2018-06-26

申请号：US14777636

申请日：2014-03-20

Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

Inventor： Adam Zlotnick ,  Lichun Li ,  Michael S. Van Nieuwenhze ,  William W. Turner

IPC: A61B5/00 ,  A61B8/00 ,  A61B10/00 ,  G01N33/569 ,  C09B11/08 ,  C09B11/24 ,  C09B23/02 ,  C09B57/00 ,  C09B57/02 ,  C09B57/10 ,  C12Q1/18 ,  A61K49/00

CPC classification number: G01N33/56983 ,  A61K49/0017 ,  C09B11/08 ,  C09B11/24 ,  C09B23/02 ,  C09B57/00 ,  C09B57/02 ,  C09B57/10 ,  C12Q1/18 ,  G01N2333/02 ,  G01N2500/02 ,  G01N2500/04 ,  G01N2500/10

Abstract: Heteroaryldihydropyrimidine (HAP)-based fluorescent stains (compounds), as well as uses of such stains as diagnostic reagents, viral-tracking agents, and/or tools for drug discovery are described. The present invention relates to heteroaryldihydropyrimidine (HAP)-based fluorescent stains (compounds), as well as uses of such stains as diagnostic reagents, viral-tracking agents, and/or tools for drug discovery.

公开(公告)号：US09796722B1

公开(公告)日：2017-10-24

申请号：US15294010

申请日：2016-10-14

Applicant: Indiana University Research and Technology Corporation

Inventor： Adam Zlotnick ,  Lichun Li ,  William W. Turner, Jr.

IPC: C07D487/04 ,  A61K47/00 ,  A61K31/519 ,  A61K45/06

CPC classification number: C07D487/04 ,  A61K31/519 ,  A61K45/06

Abstract: Novel virus assembly effector compounds having a therapeutic effect against Hepatitis B viral infection are disclosed. Assembly effector molecules described herein can lead to defective viral assembly and also may affect other viral activities associated with chronic HBV infection. Also disclosed are pharmaceutical compositions including the disclosed compounds, methods of treatment of HBV infection, and a process to synthesize the disclosed compounds.