公开(公告)号：US10183936B2

公开(公告)日：2019-01-22

申请号：US15125911

申请日：2015-03-13

Applicant: Indiana University Research and Technology Corporation ,  Assembly Biosciences, Inc.

Inventor： William W. Turner, Jr. ,  Lee Daniel Arnold ,  Hans Maag ,  Adam Zlotnick

IPC: C07D417/12 ,  C07D403/12 ,  C07D223/20 ,  C07D401/12 ,  C07D413/12 ,  C07D243/38 ,  C07D281/14 ,  A61K31/55 ,  A61K31/5513 ,  A61K31/553 ,  A61K31/554 ,  A61K45/06 ,  C07D281/16

Abstract: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

公开(公告)号：US20180099952A1

公开(公告)日：2018-04-12

申请号：US15566633

申请日：2016-04-15

Applicant: Indiana University Research and Technology Corporation

Inventor： Lee Daniel Arnold ,  Hans Maag ,  William W. Turner, Jr.

IPC: C07D403/14 ,  C07D403/04 ,  C07D401/04 ,  C07D401/14 ,  C07D417/14 ,  A61P31/20

CPC classification number: C07D403/14 ,  A61K31/496 ,  A61K31/506 ,  A61P31/20 ,  C07D213/74 ,  C07D239/42 ,  C07D239/47 ,  C07D239/48 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D409/12 ,  C07D413/04 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14

Abstract: Novel assembly effector compounds having a therapeutic effect against hepatitis B viral (HBV) infection are disclosed. Assembly effector molecules described herein can lead to defective viral assembly and also may affect other viral activities associated with chronic HBV infection. Also disclosed is a process to synthesize disclosed compounds, method of treatment of HBV by administration of disclosed compounds, and use of these compounds in the manufacture of medicaments against HBV.

公开(公告)号：US11814376B2

公开(公告)日：2023-11-14

申请号：US17140800

申请日：2021-01-04

Applicant: Assembly Biosciences, Inc. ,  INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

Inventor： William W. Turner, Jr. ,  Lee D. Arnold ,  Hans Maag ,  Leping Li ,  Mark G. Bures ,  Simon Nicolas Haydar ,  Samson Francis

IPC: A61K45/06 ,  A61K31/554 ,  A61P31/20 ,  C07D417/12 ,  C07D403/12 ,  C07D401/12 ,  C07D413/12 ,  C07D417/14 ,  C07D453/02 ,  C07D471/04 ,  C07D243/38 ,  C07D267/20 ,  C07D281/16

CPC classification number: C07D417/12 ,  A61K31/554 ,  A61K45/06 ,  A61P31/20 ,  C07D243/38 ,  C07D267/20 ,  C07D281/16 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/14 ,  C07D453/02 ,  C07D471/04

Abstract: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

公开(公告)号：US10968211B2

公开(公告)日：2021-04-06

申请号：US16426727

申请日：2019-05-30

Applicant: Assembly Biosciences, Inc. ,  INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

Inventor： William W. Turner, Jr. ,  Lee D. Arnold ,  Hans Maag ,  Leping Li ,  Mark G. Bures ,  Simon Nicolas Haydar ,  Samson Francis

IPC: C07D417/12 ,  C07D403/12 ,  A61K45/06 ,  C07D401/12 ,  C07D413/12 ,  C07D417/14 ,  C07D453/02 ,  C07D471/04 ,  A61P31/20 ,  C07D243/38 ,  C07D267/20 ,  C07D281/16

Abstract: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

公开(公告)号：US10947224B2

公开(公告)日：2021-03-16

申请号：US15965655

申请日：2018-04-27

Applicant: Indiana University Research and Technology Corporation ,  Assembly Biosciences, Inc.

Inventor： William W. Turner, Jr. ,  Lee Daniel Arnold ,  Hans Maag ,  Adam Zlotnick

IPC: A61P31/12 ,  C07D417/12 ,  C07D403/12 ,  C07D223/20 ,  C07D401/12 ,  C07D413/12 ,  C07D243/38 ,  C07D281/14 ,  A61K31/55 ,  A61K31/5513 ,  A61K31/553 ,  A61K31/554 ,  A61K45/06 ,  C07D281/16

Abstract: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

公开(公告)号：US10273228B2

公开(公告)日：2019-04-30

申请号：US15566633

申请日：2016-04-15

Applicant: Indiana University Research and Technology Corporation

Inventor： Lee Daniel Arnold ,  Hans Maag ,  William W. Turner, Jr.

IPC: C07D403/14 ,  C07D401/04 ,  C07D403/12 ,  C07D401/12 ,  C07D403/04 ,  C07D239/42 ,  C07D239/48 ,  C07D409/12 ,  C07D417/04 ,  C07D417/12 ,  C07D401/14 ,  C07D417/14 ,  C07D213/74 ,  C07D239/47 ,  C07D413/04 ,  A61K31/496 ,  A61K31/506 ,  A61P31/20

Abstract: Novel assembly effector compounds having a therapeutic effect against hepatitis B viral (HBV) infection are disclosed. Assembly effector molecules described herein can lead to defective viral assembly and also may affect other viral activities associated with chronic HBV infection. Also disclosed is a process to synthesize disclosed compounds, method of treatment of HBV by administration of disclosed compounds, and use of these compounds in the manufacture of medicaments against HBV.

公开(公告)号：US09796722B1

公开(公告)日：2017-10-24

申请号：US15294010

申请日：2016-10-14

Applicant: Indiana University Research and Technology Corporation

Inventor： Adam Zlotnick ,  Lichun Li ,  William W. Turner, Jr.

IPC: C07D487/04 ,  A61K47/00 ,  A61K31/519 ,  A61K45/06

CPC classification number: C07D487/04 ,  A61K31/519 ,  A61K45/06

Abstract: Novel virus assembly effector compounds having a therapeutic effect against Hepatitis B viral infection are disclosed. Assembly effector molecules described herein can lead to defective viral assembly and also may affect other viral activities associated with chronic HBV infection. Also disclosed are pharmaceutical compositions including the disclosed compounds, methods of treatment of HBV infection, and a process to synthesize the disclosed compounds.