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    Enzymatic substrates
    1.
    发明授权
    Enzymatic substrates 失效
    酶底物

    公开(公告)号：US4161488A

    公开(公告)日：1979-07-17

    申请号：US934297

    申请日：1978-08-17

    申请人： Jacob J. Plattner ,  Houston F. Voss ,  Susan E. Magic

    发明人： Jacob J. Plattner ,  Houston F. Voss ,  Susan E. Magic

    IPC分类号： C12Q1/37 ,  C12Q1/56 ,  C07C153/11 ,  C07C101/00

    CPC分类号： C12Q1/56 ,  C12Q1/37

    摘要： The present invention encompasses the acid addition salts of a compound of the formula ##STR1## wherein R.sub.1 represents phenylsulfonyl, benzoyl, carbobenzoxy, and the halo, loweralkyl having 1-4 carbon atoms, loweralkoxy having 1-3 carbon atoms, phenyl, or hydroxy substituted derivatives thereof; or alkanoyl having 2-12 carbon atoms; and R.sub.2 represents alkyl having 1-10 carbon atoms, or alkoxyalkyl having 2-6 carbon atoms, cycloalkyl having 5-7 carbon atoms, or benzyl and the halo, loweralkyl having 1-4 carbon atoms, loweralkoxy having 1-3 carbon atoms, hydroxy, carboxy, or phenyl substituted derivatives thereof.Compounds of the present invention are useful as analytical reagents. Enzymatic hydrolysis provides --S--R.sub.2 which can be further reacted with 5,5'-dithiobis (2-nitrobenzoic acid) to provide a colored product by which the enzyme concentration can be determined spectrophotometrically.

    摘要翻译： 本发明包括下式化合物的酸加成盐：其中R 1表示苯基磺酰基，苯甲酰基，苄氧羰基，卤素，具有1-4个碳原子的低级烷基，具有1-3个碳原子的低级烷氧基，苯基或羟基 取代衍生物; 或具有2-12个碳原子的烷酰基; R2表示具有1-10个碳原子的烷基或具有2-6个碳原子的烷氧基烷基，具有5-7个碳原子的环烷基，或苄基和卤素，具有1-4个碳原子的低级烷基，具有1-3个碳原子的低级烷氧基， 羟基，羧基或其苯基取代的衍生物。

    Chromogenic substrates
    2.
    发明授权
    Chromogenic substrates 失效
    显色底物

    公开(公告)号：US4166825A

    公开(公告)日：1979-09-04

    申请号：US934298

    申请日：1978-08-17

    申请人： Jacob J. Plattner ,  Houston F. Voss ,  Susan E. Magic

    发明人： Jacob J. Plattner ,  Houston F. Voss ,  Susan E. Magic

    IPC分类号： C12Q1/37 ,  C07C153/09

    CPC分类号： C12Q1/37

    摘要： The present invention encompasses acid addition salts of a compound of the formula ##STR1## wherein: R.sub.1 represents phenylsulfonyl, benzoyl, carbobenzoxy, and the halo, loweralkyl having 1-4 carbon atoms, loweralkoxy having 1-3 carbon atoms, phenyl, or hydroxy substituted derivatives thereof; or alkanoyl having 2-12 carbon atoms; R.sub.2 represents alkyl having 1-10 carbon atoms, alkoxyalkyl having 2-6 carbon atoms, cycloalkyl having 5-7 carbon atoms, benzyl and the halo, loweralkyl having 1-4 carbon atoms, loweralkoxy having 1-3 carbon atoms, carboxy, hydroxy, or substituted derivatives thereof; R.sub.3 represents hydrogen or guanyl, and m is 3 or 4.Compounds of the present invention are useful as analytical reagents. Enzymatic hydrolysis provides --S--R.sub.2 which can be further reacted with 5,5'-dithiobis (2-nitrobenzoic acid) to provide a colored product by which the enzyme concentration can be determined spectrophotometrically.

