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公开(公告)号：US08715573B2
公开(公告)日：2014-05-06
申请号：US11872676
申请日：2007-10-15
Applicant: Jack T. Ball , Collin A. Rich
Inventor： Jack T. Ball , Collin A. Rich
CPC classification number: G01N15/1404 , Y10T137/85978
Abstract: The fluidic system 10 of the preferred embodiment includes a sheath pump 12 to pump sheath fluid 14 from a sheath container 16 through a sample port 34 into an interrogation zone 18 and a waste pump 20 to pump the sheath fluid 14 and a sample fluid 26 as waste fluid 22 from the interrogation zone 18 into a waste container 24, and a processor 30 to calculate a time window based on the flow rate of the sample fluid 26. Preferably the processor 30 also calculates a time window for the sample fluid to reach the interrogation zone 18 from the sample port 34 based on the flow rate of the sample fluid 26. The interrogation zone 18 functions to provide a location for the fluidic system 10 and an optical analysis system 32 of the flow cytometer to cooperatively facilitate the analysis of the sample fluid 26.
Abstract translation: 优选实施例的流体系统10包括护套泵12，其将护套流体14从鞘容器16通过样品端口34泵送到询问区域18和废水泵20，以将鞘液14和样品流体26泵送为 从询问区18到废物容器24的废液22以及基于样品流体26的流速计算时间窗的处理器30.优选地，处理器30还计算样品流体到达的时间窗口 询问区18基于样品流体26的流速从采样端口34询问。询问区18用于提供流体系统10的位置和流式细胞计数器的光学分析系统32，以便协调地促进对 样品流体26。
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公开(公告)号：US08779387B2
公开(公告)日：2014-07-15
申请号：US13033299
申请日：2011-02-23
Applicant: Clare E. Rogers , Jack T. Ball , Collin A. Rich
Inventor： Clare E. Rogers , Jack T. Ball , Collin A. Rich
CPC classification number: G01N15/1429 , G01N15/1459
Abstract: A method for detecting fluorochromes in a flow cytometer, including: receiving a sample including particles each tagged with at least one of a first fluorochrome and a second fluorochrome, in which the first and second fluorochromes having distinct spillover coefficients; detecting the particles, including detecting the first and second fluorochromes with a first detector and a second detector; forming a data set for detected particles based on the detection of the first and second fluorochromes; characterizing a detected spillover coefficient for each detected fluorochrome from the data set; and sorting the detected particles into predicted fluorochrome populations based on the detected spillover coefficients. A system for detecting fluorochromes in a flow cytometer, including a flow cell, a fixed gain detection system, and a processor that generates a detected spillover coefficient for each detected particle and sorts the detected particle into predicted fluorochrome populations based on the detected spillover coefficient.
Abstract translation: 一种用于在流式细胞仪中检测荧光染料的方法，包括：接收包含每个标记有第一荧光染料和第二荧光染料中的至少一种的颗粒的样品，其中第一和第二荧光染料具有不同的溢出系数; 检测颗粒，包括用第一检测器和第二检测器检测第一和第二荧光染料; 基于第一和第二荧光色素的检测形成检测到的颗粒的数据集; 表征来自数据集的每个检测到的荧光染料的检测到的溢出系数; 并且基于检测到的溢出系数将检测到的颗粒分选成预测的荧光染色体群体。 一种用于在流式细胞仪中检测荧光染料的系统，包括流动池，固定增益检测系统和处理器，其产生每个检测到的颗粒的检测到的溢出系数，并且基于检测到的溢出系数将检测到的颗粒分解成预测的荧光染色体群。
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公开(公告)号：US08283177B2
公开(公告)日：2012-10-09
申请号：US12476860
申请日：2009-06-02
Applicant: Jack T. Ball , Aaron Kehrer , Nathaniel C. Bair , Collin A. Rich
Inventor： Jack T. Ball , Aaron Kehrer , Nathaniel C. Bair , Collin A. Rich
CPC classification number: G01N15/1404 , B01L3/02 , B01L3/5027 , B01L99/00 , G01N2015/1413 , G05D7/0682 , Y10T436/25375
Abstract: A method for cleaning a fluidic system of a flow cytometer having a sheath pump to pump sheath fluid towards an interrogation zone and a waste pump to pump the sheath fluid and a sample fluid as waste fluid from the interrogation zone, wherein the sheath pump and/or the waste pump draw sample fluid into the flow cytometer through a drawtube towards the interrogation zone. The method includes controlling the sheath pump and the waste pump to cooperatively flush a fluid out through the drawtube, thereby cleaning the fluidic system of the flow cytometer.
