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公开(公告)号：US20060142295A1
公开(公告)日：2006-06-29
申请号：US10546091
申请日：2004-03-05
IPC分类号： A61K31/506 , A61K31/496 , A61K31/497
CPC分类号： A61K31/497 , A61K31/496 , A61K31/506
摘要： This invention relates to a method of treating a hyper-proliferative disorder comprising the administration of an effective amount of a compound of Formula (I) to a patient in need thereof.
摘要翻译： 本发明涉及一种治疗高增殖病症的方法，包括向有需要的患者施用有效量的式（I）化合物。
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2.发明申请公开(公告)号：US20060019990A1
公开(公告)日：2006-01-26
申请号：US11158048
申请日：2005-06-22
申请人： Jacques Dumas , Bernd Riedl , Uday Khire , Robert Sibley , Holia Hatoum-Mokdad , Mary-Katherine Monahan , David Gunn , Timotthy Lowinger , William Scott , Roger Smith , Jill Wood
发明人： Jacques Dumas , Bernd Riedl , Uday Khire , Robert Sibley , Holia Hatoum-Mokdad , Mary-Katherine Monahan , David Gunn , Timotthy Lowinger , William Scott , Roger Smith , Jill Wood
IPC分类号： A61K31/4709 , A61K31/444 , C07D401/02
CPC分类号： C07D213/40
摘要： The invention relates to a group of quinolyl, isoquinolyl and pyridyl ureas, their the use in treating raf mediated diseases, and pharmaceutical compositions which contain these ureas for use in such therapy.
摘要翻译： 本发明涉及一组喹啉基，异喹啉基和吡啶基脲，它们在治疗raf介导的疾病中的用途，以及含有用于这种治疗的这些尿素的药物组合物。
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3.发明申请公开(公告)号：US20080027061A1
公开(公告)日：2008-01-31
申请号：US11845597
申请日：2007-08-27
申请人： Bernd Riedl , Jacques Dumas , Uday Khire , Timothy Lowinger , William Scott , Roger Smith , Jill Wood , Mary-Katherine Monahan , Reina Natero , Joel Renick , Robert Sibley
发明人： Bernd Riedl , Jacques Dumas , Uday Khire , Timothy Lowinger , William Scott , Roger Smith , Jill Wood , Mary-Katherine Monahan , Reina Natero , Joel Renick , Robert Sibley
IPC分类号： A61K31/535 , A61K31/17 , A61P19/02 , A61K31/495
CPC分类号： A61K31/5377 , A61K31/17 , A61K31/18 , A61K31/24 , A61K31/341 , A61K31/40 , A61K31/4035 , A61K31/44 , A61K31/4439 , A61K31/4453 , A61K31/495 , A61K31/496 , A61K31/535 , A61K31/5375 , Y02A50/401 , Y02A50/411 , Y02A50/414 , Y02A50/473
摘要： This invention relates to the use of a group of aryl ureas in treating p38 mediated diseases, and pharmaceutical compositions for use in such therapy.
