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公开(公告)号：US07597692B2
公开(公告)日：2009-10-06
申请号：US10800587
申请日：2004-03-15
IPC分类号： A61M31/00
CPC分类号： A61N1/30 , A61M5/427 , A61M37/00 , A61M2037/0007 , A61N1/325
摘要： The present invention relates to microscission methods and devices used for the manipulation or modification of the body tissue by the formation of microconduits in a tissue. The term “microconduit” refers to a small opening, channel, or hole into, or through, a tissue, that allows transfer of materials by liquid flow, and by electrophoresis, the microconduit being formed upon impact of a plurality of accelerated microparticles with the surface of the tissue. This process of “microscission” comprises forming at least one microconduit in tissue including the steps of: accelerating a plurality of microparticles to a velocity that causes the microparticles to penetrate a region of tissue surface upon impingement of the microparticles on the tissue surface; and directing the microparticle towards the region of tissue surface, thereby causing the microparticles to penetrate the tissue and form a microconduit in the tissue.
摘要翻译： 本发明涉及用于通过在组织中形成微管的操作或改变身体组织的微观方法和装置。 术语“微管道”是指通过液体流动允许材料转移并通过电泳的组织中的或通过组织的小的开口，通道或孔，在多个加速的微粒撞击时形成的微管， 组织表面。 “微观”的这个过程包括在组织中形成至少一个微管，其包括以下步骤：将多个微粒加速到使微粒在组织表面上碰撞时穿透组织表面区域的速度; 并将微粒引向组织表面的区域，从而使微粒穿透组织并在组织中形成微管。
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公开(公告)号：US4843034A
公开(公告)日：1989-06-27
申请号：US194720
申请日：1988-05-23
申请人： Terry O. Herndon , Glenn H. Chapman
发明人： Terry O. Herndon , Glenn H. Chapman
IPC分类号： H01L21/3205 , H01L21/768 , H01L23/532
CPC分类号： H01L23/53209 , H01L21/76877 , H01L2924/0002 , H01L2924/3011 , Y10S438/921
摘要： A method of producing interlayer conductive paths having substantially planar top surfaces in a multilayer integrated circuit structure, comprising the steps of forming elements of either a conductive or semiconductive material as a lower layer, depositing an insulative layer on top of the lower layer elements, implanting ions into one or more selected regions of the insulative layer, forming at least one upper conductor over the selected regions and sintering the integrated circuit structure sufficient to render the selected regions conductive. The invention also embraces an integrated circuit structures with interlayer conductive paths made in accordance with this method.
摘要翻译： 一种在多层集成电路结构中制造具有基本平坦的顶表面的层间导电路径的方法，包括以下步骤：形成作为下层的导电或半导体材料的元件，在下层元件的顶部上沉积绝缘层， 离子进入绝缘层的一个或多个选定区域，在所选择的区域上形成至少一个上导体，并烧结足以使选定区域导电的集成电路结构。 本发明还包括具有根据该方法制造的层间导电路径的集成电路结构。
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公开(公告)号：US5345365A
公开(公告)日：1994-09-06
申请号：US878495
申请日：1992-05-05
申请人： Terry O. Herndon , Jack I. Raffel
发明人： Terry O. Herndon , Jack I. Raffel
CPC分类号： H01L23/49816 , H01L23/49811 , H01L24/72 , H01L25/18 , H01L2924/01006 , H01L2924/01013 , H01L2924/01014 , H01L2924/01033 , H01L2924/01082 , H01L2924/14 , H01L2924/30105 , H01L2924/30107 , H05K3/303 , H05K3/326 , H05K3/4007
摘要： An interconnection system for high performance electronic hybrids employs micro-machined features on a substrate to connect directly to miniature electronic components, such as integrated circuits. The micro-machined features may include posts for connecting to bonding pads of standard components and may also include rails for alignment of components and connections to specially made components.
摘要翻译： 用于高性能电子混合器的互连系统在基板上使用微加工特征直接连接到微型电子部件，例如集成电路。 微加工的特征可以包括用于连接到标准部件的接合焊盘的柱，并且还可以包括用于将组件对准的轨道和与特定构件的连接。
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公开(公告)号：US08150505B2
公开(公告)日：2012-04-03
申请号：US11743818
申请日：2007-05-03
申请人： Terry O. Herndon
发明人： Terry O. Herndon
CPC分类号： A61B17/205 , A61B5/0531 , A61B5/063 , A61B5/14514 , A61B5/150022 , A61B5/15134 , A61B5/6826 , A61B5/6829 , A61B5/6838 , A61B2017/00026 , A61B2017/00747 , A61B2017/00761 , A61B2017/320004 , A61M37/00 , A61M37/0015
摘要： Disclosed is an apparatus that creates a number of microconduits, i.e., small holes in the stratum corneum, the outermost layer of human skin tissue, to provide a pathway therethrough, which can be used, for example, for transdermal drug delivery.
