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公开(公告)号：US07718442B2
公开(公告)日：2010-05-18
申请号：US10302647
申请日：2002-11-22
IPC分类号： G01N1/00
CPC分类号： B01L3/50853 , A01N1/02 , A01N1/0263 , B01L3/545 , B01L2300/021 , B01L2300/022 , B01L2300/044 , B01L2300/0829 , B01L2300/0851 , G01N35/028 , G01N2001/288 , Y10T436/11 , Y10T436/25 , Y10T436/2525 , Y10T436/255
摘要： A system and method operative in accordance with the present disclosure facilitate storage and retrieval of individual or discrete samples of biological, non-biological, and chemical material stored on dry media. Sample material may be disposed upon or within a porous or solid (i.e., non-porous) sample storage medium and subsequently archived in, and retrieved from, storage elements such as multi-well plates, for example, using robotic devices or other automated apparatus. The disclosed system and method enable ejection of sample material from a sealed storage element into a specific well of a multi-well daughter plate, or into a specific cuvette, test tube, or similar container. In some embodiments, a sample carrier comprising a storage medium may be punched or ejected through a first seal of the storage element with an apparatus or implement such as a disposable piercing tip, for instance, inserted through a second seal of the storage element.
摘要翻译： 根据本公开操作的系统和方法便于存储和回收存储在干燥介质上的生物，非生物和化学材料的个体或离散样品。 样品材料可以设置在多孔或固体（即，非多孔）样品存储介质上或内部，并且随后存储在存储元件例如多孔板中并从其中取出，例如使用机器人装置或其它自动化装置 。 所公开的系统和方法使得样品材料能够从密封的存储元件排出到多孔子板的特定孔中，或者进入特定的比色皿，试管或类似的容器中。 在一些实施例中，包括存储介质的样品载体可以通过存储元件的第一密封件用诸如一次性穿刺尖端的装置或工具冲压或喷射，例如通过存储元件的第二密封件插入。
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2.发明授权公开(公告)号：US06483091B1
公开(公告)日：2002-11-19
申请号：US09427967
申请日：1999-10-27
申请人： John W. Sadler , Kenneth L. Staton
发明人： John W. Sadler , Kenneth L. Staton
IPC分类号： G01J120
CPC分类号： G02B7/28
摘要： An inner control loop controls the relative position of a surface to be scanned with respect to a focal plane. An outer control loop responds to the location of the surface to be scanned with respect to a focal plane of the scan lens to generate a setpoint for the inner control loop. A sample-and-hold element disposed between the inner and outer control loops is switched by an edge or defect detector. It is preferred that the outer control loop has a time constant in the range of three to ten times longer than that of the inner control loop. The sample-and-hold element provides a gradual state transition upon the occurrence of an edge or a surface defect.
摘要翻译： 内部控制环控制相对于焦平面的待扫描表面的相对位置。 外部控制环路相对于扫描透镜的焦平面响应待扫描表面的位置，以产生用于内部控制回路的设定点。 设置在内外控制回路之间的采样保持元件由边缘或缺陷检测器切换。 优选的是，外部控制回路的时间常数在内部控制回路的3〜10倍的范围内。 采样和保持元件在发生边缘或表面缺陷时提供逐渐状态转换。
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公开(公告)号：US5945679A
公开(公告)日：1999-08-31
申请号：US132068
申请日：1998-08-17
CPC分类号： G01N21/6452 , G01N21/6428 , B01J2219/00605 , B01J2219/00659 , B01J2219/00702 , Y10S436/805
摘要： A technique for analyzing analytes in a chemical array having a plurality of pixels is provided. The apparatus of the technique contains a light source for irradiating a light beam at the pixels individually, a controller for controlling the relative position of the light source to the array, and a detector for detecting fluorescence resulting from irradiation. The controller controls the light beam generated by the light source to irradiate a first number of pixels sequentially in the array and repeating one or more times the sequential irradiation before irradiating a second number of pixels, the pixels of which are different from those of the first number of pixels. The first number of pixels includes more than one pixel but less than the total number of pixels in the array.
