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    Photoreactive system and methods for prophylactic treatment of atherosclerosis
    1.
    发明申请
    Photoreactive system and methods for prophylactic treatment of atherosclerosis 有权
    光反应性体系及预防动脉粥样硬化的方法

    公开(公告)号：US20070038204A1

    公开(公告)日：2007-02-15

    申请号：US11357358

    申请日：2006-02-17

    申请人： James Chen ,  Nicholas Yeo ,  Phillip Burwell ,  Thomas Wenger

    发明人： James Chen ,  Nicholas Yeo ,  Phillip Burwell ,  Thomas Wenger

    IPC分类号： A61B18/18 ,  A61N5/06

    CPC分类号： A61K41/0071 ,  A61N5/0601 ,  A61N5/062 ,  A61N2005/0602 ,  A61N2005/0651 ,  A61N2005/0661

    摘要： A method of manufacture and medical apparatus that provides an apparatus useful in illuminating at least a portion of a lumen of a body. The apparatus includes an elongated flexible member and a polymer encasement portion encasing a plurality of light emitters. The light emitters may be electrically coupled to one another without the use of wire bonds, and in some embodiments may be coupled without intervening electrical paths or traces. A maximum cross-sectional dimension of the polymer encasement portion may be less than twice a dimension of one of the light emitters. In some embodiments the maximum cross-sectional dimension is less than or equal to the sum of the dimension of one of the light emitters and a marginal dimension by which an outer portion of the polymer encasement portion extends beyond the light emitter. Light emitters may be arranged linearly, helically or in partially overlapping back-to-back relation.

    摘要翻译： 一种制造方法和医疗装置，其提供用于照亮身体的内腔的至少一部分的装置。 该装置包括细长的柔性构件和封装多个发光体的聚合物封装部分。 光发射器可以在不使用引线键的情况下彼此电耦合，并且在一些实施例中可以耦合而没有中间的电路径或迹线。 聚合物封装部分的最大横截面尺寸可以小于一个发光体的尺寸的两倍。 在一些实施例中，最大横截面尺寸小于或等于光发射器之一的尺寸之和和聚合物封装部分的外部部分延伸超过光发射器的边缘尺寸之和。 光发射器可以线性地，螺旋状地或以部分重叠的背靠背关系布置。

    Photoreactive system and methods for prophylactic treatment of atherosclerosis
    2.
    发明授权
    Photoreactive system and methods for prophylactic treatment of atherosclerosis 有权
    光反应性体系及预防动脉粥样硬化的方法

    公开(公告)号：US08097028B2

    公开(公告)日：2012-01-17

    申请号：US11357358

    申请日：2006-02-17

    申请人： James C. Chen ,  Nicholas Yeo ,  Phillip Burwell ,  Thomas Wenger

    发明人： James C. Chen ,  Nicholas Yeo ,  Phillip Burwell ,  Thomas Wenger

    IPC分类号： A61N5/06

    CPC分类号： A61K41/0071 ,  A61N5/0601 ,  A61N5/062 ,  A61N2005/0602 ,  A61N2005/0651 ,  A61N2005/0661

    摘要： The present invention provides a prophylactic light activated treatment method for subjects at risk of a plaque-mediated thrombotic event, such as acute coronary syndromes. In one embodiment, the subject receives a dose of photosensitizer sufficient to result in a concentration of photosensitizer in the neovascularization associated with atherosclerotic disease to permit effective photodynamic therapy. Light of a wavelength that excites the photosensitizer, but that does not to any significant extent penetrate to an adventitial layer of the blood vessel, is applied to the region of the blood vessel. The therapeutic light dose, which may be applied in sequential stages, is sufficient to cause closure of neovasculature leakage and lead to plaque stabilization and reduced adverse clinical outcomes. The present invention further provides light transmission devices and systems useful in carrying out the methods of the present invention.