摘要翻译： 公开了一种可产生许多微管道的设备，即角质层中的小孔，即人皮肤组织的最外层，以提供穿过其中的通道，其可用于例如透皮药物递送。
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公开(公告)号：US07848799B2
公开(公告)日：2010-12-07
申请号：US11206232
申请日：2005-08-17
申请人： Terry O. Herndon
发明人： Terry O. Herndon
IPC分类号： A61B5/05
CPC分类号： A61B17/1695 , A61B5/053 , A61B17/205 , A61B2017/00026 , A61B2017/00747 , A61M37/0076 , A61N1/30 , A61N1/327
摘要： The present invention relates to methods and devices for formation of microconduits in tissue, particularly using an impedance sensing drill to form microconduits. One embodiment of the invention is an impedance sensing drill comprising a drilling assembly, a control module, mechanically connected to the drilling assembly for controlling the depth of drilling by the drilling assembly; and a sensor, electrically connected to the drilling assembly and control module for detecting a change in an electrical impedance of a material being drilled. Another embodiment is a method of forming a microconduit in a material, which comprises the steps of drilling into the material, monitoring an electrical impedance of the material, and stopping the drilling into the material when a change in the impedance is detected, thereby forming microconduit.
摘要翻译： 本发明涉及用于在组织中形成微管的方法和装置，特别是使用阻抗感测钻以形成微管。 本发明的一个实施例是阻抗感测钻头，其包括钻井组件，控制模块，机械地连接到钻井组件，用于控制钻井组件的钻削深度; 以及与钻探组件和控制模块电连接的传感器，用于检测被钻探材料的电阻抗的变化。 另一个实施例是在材料中形成微型管道的方法，其包括以下步骤：在检测到阻抗变化时钻入材料中，监测材料的电阻抗，以及停止钻入材料，从而形成微管 。
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公开(公告)号：US08241229B2
公开(公告)日：2012-08-14
申请号：US12915289
申请日：2010-10-29
申请人： Terry O. Herndon
发明人： Terry O. Herndon
IPC分类号： A61B5/00
CPC分类号： A61B17/1695 , A61B5/053 , A61B17/205 , A61B2017/00026 , A61B2017/00747 , A61M37/0076 , A61N1/30 , A61N1/327
摘要： The present invention relates to methods and devices for formation of microconduits in tissue, particularly using an impedance sensing drill to form microconduits. One embodiment of the invention is an impedance sensing drill comprising a drilling assembly, a control module, mechanically connected to the drilling assembly for controlling the depth of drilling by the drilling assembly; and a sensor, electrically connected to the drilling assembly and control module for detecting a change in an electrical impedance of a material being drilled. Another embodiment is a method of forming a microconduit in a material, which comprises the steps of drilling into the material, monitoring an electrical impedance of the material, and stopping the drilling into the material when a change in the impedance is detected, thereby forming microconduit.
摘要翻译： 本发明涉及用于在组织中形成微管的方法和装置，特别是使用阻抗感测钻以形成微管。 本发明的一个实施例是阻抗感测钻头，其包括钻井组件，控制模块，机械地连接到钻井组件，用于控制钻井组件的钻削深度; 以及与钻探组件和控制模块电连接的传感器，用于检测被钻探材料的电阻抗的变化。 另一个实施例是在材料中形成微型管道的方法，其包括以下步骤：在检测到阻抗变化时钻入材料中，监测材料的电阻抗，以及停止钻入材料，从而形成微管 。
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公开(公告)号：US20090221893A1
公开(公告)日：2009-09-03
申请号：US12394139
申请日：2009-02-27
申请人： Terry O. Herndon
发明人： Terry O. Herndon
CPC分类号： A61B5/157 , A61B5/14532 , A61B5/1468 , A61B5/150022 , A61B5/150167 , A61B5/150175 , A61B5/150236 , A61B5/150412 , A61B5/150519 , A61B5/150755 , A61B5/150954 , A61B5/15109 , A61B5/15123 , A61B5/1519 , A61B5/15194
摘要： A blood glucose measuring device is equipped with a drill device, attachment assembly, and disposable sensing and measurement assembly. The attachment assembly contains an attachment ring that connects to the drill device and is used to hold the disposable sensing and measurement assembly. A detach actuating cam and output shaft are attached to the drill device. Spring tongs are attached to the output shaft by a compression ring further clamp to an end cap. A skin penetrator is attached to the end cap. The disposable sensing and measurement assembly is enclosed in a disposable case. An outer telescoping anti-bend tube is attached to the end cap. An inner anti-bend capillary sensor tube contains analyte sensors and is attached to the disposable case. The electrical conductors for the analyte sensor electrodes are attached to the capillary sensor tube and thus to the disposable case. An impedance sensing electrode on the bottom of the case provides electrical contacts to the skin. The electrical conductor to the impedance sensing electrode is attached to the bottom of the disposable case.
