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公开(公告)号：US08691946B2
公开(公告)日：2014-04-08
申请号：US13109802
申请日：2011-05-17
申请人： Isaac Gilliam Sanford , Martyn Kerry Darby , Jonathan Allen Hodges , Shrikumar Ambujakshan Nair , Yuchen Chen , Paul Theodore Hamilton , Ganesan Sathya , Hanne Gron , Michelle Steffen Jansen
发明人： Isaac Gilliam Sanford , Martyn Kerry Darby , Jonathan Allen Hodges , Shrikumar Ambujakshan Nair , Yuchen Chen , Paul Theodore Hamilton , Ganesan Sathya , Hanne Gron , Michelle Steffen Jansen
IPC分类号： A61K38/04 , A61K38/00 , A61K38/03 , C07K17/12 , C07K17/04 , C07K17/08 , C07K17/10 , C07K7/08
CPC分类号： A61K47/48992 , A61K9/0024 , A61K38/10 , A61K47/02 , A61K47/42 , A61K47/64 , A61K47/6957 , A61L27/425 , A61L27/427 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2430/02
摘要： Compositions and methods for tissue repair are provided including cell binding peptides and growth factor binding peptides. The cell binding peptides bind to one or more of stem cells, fibroblasts, or endothelial cells. The growth factor binding peptides include platelet derived growth factor (PDGF) binding peptides and growth differentiation factor (GDF) binding peptides. The tissue for repair includes tendon, muscle, connective tissue, ligament, cardiac tissue, vascular tissue, or dermis. Implantable devices for tissue repair are provided to which the cell and growth factor binding peptides are attached, such as acellular extracellular matrix having attached binding peptide.
摘要翻译： 提供组织修复的组合物和方法，包括细胞结合肽和生长因子结合肽。 细胞结合肽与干细胞，成纤维细胞或内皮细胞中的一种或多种结合。 生长因子结合肽包括血小板衍生生长因子（PDGF）结合肽和生长分化因子（GDF）结合肽。 用于修复的组织包括肌腱，肌肉，结缔组织，韧带，心脏组织，血管组织或真皮。 提供用于组织修复的可植入装置，细胞和生长因子结合肽所连接的装置，例如具有连接结合肽的细胞外细胞基质。
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公开(公告)号：US20110223142A1
公开(公告)日：2011-09-15
申请号：US13109802
申请日：2011-05-17
申请人： Isaac Gilliam Sanford , Martyn Kerry Darby , Shrikumar Ambujakshan Nair , Jonathan Allen Hodges , Yuchen Chen , Ganesan Sathya , Hanne Gron , Michelle Steffen Jansen , Paul Theodore Hamilton
发明人： Isaac Gilliam Sanford , Martyn Kerry Darby , Shrikumar Ambujakshan Nair , Jonathan Allen Hodges , Yuchen Chen , Ganesan Sathya , Hanne Gron , Michelle Steffen Jansen , Paul Theodore Hamilton
IPC分类号： A61K35/12 , C07K7/08 , C07K14/00 , A61K38/10 , A61K38/16 , A61K38/39 , C12N5/071 , A61P43/00
CPC分类号： A61K47/48992 , A61K9/0024 , A61K38/10 , A61K47/02 , A61K47/42 , A61K47/64 , A61K47/6957 , A61L27/425 , A61L27/427 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2430/02
摘要： Compositions and methods for tissue repair are provided including cell binding peptides and growth factor binding peptides. The cell binding peptides bind to one or more of stem cells, fibroblasts, or endothelial cells. The growth factor binding peptides include platelet derived growth factor (PDGF) binding peptides and growth differentiation factor (GDF) binding peptides. The tissue for repair includes tendon, muscle, connective tissue, ligament, cardiac tissue, vascular tissue, or dermis. Implantable devices for tissue repair are provided to which the cell and growth factor binding peptides are attached, such as acellular extracellular matrix having attached binding peptide.
