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1.发明授权Photoreactive system and methods for prophylactic treatment of atherosclerosis 有权光反应性体系及预防动脉粥样硬化的方法公开(公告)号：US08097028B2
公开(公告)日：2012-01-17
申请号：US11357358
申请日：2006-02-17
申请人： James C. Chen , Nicholas Yeo , Phillip Burwell , Thomas Wenger
发明人： James C. Chen , Nicholas Yeo , Phillip Burwell , Thomas Wenger
IPC分类号： A61N5/06
CPC分类号： A61K41/0071 , A61N5/0601 , A61N5/062 , A61N2005/0602 , A61N2005/0651 , A61N2005/0661
摘要： The present invention provides a prophylactic light activated treatment method for subjects at risk of a plaque-mediated thrombotic event, such as acute coronary syndromes. In one embodiment, the subject receives a dose of photosensitizer sufficient to result in a concentration of photosensitizer in the neovascularization associated with atherosclerotic disease to permit effective photodynamic therapy. Light of a wavelength that excites the photosensitizer, but that does not to any significant extent penetrate to an adventitial layer of the blood vessel, is applied to the region of the blood vessel. The therapeutic light dose, which may be applied in sequential stages, is sufficient to cause closure of neovasculature leakage and lead to plaque stabilization and reduced adverse clinical outcomes. The present invention further provides light transmission devices and systems useful in carrying out the methods of the present invention.
摘要翻译： 本发明为患有斑块介导的血栓形成事件风险的受试者，例如急性冠状动脉综合征提供预防性光活化治疗方法。 在一个实施方案中，受试者接受足以导致与动脉粥样硬化疾病相关的新血管形成中的光敏剂浓度以允许有效的光动力疗法的剂量的光敏剂。 激发光敏剂的波长的光被施加到血管的区域，而不是任何显着程度的透射到血管的外膜层。 可以按顺序施用的治疗光剂量足以引起新血管渗漏的闭合并导致斑块稳定化并减少不良临床结果。 本发明还提供了用于实施本发明的方法的光传输装置和系统。
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2.发明申请Photoreactive system and methods for prophylactic treatment of atherosclerosis 有权光反应性体系及预防动脉粥样硬化的方法公开(公告)号：US20070038204A1
公开(公告)日：2007-02-15
申请号：US11357358
申请日：2006-02-17
申请人： James Chen , Nicholas Yeo , Phillip Burwell , Thomas Wenger
发明人： James Chen , Nicholas Yeo , Phillip Burwell , Thomas Wenger
CPC分类号： A61K41/0071 , A61N5/0601 , A61N5/062 , A61N2005/0602 , A61N2005/0651 , A61N2005/0661
摘要： A method of manufacture and medical apparatus that provides an apparatus useful in illuminating at least a portion of a lumen of a body. The apparatus includes an elongated flexible member and a polymer encasement portion encasing a plurality of light emitters. The light emitters may be electrically coupled to one another without the use of wire bonds, and in some embodiments may be coupled without intervening electrical paths or traces. A maximum cross-sectional dimension of the polymer encasement portion may be less than twice a dimension of one of the light emitters. In some embodiments the maximum cross-sectional dimension is less than or equal to the sum of the dimension of one of the light emitters and a marginal dimension by which an outer portion of the polymer encasement portion extends beyond the light emitter. Light emitters may be arranged linearly, helically or in partially overlapping back-to-back relation.
摘要翻译： 一种制造方法和医疗装置，其提供用于照亮身体的内腔的至少一部分的装置。 该装置包括细长的柔性构件和封装多个发光体的聚合物封装部分。 光发射器可以在不使用引线键的情况下彼此电耦合，并且在一些实施例中可以耦合而没有中间的电路径或迹线。 聚合物封装部分的最大横截面尺寸可以小于一个发光体的尺寸的两倍。 在一些实施例中，最大横截面尺寸小于或等于光发射器之一的尺寸之和和聚合物封装部分的外部部分延伸超过光发射器的边缘尺寸之和。 光发射器可以线性地，螺旋状地或以部分重叠的背靠背关系布置。
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公开(公告)号：US20180200088A1
公开(公告)日：2018-07-19
申请号：US15886629
申请日：2018-02-01
CPC分类号： A61F2/852 , A61F2/82 , A61F2/915 , A61F2/958 , A61F2002/068 , A61F2002/828 , A61F2210/0014 , A61F2230/0091
摘要： There is disclosed a method of treating hypoxia in tissue of a blood vessel, the method comprising placing a stent in the vessel, the stent having a centre line which curves in three dimensions to promote the supply of oxygen from the blood flowing in the lumen of the stented vessel to the vessel wall. There is disclosed a method of treating a subject with diabetic atherosclerosis, the method comprising placing a stent in a blood vessel of the subject, the stent having a centre line which curves in three dimensions to promote the supply of oxygen from the blood flowing in the lumen of the stented vessel to the vessel wall.
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公开(公告)号：US20140277352A1
公开(公告)日：2014-09-18
申请号：US14212693
申请日：2014-03-14
CPC分类号： A61F2/852 , A61F2/82 , A61F2/915 , A61F2/958 , A61F2002/068 , A61F2002/828 , A61F2210/0014 , A61F2230/0091
摘要： There is disclosed a method of treating hypoxia in tissue of a blood vessel, the method comprising placing a stent in the vessel, the stent having a centre line which curves in three dimensions to promote the supply of oxygen from the blood flowing in the lumen of the stented vessel to the vessel wall. There is disclosed a method of treating a subject with diabetic atherosclerosis, the method comprising placing a stent in a blood vessel of the subject, the stent having a centre line which curves in three dimensions to promote the supply of oxygen from the blood flowing in the lumen of the stented vessel to the vessel wall.
摘要翻译： 公开了一种治疗血管组织中的缺氧的方法，所述方法包括将支架放置在血管内，所述支架具有三维曲线的中心线，以促进从在内腔中流动的血液中供氧 将支架血管置于血管壁。 公开了一种用糖尿病动脉粥样硬化治疗受试者的方法，所述方法包括将支架置于受试者的血管中，所述支架具有三维曲线的中心线，以促进从在血液中流动的血液中供氧 支架血管的内腔到血管壁。
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公开(公告)号：US20180168831A1
公开(公告)日：2018-06-21
申请号：US15886589
申请日：2018-02-01
CPC分类号： A61F2/852 , A61F2/82 , A61F2/915 , A61F2/958 , A61F2002/068 , A61F2002/828 , A61F2210/0014 , A61F2230/0091
摘要： There is disclosed a method of treating hypoxia in tissue of a blood vessel, the method comprising placing a stent in the vessel, the stent having a centre line which curves in three dimensions to promote the supply of oxygen from the blood flowing in the lumen of the stented vessel to the vessel wall. There is disclosed a method of treating a subject with diabetic atherosclerosis, the method comprising placing a stent in a blood vessel of the subject, the stent having a centre line which curves in three dimensions to promote the supply of oxygen from the blood flowing in the lumen of the stented vessel to the vessel wall.
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