    摘要翻译： 本发明包括下式化合物的酸加成盐：其中：R 1表示苯基磺酰基，苯甲酰基，苄氧羰基，卤素，具有1-4个碳原子的低级烷基，具有1-3个碳原子的低级烷氧基，苯基或羟基 取代衍生物; 或具有2-12个碳原子的烷酰基; R2表示具有1-10个碳原子的烷基，具有2-6个碳原子的烷氧基烷基，具有5-7个碳原子的环烷基，苄基和卤素，具有1-4个碳原子的低级烷基，具有1-3个碳原子的低级烷氧基，羧基，羟基 或其取代的衍生物; R3表示氢或脒基，m表示3或4。

    Chromogenic substrates
    3.
    发明授权
    Chromogenic substrates 失效
    显色底物

    公开(公告)号：US4219497A

    公开(公告)日：1980-08-26

    申请号：US27578

    申请日：1979-04-06

    申请人： Jacob J. Plattner ,  Stephen D. Stroupe ,  Houston F. Voss

    发明人： Jacob J. Plattner ,  Stephen D. Stroupe ,  Houston F. Voss

    IPC分类号： C07D207/46 ,  C12Q1/37 ,  C07C103/87 ,  C07C129/12

    CPC分类号： C07D207/46 ,  C12Q1/37

    摘要： The present invention comprises compounds of the formula ##STR1## and the biologically acceptable acid addition salts thereof wherein R.sub.1 represents hydrogen, or lower alkyl having 1-4 carbon atoms; R.sub.2 represents p-hydroxybenzyl or benzyl; R.sub.3 represents an alkyl having 1-6 carbon atoms; R.sub.4 represents amino or guanidino; R.sub.5 represents p-nitrophenyl, methylnitrophenyl, dinitrophenyl, naphthyl, or nitronaphthyl; and n is 3 or 4.

    摘要翻译： 本发明包括式“IMAGE”的化合物及其生物可接受的酸加成盐，其中R 1表示氢或具有1-4个碳原子的低级烷基; R2代表对羟基苄基或苄基; R3表示具有1-6个碳原子的烷基; R4表示氨基或胍基; R5表示对硝基苯基，甲基硝基苯基，二硝基苯基，萘基或硝基萘基; n为3或4。

    Boron containing small molecules as antiprotozoal agents
    4.
    发明授权
    Boron containing small molecules as antiprotozoal agents 有权
    含有小分子的硼作为抗原虫剂

    公开(公告)号：US09440994B2

    公开(公告)日：2016-09-13

    申请号：US12852351

    申请日：2010-08-06

    申请人： Daitao Chen ,  Matthew Orr ,  Jessica Sligar ,  Robert Jacobs ,  Jacob J. Plattner

    发明人： Daitao Chen ,  Matthew Orr ,  Jessica Sligar ,  Robert Jacobs ,  Jacob J. Plattner

    IPC分类号： C07F5/02

    CPC分类号： C07F5/025 ,  A01N55/08 ,  A61K31/69

    摘要： This invention provides, among other things, novel compounds useful for treating protozoal infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent. The exemplary compounds have the following formula: wherein X is selected from the group consisting of substituted phenyl, substituted or unsubstituted heteroaryl and unsubstituted cycloalkyl; R3a is selected from the group consisting of H, unsubstituted C1 or C2 or C3 or C4 or C5 or C6 alkyl and unsubstituted C3 or C4 or C5 or C6 cycloalkyl; R3b is selected from the group consisting of H, unsubstituted C1 or C2 or C3 or C4 or C5 or C6 alkyl and unsubstituted C3 or C4 or C5 or C6 cycloalkyl; with the proviso that R3a and R3b, along with the atom to which they are attached, are optionally joined to form a 3 or 4 or 5 or 6 membered ring, with the proviso that R3a and R3b cannot both be H, or a salt thereof.