摘要翻译： 提供组织修复的组合物和方法，包括细胞结合肽和生长因子结合肽。 细胞结合肽与干细胞，成纤维细胞或内皮细胞中的一种或多种结合。 生长因子结合肽包括血小板衍生生长因子（PDGF）结合肽和生长分化因子（GDF）结合肽。 用于修复的组织包括肌腱，肌肉，结缔组织，韧带，心脏组织，血管组织或真皮。 提供用于组织修复的可植入装置，细胞和生长因子结合肽所连接的装置，例如具有连接结合肽的细胞外细胞基质。
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公开(公告)号：US20110117167A1
公开(公告)日：2011-05-19
申请号：US12949104
申请日：2010-11-18
申请人： Isaac Gilliam Sanford , Michelle Steffen Jansen , Paul Theodore Hamilton , Jonathan Allen Hodges , Shrikumar Ambujakshan Nair , Yuchen Chen , Martyn Kerry Darby , Hanne Gron , Ganesan Sathya
发明人： Isaac Gilliam Sanford , Michelle Steffen Jansen , Paul Theodore Hamilton , Jonathan Allen Hodges , Shrikumar Ambujakshan Nair , Yuchen Chen , Martyn Kerry Darby , Hanne Gron , Ganesan Sathya
IPC分类号： A61K9/00 , C07K14/00 , C07K7/08 , C07K14/78 , C12N5/071 , C12N5/078 , A61K35/12 , A61K35/32 , A61K35/28 , A61K35/14 , A61K35/16 , A61K35/48 , A61K35/50 , C07K19/00 , A61K38/16 , A61K38/10 , A61K38/39 , A61P17/02 , A61P19/04 , A61P21/00 , A61P19/00 , A61P9/00 , C07K9/00 , C08G63/91 , A61K38/14 , A61K31/765 , C12N5/077
CPC分类号： A61K47/48992 , A61K9/0024 , A61K38/10 , A61K47/02 , A61K47/42 , A61K47/64 , A61K47/6957 , A61L27/425 , A61L27/427 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2430/02
摘要： Compositions and methods for tissue repair are provided including cell binding peptides and growth factor binding peptides. The cell binding peptides bind to one or more of stem cells, fibroblasts, or endothelial cells. The growth factor binding peptides include platelet derived growth factor (PDGF) binding peptides and growth differentiation factor (GDF) binding peptides. The tissue for repair includes tendon, muscle, connective tissue, ligament, cardiac tissue, vascular tissue, or dermis. Implantable devices for tissue repair are provided to which the cell and growth factor binding peptides are attached, such as acellular extracellular matrix having attached binding peptide.
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公开(公告)号：US08779089B2
公开(公告)日：2014-07-15
申请号：US12949104
申请日：2010-11-18
申请人： Isaac Gilliam Sanford , Michelle Steffen Jansen , Paul Theodore Hamilton , Jonathan Allen Hodges , Shrikumar Ambujakshan Nair , Yuchen Chen , Martyn Kerry Darby , Hanne Gron , Ganesan Sathya
发明人： Isaac Gilliam Sanford , Michelle Steffen Jansen , Paul Theodore Hamilton , Jonathan Allen Hodges , Shrikumar Ambujakshan Nair , Yuchen Chen , Martyn Kerry Darby , Hanne Gron , Ganesan Sathya
IPC分类号： A61K38/10 , C07K17/00 , C07K17/12 , C07K7/08 , C07K17/08 , C07K17/10 , A61K47/48 , A61K47/02 , A61K9/00 , A61L27/54 , A61L27/58 , A61K47/42 , A61L27/42
CPC分类号： A61K47/48992 , A61K9/0024 , A61K38/10 , A61K47/02 , A61K47/42 , A61K47/64 , A61K47/6957 , A61L27/425 , A61L27/427 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2430/02
摘要： Compositions and methods for tissue repair are provided including cell binding peptides and growth factor binding peptides. The cell binding peptides bind to one or more of stem cells, fibroblasts, or endothelial cells. The growth factor binding peptides include platelet derived growth factor (PDGF) binding peptides and growth differentiation factor (GDF) binding peptides. The tissue for repair includes tendon, muscle, connective tissue, ligament, cardiac tissue, vascular tissue, or dermis. Implantable devices for tissue repair are provided to which the cell and growth factor binding peptides are attached, such as acellular extracellular matrix having attached binding peptide.