Abstract translation: 一种用于清洗流式细胞仪的流体系统的方法，所述流式细胞仪具有护套泵以将鞘液朝向询问区泵送，而废泵泵送鞘液和作为来自询问区的废液的样品流体，其中护套泵和/ 或废泵将样品流体通过拉管朝向询问区抽入流式细胞仪。 该方法包括控制护套泵和废水泵通过抽吸管共同冲洗流体，从而清洗流式细胞仪的流体系统。
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公开(公告)号：US08004674B2
公开(公告)日：2011-08-23
申请号：US12476877
申请日：2009-06-02
Applicant: Jack T. Ball , Collin A. Rich , Clare E. Rogers
Inventor： Jack T. Ball , Collin A. Rich , Clare E. Rogers
IPC: G01J3/30
CPC classification number: G01J3/4406
Abstract: A system for a flow cytometer that collects data for a sample prepared with a plurality of fluorochromes that includes a fixed gain detection system that collects data for a plurality of fluorescence channels, fluorochrome compensation factors for a plurality of fluorochromes types, and a computer system that has an interface that gathers fluorochrome information of the sample and an analysis program that compensates for spectral spillover in the collected data. The fixed gain detection system preferably has a wide dynamic range. A fluorochrome compensation factor preferably remains constant for a fixed gain detection system. The analysis program preferably uses the fluorochrome compensation factors to compensate for spectral spillover.
Abstract translation: 一种用于流式细胞计数器的系统，其收集由多个荧光染料制备的样品的数据，所述荧光染料包括收集多个荧光通道的数据的固定增益检测系统，用于多个荧光染料类型的荧光染料补偿因子，以及计算机系统， 具有收集样品的荧光染料信息的界面和补偿收集的数据中的光谱外溢的分析程序。 固定增益检测系统优选具有宽的动态范围。 对于固定增益检测系统，荧光染料补偿因子优选保持恒定。 分析程序优选使用荧光染料补偿因子来补偿光谱溢出。
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公开(公告)号：US20110061471A1
公开(公告)日：2011-03-17
申请号：US12942846
申请日：2010-11-09
Applicant: Collin A. Rich , Jack T. Ball , Grant C. Howes
Inventor： Collin A. Rich , Jack T. Ball , Grant C. Howes
IPC: G01N1/20
CPC classification number: G01N15/14
Abstract: A system and method for a flow cytometer system including a sheath pump that pumps sheath fluid from a sheath container into an interrogation zone, a waste pump that pumps waste fluid from the interrogation zone into a waste container, wherein the sheath pump and waste pump cooperatively and simultaneously draw sample fluid from a sample container into the interrogation zone, a controller that adjusts the flow rate of the sample fluid from the sample container into the interrogation zone, and a sensor system that coordinates with the controller to measure the amount of sample fluid in the sample container when the controller substantially pauses the sample fluid flow from the sample container into the interrogation zone. The system may further include a processor that monitors a measured volume of sample fluid introduced into the flow cytometer and an expected sample volume.
