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公开(公告)号：US08993630B2
公开(公告)日：2015-03-31
申请号：US13128274
申请日：2009-10-28
IPC分类号： A01N41/06 , A61K31/18 , A01N43/40 , C07C303/00 , C07C307/00 , C07C309/00 , C07C311/00 , C07D213/72 , C07C311/08
CPC分类号： C07C311/08
摘要： The present invention relates to substituted sulphonamido phenoxybenzamide compounds of general formula (I): in which A, R1, R2, R3, R4, R5, R6, R7, R8 and n are as defined in the claims, to pharmaceutical compositions and combinations containing said compounds, to methods of preparing said compounds, and to the use of said compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及通式（I）的取代磺酰胺基苯氧基苯甲酰胺化合物：其中A，R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8和n如权利要求中所定义， 所述化合物，制备所述化合物的方法，以及所述化合物或组合物用于治疗高增殖性和/或血管生成障碍，作为唯一试剂或与其它活性成分组合的用途。
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公开(公告)号：US20110218219A1
公开(公告)日：2011-09-08
申请号：US13128274
申请日：2009-10-28
IPC分类号： A61K31/18 , C07C311/08 , C12N5/00 , C07C303/40 , C07C303/38 , C07D213/76 , A61K31/44 , A61P35/00 , A61P17/06 , A61P37/06 , A61P29/00 , A61P27/02 , B65D85/00
CPC分类号： C07C311/08
摘要： The present invention relates to substituted sulphonamido phenoxybenzamide compounds of general formula (I): in which A, R1, R2, R3, R4, R5, R6, R7, R8 and n are as defined in the claims, to pharmaceutical compositions and combinations containing said compounds, to methods of preparing said compounds, and to the use of said compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及通式（I）的取代磺酰胺基苯氧基苯甲酰胺化合物：其中A，R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8和n如权利要求中所定义， 所述化合物，制备所述化合物的方法，以及所述化合物或组合物用于治疗高增殖性和/或血管生成障碍，作为唯一试剂或与其它活性成分组合的用途。
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公开(公告)号：US20120263714A1
公开(公告)日：2012-10-18
申请号：US13502545
申请日：2010-10-12
IPC分类号： A61K31/165 , C07C303/40 , A61K31/513 , A61K39/395 , A61K31/337 , A61K31/427 , A61K31/573 , A61K31/704 , A61K38/14 , A61K33/24 , A61K31/282 , A61K31/69 , A61K31/52 , A61K31/7076 , A61K31/664 , A61P35/00 , A61P37/02 , A61P29/00 , C07C307/10
CPC分类号： C07C307/06 , A61K31/10 , A61K31/136 , A61K31/145 , A61K31/18
摘要： The present invention relates to substituted halophenoxybenzamide derivative compounds of general formula (I) in which R1, R2, R3, R3a, R4, R5, R6, Ra, Rb, Rc, and X are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及通式（I）的取代的卤代苯氧基苯甲酰胺衍生物，其中R1，R2，R3，R3a，R4，R5，R6，Ra，Rb，Rc和X如权利要求中所定义， 所述化合物，包含所述化合物的药物组合物和组合以及用于制备用于治疗或预防疾病，特别是高增殖性和/或血管生成障碍的药物组合物的所述化合物用作单一药剂或 与其他活性成分组合。
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公开(公告)号：US20140255392A1
公开(公告)日：2014-09-11
申请号：US14110105
申请日：2012-03-28
IPC分类号： C07D471/04 , A61K31/444 , A61K45/06 , A61K31/437
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K45/06 , A61K2300/00
摘要： The present invention relates to substituted imidazopyridine compounds of general formula (I) in which R3, R5 and A are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及通式（I）的取代的咪唑并吡啶化合物，其中R3，R5和A如权利要求中所定义，所述化合物的制备方法，药物组合物和包含所述化合物的组合以及所述化合物的用途 用于制造用于治疗或预防疾病，特别是高增殖性和/或血管生成障碍的药物组合物，作为唯一试剂或与其它活性成分组合。
