公开(公告)号：US20110117167A1

公开(公告)日：2011-05-19

申请号：US12949104

申请日：2010-11-18

申请人： Isaac Gilliam Sanford ,  Michelle Steffen Jansen ,  Paul Theodore Hamilton ,  Jonathan Allen Hodges ,  Shrikumar Ambujakshan Nair ,  Yuchen Chen ,  Martyn Kerry Darby ,  Hanne Gron ,  Ganesan Sathya

发明人： Isaac Gilliam Sanford ,  Michelle Steffen Jansen ,  Paul Theodore Hamilton ,  Jonathan Allen Hodges ,  Shrikumar Ambujakshan Nair ,  Yuchen Chen ,  Martyn Kerry Darby ,  Hanne Gron ,  Ganesan Sathya

IPC分类号： A61K9/00 ,  C07K14/00 ,  C07K7/08 ,  C07K14/78 ,  C12N5/071 ,  C12N5/078 ,  A61K35/12 ,  A61K35/32 ,  A61K35/28 ,  A61K35/14 ,  A61K35/16 ,  A61K35/48 ,  A61K35/50 ,  C07K19/00 ,  A61K38/16 ,  A61K38/10 ,  A61K38/39 ,  A61P17/02 ,  A61P19/04 ,  A61P21/00 ,  A61P19/00 ,  A61P9/00 ,  C07K9/00 ,  C08G63/91 ,  A61K38/14 ,  A61K31/765 ,  C12N5/077

CPC分类号： A61K47/48992 ,  A61K9/0024 ,  A61K38/10 ,  A61K47/02 ,  A61K47/42 ,  A61K47/64 ,  A61K47/6957 ,  A61L27/425 ,  A61L27/427 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/414 ,  A61L2430/02

摘要： Compositions and methods for tissue repair are provided including cell binding peptides and growth factor binding peptides. The cell binding peptides bind to one or more of stem cells, fibroblasts, or endothelial cells. The growth factor binding peptides include platelet derived growth factor (PDGF) binding peptides and growth differentiation factor (GDF) binding peptides. The tissue for repair includes tendon, muscle, connective tissue, ligament, cardiac tissue, vascular tissue, or dermis. Implantable devices for tissue repair are provided to which the cell and growth factor binding peptides are attached, such as acellular extracellular matrix having attached binding peptide.

公开(公告)号：US08779089B2

公开(公告)日：2014-07-15

申请号：US12949104

申请日：2010-11-18

申请人： Isaac Gilliam Sanford ,  Michelle Steffen Jansen ,  Paul Theodore Hamilton ,  Jonathan Allen Hodges ,  Shrikumar Ambujakshan Nair ,  Yuchen Chen ,  Martyn Kerry Darby ,  Hanne Gron ,  Ganesan Sathya

发明人： Isaac Gilliam Sanford ,  Michelle Steffen Jansen ,  Paul Theodore Hamilton ,  Jonathan Allen Hodges ,  Shrikumar Ambujakshan Nair ,  Yuchen Chen ,  Martyn Kerry Darby ,  Hanne Gron ,  Ganesan Sathya

IPC分类号： A61K38/10 ,  C07K17/00 ,  C07K17/12 ,  C07K7/08 ,  C07K17/08 ,  C07K17/10 ,  A61K47/48 ,  A61K47/02 ,  A61K9/00 ,  A61L27/54 ,  A61L27/58 ,  A61K47/42 ,  A61L27/42

CPC分类号： A61K47/48992 ,  A61K9/0024 ,  A61K38/10 ,  A61K47/02 ,  A61K47/42 ,  A61K47/64 ,  A61K47/6957 ,  A61L27/425 ,  A61L27/427 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/414 ,  A61L2430/02

摘要： Compositions and methods for tissue repair are provided including cell binding peptides and growth factor binding peptides. The cell binding peptides bind to one or more of stem cells, fibroblasts, or endothelial cells. The growth factor binding peptides include platelet derived growth factor (PDGF) binding peptides and growth differentiation factor (GDF) binding peptides. The tissue for repair includes tendon, muscle, connective tissue, ligament, cardiac tissue, vascular tissue, or dermis. Implantable devices for tissue repair are provided to which the cell and growth factor binding peptides are attached, such as acellular extracellular matrix having attached binding peptide.