摘要翻译： 提供了一种用于分析具有多个像素的化学阵列中的分析物的技术。 该技术的装置包括用于单独照射像素的光束的光源，用于控制光源相对于阵列的相对位置的控制器，以及用于检测由照射产生的荧光的检测器。 控制器控制由光源产生的光束，在阵列中依次照射第一数量的像素，并且在照射第二数量的像素之前重复一次或多次顺序照射，其中像素与第一像素的像素不同 像素数 第一数量的像素包括多于一个像素但小于阵列中的像素总数。
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公开(公告)号：US5837475A
公开(公告)日：1998-11-17
申请号：US790775
申请日：1997-01-30
CPC分类号： G01N21/6452 , G01N21/6428 , B01J2219/00605 , B01J2219/00659 , B01J2219/00702 , Y10S436/805
摘要： A technique for analyzing analytes in a chemical array having a plurality of pixels is provided. The apparatus of the technique contains a light source for irradiating a light beam at the pixels individually, a controller for controlling the relative position of the light source to the array, and a detector for detecting fluorescence resulting from irradiation. The controller controls the light beam generated by the light source to irradiate a first number of pixels sequentially in the array and repeating one or more times the sequential irradiation before irradiating a second number of pixels, the pixels of which are different from those of the first number of pixels. The first number of pixels includes more than one pixel but less than the total number of pixels in the array.
摘要翻译： 提供了一种用于分析具有多个像素的化学阵列中的分析物的技术。 该技术的装置包括用于单独照射像素的光束的光源，用于控制光源相对于阵列的相对位置的控制器，以及用于检测由照射产生的荧光的检测器。 控制器控制由光源产生的光束，在阵列中依次照射第一数量的像素，并且在照射第二数量的像素之前重复一次或多次顺序照射，其中像素与第一像素的像素不同 像素数 第一数量的像素包括多于一个像素但小于阵列中的像素总数。
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公开(公告)号：US07828528B2
公开(公告)日：2010-11-09
申请号：US11851212
申请日：2007-09-06
申请人： Mark C. Estes , Mitchell Wenger , John W. Sadler
发明人： Mark C. Estes , Mitchell Wenger , John W. Sadler
CPC分类号： A61M5/14244 , A61M5/14526 , A61M5/16831 , A61M5/1723 , A61M2005/14268 , A61M2005/31518 , G01P13/0013 , G01P13/004 , G01P13/0073
摘要： Some embodiments of an infusion pump system may include an occlusion sensor system that communicates with control circuitry to detect the presence of an occlusion. In some embodiments, the occlusion sensor system includes first components that are located within a disposable and non-reusable pump device, and second components that are located within a reusable controller device, the second components being in operable communication with the first components to determine whether a fluid is flowing from the pump device.
摘要翻译： 输注泵系统的一些实施例可以包括与控制电路通信以检测咬合的存在的闭塞传感器系统。 在一些实施例中，闭塞传感器系统包括位于一次性和不可重复使用的泵装置内的第一部件和位于可重复使用的控制器装置内的第二部件，第二部件与第一部件可操作地通信以确定是否 流体从泵装置流出。
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公开(公告)号：US07412085B2
公开(公告)日：2008-08-12
申请号：US11375658
申请日：2006-03-13
IPC分类号： G06K9/00
CPC分类号： G06K9/3216 , B01J2219/00378 , B01J2219/00608 , B01J2219/00612 , B01J2219/00659 , B01J2219/00693 , B01J2219/00704 , B01J2219/00722 , B01J2219/00725 , C12Q1/6837 , G06F19/20 , G06F19/24 , G06T7/73 , G06T2207/30072
摘要： Methods for correcting systematic errors in the measured position of deposited features of a nucleic acid array on a substrate. Systematic errors are modeled by an algorithmic model based on measuring the positions (and possibly other properties) of a subset of the features, and a model is constructed for predicting deviations in feature position from an ideal grid. Deviations arising in the deposition process, the scanning process, or both may be corrected.
摘要翻译： 用于校正基底上核酸阵列的沉积特征的测量位置的系统误差的方法。 系统误差是通过基于测量特征子集的位置（以及可能的其他属性）的算法模型来建模的，并且构建用于预测特征位置与理想网格的偏差的模型。 在沉积过程中产生的偏差，扫描过程或两者都可以被校正。
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公开(公告)号：US07027629B2
公开(公告)日：2006-04-11
申请号：US10238922
申请日：2002-09-09
IPC分类号： G06K9/00
CPC分类号： G06K9/3216 , B01J2219/00378 , B01J2219/00608 , B01J2219/00612 , B01J2219/00659 , B01J2219/00693 , B01J2219/00704 , B01J2219/00722 , B01J2219/00725 , C12Q1/6837 , G06F19/20 , G06F19/24 , G06T7/73 , G06T2207/30072
摘要： Methods for correcting systematic errors in the measured position of deposited features of a nucleic acid array on a substrate. Systematic errors are modeled by an algorithmic model based on measuring the positions (and possibly other properties) of a subset of the features, and a model is constructed for predicting deviations in feature position from an ideal grid. Deviations arising in the deposition process, the scanning process, or both may be corrected.
