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公开(公告)号：US06706032B2
公开(公告)日：2004-03-16
申请号：US09878155
申请日：2001-06-07
申请人： James C. Weaver , R. Rox Anderson , Terry O Herndon , T. R. Gowrishankar , Elizabeth A. Gift , Salvador Gonzalez
发明人： James C. Weaver , R. Rox Anderson , Terry O Herndon , T. R. Gowrishankar , Elizabeth A. Gift , Salvador Gonzalez
IPC分类号： A61M3100
摘要： The present invention relates to methods and devices used for the formation of microconduits in a tissue. The term “microconduit” refers to a small opening, channel, or hole into, or through, a tissue, that allows transfer of materials by liquid flow, and by electrophoresis, the microconduit being formed upon impact of a plurality of accelerated microparticles with the surface of the tissue. A method is described for forming at least one microconduit in tissue including the steps of: accelerating a plurality of microparticles to a velocity that causes the microparticles to penetrate a region of tissue surface upon impingement of the microparticles on the tissue surface; and directing the microparticle towards the region of tissue surface, thereby causing the microparticles to penetrate the tissue and form a microconduit in the tissue. According to an embodiment, microparticles are accelerated by being hit with a moving, solid surface. In another embodiment, microparticles are accelerated by a flowing gas or liquid. Also described are methods and devices for using microconduits to deliver therapeutic molecules and ions into tissue, or for extraction of chemical analytes out of tissue. Also described is a method of nail piercing to accommodate jewelry.
摘要翻译： 本发明涉及用于在组织中形成微管的方法和装置。 术语“微管道”是指通过液体流动允许材料转移并通过电泳的组织中的或通过组织的小的开口，通道或孔，在多个加速的微粒撞击时形成的微管， 组织表面。 描述了一种用于在组织中形成至少一个微管的方法，包括以下步骤：将多个微粒加速到使微粒在组织表面上碰撞时穿透组织表面区域的速度; 并将微粒引向组织表面的区域，从而使微粒穿透组织并在组织中形成微管。 根据一个实施例，通过用移动的固体表面击打微粒被加速。 在另一个实施方案中，微粒被流动的气体或液体加速。 还描述了使用微管道将治疗分子和离子递送到组织中或从组织中提取化学分析物的方法和装置。 还描述了一种钉子穿孔以适应首饰的方法。
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公开(公告)号：US07597692B2
公开(公告)日：2009-10-06
申请号：US10800587
申请日：2004-03-15
IPC分类号： A61M31/00
CPC分类号： A61N1/30 , A61M5/427 , A61M37/00 , A61M2037/0007 , A61N1/325
摘要： The present invention relates to microscission methods and devices used for the manipulation or modification of the body tissue by the formation of microconduits in a tissue. The term “microconduit” refers to a small opening, channel, or hole into, or through, a tissue, that allows transfer of materials by liquid flow, and by electrophoresis, the microconduit being formed upon impact of a plurality of accelerated microparticles with the surface of the tissue. This process of “microscission” comprises forming at least one microconduit in tissue including the steps of: accelerating a plurality of microparticles to a velocity that causes the microparticles to penetrate a region of tissue surface upon impingement of the microparticles on the tissue surface; and directing the microparticle towards the region of tissue surface, thereby causing the microparticles to penetrate the tissue and form a microconduit in the tissue.
摘要翻译： 本发明涉及用于通过在组织中形成微管的操作或改变身体组织的微观方法和装置。 术语“微管道”是指通过液体流动允许材料转移并通过电泳的组织中的或通过组织的小的开口，通道或孔，在多个加速的微粒撞击时形成的微管， 组织表面。 “微观”的这个过程包括在组织中形成至少一个微管，其包括以下步骤：将多个微粒加速到使微粒在组织表面上碰撞时穿透组织表面区域的速度; 并将微粒引向组织表面的区域，从而使微粒穿透组织并在组织中形成微管。
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公开(公告)号：US5749847A
公开(公告)日：1998-05-12
申请号：US471642
申请日：1995-06-06
IPC分类号： A61B5/00 , A61K38/38 , A61K38/48 , A61K41/00 , A61K48/00 , A61N1/32 , C07K14/82 , C12N15/87 , A61M31/00
CPC分类号： C12N15/87 , A61B5/14514 , A61K38/385 , A61K38/48 , A61K38/4873 , A61K41/0047 , A61K48/00 , A61N1/325 , A61N1/327 , C07K14/82 , A61B5/14532
摘要： A method for delivering a nucleotide into an organism includes applying a composition which includes a nucleotide component to epidermis of the organism. The epidermis is electroporated, whereby at least a portion of the composition enters or passes across the epidermis, thereby delivering the nucleotide into the organism. An example of a suitable nucleotide which can be delivered by the method of the invention includes antisense oligodeoxynucleotides for treatment of melanomas.
