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公开(公告)号：US4894385A
公开(公告)日：1990-01-16
申请号：US818873
申请日：1986-01-14
IPC分类号： C07D409/06 , A61K31/415 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61P7/02 , A61P43/00 , C07D233/60 , C07D333/00 , C07D401/06 , C07D405/06 , C07D521/00 , C12N9/99
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08
摘要： Compounds of formula (I): ##STR1## (wherein n is 0, 1 or 2 and R.sup.1, R.sup.2, R.sup.4, R.sup.5, R.sup.6, X, Y and Z are a variety of groups and atoms) have the ability to inhibit the synthesis of thromboxane A.sub.2 and hence are useful in the treatment or prophylaxis of thrombotic conditions.
摘要翻译： 式（I）化合物：其中n为0,1或2，R 1，R 2，R 4，R 5，R 6，X，Y和Z为各种基团和原子） 抑制血栓素A2的合成，因此可用于治疗或预防血栓形成。
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公开(公告)号：US4847272A
公开(公告)日：1989-07-11
申请号：US007375
申请日：1987-01-27
IPC分类号： A61K31/381 , A61K31/415 , A61K31/44 , A61P7/02 , C07D333/54 , C07D333/56 , C07D333/68 , C07D409/06 , C07D521/00
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D409/06
摘要： Compounds of formula (I): ##STR1## (wherein n is 0 or 1, R.sup.1 and R.sup.2 are hydrogen or alkyl, one of A.sup.1 and A.sup.2 is --Z--Y and the other is --W--COOH, where W and Z are alkenylene or alkylene and Y is imidazolyl or pyridyl, and the broken lines represent two single bonds or one single bond and one double bond) and their salts, esters and amides have the ability to inhibit the synthesis of thromboxane A.sub.2 and hence are useful in the treatment or prophylaxis of thrombotic conditions. They may be prepared by introducing an imidazolyl or pyridyl group into the corresponding compound in which Y is replaced by an active group or atom.
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公开(公告)号：US5021444A
公开(公告)日：1991-06-04
申请号：US354984
申请日：1989-05-19
IPC分类号： A61K31/381 , A61K31/415 , A61K31/44 , A61P7/02 , C07D333/54 , C07D333/56 , C07D333/68 , C07D409/06 , C07D521/00
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D409/06
摘要： Compounds of formula (I): ##STR1## (wherein n is 0 or 1, R.sup.1 and R.sup.2 are hydrogen or alkyl, one of A.sup.1 and A.sup.2 is --Z--Y and the other is --W--COOH, where W and Z are alkenylene or alkylene and Y is imidazolyl or pyridyl, and the broken lines represent two single bonds or one single bond and one double bond) and their salts, esters and amides have the ability to inhibit the synthesis of thromboxane A.sub.2 and hence are useful in the treatment of prophylaxis of thrombotic conditions. They may be prepared by introducing an imidazolyl or pyridyl group into the corresponding compound in which Y is replaced by an active group or atom.
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">4.发明授权Compounds, named the "Leustroducsins", their preparation and their therapeutic uses 失效化合物，命名为“Leustroducsins”，其制备及其治疗用途
公开(公告)号：US5334587A
公开(公告)日：1994-08-02
申请号：US857162
申请日：1992-03-25
申请人： Takafumi Kohama , Isao Kaneko , Takemichi Nakamura , Takeshi Kagasaki , Ryuzo Enokita , Keiichi Matsuda
发明人： Takafumi Kohama , Isao Kaneko , Takemichi Nakamura , Takeshi Kagasaki , Ryuzo Enokita , Keiichi Matsuda
IPC分类号： C07D309/38 , A61K31/655 , A61K31/665 , A61P7/00 , A61P31/10 , C07F9/117 , C07F9/655 , C12N1/14 , C12P9/00 , C12P17/06 , C12R1/465 , C07F9/06
CPC分类号： C07F9/6552 , C12P17/06 , Y10S435/903
摘要： New compounds, which we have named the "Leustroducsins" have the formula (I): ##STR1## in which R represents a 5-methylhexanoyloxy group, a 6-methyloctanoyloxy group or a 7-methyloctanoyloxy group, and salts thereof, and may be prepared by fermentation using a microorganism of the genus Streptomyces, especially a strain of the species Streptomyces platensis, such as strain SANK 60191 (FERM BP-3288). These compounds may be used for the treatment or prophylaxis of: adverse reactions resulting from cancer chemotherapy or radiotherapy; infections; cancer; cerebral dysfunction; and fungal infections.
摘要翻译： 我们命名为“雷诺霉素”的新化合物具有式（I）：其中R表示5-甲基己酰氧基，6-甲基辛酰氧基或7-甲基辛酰氧基的式（I）及其盐， 并且可以通过使用链霉菌属的微生物，特别是品种Streptomyces platensis的菌株如菌株SANK 60191（FERM BP-3288）的发酵来制备。 这些化合物可用于治疗或预防：由癌症化疗或放射治疗引起的不良反应; 感染; 癌症; 脑功能障碍; 和真菌感染。
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公开(公告)号：US5614521A
公开(公告)日：1997-03-25
申请号：US427664
申请日：1995-04-24
IPC分类号： A61K31/16 , A61K31/135 , A61K31/165 , A61K31/38 , A61K31/381 , A61K31/47 , A61K31/535 , A61K31/5375 , A61P9/00 , A61P25/28 , A61P43/00 , C07C57/03 , C07C205/06 , C07C233/07 , C07C233/08 , C07C235/32 , C07C235/34 , C07C235/36 , C07C237/20 , C07C237/22 , C07D215/14 , C07D215/38 , C07D295/18 , C07D295/185 , C07D333/56 , C07D333/68 , C07C233/00 , C07D265/30
CPC分类号： C07D215/38 , C07C235/34 , C07C235/36 , C07C237/20 , C07C237/22 , C07D295/185 , C07D333/68 , C07C2102/08 , C07C2103/74
摘要： A compound of the formula (I): ##STR1## wherein R.sup.1 is an unsubstituted or substituted amino group, a protected amino group, or a nitro group; R.sup.2 is an unsubstituted or substituted amino group, a protected amino group, an unsubstituted or substituted hydroxy group or a protected hydroxy group; R.sup.3 is an unsubstituted or substituted amino group, m is 0 to 2; n is 0 to 6; with the proviso that when m is 0, then n is an integer from 2 to 6, and pharmaceutically acceptable salts thereof. Compounds of formula (I) except those wherein R.sup.1 is a nitro group have activity in promoting the production of nerve growth factor.