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公开(公告)号：US09388140B2
公开(公告)日：2016-07-12
申请号：US14008981
申请日：2012-03-28
申请人： Ulrich Klar , Marcus Koppitz , Duy Nguyen , Dirk Kosemund , Roland Neuhaus , Gerhard Siemeister
发明人： Ulrich Klar , Marcus Koppitz , Duy Nguyen , Dirk Kosemund , Roland Neuhaus , Gerhard Siemeister
IPC分类号： A61K31/415 , C07D235/00 , C07D235/18 , C07D231/56 , C07D235/08 , C07D401/04 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/12 , A61K45/06 , A61K31/4184 , A61K31/4196 , A61K31/422 , A61K31/4439 , A61K31/5377 , C07D401/06
CPC分类号： C07D235/08 , A61K31/4184 , A61K31/4196 , A61K31/422 , A61K31/4439 , A61K31/5377 , A61K45/06 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/12 , A61K2300/00
摘要： The present invention relates to substituted benzimidazole compounds of general formula (I) in which R3, R5 and A are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及通式（I）的取代的苯并咪唑化合物，其中R3，R5和A如权利要求中所定义，所述化合物的制备方法，药物组合物和包含所述化合物的组合以及所述化合物的用途 用于制造用于治疗或预防疾病，特别是高增殖性和/或血管生成障碍的药物组合物，作为唯一试剂或与其它活性成分组合。
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公开(公告)号：US20140302010A1
公开(公告)日：2014-10-09
申请号：US14008981
申请日：2012-03-28
申请人： Ulrich Klar , Marcus Koppitz , Duy Nguyen , Dirk Kosemund , Roland Neuhaus , Gerhard Siemeister
发明人： Ulrich Klar , Marcus Koppitz , Duy Nguyen , Dirk Kosemund , Roland Neuhaus , Gerhard Siemeister
IPC分类号： C07D235/08 , C07D401/06 , A61K31/4439 , C07D405/12 , A61K45/06 , A61K31/5377 , C07D413/12 , A61K31/422 , C07D403/12 , A61K31/4196 , A61K31/4184 , C07D403/04
CPC分类号： C07D235/08 , A61K31/4184 , A61K31/4196 , A61K31/422 , A61K31/4439 , A61K31/5377 , A61K45/06 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/12 , A61K2300/00
摘要： The present invention relates to substituted benzimidazole compounds of general formula (I) in which R3, R5 and A are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及通式（I）的取代的苯并咪唑化合物，其中R3，R5和A如权利要求中所定义，所述化合物的制备方法，药物组合物和包含所述化合物的组合以及所述化合物的用途 用于制造用于治疗或预防疾病，特别是高增殖性和/或血管生成障碍的药物组合物，作为唯一试剂或与其它活性成分组合。
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公开(公告)号：US09676766B2
公开(公告)日：2017-06-13
申请号：US13512701
申请日：2010-11-17
申请人： Volker Schulze , Marcus Koppitz , Dirk Kosemund , Hartmut Schirok , Benjamin Bader , Philip Lienau , Antje Margret Wengner , Hans Briem , Simon Holton , Gerhard Siemeister , Stefan Prechtl , Ulf Bömer
发明人： Volker Schulze , Marcus Koppitz , Dirk Kosemund , Hartmut Schirok , Benjamin Bader , Philip Lienau , Antje Margret Wengner , Hans Briem , Simon Holton , Gerhard Siemeister , Stefan Prechtl , Ulf Bömer
IPC分类号： A61K31/437 , A61K31/5377 , C07D491/08 , C07D471/04
CPC分类号： C07D471/04 , A61K31/437 , A61K31/5377 , A61K2300/00
摘要： The present invention relates to triazolopyridine compounds of general formula (I) which are Monopolar Spindle 1 kinase (Mps-1 or TTK) inhibitors: Formula (I), in which R1, R2, R3, R4, and R5 are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis proliferative of diseases, as well as to intermediate compounds useful in the preparation of said compounds.