公开(公告)号：US08691946B2

公开(公告)日：2014-04-08

申请号：US13109802

申请日：2011-05-17

申请人： Isaac Gilliam Sanford ,  Martyn Kerry Darby ,  Jonathan Allen Hodges ,  Shrikumar Ambujakshan Nair ,  Yuchen Chen ,  Paul Theodore Hamilton ,  Ganesan Sathya ,  Hanne Gron ,  Michelle Steffen Jansen

发明人： Isaac Gilliam Sanford ,  Martyn Kerry Darby ,  Jonathan Allen Hodges ,  Shrikumar Ambujakshan Nair ,  Yuchen Chen ,  Paul Theodore Hamilton ,  Ganesan Sathya ,  Hanne Gron ,  Michelle Steffen Jansen

IPC分类号： A61K38/04 ,  A61K38/00 ,  A61K38/03 ,  C07K17/12 ,  C07K17/04 ,  C07K17/08 ,  C07K17/10 ,  C07K7/08

CPC分类号： A61K47/48992 ,  A61K9/0024 ,  A61K38/10 ,  A61K47/02 ,  A61K47/42 ,  A61K47/64 ,  A61K47/6957 ,  A61L27/425 ,  A61L27/427 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/414 ,  A61L2430/02

摘要： Compositions and methods for tissue repair are provided including cell binding peptides and growth factor binding peptides. The cell binding peptides bind to one or more of stem cells, fibroblasts, or endothelial cells. The growth factor binding peptides include platelet derived growth factor (PDGF) binding peptides and growth differentiation factor (GDF) binding peptides. The tissue for repair includes tendon, muscle, connective tissue, ligament, cardiac tissue, vascular tissue, or dermis. Implantable devices for tissue repair are provided to which the cell and growth factor binding peptides are attached, such as acellular extracellular matrix having attached binding peptide.

摘要翻译： 提供组织修复的组合物和方法，包括细胞结合肽和生长因子结合肽。 细胞结合肽与干细胞，成纤维细胞或内皮细胞中的一种或多种结合。 生长因子结合肽包括血小板衍生生长因子（PDGF）结合肽和生长分化因子（GDF）结合肽。 用于修复的组织包括肌腱，肌肉，结缔组织，韧带，心脏组织，血管组织或真皮。 提供用于组织修复的可植入装置，细胞和生长因子结合肽所连接的装置，例如具有连接结合肽的细胞外细胞基质。

公开(公告)号：US20110223142A1

公开(公告)日：2011-09-15

申请号：US13109802

申请日：2011-05-17

申请人： Isaac Gilliam Sanford ,  Martyn Kerry Darby ,  Shrikumar Ambujakshan Nair ,  Jonathan Allen Hodges ,  Yuchen Chen ,  Ganesan Sathya ,  Hanne Gron ,  Michelle Steffen Jansen ,  Paul Theodore Hamilton

发明人： Isaac Gilliam Sanford ,  Martyn Kerry Darby ,  Shrikumar Ambujakshan Nair ,  Jonathan Allen Hodges ,  Yuchen Chen ,  Ganesan Sathya ,  Hanne Gron ,  Michelle Steffen Jansen ,  Paul Theodore Hamilton

IPC分类号： A61K35/12 ,  C07K7/08 ,  C07K14/00 ,  A61K38/10 ,  A61K38/16 ,  A61K38/39 ,  C12N5/071 ,  A61P43/00

CPC分类号： A61K47/48992 ,  A61K9/0024 ,  A61K38/10 ,  A61K47/02 ,  A61K47/42 ,  A61K47/64 ,  A61K47/6957 ,  A61L27/425 ,  A61L27/427 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/414 ,  A61L2430/02

摘要： Compositions and methods for tissue repair are provided including cell binding peptides and growth factor binding peptides. The cell binding peptides bind to one or more of stem cells, fibroblasts, or endothelial cells. The growth factor binding peptides include platelet derived growth factor (PDGF) binding peptides and growth differentiation factor (GDF) binding peptides. The tissue for repair includes tendon, muscle, connective tissue, ligament, cardiac tissue, vascular tissue, or dermis. Implantable devices for tissue repair are provided to which the cell and growth factor binding peptides are attached, such as acellular extracellular matrix having attached binding peptide.

摘要翻译： 提供组织修复的组合物和方法，包括细胞结合肽和生长因子结合肽。 细胞结合肽与干细胞，成纤维细胞或内皮细胞中的一种或多种结合。 生长因子结合肽包括血小板衍生生长因子（PDGF）结合肽和生长分化因子（GDF）结合肽。 用于修复的组织包括肌腱，肌肉，结缔组织，韧带，心脏组织，血管组织或真皮。 提供用于组织修复的可植入装置，细胞和生长因子结合肽所连接的装置，例如具有连接结合肽的细胞外细胞基质。

公开(公告)号：US20100098737A1

公开(公告)日：2010-04-22

申请号：US12253750

申请日：2008-10-17

申请人： Martyn Kerry Darby ,  Isaac Gilliam Sanford ,  Ray Edward Benson, III ,  Hanne Gron ,  Paul Theodore Hamilton ,  Shrikumar Ambujakshan Nair

