公开(公告)号：US06486898B1

公开(公告)日：2002-11-26

申请号：US09282321

申请日：1999-03-31

申请人： Jacquelyn Martino ,  Nevenka Dimitrova ,  Kaushal Kurapati

发明人： Jacquelyn Martino ,  Nevenka Dimitrova ,  Kaushal Kurapati

IPC分类号： G09G500

CPC分类号： G06F17/30014 ,  G06F17/30716 ,  G06F17/30722 ,  G06F17/30855 ,  G06F17/30882

摘要： Information nodes are dynamically organized and information related to each node is displayed in dependence upon a user's indicated reference node. The information related to the reference node is displayed prominently, and information items related to the other nodes are displayed with a prominence that reflects each node's degree of separation from the user selected reference node. Both size and position are used to indicate prominence. To present a consistent interface regardless of the user's point of reference, recursive techniques, such as fractal based algorithms, are used in a preferred embodiment.

摘要翻译： 信息节点被动态组织，并且依赖于用户指示的参考节点显示与每个节点相关的信息。 显着地显示与参考节点相关的信息，并且显示与其他节点相关的信息项，其突出显示每个节点与用户选择的参考节点的分离度。 大小和位置均用于表示突出。 为了呈现一致的界面，无论用户的参考点如何，在优选实施例中使用递归技术，例如基于分形的算法。

公开(公告)号：US20050028194A1

公开(公告)日：2005-02-03

申请号：US10932460

申请日：2004-09-02

申请人： Jan Elenbaas ,  Nevenka Dimitrova ,  Thomas McGee ,  Mark Simpson ,  Jacquelyn Martino ,  Mohamed Abdel-Mottaleb ,  Marjorie Garrett ,  Carolyn Ramsey ,  Hsiang-Lung Wu ,  Ranjit Desai

发明人： Jan Elenbaas ,  Nevenka Dimitrova ,  Thomas McGee ,  Mark Simpson ,  Jacquelyn Martino ,  Mohamed Abdel-Mottaleb ,  Marjorie Garrett ,  Carolyn Ramsey ,  Hsiang-Lung Wu ,  Ranjit Desai

IPC分类号： G06F17/30 ,  G11B27/22 ,  G11B27/28 ,  H04N7/16 ,  H04N7/173 ,  H04N7/10 ,  H04N7/025 ,  G06F7/00 ,  H04N5/445

CPC分类号： H04N21/4334 ,  G06F16/735 ,  G06F16/739 ,  G06F16/743 ,  G06F16/78 ,  G06F16/7834 ,  G06F16/7844 ,  G11B27/22 ,  G11B27/28 ,  H04N7/163 ,  H04N21/440281 ,  H04N21/4532 ,  H04N21/454 ,  H04N21/458 ,  H04N21/4751 ,  H04N21/4821 ,  H04N21/812 ,  H04N21/8153

摘要： A video retrieval system is presented that allows a user to quickly and easily select and receive stories of interest from a video stream. The video retrieval system classifies stories and delivers samples of selected stories that match each user's current preference. The user's preferences may include particular broadcast networks, persons, story topics, keywords, and the like. Key frames of each selected story are sequentially displayed; when the user views a frame of interest, the user selects the story that is associated with the key frame for more detailed viewing. This invention is particularly well suited for targeted news retrieval. In a preferred embodiment, news stories are stored, and the selection of a news story for detailed viewing based on the associated key frames effects a playback of the selected news story. The principles of this invention also allows a user to effect a directed search of other types of broadcasts as well. For example, the user may initiate an automated scan that presents samples of broadcasts that conform to the user's current preferences, akin to directed channel-surfing.

摘要翻译： 提出了一种视频检索系统，其允许用户从视频流中快速且容易地选择和接收感兴趣的故事。 视频检索系统对故事进行分类，并提供与每个用户当前偏好匹配的所选故事的样本。 用户的偏好可以包括特定的广播网络，人物，故事主题，关键词等。 依次显示每个选定故事的关键帧; 当用户观看感兴趣的框架时，用户选择与关键帧相关联的故事以进行更详细的观看。 本发明特别适用于有针对性的新闻检索。 在优选实施例中，存储新闻故事，并且基于相关联的关键帧选择用于详细查看的新闻故事影响所选择的新闻故事的回放。 本发明的原理还允许用户也对其他类型的广播进行定向搜索。 例如，用户可以启动自动扫描，其呈现符合用户当前偏好的广播样本，类似于定向频道冲浪。