摘要翻译： 将核苷酸递送至生物体的方法包括将包含核苷酸组分的组合物施用于生物体的表皮。 电穿孔表皮，由此组合物的至少一部分进入或穿过表皮，从而将核苷酸输送到生物体内。 可以通过本发明的方法递送的合适的核苷酸的实例包括用于治疗黑素瘤的反义寡脱氧核苷酸。
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公开(公告)号：US5667491A
公开(公告)日：1997-09-16
申请号：US487470
申请日：1995-06-07
IPC分类号： A61B5/00 , A61K38/38 , A61K38/48 , A61K41/00 , A61K48/00 , A61N1/32 , C07K14/82 , C12N15/87 , A61M31/00
CPC分类号： A61N1/0412 , A61B5/14514 , A61B5/418 , A61K31/00 , A61K41/0047 , A61K48/00 , A61N1/325 , A61N1/327 , C07K14/82 , C12N15/87 , G01N33/50 , A61B5/14532 , A61N1/0452
摘要： A method is disclosed for treating tissue in response to a stimulus generated by the tissue. In one embodiment, the method transdermally treats an organism in response to a stimulus. In this embodiment, the medication is applied to epidermis of the organism, and the epidermis is electroporated in response to a stimulus, whereby the medication passes through the epidermis at a rate sufficient to alter the stimulus, thereby transdermally treating the organism. In another embodiment, the method measures a blood component content of blood. A portion of epidermis is electroporated to cause an aqueous fluid to be directed through an electroporated epidermis to a surface of the epidermis. Thereafter, the blood component content of the aqueous fluid is measured for correlation with a known aqueous fluid blood component content associated with a known concentration of blood component in the blood. The blood component concentration of the blood can thereby be measured. In still another embodiment, the method includes directing a medication to the tissue which can alter the stimulus when the tissue is electroporated, and electroporating the tissue in response to a stimulus, whereby the medication passes through the tissue in an amount sufficient to alter the stimulus, thereby treating the organism.
摘要翻译： 公开了一种响应于由组织产生的刺激来治疗组织的方法。 在一个实施方案中，所述方法响应于刺激经皮处理生物体。 在该实施方案中，将药物施用于生物体的表皮，并且响应于刺激而对表皮进行电穿孔，由此药物以足以改变刺激的速率通过表皮，从而透皮治疗生物体。 在另一个实施方案中，该方法测量血液的血液成分含量。 将一部分表皮电穿孔以使含水液体通过电穿孔表皮导入表皮表面。 此后，测量含水流体的血液成分含量与已知的血液中血液成分浓度相关的含水液体成分含量的相关性。 因此可以测量血液的血液成分浓度。 在另一个实施方案中，该方法包括将药物引导到组织，当组织被电穿孔时可以改变刺激，并响应于刺激电穿孔组织，由此药物以足以改变刺激的量通过组织 ，从而治疗生物体。
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公开(公告)号：US5547467A
公开(公告)日：1996-08-20
申请号：US096512
申请日：1993-07-23
IPC分类号： A61B5/00 , A61K38/38 , A61K38/48 , A61K41/00 , A61K48/00 , A61N1/32 , C07K14/82 , C12N15/87 , A61M37/00
CPC分类号： A61N1/0412 , A61B5/14514 , A61B5/418 , A61K31/00 , A61K41/0047 , A61K48/00 , A61N1/325 , A61N1/327 , C07K14/82 , C12N15/87 , G01N33/50 , A61B5/14532 , A61N1/0452
摘要： A method is disclosed for treating tissue in response to a stimulus generated by the tissue. In one embodiment, the method transdermally treats an organism in response to a stimulus. In this embodiment, the medication is applied to epidermis of the organism, and the epidermis is electroporated in response to a stimulus, whereby the medication passes through the epidermis at a rate sufficient to alter the stimulus, thereby transdermally treating the organism. In another embodiment, the method measures a blood component content of blood. A portion of epidermis is electroporated to cause an aqueous fluid to be directed through an electroporated epidermis to a surface of the epidermis. Thereafter, the blood component content of the aqueous fluid is measured for correlation with a known aqueous fluid blood component content associated with a known concentration of blood component in the blood. The blood component concentration of the blood can thereby be measured. In still another embodiment, the method includes directing a medication to the tissue which can alter the stimulus when the tissue is electroporated, and electroporating the tissue in response to a stimulus, whereby the medication passes through the tissue in an amount sufficient to alter the stimulus, thereby treating the organism.