摘要翻译： 本发明涉及一组芳基脲在治疗p38介导的疾病中的用途，以及用于此类治疗的药物组合物。
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4.发明申请INHIBITION OF RAF KINASE USING ARYL AND HETEROARYL SUBSTITUTED HETEROCYCLIC UREAS 失效使用ARYL和HETEROARYL取代的杂环类URAAS对RAF激酶的抑制作用公开(公告)号：US20080009527A1
公开(公告)日：2008-01-10
申请号：US11768533
申请日：2007-06-26
申请人： Jacques Dumas , Uday Khire , Timothy Lowinger , Bernard Riedl , William Scott , Roger Smith , Jill Wood , Holia Hatoum-Mokdad , Jeffrey Johnson , Aniko Redman , Robert Sibley
发明人： Jacques Dumas , Uday Khire , Timothy Lowinger , Bernard Riedl , William Scott , Roger Smith , Jill Wood , Holia Hatoum-Mokdad , Jeffrey Johnson , Aniko Redman , Robert Sibley
IPC分类号： A61K31/4439 , A61K31/415 , A61P35/00 , C07D401/12 , C07D405/04 , C07D231/38 , A61K31/443
CPC分类号： C07D231/40 , C07D333/36 , C07D401/12 , C07D405/04
摘要： Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se,
摘要翻译： 用raf激酶介导的肿瘤治疗方法，用取代的脲化合物和这些化合物本身，
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公开(公告)号：US20070244120A1
公开(公告)日：2007-10-18
申请号：US11768112
申请日：2007-06-25
申请人： Jacques Dumas , Uday Khire , Timothy Lowinger , Holger Paulsen , Bernd Riedl , William Scott , Roger Smith , Jill Wood , Holia Hatoum-Mokdad , Jeffrey Johnson , Wendy Lee , Aniko Redman , Robert Sibley , Joel Renick
发明人： Jacques Dumas , Uday Khire , Timothy Lowinger , Holger Paulsen , Bernd Riedl , William Scott , Roger Smith , Jill Wood , Holia Hatoum-Mokdad , Jeffrey Johnson , Wendy Lee , Aniko Redman , Robert Sibley , Joel Renick
IPC分类号： A61K31/5377 , A61K31/09 , A61K31/136 , A61K31/381 , A61K31/4164 , A61K31/4196 , A61K31/42 , A61K31/426 , C07D401/12 , C07D231/10 , A61K31/44 , A61K31/4427 , A61K31/4439 , A61K31/4709 , A61K31/496 , A61K31/497
CPC分类号： C07D231/40 , C07D207/34 , C07D259/00 , C07D261/14 , C07D271/113 , C07D285/135 , C07D333/36 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se.
摘要翻译： 治疗由raf激酶介导的肿瘤与取代的脲化合物及其化合物本身的方法。
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公开(公告)号：US07351834B1
公开(公告)日：2008-04-01
申请号：US09889227
申请日：2000-01-12
申请人： Bernd Riedl , Jacques Dumas , Uday Khire , Timothy Lowinger , William Scott , Roger A. Smith , Jill E. Wood , Mary-Katherine Monahan , Reina Natero , Joel Renick , Robert Sibley
发明人： Bernd Riedl , Jacques Dumas , Uday Khire , Timothy Lowinger , William Scott , Roger A. Smith , Jill E. Wood , Mary-Katherine Monahan , Reina Natero , Joel Renick , Robert Sibley
IPC分类号： C07D213/30 , A61K31/44
CPC分类号： C07D209/48 , C07C251/48 , C07C275/28 , C07C275/30 , C07C275/32 , C07C275/36 , C07C275/40 , C07C311/29 , C07C317/22 , C07D207/09 , C07D209/46 , C07D213/74 , C07D213/75 , C07D213/79 , C07D213/81 , C07D213/82 , C07D295/12 , C07D295/13 , C07D295/135 , C07D295/18 , C07D295/192 , C07D307/14 , C07D401/12
摘要： This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.
摘要翻译： 本发明涉及一组芳基脲在治疗raf介导的疾病中的用途，以及用于此类治疗的药物组合物。
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7.发明授权Hydroxy, ω-carboxyaryl substituted diphenyl ureas and dirivatives thereof as raf kinase inhibitors 有权羟基，ω-羧基芳基取代的二苯基脲和其衍生物作为raf激酶抑制剂公开(公告)号：US07528255B2
公开(公告)日：2009-05-05
申请号：US10071248
申请日：2002-02-11
申请人： Bernd Riedl , Jacques Dumas , Uday Khire , Timothy Lowinger , William Scott , Roger Smith , Jill Wood
发明人： Bernd Riedl , Jacques Dumas , Uday Khire , Timothy Lowinger , William Scott , Roger Smith , Jill Wood
IPC分类号： C07D211/72 , C07D213/62 , C07D213/78
CPC分类号： C07D295/192 , A61K31/17 , A61K31/18 , A61K31/24 , A61K31/341 , A61K31/40 , A61K31/4035 , A61K31/44 , A61K31/4439 , A61K31/4453 , A61K31/495 , A61K31/496 , A61K31/5375 , A61K31/5377 , C07C275/28 , C07C275/30 , C07C275/32 , C07C275/36 , C07C275/40 , C07C311/29 , C07C317/22 , C07D209/46 , C07D209/48 , C07D209/50 , C07D213/75 , C07D213/80 , C07D213/81 , C07D295/073 , C07D295/12 , C07D295/13 , C07D295/135 , C07D295/18 , C07D401/12 , C07F7/1804
摘要： The invention relates to the use of a group of aryl ureas in treating raf mediated diseases and pharmaceutical compositions for use in such therapy of the formula wherein, Y is NHR Hal is chlorine or bromine, R is H, CH3 or CH2OH, and X1 to X7 are each, independently, H, OH or —OC(O)C1-C4 alkyl, or a salt purified stereoisomer thereof, wherein at least one of X1 to X7 is OH or —OC(O)C1-C4 alkyl.