公开(公告)号：US20130196877A1

公开(公告)日：2013-08-01

申请号：US13877346

申请日：2011-10-04

申请人： Nilanjana Banerjee ,  Angel Janevski ,  Sitharthan Kamalakaran ,  Vinay Varadan ,  Nevenka Dimitrova ,  Robert Lucito

发明人： Nilanjana Banerjee ,  Angel Janevski ,  Sitharthan Kamalakaran ,  Vinay Varadan ,  Nevenka Dimitrova ,  Robert Lucito

IPC分类号： G06F19/20

CPC分类号： G16B25/00 ,  G16B5/00 ,  G16B20/00

摘要： The present invention relates to a method for identifying multi-modal associations between biomedical markers which allows for the determination of network nodes and/or high ranking network members or combinations thereof, indicative of having a diagnostic, prognostic or predictive value for a medical condition, in particular ovarian cancer. The present invention further relates to a biomedical marker or group of biomedical markers associated with a high likelihood of responsiveness of a subject to a cancer therapy, preferably a platinum based cancer therapy, wherein said bio-medical marker or group of biomedical markers comprises at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 8, 19, 20 or all markers selected from PKMYT1, SKIL, RAB8A, HIRIP3, CTNNB1, NGFR, ZCCHC11, LSP1, CD200, PAX8, CYBRD1, HOXC11, TCEAL1, FZD10,FZD1, BBS4, IRS2, TLX3, TSPAN2, TXN, and CFLAR. Furthermore, an assay for detecting, diagnosing, graduating, monitoring or prognosticating a medical condition, or for detecting, 1 diagnosing, monitoring or prognosticating the responsiveness of a subject to a therapy against said medical condition, in particular ovarian cancer, is provided, as well as a corresponding method for classifying a subject comprising and a medical decision support system.

摘要翻译： 本发明涉及一种用于识别生物医学标记之间的多模式关联的方法，其允许确定网络节点和/或高排名网络成员或其组合，指示具有用于医疗状况的诊断，预后或预测值， 特别是卵巢癌。 本发明还涉及与受试者对癌症治疗（优选基于铂的癌症治疗）的高反应性的高可能性相关联的生物医学标记物或生物医学标记物组，其中所述生物医学标记物或生物医学标记物组至少包括 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,8,19,20或选自PKMYT1，SKIL，RAB8A， HIRIP3，CTNNB1，NGFR，ZCCHC11，LSP1，CD200，PAX8，CYBRD1，HOXC11，TCEAL1，FZD10，FZD1，BBS4，IRS2，TLX3，TSPAN2，TXN和CFLAR。 此外，提供了用于检测，诊断，毕业，监测或预测医学状况或用于检测1诊断，监测或预测受试者对于针对所述医学病症，特别是卵巢癌的治疗的反应性的测定法，作为 以及用于分类受试者的相应方法以及医疗决策支持系统。

公开(公告)号：US08357112B2

公开(公告)日：2013-01-22

申请号：US12530243

申请日：2008-03-03

申请人： Nevenka Dimitrova ,  Christopher S. Hall ,  Chien T. Chin

发明人： Nevenka Dimitrova ,  Christopher S. Hall ,  Chien T. Chin

IPC分类号： A61B17/20

CPC分类号： A61B8/481 ,  A61K9/0009 ,  A61K41/0028 ,  A61K47/6925 ,  A61M37/0092

摘要： This invention relates to a method and an apparatus of controlling a release of a material carried by ultrasound sensitive particles, the release being caused by irradiating the ultrasound sensitive particles with an ultrasonic pulse having acoustic properties selected so as to interact with the ultrasound sensitive particles and thus causing the release of the material. The ultrasound sensitive particles comprise sub-groups of ultrasound sensitive particles, the ultrasound sensitive particles within the same sub-group having their respective acoustic property causing each respective sub-group to interact independently with the sound wave.