摘要翻译： 公开了一种响应于由组织产生的刺激来治疗组织的方法。 在一个实施方案中，所述方法响应于刺激经皮处理生物体。 在该实施方案中，将药物施用于生物体的表皮，并且响应于刺激而对表皮进行电穿孔，由此药物以足以改变刺激的速率通过表皮，从而透皮治疗生物体。 在另一个实施方案中，该方法测量血液的血液成分含量。 将一部分表皮电穿孔以使含水液体通过电穿孔表皮导入表皮表面。 此后，测量含水流体的血液成分含量与已知的血液中血液成分浓度相关的含水液体成分含量的相关性。 因此可以测量血液的血液成分浓度。 在另一个实施方案中，该方法包括将药物引导到组织，当组织被电穿孔时可以改变刺激，并响应于刺激电穿孔组织，由此药物以足以改变刺激的量通过组织 ，从而治疗生物体。
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公开(公告)号：US4699942A
公开(公告)日：1987-10-13
申请号：US770939
申请日：1985-08-30
申请人： James C. Weaver , Wayne P. Pruett
发明人： James C. Weaver , Wayne P. Pruett
摘要： Compositions suitable for molding are produced by examining a (1) polyethylene terephthalate polyester, (2) a low molecular weight polyethylene mold release agent (3) talc as nucleating agent, (4) carbon black, (5) a hindered phenolic antioxidant and (6) other optional ingredients such as reinforcing glass fibers.
摘要翻译： 通过检查（1）聚对苯二甲酸乙二醇酯聚酯，（2）低分子量聚乙烯脱模剂（3）作为成核剂的滑石粉，（4）炭黑，（5）受阻酚抗氧化剂和（ 6）其他任选成分如增强玻璃纤维。
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公开(公告)号：US6085115A
公开(公告)日：2000-07-04
申请号：US83497
申请日：1998-05-22
申请人： James C. Weaver , Uwe Pliquett , Rita Vanbever , Thiruvallur R. Gowrishankar , Thomas E. Zewert
发明人： James C. Weaver , Uwe Pliquett , Rita Vanbever , Thiruvallur R. Gowrishankar , Thomas E. Zewert
IPC分类号： A61B5/0402 , A61B5/04
CPC分类号： A61B5/04025
摘要： A method for measuring biopotential of an organism includes electroporating a portion of a tissue surface of the organism. The biopotential of the organism is then measured with electrodes at the electroporated portion of the organism. The portion of the organism that is electroporated can be, for example, a skin surface of the organism. A resistance-decreasing agent, such as heparin, sodium thiosulfate, thioglycolic acid solution and dithioglycolic acid can be applied to the tissue surface to facilitate reduction in electrical resistance. Another example of a resistance-decreasing agent is a keratin-disrupting agent, such as sulforhodamine. Examples of suitable biopotential measurements include electrocardiographic, electroencephalographic, electromyographic, electrohysterographic and elctrokymographic measurements. The method decreases skin resistance to diminish unwanted electrical voltages that compete with biopotential measurements, thereby significantly improving the biopotential measurement.