Abstract translation: 一种用于流式细胞仪系统的系统和方法，包括将鞘液从皮肤容器泵送到询问区的鞘泵，将废液从询问区泵送到废液容器中的废泵，其中鞘泵和废泵协同 同时将样品流体从样品容器中抽出到询问区中，控制器调节样品流体从样品容器进入询问区的流量，以及与控制器协调测量样品流量的传感器系统 在样品容器中，当控制器基本上暂停样品流体从样品容器进入询问区时。 该系统还可以包括处理器，其监测引入流式细胞仪中的样品流体的测量体积和预期的样品体积。
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Patent Agency Ranking
6.发明授权公开(公告)号：US08507279B2
公开(公告)日：2013-08-13
申请号：US12792536
申请日：2010-06-02
Applicant: Jack T. Ball , Grant C. Howes , Collin A. Rich
Inventor： Jack T. Ball , Grant C. Howes , Collin A. Rich
CPC classification number: G01N33/5094 , G01N15/1012 , G01N15/14 , G01N15/1404 , G01N15/1459 , G01N33/56972 , G01N2015/1006 , G01N2015/1018 , G01N2015/1486 , G01N2333/70514 , Y10T436/10 , Y10T436/101666
Abstract: A system and method for a flow cytometer system including a prepared sample fluid with reference beads; an interrogation zone that analyzes the prepared sample fluid; a peristaltic pump system that draws the sample fluid through the interrogation zone; and a processor that monitors a measured volume of sample fluid sampled by the peristaltic pump system and an expected sample volume based on data generated by the analysis of the sample fluid. A system and method is additionally described using an alternative volume sensing fluidic system.
Abstract translation: 一种用于流式细胞仪系统的系统和方法，其包括具有参比珠的制备的样品流体; 一个询问区，分析制备的样品液; 蠕动泵系统，通过询问区抽取样品液; 以及处理器，其基于通过对样品流体的分析产生的数据监测由蠕动泵系统采样的样品流体的测量体积和预期样品体积。 使用替代的体积感测流体系统另外描述系统和方法。
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公开(公告)号：US20110204259A1
公开(公告)日：2011-08-25
申请号：US13033299
申请日：2011-02-23
Applicant: Clare E. Rogers , Jack T. Ball , Collin A. Rich
Inventor： Clare E. Rogers , Jack T. Ball , Collin A. Rich
IPC: G01J1/58
CPC classification number: G01N15/1429 , G01N15/1459
Abstract: A method for detecting fluorochromes in a flow cytometer, including: receiving a sample including particles each tagged with at least one of a first fluorochrome and a second fluorochrome, in which the first and second fluorochromes having distinct spillover coefficients; detecting the particles, including detecting the first and second fluorochromes with a first detector and a second detector; forming a data set for detected particles based on the detection of the first and second fluorochromes; characterizing a detected spillover coefficient for each detected fluorochrome from the data set; and sorting the detected particles into predicted fluorochrome populations based on the detected spillover coefficients. A system for detecting fluorochromes in a flow cytometer, including a flow cell, a fixed gain detection system, and a processor that generates a detected spillover coefficient for each detected particle and sorts the detected particle into predicted fluorochrome populations based on the detected spillover coefficient.
Abstract translation: 一种用于在流式细胞仪中检测荧光染料的方法，包括：接收包含每个标记有第一荧光染料和第二荧光染料中的至少一种的颗粒的样品，其中第一和第二荧光染料具有不同的溢出系数; 检测颗粒，包括用第一检测器和第二检测器检测第一和第二荧光染料; 基于第一和第二荧光色素的检测形成检测到的颗粒的数据集; 表征来自数据集的每个检测到的荧光染料的检测到的溢出系数; 并且基于检测到的溢出系数将检测到的颗粒分选成预测的荧光染色体群体。 一种用于在流式细胞仪中检测荧光染料的系统，包括流动池，固定增益检测系统和处理器，其产生每个检测到的颗粒的检测到的溢出系数，并且基于检测到的溢出系数将检测到的颗粒分解成预测的荧光染色体群。
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8.发明申请公开(公告)号：US20110008816A1
公开(公告)日：2011-01-13
申请号：US12792536
申请日：2010-06-02
Applicant: Jack T. Ball , Grant C. Howes , Collin A. Rich
Inventor： Jack T. Ball , Grant C. Howes , Collin A. Rich
CPC classification number: G01N33/5094 , G01N15/1012 , G01N15/14 , G01N15/1404 , G01N15/1459 , G01N33/56972 , G01N2015/1006 , G01N2015/1018 , G01N2015/1486 , G01N2333/70514 , Y10T436/10 , Y10T436/101666
Abstract: A system and method for a flow cytometer system including a prepared sample fluid with reference beads; an interrogation zone that analyzes the prepared sample fluid; a peristaltic pump system that draws the sample fluid through the interrogation zone; and a processor that monitors a measured volume of sample fluid sampled by the peristaltic pump system and an expected sample volume based on data generated by the analysis of the sample fluid. A system and method is additionally described using an alternative volume sensing fluidic system.