摘要翻译： 本发明涉及一种控制由超声敏感颗粒携带的材料的释放的方法和装置，该释放是通过用选择的声学性质的超声脉冲照射超声波敏感颗粒而引起的，以便与超声敏感颗粒相互作用， 从而导致材料的释放。 超声敏感颗粒包括超声敏感颗粒的子组，相同子组内的超声敏感颗粒具有各自的声学特性，导致每个相应的子组与声波独立地相互作用。

公开(公告)号：US08199991B2

公开(公告)日：2012-06-12

申请号：US12516931

申请日：2007-12-03

申请人： Lalitha Agnihotri ,  James David Schaffer ,  Nevenka Dimitrova

发明人： Lalitha Agnihotri ,  James David Schaffer ,  Nevenka Dimitrova

IPC分类号： G06K9/36

CPC分类号： G06K9/00134 ,  G06K9/3233 ,  G06K9/3275 ,  G06T7/70 ,  G06T2207/20056 ,  G06T2207/30072

摘要： A method of automatically identifying the microarray chip corners and probes, even if there are no probes at the corners, in a high density and high resolution microarray scanned image having an image space, wherein the method minimizes the error distortions in the image arising in the scanning process by applying to the image a multipass corner finding algorithm comprising: (a) applying a Radon transform to an input microarray image to project the image into an angle and distance space where it is possible to find the orientation of the straight lines; (b) applying a fast Fourier transform to the projected image of (a) to find the optimal tilting angle of the projected image; (c) determining the optimal first and last local maxima for the optimal tilting angle; (d) back projecting the determined first and last local maxima to the image space to find the first approximation of the first and last column lines of the image; (e) rotating the image and repeating steps (a) through (d) to find the first approximation of the top and bottom row lines of the image; (f) determining the first approximation of the four corners of the image from the intersection of the column and row lines; (g) applying a heuristic for determining if the first approximation of step (f) is sufficient; and (h) optionally trimming the scanned image around the first approximation of the four corners and repeating steps (a) through (f).

摘要翻译： 即使在具有图像空间的高密度和高分辨率的微阵列扫描图像中，即使在角落处没有探针也能够自动识别微阵列芯片角部和探针的方法，其中该方法使图像中产生的图像中的误差失真最小化 扫描过程，通过向图像应用多点角发现算法，包括：（a）将Radon变换应用于输入微阵列图像以将图像投影到可以找到直线的取向的角度和距离空间中; （b）对（a）的投影图像应用快速傅立叶变换以找到投影图像的最佳倾斜角; （c）确定最佳倾斜角的最佳第一和最后局部最大值; （d）将确定的第一和最后局部最大值向前投影到图像空间，以找到图像的第一列和最后一列的第一近似; （e）旋转图像并重复步骤（a）至（d）以找到图像的顶行和下行行的第一近似值; （f）从列和行之间的交点确定图像的四个角的第一近似值; （g）应用启发式来确定步骤（f）的第一近似是否足够; 和（h）可选地修整围绕四个角的第一近似的扫描图像并重复步骤（a）至（f）。

公开(公告)号：US20120053071A1

公开(公告)日：2012-03-01

申请号：US13140972

申请日：2009-12-14

申请人： Nevenka Dimitrova ,  Chetan Mittal ,  Sitharthan Kamalakaran

发明人： Nevenka Dimitrova ,  Chetan Mittal ,  Sitharthan Kamalakaran

IPC分类号： C40B30/04 ,  C40B30/00 ,  G06F19/00 ,  C12Q1/68

CPC分类号： C12Q1/6827 ,  C12Q2523/125

摘要： The present invention relates to a method for the detection of a DNA methylation signature associated with the presence of or the predisposition to develop a disorder, the method comprising the identification of one or more candidate genes exhibiting differential DNA methylation in target and reference samples as well as the respective determination of the nucleic acid sites in said candidate genes that are differentially methylated and the recognition sites for DNA binding factors, said DNA binding factors each recognizing such a differentially methylated nucleic acid site, wherein the patterns of differentially methylated nucleic acid sites and of DNA binding factor recognition sites obtained together represent a DNA methylation signature that is indicative for the presence of or the predisposition to develop a disorder in a target sample.