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公开(公告)号：US08032226B2
公开(公告)日：2011-10-04
申请号：US11851989
申请日：2007-09-07
申请人： Steve Miller , John W. Sadler
发明人： Steve Miller , John W. Sadler
CPC分类号： A61M5/172 , A61M5/14244 , A61M5/14566 , A61M2005/14268 , A61M2005/31518 , A61M2205/16 , A61M2205/52 , G06F19/00 , G06F19/3468 , G16H40/60
摘要： Some embodiments of an infusion pump system can include a controller device that communicates with a pump device, the pump device having a memory device. The controller device can be configured to record controller-related data, such as user profile data on the memory device of the pump device. This user profile data that is stored in the memory of the pump device can serves as a data backup system that permits the user to program a new controller device in a situation where the original controller device is lost or damaged. In addition or in the alternative, the controller device can be configured to receive controller-related data, such as software update programs or backup controller data, from the memory device of the pump device.
摘要翻译： 输注泵系统的一些实施例可以包括与泵装置通信的控制器装置，所述泵装置具有存储装置。 控制器设备可被配置为将控制器相关数据（诸如用户简档数据）记录在泵装置的存储器设备上。 存储在泵装置的存储器中的用户简档数据可以用作数据备份系统，其允许用户在原始控制器设备丢失或损坏的情况下编程新的控制器设备。 另外或替代地，控制器设备可被配置为从泵装置的存储器装置接收控制器相关数据，例如软件更新程序或备用控制器数据。
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公开(公告)号：US20110224574A1
公开(公告)日：2011-09-15
申请号：US13063948
申请日：2009-11-13
CPC分类号： G01N33/5091 , A61B90/361 , A61B2090/3908 , A61B2090/395 , G01N1/312 , G01N21/6458 , G01N33/57415 , G01N33/5743 , G01N2021/6439 , G02B21/16
摘要： The disclosure relates generally to methods and systems for processing biological samples obtained from a subject having, or believed to have, a cell proliferation disorder. The disclosure further relates to methods and systems for detecting an object of interest in a biological sample.
摘要翻译： 本公开一般涉及用于处理从患有或相信具有细胞增殖病症的受试者获得的生物样品的方法和系统。 本公开还涉及用于检测生物样品中感兴趣对象的方法和系统。
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10.发明授权Method and system for operating a laser device employing an integral power-regulation sensor 失效用于操作采用集成功率调节传感器的激光装置的方法和系统
公开(公告)号：US5763870A
公开(公告)日：1998-06-09
申请号：US764910
申请日：1996-12-13
IPC分类号： G02B5/30 , H01S5/0683 , G11B7/00
CPC分类号： G02B5/3083 , H01S5/0683
摘要： A method and system of operating a laser device includes utilizing an integral power-regulation sensor of the laser device to detect energy back reflected from an object of interest and then using the detected signal as a basis for determining a characteristic related to the object of interest. In the preferred embodiment, the determined characteristic is the position of the beam focus relative to a surface of the object. Also in the preferred embodiment, the integral power-regulation sensor is disconnected from power-regulation circuitry during the focusing operation. Interaction of the back reflected energy and the outgoing beam can be reduced by introducing beam rotation, such as by providing a quarter-wave plate along the beam path. Focusing sensitivity can be increased by locating reflective targets over the surface and by executing AC measurements to filter DC components from the signal.
摘要翻译： 操作激光装置的方法和系统包括利用激光装置的整体功率调节传感器来检测从感兴趣对象反射的能量，然后使用检测到的信号作为确定与感兴趣对象有关的特征的基础 。 在优选实施例中，确定的特性是相对于物体表面的光束聚焦的位置。 同样在优选实施例中，集中功率调节传感器在聚焦操作期间与功率调节电路断开连接。 通过引入光束旋转，例如通过沿光束路径提供四分之一波片，可以减少后反射能量和输出光束的相互作用。 可以通过将反射目标定位在表面上并通过执行AC测量来从信号中滤除直流分量来提高对焦灵敏度。
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