    摘要翻译： 本发明为患有斑块介导的血栓形成事件风险的受试者，例如急性冠状动脉综合征提供预防性光活化治疗方法。 在一个实施方案中，受试者接受足以导致与动脉粥样硬化疾病相关的新血管形成中的光敏剂浓度以允许有效的光动力疗法的剂量的光敏剂。 激发光敏剂的波长的光被施加到血管的区域，而不是任何显着程度的透射到血管的外膜层。 可以按顺序施用的治疗光剂量足以引起新血管渗漏的闭合并导致斑块稳定化并减少不良临床结果。 本发明还提供了用于实施本发明的方法的光传输装置和系统。

    Porous ceramic
    4.
    发明授权
    Porous ceramic 失效
    多孔陶瓷

    公开(公告)号：US06737376B1

    公开(公告)日：2004-05-18

    申请号：US09743244

    申请日：2001-06-08

    申请人： Klaus Heckmann ,  Thomas Wenger

    发明人： Klaus Heckmann ,  Thomas Wenger

    IPC分类号： C04B3510

    CPC分类号： C04B38/0045 ,  C04B2111/00793 ,  C04B2111/0081 ,  C04B2111/00836 ,  C04B35/01 ,  C04B35/447 ,  C04B38/0003

    摘要： Porous ceramics are described, which are produced by a) mixing an aqueous solution of a suitable ionotropically orientable polyanion, either with oxides, hydroxides or hydrated oxides, which are present in the form of a sol, of the metals Al, Zr, Ti and Nb, or with finely crystalline oxides, hydroxides or hydrated oxides, which are present in suspension, of these metals, or with finely crystalline tricalcium phosphate or apatite which are present in suspension, b) bringing the mixed sol obtained as in a) or the suspension obtained as in a) into contact with a solution of a salt of a di- or trivalent metal cation in order to produce an ionotropic gel body, c) compacting the gel body by introducing it into electrolyte solutions which further enhance the syneresis of the polyelectrolyte which was originally formed, d) washing the gel body with water and subsequently impregnating it with a readily volatile, water-miscible solvent, e) freeing the anhydrous gel body or gel bodies obtained as in d) from the readily volatile, water-miscible solvent, f) burning out the organic constituents from the dry gel body or the dry gel bodies obtained as in e), g) sintering the product obtained as in f). A capillary frit is also described. Moreover, the invention describes the use of these materials as a catalyst or as a catalyst support, as a ceramic component for composite materials, as a reversible flow filter and as a slab-like sorbent for chromatography columns, as well as the use of a composite material, which is produced from a granular material of the ceramics which are described, as a dental material, particularly as a dental cement.

    摘要翻译： 描述了通过以下方法制备的多孔陶瓷：a）将金属Al，Zr，Ti和Nb中以溶胶形式存在的合适的可离子取向的聚阴离子，即金属，氢氧化物或水合氧化物的水溶液混合， 或这些金属中存在于悬浮液中的精细结晶氧化物，氢氧化物或水合氧化物，或与悬浮液中存在的细晶磷酸三钙或磷灰石，b）使得得到的混合溶胶或所得悬浮液 如同a）与二价或三价金属阳离子盐的溶液接触以产生离子型凝胶体，c）通过将凝胶体引入电解质溶液中来压实凝胶体，所述电解质溶液进一步增强聚电解质的脱水收缩， 最初形成，d）用水洗涤凝胶体，随后用容易挥发的水混溶性溶剂浸渍，e）释放如d）f所得的无水凝胶体或凝胶体 f）易挥发的水溶性溶剂，f）从如干燥凝胶体或如e）所得的干燥凝胶体中烧掉有机成分，g）烧结如f）所得的产物。还描述了毛细管玻璃料 。 此外，本发明描述了这些材料作为催化剂或作为催化剂载体的用途，作为复合材料的陶瓷组分，可逆流动过滤器和用于色谱柱的板状吸附剂，以及使用 复合材料，其由作为牙科材料的陶瓷的颗粒材料制成，特别是作为牙科粘固剂。