摘要翻译： 本发明涉及一种用于检测与发生病症的存在或倾向相关的DNA甲基化特征的方法，所述方法包括鉴定靶和参照样品中显示差异DNA甲基化的一个或多个候选基因 作为差异甲基化的所述候选基因中的核酸位点和DNA结合因子的识别位点的各自测定，所述DNA结合因子各自识别这样的差异甲基化核酸位点，其中差异甲基化的核酸位点和 一起获得的DNA结合因子识别位点代表一种DNA甲基化特征，其指示在目标样品中存在发生障碍的倾向或倾向。

公开(公告)号：US20110189098A1

公开(公告)日：2011-08-04

申请号：US12993109

申请日：2009-05-14

申请人： Nevenka Dimitrova ,  Chetan Mital

发明人： Nevenka Dimitrova ,  Chetan Mital

IPC分类号： A61K49/00 ,  C12Q1/68 ,  C07H21/00

CPC分类号： C12N15/62 ,  C07K14/43595 ,  C07K14/71 ,  C07K2319/60 ,  C12Q1/6897 ,  C12Q2537/164 ,  C12Q2525/207 ,  C12Q2525/143

摘要： The present invention relates to a method of non-invasively monitoring the expression of a gene of interest in a cell when contacting said cell with a compound influencing the expression of said gene of interest. The present invention is also concerned with different isolated nucleic acid molecules comprising a coding sequence. Said coding sequence comprises a gene of interest-sequence encoding a gene of interest-polypeptide fused to a reporter sequence encoding a fluorescent reporter polypeptide and is operatively coupled to a promoter sequence. The present invention is also concerned with the use of a method and a nucleic acid molecule of the invention for delivering a compound influencing the expression of a gene of interest in a cell, monitoring the delivery of said compound as well as monitoring the influence on the expression of said gene fluorescence of interest induced by said compound at the same time.

摘要翻译： 本发明涉及当使所述细胞与影响目标基因表达的化合物接触时非侵入性地监测细胞中目的基因的表达的方法。 本发明还涉及包含编码序列的不同分离的核酸分子。 所述编码序列包含编​​码与编码荧光报道多肽的报告基因融合的感兴趣基因多肽的目标基因序列，并且可操作地偶联至启动子序列。 本发明还涉及本发明的方法和核酸分子用于递送影响细胞中目的基因表达的化合物，监测所述化合物的递送以及监测对所述化合物的影响 所述化合物同时诱导的所述感兴趣的基因荧光的表达。

公开(公告)号：US20100239502A1

公开(公告)日：2010-09-23

申请号：US12668551

申请日：2008-06-26

申请人： Evan Edward Santo ,  Nevenka Dimitrova ,  CHIEN Ting Chien

发明人： Evan Edward Santo ,  Nevenka Dimitrova ,  CHIEN Ting Chien

IPC分类号： A61K49/00 ,  C12N15/85 ,  C12Q1/68

CPC分类号： C12N15/1086 ,  C12Q1/6897 ,  C12Q2565/101

摘要： The invention features compositions and methods for in vivo expression analysis. The data presented herein demonstrates that ultrasound-enhanced delivery and/or expression of a composition for expression analysis comprising microbubbles vectors as well as a genetic payload, comprising a “always-on” promoter, a “reference” reporter gene, a “query” promoter and an “answer” reporter gene, enables in vivo analysis of gene expression both without requiring prior preparation (especially genetic modification) of the test subject (animal or patient) and without causing long term or systemic effects on the subject. Such an invention can be used, for example, to query the epigenotypic or phenotypic response of the individual subject to a foreign effector substance such as a pyrogen, pharmaceutical compound, pharmaceutical lead compound, an allergen, an autoimmunogene, a toxin, a polyclonal antibody, a monoclonal antibody, an antigen, a lipid, a carbohydrate, a peptide, a protein, a protein-complex, an amino acid, a fatty acid, a nucleotide, DNA, RNA, PNA, siRNA and micro RNA.

摘要翻译： 本发明的特征在于用于体内表达分析的组合物和方法。 本文提供的数据表明包括微泡载体和遗传有效载荷的用于表达分析的组合物的超声增强递送和/或表达，包括“始终在上”启动子，“参考”报告基因，“查询” 启动子和“答案”报告基因，能够在不需要测试对象（动物或患者）的事先准备（特别是遗传修饰）的情况下进行基因表达的体内分析，并且不会对受试者造成长期或全身影响。 这样的发明可以用于例如查询个体受试者对外源性效应物质如热原，药物化合物，药物引导化合物，变应原，自身免疫原，毒素，多克隆抗体的表型表型或表型反应 ，单克隆抗体，抗原，脂质，碳水化合物，肽，蛋白质，蛋白质复合物，氨基酸，脂肪酸，核苷酸，DNA，RNA，PNA，siRNA和微RNA。