发明人： Martyn Kerry Darby ,  Isaac Gilliam Sanford ,  Ray Edward Benson, III ,  Hanne Gron ,  Paul Theodore Hamilton ,  Shrikumar Ambujakshan Nair

IPC分类号： A61F2/00 ,  A61K38/16 ,  A61L33/12 ,  C07H21/04 ,  C12N15/64 ,  A61P31/04

CPC分类号： A61L27/34 ,  A61K38/16 ,  A61L27/54 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/252 ,  A61L2300/406 ,  C07K2319/20

摘要： The presently disclosed subject matter relates to peptides having binding affinity for glycopeptide antibiotics and methods and compositions for delivering glycopeptide antibiotic to the surface of medical devices. The peptide compositions can comprise a peptide having binding affinity for a surface material of a medical device that is coupled to the peptide having binding affinity for glycopeptide antibiotic. Also provided are methods of applying the peptide compositions to a medical device by contacting the peptide compositions with a surface of the medical device. In addition, kits are provided comprising the peptide compositions.

摘要翻译： 目前公开的主题涉及对糖肽抗生素具有结合亲和力的肽以及将糖肽抗生素递送到医疗器械表面的方法和组合物。 肽组合物可以包含对与对糖肽抗生素具有结合亲和力的肽偶联的医疗器械的表面材料具有结合亲和力的肽。 还提供了通过使肽组合物与医疗装置的表面接触来将肽组合物应用于医疗装置的方法。 此外，提供了包含肽组合物的试剂盒。

公开(公告)号：US20110117171A1

公开(公告)日：2011-05-19

申请号：US12949069

申请日：2010-11-18

申请人： Mora Carolynne Melican ,  Isaac Gilliam Sanford ,  Jonathan Allen Hodges ,  Shrikumar Ambujakshan Nair ,  Martyn Kerry Darby

发明人： Mora Carolynne Melican ,  Isaac Gilliam Sanford ,  Jonathan Allen Hodges ,  Shrikumar Ambujakshan Nair ,  Martyn Kerry Darby

IPC分类号： A61K9/00 ,  C12N5/071 ,  C12N5/078 ,  A61K35/12 ,  A61K35/32 ,  A61K35/28 ,  A61K35/14 ,  A61K35/16 ,  A61K35/48 ,  A61K35/50 ,  A61K33/42 ,  A61K33/10 ,  A61K33/06 ,  A61K33/00 ,  A61P19/08

CPC分类号： A61K47/64 ,  A61K9/0024 ,  A61K38/10 ,  A61K47/02 ,  A61K47/42 ,  A61K47/6957 ,  A61L27/425 ,  A61L27/427 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/414 ,  A61L2430/02

摘要： Compositions and methods are provided for promoting bone growth. An implantable bone graft material is provided comprising a resorbable ceramic and a resorbable polymer, wherein the polymer comprises a covalently attached stem cell binding peptide. The implantable bone graft materials are useful for promoting bone growth in a subject.

摘要翻译： 提供用于促进骨生长的组合物和方法。 提供了一种可植入的骨移植材料，其包括可再吸收的陶瓷和可再吸收的聚合物，其中所述聚合物包含共价连接的干细胞结合肽。 可植入骨移植材料可用于促进受试者的骨生长。

公开(公告)号：US20110117169A1

公开(公告)日：2011-05-19

申请号：US12949767

申请日：2010-11-18

申请人： Isaac Gilliam Sanford ,  Dalia Isolda Juzumiene ,  Shrikumar Ambujakshan Nair ,  Martyn Kerry Darby ,  Jonathan Allen Hodges

发明人： Isaac Gilliam Sanford ,  Dalia Isolda Juzumiene ,  Shrikumar Ambujakshan Nair ,  Martyn Kerry Darby ,  Jonathan Allen Hodges

IPC分类号： A61K9/00 ,  C12N5/071 ,  C12M1/00 ,  A61K35/12 ,  C12N5/073 ,  C12N5/078 ,  A61P17/02

CPC分类号： A61K47/64 ,  A61K9/0024 ,  A61K38/10 ,  A61K47/02 ,  A61K47/42 ,  A61K47/6957 ,  A61L27/425 ,  A61L27/427 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/414 ,  A61L2430/02

摘要： Compositions and methods are provided for capturing cells. Cell binding peptides are provided that bind to one or more of stem cells, fibroblasts, or endothelial cells. In the methods, a sample containing cells is contacted with a cell binding peptide attached to a substrate, and the cells present in the sample are captured onto the substrate through binding to the cell binding peptide.

摘要翻译： 提供组合物和方法用于捕获细胞。 提供结合一种或多种干细胞，成纤维细胞或内皮细胞的细胞结合肽。 在该方法中，将含有细胞的样品与附着于底物的细胞结合肽接触，通过结合细胞结合肽将存在于样品中的细胞捕获到底物上。