摘要翻译： 本发明涉及一组芳基脲在治疗raf介导的疾病中的用途以及用于下列治疗的药物组合物：其中Y是NHR Hal是氯或溴，R是H，CH3或CH2OH，X1至 X 7各自独立地为H，OH或-OC（O）C 1 -C 4烷基或其盐纯化的立体异构体，其中X 1至X 7中的至少一个为OH或-OC（O）C 1 -C 4烷基。
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公开(公告)号：US06943172B2
公开(公告)日：2005-09-13
申请号：US10349176
申请日：2003-01-23
IPC分类号： C07D239/48 , A61K31/505 , A61K31/506 , A61K31/517 , A61P7/02 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/06 , A61P15/10 , A61P19/10 , A61P25/00 , A61P25/06 , A61P25/28 , A61P27/06 , A61P35/00 , A61P43/00 , C07D401/12 , C07D401/14
CPC分类号： C07D401/12 , C07D401/14
摘要： Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
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公开(公告)号：US20050192304A1
公开(公告)日：2005-09-01
申请号：US11107793
申请日：2005-04-18
申请人： Dhanapalan Nagarathnam , Jacques Dumas , Holia Hatoum-Mokdad , Stephen Boyer , Chunguang Wang , Hans Pluempe , Achim Feurer , Samir Bennabi
发明人： Dhanapalan Nagarathnam , Jacques Dumas , Holia Hatoum-Mokdad , Stephen Boyer , Chunguang Wang , Hans Pluempe , Achim Feurer , Samir Bennabi
IPC分类号： A61K31/505 , A61K31/506 , A61K31/517 , A61K31/519 , A61P7/02 , A61P9/10 , A61P9/12 , A61P9/14 , A61P11/06 , A61P15/10 , A61P19/10 , A61P25/00 , A61P25/28 , A61P27/06 , A61P35/00 , A61P43/00 , C07B57/00 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D471/04 , C07D43/02
CPC分类号： C07D239/48 , A61K31/506 , C07D401/12 , C07D403/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D471/04
摘要： Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
摘要翻译： 公开了其化合物及其衍生物，其合成及其作为Rho-激酶抑制剂的用途。 这些化合物可用于抑制肿瘤生长，治疗勃起功能障碍和治疗由Rho-激酶介导的其它适应症，例如冠心病。
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公开(公告)号：US06924290B2
公开(公告)日：2005-08-02
申请号：US10349177
申请日：2003-01-23
申请人： Dhanapalan Nagarathnam , Jacques Dumas , Holia Hatoum-Mokdad , Stephen Boyer , Chunguang Wang , Hans Pluempe , Achim Feurer , Samir Bennabi
发明人： Dhanapalan Nagarathnam , Jacques Dumas , Holia Hatoum-Mokdad , Stephen Boyer , Chunguang Wang , Hans Pluempe , Achim Feurer , Samir Bennabi
IPC分类号： A61K31/505 , A61K31/506 , A61K31/517 , A61K31/519 , A61P7/02 , A61P9/10 , A61P9/12 , A61P9/14 , A61P11/06 , A61P15/10 , A61P19/10 , A61P25/00 , A61P25/28 , A61P27/06 , A61P35/00 , A61P43/00 , C07B57/00 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D471/04
CPC分类号： C07D239/48 , A61K31/506 , C07D401/12 , C07D403/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D471/04
摘要： Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
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