公开(公告)号：US20090129647A1

公开(公告)日：2009-05-21

申请号：US12282435

申请日：2007-03-07

申请人： Nevenka Dimitrova ,  Yee Him Cheung

发明人： Nevenka Dimitrova ,  Yee Him Cheung

IPC分类号： G06K9/00

CPC分类号： G06F19/22 ,  G06F19/24 ,  G06F19/26

摘要： Spectrogram extraction from DNA sequence has been known since 2001. A DNA spectrogram is generated by applying Fourier transform to convert a symbolic DNA sequence consisting of letters A, T, C, G into a visual representation that highlights periodicities of co-occurrence of DNA patterns. Given a DNA sequence or whole genomes, with this method it is easy to generate a large number of spectrogram images. However, the difficult part is to elucidate where are the repetitive patterns and to associate a biological and clinical meaning to them. The present disclosure provides systems and methods that facilitate the location and/or identification of repetitive DNA patterns, such as CpG islands, Alu repeats, tandem repeats and various types of satellite repeats. These repetitive elements can be found within a chromosome, within a genome or across genomes of various species. The disclosed systems and methods apply image processing operators to find prominent features in the vertical and horizontal direction of the DNA spectrograms. Systems and methods for fast, full scale analysis of the derived images using supervised machine learning methods are also disclosed. The disclosed systems and methods for detecting and/or classifying repetitive DNA patterns include: (a) comparative histogram method, (b) feature selection and classification using support vector machines and genetic algorithms, and (c) generation of spectrovideo from a plurality of spectral images.

摘要翻译： 从2001年开始，DNA序列的谱图提取是已知的。通过应用傅立叶变换将由字母A，T，C，G组成的符号DNA序列转换成突出显示DNA图案共同出现周期的视觉表示，生成DNA谱图 。 给定一个DNA序列或整个基因组，用这种方法很容易产生大量的谱图。 然而，困难的部分是阐明重复模式在哪里，并将生物和临床意义与他们联系起来。 本公开提供了促进重复DNA模式（例如CpG岛，Alu重复序列，串联重复序列和各种类型的卫星重复）的定位和/或识别的系统和方法。 这些重复元件可以在染色体内，基因组内或各种物种的基因组中发现。 所公开的系统和方法应用图像处理算子以在DNA谱图的垂直和水平方向上发现显着特征。 还公开了使用监督机器学习方法对衍生图像进行快速，全面分析的系统和方法。 用于检测和/或分类重复DNA模式的所公开的系统和方法包括：（a）比较直方图方法，（b）使用支持向量机和遗传算法的特征选择和分类，以及（c）从多个光谱 图片。

公开(公告)号：US07457811B2

公开(公告)日：2008-11-25

申请号：US10178015

申请日：2002-06-21

申请人： Angel Janevski ,  Nevenka Dimitrova ,  Lalitha Agnihotri

发明人： Angel Janevski ,  Nevenka Dimitrova ,  Lalitha Agnihotri

IPC分类号： G06F17/00

CPC分类号： G06F17/30828 ,  G06F17/30867 ,  H04N21/44218 ,  H04N21/44222 ,  Y10S707/99942 ,  Y10S707/99943 ,  Y10S707/99944 ,  Y10S707/99945

摘要： A content maintenance system uses a time-dependent precipitation function for iteratively augmenting or removing content over time, after an initial demonstration of user interest. A plurality of parallel precipitation processes can be launched simultaneously in response to different facets of a user expression of interest. Precipitation is dependent on highlighting or extracting segment descriptors from content of interest to the user. Then segments are filtered, rated, annotated and/or prioritized from that content. The remaining segments are matched against stored search structures. When the segments match, they are precipitated out for storage and can generate new search structures.

摘要翻译： 在用户感兴趣的初步演示之后，内容维护系统使用时间依赖的降水函数来迭代地增加或移除内容。 响应于感兴趣的用户表达的不同方面，可以同时启动多个并行降水过程。 降水取决于从用户感兴趣的内容中突出显示或提取片段描述符。 然后，细分受到过滤，评分，注释和/或从内容中排列。 剩余的段与存储的搜索结构匹配。 当段匹配时，它们被沉淀出来用于存储，并且可以生成新的搜索结构。