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1.
公开(公告)号:US09340528B2
公开(公告)日:2016-05-17
申请号:US13393583
申请日:2010-08-24
申请人: Benjamin Bader , Ulf Bömer , Stuart Ince , Marcus Koppitz , Philip Lienau , Tobias Marquardt , Duy Nguyen , Stefan Prechtl , Gerhard Siemeister , Christof Wegscheid-Gerlach
发明人: Benjamin Bader , Ulf Bömer , Stuart Ince , Marcus Koppitz , Philip Lienau , Tobias Marquardt , Duy Nguyen , Stefan Prechtl , Gerhard Siemeister , Christof Wegscheid-Gerlach
IPC分类号: A01N43/58 , A01N43/60 , A61K31/50 , A61K31/495 , C07D401/14 , C07D401/04 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D487/04
CPC分类号: C07D401/14 , C07D401/04 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D487/04
摘要: The present invention relates to substituted aminoquinoxaline compounds of general formula (I) in which (II), R2, R3, R4, R6, R7, n and m are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.
摘要翻译: 本发明涉及通式(I)的取代氨基喹喔啉化合物,其中(II),R2,R3,R4,R6,R7,n和m如说明书和权利要求书中所给出,涉及制备所述化合物的方法 涉及包含所述化合物的药物组合物和组合,用于制备用于治疗或预防疾病的药物组合物的所述化合物的用途,以及可用于制备所述化合物的中间体化合物。
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2.
公开(公告)号:US20120263708A1
公开(公告)日:2012-10-18
申请号:US13393583
申请日:2010-08-24
申请人: Benjamin Bader , Ulf Bömer , Stuart Ince , Marcus Koppitz , Philip Lienau , Tobias Marquardt , Duy Nguyen , Stefan Prechtl , Gerhard Siemeister , Christof Wegscheid-Gerlach
发明人: Benjamin Bader , Ulf Bömer , Stuart Ince , Marcus Koppitz , Philip Lienau , Tobias Marquardt , Duy Nguyen , Stefan Prechtl , Gerhard Siemeister , Christof Wegscheid-Gerlach
IPC分类号: A61K31/498 , A61K31/5377 , C07D413/14 , C07D401/04 , C07D401/14 , C07D403/04 , A61K31/551 , C07D403/14 , C07D405/14 , C07D409/14 , C07D487/04 , A61K31/4985 , A61K31/506 , A61K31/573 , A61K31/565 , A61K31/704 , A61K38/14 , A61K31/7048 , A61K31/675 , A61K31/7068 , A61K31/7076 , A61K31/69 , A61K33/24 , A61K39/395 , A61P35/00 , A61P29/00 , A61P37/00 , A61P35/02 , A61P35/04 , A61K31/513 , A61K31/501 , C07D413/04
CPC分类号: C07D401/14 , C07D401/04 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D487/04
摘要: The present invention relates to substituted aminoquinoxaline compounds of general formula (I) in which (II), R2, R3, R4, R6, R7, n and m are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.
摘要翻译: 本发明涉及通式(I)的取代氨基喹喔啉化合物,其中(II),R2,R3,R4,R6,R7,n和m如说明书和权利要求书中所给出,涉及制备所述化合物的方法 涉及包含所述化合物的药物组合物和组合,用于制备用于治疗或预防疾病的药物组合物的所述化合物的用途,以及可用于制备所述化合物的中间体化合物。
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公开(公告)号:US20130121994A1
公开(公告)日:2013-05-16
申请号:US13512721
申请日:2010-11-26
申请人: Marcus Koppitz , Volker Schulze , Dirk Kosemund , Hartmut Schirok , Benjamin Bader , Philip Lienau , Tobias Marquardt , Christof Wegscheid-Gerlach , Gerhard Siemeister , Stefan Prechtl , Antje Margret Wengner , Ulf Bömer
发明人: Marcus Koppitz , Volker Schulze , Dirk Kosemund , Hartmut Schirok , Benjamin Bader , Philip Lienau , Tobias Marquardt , Christof Wegscheid-Gerlach , Gerhard Siemeister , Stefan Prechtl , Antje Margret Wengner , Ulf Bömer
IPC分类号: C07D471/04 , A61K31/506 , A61K31/444 , A61K31/337 , A61K39/395 , A61K33/24 , A61K31/282 , A61K31/513 , A61K31/664 , A61K31/427 , A61K31/573 , A61K31/565 , A61K31/704 , A61K31/7076 , A61K31/437
CPC分类号: C07D471/04 , A61K31/282 , A61K31/337 , A61K31/427 , A61K31/437 , A61K31/444 , A61K31/506 , A61K31/513 , A61K31/565 , A61K31/573 , A61K31/664 , A61K31/704 , A61K31/7076 , A61K33/24 , A61K39/3955
摘要: The present invention relates to triazolopyridine compounds of general formula (I) which are Monopolar Spindle 1 kinase (Mps-1 or TTK) inhibitors in which R1, R2, R3, R4, and R5 are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of proliferative diseases, as well as to intermediate compounds useful in the preparation of said compounds.