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公开(公告)号：US20110117165A1
公开(公告)日：2011-05-19
申请号：US12948978
申请日：2010-11-18
申请人： Mora Carolynne Melican , Paul Theodore Hamilton , Jonathan Allen Hodges , Shrikumar Ambujakshan Nair , Yuchen Chen
发明人： Mora Carolynne Melican , Paul Theodore Hamilton , Jonathan Allen Hodges , Shrikumar Ambujakshan Nair , Yuchen Chen
CPC分类号： A61K47/64 , A61K9/0024 , A61K38/10 , A61K47/02 , A61K47/42 , A61K47/6957 , A61L27/425 , A61L27/427 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2430/02
摘要： Compositions and methods are provided for promoting bone growth. An implantable bone graft material is provided comprising a resorbable ceramic and a resorbable polymer, wherein the polymer comprises a covalently attached BMP binding peptide. In addition, an implantable bone graft material is provided consisting essentially of a resorbable β-TCP and a resorbable polymer, wherein the β-TCP has a total porosity of about 50% or greater and wherein the β-TCP has a particle size ranging from about 100 micron to about 300 micron. The implantable bone graft materials are useful for promoting bone growth in a subject.
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6.发明申请METHODS AND COMPOSITIONS FOR DELIVERY OF GROWTH FACTOR TO FIBROUS CONNECTIVE TISSUE 失效用于将生长因子递送到纤维连接组织的方法和组合物公开(公告)号：US20090098175A1
公开(公告)日：2009-04-16
申请号：US12204731
申请日：2008-09-04
申请人： Benjamin Marcus Buehrer , Paul Theodore Hamilton , Dalia Izolda Juzumiene , Shrikumar Ambujakshan Nair , Yuchen Chen
发明人： Benjamin Marcus Buehrer , Paul Theodore Hamilton , Dalia Izolda Juzumiene , Shrikumar Ambujakshan Nair , Yuchen Chen
CPC分类号： C07K14/71 , A61K9/0024 , A61K38/00 , A61L27/227 , A61L27/54 , A61L2300/25 , A61L2300/414 , A61L2300/606 , C07K2319/20
摘要： The presently disclosed subject matter relates to a peptide composition for non-covalently localizing fibrous connective tissue-inducing growth factor to a surface of an implant, the composition comprising a peptide having binding affinity for a surface material of an implant coupled to a peptide having binding affinity for a fibrous connective tissue-inducing growth factor. Methods are provided for delivering fibrous connective tissue-inducing growth factor GDF-7 in an amount effective to promote fibrous connective tissue repair and fibrous connective tissue formation. Also provided are methods of applying the peptide composition to an implant by contacting the composition with a surface of the implant; and kits comprising the compositions.
摘要翻译： 目前公开的主题涉及用于非共价定位的纤维结缔组织诱导生长因子到植入物表面的肽组合物，该组合物包含与对具有结合的肽偶联的植入物的表面材料具有结合亲和力的肽 对纤维结缔组织诱导生长因子的亲和力。 提供用于递送纤维结缔组织诱导生长因子GDF-7的方法，其量有效促进纤维结缔组织修复和纤维结缔组织形成。 还提供了通过使组合物与植入物的表面接触来将肽组合物施用于植入物的方法; 和包含该组合物的试剂盒。
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公开(公告)号：US08933029B2
公开(公告)日：2015-01-13
申请号：US10229368
申请日：2002-08-26
申请人： Patricia J. McNicol , Sonia K. Pawlak , Evelina Rubinchik , Dale Cameron , Maria Marta Guarna , Janet R. Fraser , Shafique Fidai , Yuchen Chen , Timothy J. Krieger
发明人： Patricia J. McNicol , Sonia K. Pawlak , Evelina Rubinchik , Dale Cameron , Maria Marta Guarna , Janet R. Fraser , Shafique Fidai , Yuchen Chen , Timothy J. Krieger
摘要： Antimicrobial and/or anti-inflammatory peptide compositions and therapeutic uses thereof are provided. The peptides and analogs or derivatives thereof may be used as an antimicrobial agent and/or as an anti-inflammatory agent. In certain embodiments, the peptides are cationic peptides. The peptides are useful for the treatment of inflammatory diseases, such as microorganism-caused infections, acne, and psoriasis. The peptides and peptide formulations may be used topically or parenterally.