摘要翻译： 式（I）的化合物：其中R 1是未取代或取代的氨基，保护的氨基或硝基; R2是未取代或取代的氨基，保护的氨基，未取代或取代的羟基或被保护的羟基; R3是未取代或取代的氨基，m是0-2; n为0〜6; 条件是当m为0时，n为2至6的整数，及其药学上可接受的盐。 式（I）的化合物除了其中R 1是硝基的那些具有促进神经生长因子产生的活性。
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公开(公告)号：US5643925A
公开(公告)日：1997-07-01
申请号：US837491
申请日：1992-02-18
IPC分类号： A61K31/16 , A61K31/135 , A61K31/165 , A61K31/38 , A61K31/381 , A61K31/47 , A61K31/535 , A61K31/5375 , A61P9/00 , A61P25/28 , A61P43/00 , C07C57/03 , C07C205/06 , C07C233/07 , C07C233/08 , C07C235/32 , C07C235/34 , C07C235/36 , C07C237/20 , C07C237/22 , C07D215/14 , C07D215/38 , C07D295/18 , C07D295/185 , C07D333/56 , C07D333/68 , A01N43/42
CPC分类号： C07D215/38 , C07C235/34 , C07C235/36 , C07C237/20 , C07C237/22 , C07D295/185 , C07D333/68 , C07C2102/08 , C07C2103/74
摘要： Novel benzene derivatives are provided of the general formula (I): ##STR1## [wherein R.sup.1 represents an amino group, a substituted amino group, a protected amino group, or a nitro group; R.sup.2 represents an amino group, a substituted amino group, a protected amino group, a hydroxy group, a substituted hydroxy group, or a protected hydroxy group; R.sup.3 represents an amino group, a substituted amino, a heterocyclyl group having a ring nitrogen atom as the point of binding, or a substituted heterocyclyl group having a ring nitrogen atom as the point of binding; m is 0 to 2; n is 0 to 6; with the proviso that when m is 0, then n represents an integer from 2 to 6] and salts thereof.Compounds of formula (I) except those wherein R.sup.1 is a nitro group have activity in promoting production of nerve growth factor. Compounds of formula (I) wherein R.sup.1 is a nitro group are intermediates for compounds of formula (I) wherein R.sup.1 is an amino group.
摘要翻译： 提供通式（I）的新型苯衍生物：其中R1表示氨基，取代氨基，被保护的氨基或硝基; R2表示氨基，取代氨基，保护氨基，羟基，取代羟基或被保护的羟基; R3表示氨基，取代氨基，具有环氮原子作为结合点的杂环基或具有环氮原子作为结合点的取代的杂环基; m为0〜2; n为0〜6; 条件是当m为0时，n表示2至6的整数]及其盐。 式（I）的化合物除了其中R1是硝基之外，具有促进神经生长因子产生的活性。 其中R 1是硝基的式（I）化合物是其中R 1是氨基的式（I）化合物的中间体。
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公开(公告)号：US5443972A
公开(公告)日：1995-08-22
申请号：US239284
申请日：1994-05-06
申请人： Takafumi Kohama , Isao Kaneko , Takemichi Nakamura , Takeshi Kagasaki , Ryuzo Enokita , Keiichi Matsuda
发明人： Takafumi Kohama , Isao Kaneko , Takemichi Nakamura , Takeshi Kagasaki , Ryuzo Enokita , Keiichi Matsuda
IPC分类号： C07D309/38 , A61K31/655 , A61K31/665 , A61P7/00 , A61P31/10 , C07F9/117 , C07F9/655 , C12N1/14 , C12P9/00 , C12P17/06 , C12R1/465
CPC分类号： C07F9/6552 , C12P17/06 , Y10S435/903
摘要： New compounds, which we have named the "Leustroducsins" have the formula (I): ##STR1## in which R represents a 5-methylhexanoyloxy group, a 6-methyloctanoyloxy group or a 7-methyloctanoyloxy group, and salts thereof, and may be prepared by fermentation using a microorganism of the genus Streptomyces, especially a strain of the species Streptomyces platensis, such as strain SANK 60191 (FERM BP-3288). These compounds may be used for the treatment or prophylaxis of: adverse reactions resulting from cancer chemotherapy or radiotherapy; infections; cancer; cerebral dysfunction; and fungal infections.
摘要翻译： 我们命名为“雷诺霉素”的新化合物具有式（I）：其中R表示5-甲基己酰氧基，6-甲基辛酰氧基或7-甲基辛酰氧基的式（I）及其盐， 并且可以通过使用链霉菌属的微生物，特别是品种Streptomyces platensis的菌株如菌株SANK 60191（FERM BP-3288）的发酵来制备。 这些化合物可用于治疗或预防：由癌症化疗或放射治疗引起的不良反应; 感染; 癌症; 脑功能障碍; 和真菌感染。
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