摘要翻译: 本发明涉及通式(I)的三唑并吡啶化合物,其是单极主轴1激酶(Mps-1或TTK)抑制剂,其中R1,R2,R3,R4和R5如说明书和权利要求书中所给出, 涉及制备所述化合物的方法,包含所述化合物的药物组合物和组合,以及所述化合物用于制备用于治疗或预防增殖性疾病的药物组合物的用途,以及可用于制备所述化合物的中间体化合物。
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公开(公告)号:US20120128662A1
公开(公告)日:2012-05-24
申请号:US13264627
申请日:2010-04-24
申请人: Marcus Koppitz , Benjamin Bader , Ulf Bömer , Bertolt Kreft , Philip Lienau , Tobias Marquardt , Stefan Prechtl , Gerhard Siemeister , Christof Wegscheid-Gerlach
发明人: Marcus Koppitz , Benjamin Bader , Ulf Bömer , Bertolt Kreft , Philip Lienau , Tobias Marquardt , Stefan Prechtl , Gerhard Siemeister , Christof Wegscheid-Gerlach
IPC分类号: A61K31/4985 , A61K31/5377 , A61K31/573 , A61K31/565 , A61K31/7048 , A61P35/02 , A61K31/675 , A61K33/24 , A61K31/69 , A61K39/395 , A61P35/00 , A61P35/04 , C07D487/04 , A61K31/7064
CPC分类号: C07D487/02
摘要: The present invention relates to substituted imidazoquinoxaline compounds of general formula (I) as inhibitors of Mps-1 Kinase or TTK, and being active against inflammation and cancer.
摘要翻译: 本发明涉及作为Mps-1激酶或TTK的抑制剂的通式(I)的取代咪唑并喹喔啉化合物,并且对炎症和癌症具有活性。
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公开(公告)号:US08729082B2
公开(公告)日:2014-05-20
申请号:US13264627
申请日:2010-04-24
申请人: Marcus Koppitz , Benjamin Bader , Ulf Bömer , Bertolt Kreft , Philip Lienau , Tobias Marquardt , Stefan Prechtl , Gerhard Siemeister , Christof Wegscheid-Gerlach
发明人: Marcus Koppitz , Benjamin Bader , Ulf Bömer , Bertolt Kreft , Philip Lienau , Tobias Marquardt , Stefan Prechtl , Gerhard Siemeister , Christof Wegscheid-Gerlach
IPC分类号: A61K31/4985 , A61K31/5377 , C07D487/04
CPC分类号: C07D487/02
摘要: The present invention relates to substituted imidazoquinoxaline compounds of general formula (I) as inhibitors of Mps-1 Kinase or TTK, and being active against inflammation and cancer.
摘要翻译: 本发明涉及作为Mps-1激酶或TTK的抑制剂的通式(I)的取代咪唑并喹喔啉化合物,并且对炎症和癌症具有活性。
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公开(公告)号:US09676766B2
公开(公告)日:2017-06-13
申请号:US13512701
申请日:2010-11-17
申请人: Volker Schulze , Marcus Koppitz , Dirk Kosemund , Hartmut Schirok , Benjamin Bader , Philip Lienau , Antje Margret Wengner , Hans Briem , Simon Holton , Gerhard Siemeister , Stefan Prechtl , Ulf Bömer
发明人: Volker Schulze , Marcus Koppitz , Dirk Kosemund , Hartmut Schirok , Benjamin Bader , Philip Lienau , Antje Margret Wengner , Hans Briem , Simon Holton , Gerhard Siemeister , Stefan Prechtl , Ulf Bömer
IPC分类号: A61K31/437 , A61K31/5377 , C07D491/08 , C07D471/04
CPC分类号: C07D471/04 , A61K31/437 , A61K31/5377 , A61K2300/00
摘要: The present invention relates to triazolopyridine compounds of general formula (I) which are Monopolar Spindle 1 kinase (Mps-1 or TTK) inhibitors: Formula (I), in which R1, R2, R3, R4, and R5 are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis proliferative of diseases, as well as to intermediate compounds useful in the preparation of said compounds.
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公开(公告)号:US20120328610A1
公开(公告)日:2012-12-27
申请号:US13512701
申请日:2010-11-17
申请人: Volker Schulze , Marcus Koppitz , Dirk Kosemund , Hartmut Schirok , Benjamin Bader , Philip Lienau , Antje Margret Wengner , Hans Briem , Simon Holton , Gerhard Siemeister , Stefan Prechtl , Ulf Bömer
发明人: Volker Schulze , Marcus Koppitz , Dirk Kosemund , Hartmut Schirok , Benjamin Bader , Philip Lienau , Antje Margret Wengner , Hans Briem , Simon Holton , Gerhard Siemeister , Stefan Prechtl , Ulf Bömer
IPC分类号: A61K31/437 , A61K31/444 , A61K31/496 , A61K31/5377 , A61K31/4545 , A61K31/573 , A61K31/567 , A61K31/4745 , A61K31/704 , A61K38/14 , A61K31/664 , A61K31/513 , A61K31/7076 , A61K31/69 , A61K33/24 , A61K31/519 , A61K39/395 , A61P35/00 , A61P35/02 , A61P35/04 , A61K31/7068 , A61K31/52 , C07D471/04
CPC分类号: C07D471/04 , A61K31/437 , A61K31/5377 , A61K2300/00
摘要: The present invention relates to triazolopyridine compounds of general formula (I) which are Monopolar Spindle 1 kinase (Mps-1 or TTK) inhibitors: Formula (I), in which R1, R2, R3, R4, and R5 are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis proliferative of diseases, as well as to intermediate compounds useful in the preparation of said compounds.