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8.发明授权Methods and compositions for delivery of growth factor to fibrous connective tissue 失效将生长因子递送至纤维结缔组织的方法和组合物公开(公告)号：US08067021B2
公开(公告)日：2011-11-29
申请号：US12204731
申请日：2008-09-04
CPC分类号： C07K14/71 , A61K9/0024 , A61K38/00 , A61L27/227 , A61L27/54 , A61L2300/25 , A61L2300/414 , A61L2300/606 , C07K2319/20
摘要： The presently disclosed subject matter relates to a peptide composition for non-covalently localizing fibrous connective tissue-inducing growth factor to a surface of an implant, the composition comprising a peptide having binding affinity for a surface material of an implant coupled to a peptide having binding affinity for a fibrous connective tissue-inducing growth factor. Methods are provided for delivering fibrous connective tissue-inducing growth factor GDF-7 in an amount effective to promote fibrous connective tissue repair and fibrous connective tissue formation. Also provided are methods of applying the peptide composition to an implant by contacting the composition with a surface of the implant; and kits comprising the compositions.
摘要翻译： 目前公开的主题涉及用于非共价定位的纤维结缔组织诱导生长因子到植入物表面的肽组合物，该组合物包含与对具有结合的肽偶联的植入物的表面材料具有结合亲和力的肽 对纤维结缔组织诱导生长因子的亲和力。 提供用于递送有效促进纤维结缔组织修复和纤维结缔组织形成的纤维结缔组织诱导生长因子GDF-7的方法。 还提供了通过使组合物与植入物的表面接触来将肽组合物施用于植入物的方法; 和包含该组合物的试剂盒。
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9.发明申请公开(公告)号：US20050153876A1
公开(公告)日：2005-07-14
申请号：US10880442
申请日：2004-06-28
申请人： Dale Cameron , Vincent Boyd , Richard Leese , William Curran , Donald Borders , Paulo Sgarbi , Shirley Wacowich-Sgarbi , Mathew Nodwell , Yuchen Chen , Qi Jia , Dominique Dugourd
发明人： Dale Cameron , Vincent Boyd , Richard Leese , William Curran , Donald Borders , Paulo Sgarbi , Shirley Wacowich-Sgarbi , Mathew Nodwell , Yuchen Chen , Qi Jia , Dominique Dugourd
摘要： The present invention provides derivatives of lipopeptide antibiotics that display antimicrobial activity against microorganisms, methods and compounds for synthesizing such antimicrobial derivatives and analogues, and methods of using the compounds in a variety of contexts, including in the treatment and prevention of microbial infections.
摘要翻译： 本发明提供显示抗微生物抗微生物活性的脂肽抗生素衍生物，用于合成这种抗微生物衍生物和类似物的方法和化合物，以及在多种情况下使用该化合物的方法，包括在治疗和预防微生物感染中。
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10.发明授权公开(公告)号：US07868135B2
公开(公告)日：2011-01-11
申请号：US10880442
申请日：2004-06-28
申请人： Dale R. Cameron , Vincent A. Boyd , Richard A. Leese , William V. Curran , Donald B. Borders , Paulo W. M. Sgarbi , Shirley A. Wacowich-Sgarbi , Matthew Nodwell , Yuchen Chen , Qi Jia , Dominique Dugourd
发明人： Dale R. Cameron , Vincent A. Boyd , Richard A. Leese , William V. Curran , Donald B. Borders , Paulo W. M. Sgarbi , Shirley A. Wacowich-Sgarbi , Matthew Nodwell , Yuchen Chen , Qi Jia , Dominique Dugourd
IPC分类号： A61K38/12
摘要： The present invention provides derivatives of lipopeptide antibiotics that display antimicrobial activity against microorganisms, methods and compounds for synthesizing such antimicrobial derivatives and analogues, and methods of using the compounds in a variety of contexts, including in the treatment and prevention of microbial infections.
摘要翻译： 本发明提供显示抗微生物抗微生物活性的脂肽抗生素衍生物，用于合成这种抗微生物衍生物和类似物的方法和化合物，以及在多种情况下使用该化合物的方法，包括在治疗和预防微生物感染中。
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