摘要翻译： 血糖测量装置配备有钻孔装置，附件组件和一次性感测和测量组件。 附接组件包括连接到钻孔装置并用于保持一次性感测和测量组件的附接环。 分离致动凸轮和输出轴附接到钻孔装置。 弹簧钳通过压缩环连接到输出轴，进一步夹紧到端盖。 皮肤穿透器连接到端盖。 一次性感测和测量组件被封装在一次性外壳中。 外伸缩式防弯管连接在端盖上。 内部抗弯曲毛细管传感器管包含分析物传感器并附接到一次性外壳。 用于分析物传感器电极的电导体附接到毛细管传感器管，从而连接到一次性外壳。 壳体底部的阻抗感应电极提供与皮肤的电接触。 到阻抗感测电极的电导体连接到一次性外壳的底部。
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8.发明授权
公开(公告)号：US5087589A
公开(公告)日：1992-02-11
申请号：US371587
申请日：1989-06-26
申请人： Glenn H. Chapman , Terry O. Herndon
发明人： Glenn H. Chapman , Terry O. Herndon
IPC分类号： H01L21/3205 , H01L21/768 , H01L23/532
CPC分类号： H01L23/53209 , H01L21/76877 , H01L2924/0002 , H01L2924/3011 , Y10S438/921
摘要： A method of fabricating programmable interlayer conductive links in a multilayer integrated circuit structure, comprising the steps of forming elements of either a conductive or semiconductive material as a lower layer, depositing an insulative layer on top of the lower layer elements, implanting ions into one or more link regions of the insulative layer, forming at least one upper conductor over the implanted regions and selectively applying sufficient energy to at least one of the implanted regions of the integrated circuit structure to render the selected link region conductive. The invention also embraces customized integrated circuit structures with interlayer conductive paths made in accordance with this method.
摘要翻译： 一种在多层集成电路结构中制造可编程层间导电链路的方法，包括以下步骤：形成作为下层的导电或半导体材料的元件，在下层元件的顶部上沉积绝缘层，将离子注入到一个或多个 绝缘层的更多连接区域，在注入区域上形成至少一个上导体，并且向集成电路结构的至少一个注入区域选择性地施加足够的能量以使所选择的链路区域导通。 本发明还包括根据该方法制造的具有层间导电路径的定制集成电路结构。
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公开(公告)号：US08636748B2
公开(公告)日：2014-01-28
申请号：US12915322
申请日：2010-10-29
申请人： Terry O. Herndon
发明人： Terry O. Herndon
IPC分类号： A61B17/50
CPC分类号： A61B17/1695 , A61B5/053 , A61B17/205 , A61B2017/00026 , A61B2017/00747 , A61M37/0076 , A61N1/30 , A61N1/327
摘要： The present invention relates to methods and devices for formation of microconduits in tissue, particularly using an impedance sensing drill to form microconduits. One embodiment of the invention is an impedance sensing drill comprising a drilling assembly, a control module, mechanically connected to the drilling assembly for controlling the depth of drilling by the drilling assembly; and a sensor, electrically connected to the drilling assembly and control module for detecting a change in an electrical impedance of a material being drilled. Another embodiment is a method of forming a microconduit in a material, which comprises the steps of drilling into the material, monitoring an electrical impedance of the material, and stopping the drilling into the material when a change in the impedance is detected, thereby forming microconduit.
摘要翻译： 本发明涉及用于在组织中形成微管的方法和装置，特别是使用阻抗感测钻以形成微管。 本发明的一个实施例是阻抗感测钻头，其包括钻井组件，控制模块，机械地连接到钻井组件，用于控制钻井组件的钻削深度; 以及与钻探组件和控制模块电连接的传感器，用于检测被钻探材料的电阻抗的变化。 另一个实施例是在材料中形成微型管道的方法，其包括以下步骤：在检测到阻抗变化时钻入材料中，监测材料的电阻抗，以及停止钻入材料，从而形成微管 。
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公开(公告)号：US20110046626A1
公开(公告)日：2011-02-24
申请号：US12915322
申请日：2010-10-29
申请人： Terry O. Herndon
发明人： Terry O. Herndon
CPC分类号： A61B17/1695 , A61B5/053 , A61B17/205 , A61B2017/00026 , A61B2017/00747 , A61M37/0076 , A61N1/30 , A61N1/327
摘要： The present invention relates to methods and devices for formation of microconduits in tissue, particularly using an impedance sensing drill to form microconduits. One embodiment of the invention is an impedance sensing drill comprising a drilling assembly, a control module, mechanically connected to the drilling assembly for controlling the depth of drilling by the drilling assembly; and a sensor, electrically connected to the drilling assembly and control module for detecting a change in an electrical impedance of a material being drilled. Another embodiment is a method of forming a microconduit in a material, which comprises the steps of drilling into the material, monitoring an electrical impedance of the material, and stopping the drilling into the material when a change in the impedance is detected, thereby forming microconduit.
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