Abstract translation: 一种用于流式细胞仪系统的系统和方法，其包括具有参比珠的制备的样品流体; 一个询问区，分析制备的样品液; 蠕动泵系统，通过询问区抽取样品液; 以及处理器，其基于通过对样品流体的分析产生的数据监测由蠕动泵系统采样的样品流体的测量体积和预期样品体积。 使用替代的体积感测流体系统另外描述系统和方法。
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公开(公告)号：US20100302536A1
公开(公告)日：2010-12-02
申请号：US12476877
申请日：2009-06-02
Applicant: Jack T. Ball , Collin A. Rich , Rogers E. Clare
Inventor： Jack T. Ball , Collin A. Rich , Rogers E. Clare
IPC: G01J3/30
CPC classification number: G01J3/4406
Abstract: A system for a flow cytometer that collects data for a sample prepared with a plurality of fluorochromes that includes a fixed gain detection system that collects data for a plurality of fluorescence channels, fluorochrome compensation factors for a plurality of fluorochromes types, and a computer system that has an interface that gathers fluorochrome information of the sample and an analysis program that compensates for spectral spillover in the collected data. The fixed gain detection system preferably has a wide dynamic range. A fluorochrome compensation factor preferably remains constant for a fixed gain detection system. The analysis program preferably uses the fluorochrome compensation factors to compensate for spectral spillover.
Abstract translation: 一种用于流式细胞计数器的系统，其收集由多个荧光染料制备的样品的数据，所述荧光染料包括收集多个荧光通道的数据的固定增益检测系统，用于多个荧光染料类型的荧光染料补偿因子，以及计算机系统， 具有收集样品的荧光染料信息的界面和补偿收集的数据中的光谱外溢的分析程序。 固定增益检测系统优选具有宽的动态范围。 对于固定增益检测系统，荧光染料补偿因子优选保持恒定。 分析程序优选使用荧光染料补偿因子来补偿光谱溢出。
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公开(公告)号：US20080152542A1
公开(公告)日：2008-06-26
申请号：US11872676
申请日：2007-10-15
Applicant: Jack T. Ball , Collin A. Rich
Inventor： Jack T. Ball , Collin A. Rich
CPC classification number: G01N15/1404 , Y10T137/85978
Abstract: The fluidic system 10 of the preferred embodiment includes a sheath pump 12 to pump sheath fluid 14 from a sheath container 16 through a sample port 34 into an interrogation zone 18 and a waste pump 20 to pump the sheath fluid 14 and a sample fluid 26 as waste fluid 22 from the interrogation zone 18 into a waste container 24, and a processor 30 to calculate a time window based on the flow rate of the sample fluid 26. Preferably the processor 30 also calculates a time window for the sample fluid to reach the interrogation zone 18 from the sample port 34 based on the flow rate of the sample fluid 26. The interrogation zone 18 functions to provide a location for the fluidic system 10 and an optical analysis system 32 of the flow cytometer to cooperatively facilitate the analysis of the sample fluid 26.
Abstract translation: 优选实施例的流体系统10包括护套泵12，其将护套流体14从鞘容器16通过样品端口34泵送到询问区域18和废水泵20，以将鞘液14和样品流体26泵送为 从询问区18到废物容器24的废液22以及基于样品流体26的流速计算时间窗的处理器30.优选地，处理器30还计算样品流体到达的时间窗口 询问区18基于样品流体26的流速从采样端口34询问。询问区18用于提供流体系统10的位置和流式细胞计数器的光学分析系统32，以便协调地促进对 样品流体26。
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