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公开(公告)号：US09468642B2
公开(公告)日：2016-10-18
申请号：US13635734
申请日：2011-03-16
申请人： Ulrich Klar , Marcus Koppitz , Dirk Kosemund , Rolf Bohlmann , Benjamin Bader , Philip Lienau , Gerhard Siemeister , Stefan Prechtl , Duy Nguyen , William Scott
发明人： Ulrich Klar , Marcus Koppitz , Dirk Kosemund , Rolf Bohlmann , Benjamin Bader , Philip Lienau , Gerhard Siemeister , Stefan Prechtl , Duy Nguyen , William Scott
IPC分类号： C07D487/14 , A61K31/519 , C07D487/04 , A61K45/06
CPC分类号： A61K31/519 , A61K45/06 , C07D487/04 , C07D487/14
摘要： The present invention relates to imidazopyrazine compounds of general Formula (I): in which X, R1, R2, R3a, R3b, R4a, R4b, R4C, and R4D are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.
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9.发明授权公开(公告)号：US09340528B2
公开(公告)日：2016-05-17
申请号：US13393583
申请日：2010-08-24
申请人： Benjamin Bader , Ulf Bömer , Stuart Ince , Marcus Koppitz , Philip Lienau , Tobias Marquardt , Duy Nguyen , Stefan Prechtl , Gerhard Siemeister , Christof Wegscheid-Gerlach
发明人： Benjamin Bader , Ulf Bömer , Stuart Ince , Marcus Koppitz , Philip Lienau , Tobias Marquardt , Duy Nguyen , Stefan Prechtl , Gerhard Siemeister , Christof Wegscheid-Gerlach
IPC分类号： A01N43/58 , A01N43/60 , A61K31/50 , A61K31/495 , C07D401/14 , C07D401/04 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D487/04
CPC分类号： C07D401/14 , C07D401/04 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D487/04
摘要： The present invention relates to substituted aminoquinoxaline compounds of general formula (I) in which (II), R2, R3, R4, R6, R7, n and m are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.
摘要翻译： 本发明涉及通式（I）的取代氨基喹喔啉化合物，其中（II），R2，R3，R4，R6，R7，n和m如说明书和权利要求书中所给出，涉及制备所述化合物的方法 涉及包含所述化合物的药物组合物和组合，用于制备用于治疗或预防疾病的药物组合物的所述化合物的用途，以及可用于制备所述化合物的中间体化合物。
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公开(公告)号：US09255100B2
公开(公告)日：2016-02-09
申请号：US13822175
申请日：2011-09-06
申请人： Ulrich Klar , Marcus Koppitz , Rolf Jautelat , Dirk Kosemund , Rolf Bohlmann , Philip Lienau , Gerhard Siemeister , Antje Margret Wengner
发明人： Ulrich Klar , Marcus Koppitz , Rolf Jautelat , Dirk Kosemund , Rolf Bohlmann , Philip Lienau , Gerhard Siemeister , Antje Margret Wengner
IPC分类号： C07D487/04 , A61K31/5025 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D471/04
CPC分类号： C07D487/04 , A61K31/5025 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D471/04
摘要： The present invention relates to substituted imidazopyridazine compounds of general formula (I), which are Mps-1 (Monopolar Spindle 1) Kinase inhibitors (also known as Tyrosine Threonine Kinase, TTK) in which R3, R5, and A are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及通式（I）的取代的咪唑并哒嗪化合物，其是Mps-1（单极主轴1）激酶抑制剂（也称为酪氨酸苏氨酸激酶，TTK），其中R3，R5和A如 对于制备所述化合物的方法，涉及包含所述化合物的药物组合物和组合，以及所述化合物用于制备用于治疗或预防疾病，特别是高增殖和/或血管生成障碍的药物组合物的用途 ，作为唯一的药剂或与其它活性成分组合。
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