摘要翻译： 用于测量生物体的生物潜力的方法包括电穿孔生物体的组织表面的一部分。 然后用生物体的电穿孔部分的电极测量生物体的生物潜力。 电穿孔的生物体的部分可以是例如生物体的皮肤表面。 电阻降低剂如肝素，硫代硫酸钠，巯基乙酸溶液和二硫代乙醇酸可以施加到组织表面以便于降低电阻。 抗性降低剂的另一个实例是角蛋白破坏剂，例如磺酰罗丹明。 合适的生物电位测量的实例包括心电图，脑电图，肌电描记术，电积电图和电压测量。 该方法降低皮肤抵抗力，减少与生物电位测量竞争的不需要的电压，从而显着改善生物电位测量。
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公开(公告)号：US6041253A
公开(公告)日：2000-03-21
申请号：US626021
申请日：1996-04-01
CPC分类号： A61N1/325 , A61B5/14514 , A61K41/0047 , A61K9/0009 , A61M37/0092 , A61N1/0412 , A61N1/327 , A61M2037/0007 , A61N1/042 , A61N1/0428
摘要： Transdermal transport of molecules during sonophoresis (delivery or extraction) can be further enhanced by application of an electric field, for example, electroporation or iontophoresis. In a preferred embodiment the ultrasound is low frequency ultrasound which induces cavitation of the lipid layers of the stratum corneum (SC). This method provides higher drug transdermal fluxes, allows rapid control of transdermal fluxes, and allows drug delivery or analyte extraction at lower ultrasound intensities than when ultrasound is applied in the absence of an electric field.
摘要翻译： 可以通过施加电场（例如电穿孔或离子电渗疗法）来进一步增强超声波输送（递送或提取）期间分子的透皮转运。 在优选实施例中，超声是低频超声，其引起角质层（SC）的脂质层的空化。 该方法提供较高的药物透皮通量，允许快速控制透皮通量，并且能够在不存在电场的情况下以较低的超声强度进行药物递送或分析物提取。
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公开(公告)号：US5640169A
公开(公告)日：1997-06-17
申请号：US546701
申请日：1995-10-23
申请人： James C. Weaver
发明人： James C. Weaver
IPC分类号： H01Q1/42
CPC分类号： H01Q1/42
摘要： A protected antenna apparatus including an elongated tube; a cable having an upper end with a pair of separate bare leads extending therefrom, a lower end with a connector secured thereto, and an intermediate portion extended between the ends; a twin-lead transmission line having a central axis, a free upper end, a lower end with the bare leads extending therefrom and interconnected together, an intermediate location therebetween wherein each lead is connected with one of the bare leads of the cable, and a notch formed on an upper extent of the line at a location between the intermediate location and the upper end to thereby divide one of the leads into two different pieces and thus create a J-pole antenna having a short leg, a long leg, and an impedance matching stub portion therebetween, and wherein the antenna transmits radio signals of a characteristic frequency as a function of the lengths of the legs and the stub portion; and a coupling mechanism for securing the antenna within the tube and along a longitudinal extent thereof.
摘要翻译： 一种受保护的天线装置，包括细长管; 电缆，其上端具有从其延伸的一对单独的裸露引线，具有固定到其上的连接器的下端和在端部之间延伸的中间部分; 双引线传输线，具有中心轴线，自由上端，下端，裸引线从其延伸并互连在一起，其间的中间位置，其中每个引线与电缆的裸线之一连接， 形成在中间位置和上端之间的位置处的线的上部范围上的凹口，从而将引线中的一个分成两个不同的部分，从而形成具有短腿，长腿和 其间的阻抗匹配短截线部分，并且其中天线将特征频率的无线电信号作为腿部和短截线部分的长度传播; 以及用于将天线固定在管内并沿其纵向范围的联接机构。
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10.发明授权Process for chemical measurement in small volume samples by fluorescent indicators 失效通过荧光指示剂对小体积样品进行化学测量的过程
公开(公告)号：US4916060A
公开(公告)日：1990-04-10
申请号：US372127
申请日：1989-06-27
申请人： James C. Weaver
发明人： James C. Weaver
IPC分类号： G01N33/52
CPC分类号： G01N33/52 , Y10S436/80 , Y10T436/143333
摘要： Detection or measurement of chemical indicator paramaters such as pH or of the concentration reactants of chemical reactions is accomplished by employing at least two fluorescent species with predominant emission at different optical wavelength regions, such that a synthesized fluorescence color change is created. In this manner, measurement is improved and simple visual inspection can reveal whether or not a chemical reaction or parameter has changed significantly, while retaining the sensitivity of fluorescence measurement or detection.
摘要翻译： 通过采用在不同光学波长区域具有主要发射的至少两种荧光物质来实现化学指示剂参数的检测或测量，例如pH或化学反应的浓度反应物，从而产生合成的荧光颜色变化。 以这种方式，改进了测量，并且简单的目视检查可以揭示化学反应或参数是否显着变化，同时保持荧光测量或检测的灵敏度。
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