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公开(公告)号:US20150118322A1
公开(公告)日:2015-04-30
申请号:US14514137
申请日:2014-10-14
Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Inventor: Ya-Chin LO , Hsiang-Fa LIANG , Ming-Cheng WEI , Maggie J.M. LU , Min-Ying LIN , Chih-Peng LIU , Chun-MIN LIU , Hsiang-Wen TSENG , Tse-Min TENG , Jui-Hsiang CHEN , Yi-Man CHOU , Yi-Ting HSIEH , Chia-Mu TU
IPC: C08B37/08 , A61K33/24 , A61K31/4745 , A61K31/7036 , A61K47/48 , A61K31/704
CPC classification number: A61K33/24 , A61K31/4172 , A61K31/4745 , A61K31/555 , A61K31/7036 , A61K31/704 , A61K31/728 , A61K45/06 , A61K47/542 , A61K47/61 , A61K47/6921 , A61K2300/00
Abstract: The disclosure provides a biomedical composition, including: a hyaluronic acid; a modified histidine; and a polymer or C4-C20 alkane, wherein the modified histidine and the polymer or C4-C20 alkane are grafted to at least one primary hydroxyl group of the hyaluronic acid to allow the hyaluronic acid to form a hyaluronic acid derivative, wherein a graft ratio of the modified histidine is about 1-100%, and a graft ratio of the polymer or C4-C20 alkane is about 0-40%.
Abstract translation: 本公开提供了一种生物医学组合物,其包括:透明质酸; 修饰的组氨酸 和聚合物或C 4 -C 20烷烃,其中将经修饰的组氨酸和聚合物或C 4 -C 20烷烃接枝至透明质酸的至少一个伯羟基,以使透明质酸形成透明质酸衍生物,其中接枝率 的改性组氨酸约为1-100%,聚合物或C4-C20烷烃的接枝率约为0-40%。
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公开(公告)号:US20140186415A1
公开(公告)日:2014-07-03
申请号:US14132796
申请日:2013-12-18
Applicant: Industrial Technology Research Institute
Inventor: Ting-Yu SHIH , Tse-Min TENG , Chia-Chun WANG , Yu-Hua CHEN , Jui-Hsiang CHEN , Mei-Ju YANG , Shu-Fang CHIANG , Yen-Chun CHEN , Chia-Ni CHANG
CPC classification number: A61K31/4172 , A61K31/715 , A61K31/717 , A61K31/728 , A61K31/765 , A61K47/58 , A61K47/61 , A61L15/24 , A61L15/28 , A61L15/44 , A61L27/16 , A61L27/20 , A61L27/54 , A61L29/041 , A61L29/043 , A61L29/16 , A61L31/042 , A61L31/048 , A61L31/16 , A61L2300/204 , A61L2300/434 , C08B11/04 , C08B11/08 , C08B11/20 , C08B15/06 , C08B37/0072 , C08L1/08 , C08L1/26 , C08L1/284 , C08L5/08
Abstract: A polymer composition including a polymer having a hydroxyl group and a histidine or a histidine derivative grafted to the polymer having a hydroxyl group. A polymer material is also provided, including a polymer composition which includes a polymer having a hydroxyl group, and a histidine or a histidine derivative grafted to the polymer having a hydroxyl group.
Abstract translation: 包括具有羟基的聚合物和接枝到具有羟基的聚合物上的组氨酸或组氨酸衍生物的聚合物组合物。 还提供了聚合物材料,包括包含具有羟基的聚合物的聚合物组合物和接枝到具有羟基的聚合物上的组氨酸或组氨酸衍生物。
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