摘要翻译: 本发明涉及通式(I)的三唑并吡啶化合物,它们是单极主轴1激酶(Mps-1或TTK)抑制剂:式(I),其中R 1,R 2,R 3,R 4和R 5如 描述和权利要求书中涉及制备所述化合物的方法,药物组合物和包含所述化合物的组合,用于制备用于治疗或预防疾病增殖的药物组合物的所述化合物的用途,以及可用于 所述化合物的制备。
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公开(公告)号:US09669034B2
公开(公告)日:2017-06-06
申请号:US14122063
申请日:2012-05-21
申请人: Ulrich Lücking , Rolf Bohlmann , Arne Scholz , Gerhard Siemeister , Mark Jean Gnoth , Ulf Bömer , Dirk Kosemund , Philip Lienau , Gerd Rühter , Carsten Schultz-Fademrecht
发明人: Ulrich Lücking , Rolf Bohlmann , Arne Scholz , Gerhard Siemeister , Mark Jean Gnoth , Ulf Bömer , Dirk Kosemund , Philip Lienau , Gerd Rühter , Carsten Schultz-Fademrecht
IPC分类号: C07D251/42 , C07D251/44 , C07D405/04 , A61K31/53 , A61P35/00 , C07D251/16 , C07D251/22 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07C381/10
CPC分类号: A61K31/53 , C07B59/002 , C07B2200/05 , C07C381/10 , C07D251/16 , C07D251/22 , C07D251/42 , C07D251/44 , C07D401/12 , C07D405/04 , C07D405/12 , C07D413/12 , C07D417/12
摘要: The present invention relates to 4-aryl-N-phenyl-1,3,5-triazin-2-amines containing a sulfoximine group of general formula (I) or (Ia) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I) or (Ia).
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公开(公告)号:US08916557B2
公开(公告)日:2014-12-23
申请号:US14112484
申请日:2012-04-18
申请人: Ulrich Lücking , Rolf Bohlmann , Arne Scholz , Gerhard Siemeister , Mark Jean Gnoth , Ulf Bömer , Gerd Rühter , Carsten Schultz-Fademrecht , Dirk Kosemund , Philip Lienau
发明人: Ulrich Lücking , Rolf Bohlmann , Arne Scholz , Gerhard Siemeister , Mark Jean Gnoth , Ulf Bömer , Gerd Rühter , Carsten Schultz-Fademrecht , Dirk Kosemund , Philip Lienau
IPC分类号: C07D251/42 , C07D401/04 , C07D405/04 , C07D401/12 , C07D405/12
CPC分类号: C07D251/42 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12
摘要: The present invention relates to substituted 4-Aryl-N-phenyl-1,3,5-triazin-2-amines of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).
摘要翻译: 本发明涉及如本文所述和定义的通式(I)的取代的4-芳基-N-苯基-1,3,5-三嗪-2-胺及其制备方法及其用于治疗和/ 或预防疾病,特别是高增殖性疾病和/或病毒诱导的传染病和/或心血管疾病。 本发明还涉及可用于制备所述通式(I)化合物的中间体化合物。
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公开(公告)号:US09108926B2
公开(公告)日:2015-08-18
申请号:US14343983
申请日:2012-09-13
申请人: Ulrich Lücking , Dirk Kosemund , Arne Scholz , Philip Lienau , Gerhard Siemeister , Ulf Bömer , Rolf Bohlmann
发明人: Ulrich Lücking , Dirk Kosemund , Arne Scholz , Philip Lienau , Gerhard Siemeister , Ulf Bömer , Rolf Bohlmann
IPC分类号: C07D239/42 , C07D401/12 , C07D407/04 , A61K31/505 , A61K31/506 , C07D405/04
CPC分类号: C07D239/42 , A61K31/505 , A61K31/506 , C07D401/12 , C07D405/04 , C07D407/04
摘要: The present invention relates to disubstituted 5-fluoro-pyrimidines of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).
摘要翻译: 本发明涉及如本文所述和定义的通式(I)的二取代的5-氟 - 嘧啶及其制备方法,其用于治疗和/或预防病症,特别是高增殖性疾病和/ 或病毒诱导的传染病和/或心血管疾病。 本发明还涉及可用于制备所述通式(I)化合物的中间体化合物。
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