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公开(公告)号：US20050074788A1
公开(公告)日：2005-04-07
申请号：US10740256
申请日：2003-12-18
申请人： James Dahlberg , Hatim Allawi , Victor Lyamichev , Bruce Neri , Marilyn Olson-Munoz , LuAnne Chehak , Sarah Olson
发明人： James Dahlberg , Hatim Allawi , Victor Lyamichev , Bruce Neri , Marilyn Olson-Munoz , LuAnne Chehak , Sarah Olson
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6816 , C12Q2565/1015 , C12Q2561/109 , C12Q2525/207
摘要： The present invention relates to compositions and methods for the detection and characterization of interfering RNAs such as micro RNAs (miRNAs) and small interfering RNAs (siRNAs) and other short nucleic acid molecules. More particularly, the present invention relates to improved methods for the detection and quantitation of interfering RNA expression. The present invention further provides for the detection of variants and types of miRNAs and siRNAs.
摘要翻译： 本发明涉及用于检测和表征干扰RNA如微RNA（miRNA）和小干扰RNA（siRNA）和其他短核酸分子的组合物和方法。 更具体地，本发明涉及用于检测和定量干扰RNA表达的改进方法。 本发明还提供了miRNA和siRNA的变体和类型的检测。
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公开(公告)号：US20070065815A1
公开(公告)日：2007-03-22
申请号：US11515854
申请日：2006-09-05
申请人： Fang Dong , Victor Lyamichev , James Prudent , Lance Fors , Bruce Neri , Mary Brow , Todd Anderson , James Dahlberg
发明人： Fang Dong , Victor Lyamichev , James Prudent , Lance Fors , Bruce Neri , Mary Brow , Todd Anderson , James Dahlberg
CPC分类号： C12Q1/6832 , C12Q1/701 , C12Q2565/133 , C12Q2521/301
摘要： The present invention relates to methods and compositions for analyzing nucleic acids. In particular, the present invention provides methods and compositions for the detection and characterization of nucleic acid sequences and sequence changes. The methods of the present invention permit the detection and/or identification of genetic polymorphism such as those associated with human disease and permit the identification of pathogens (e.g., viral and bacterial strain identification).
摘要翻译： 本发明涉及用于分析核酸的方法和组合物。 特别地，本发明提供了用于检测和表征核酸序列和序列变化的方法和组合物。 本发明的方法允许检测和/或鉴定遗传多态性，例如与人类疾病相关的遗传多态性，并允许鉴定病原体（例如病毒和细菌菌株鉴定）。
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公开(公告)号：US20050014163A1
公开(公告)日：2005-01-20
申请号：US10655362
申请日：2003-09-04
申请人： Fang Dong , Victor Lyamichev , James Prudent , Lance Fors , Bruce Neri , Mary Ann Brow , Todd Anderson , James Dahlberg
发明人： Fang Dong , Victor Lyamichev , James Prudent , Lance Fors , Bruce Neri , Mary Ann Brow , Todd Anderson , James Dahlberg
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6832 , C12Q1/701 , C12Q2565/133 , C12Q2521/301
摘要： The present invention relates to methods and compositions for analyzing nucleic acids. In particular, the present invention provides methods and compositions for the detection and characterization of nucleic acids and sequence changes. The methods of the present invention permit the detection and/or identification of genetic polymorphism such as those associated with human disease and permit the identification of pathogens (e.g., viral and bacterial strain identification).
摘要翻译： 本发明涉及用于分析核酸的方法和组合物。 特别地，本发明提供了用于检测和表征核酸和序列变化的方法和组合物。 本发明的方法允许检测和/或鉴定遗传多态性，例如与人类疾病相关的遗传多态性，并允许鉴定病原体（例如病毒和细菌菌株鉴定）。
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公开(公告)号：US20050158716A1
公开(公告)日：2005-07-21
申请号：US10409594
申请日：2003-04-08
申请人： James Dahlberg , Mary Brow , Victor Lyamichev
发明人： James Dahlberg , Mary Brow , Victor Lyamichev
IPC分类号： C07H21/00 , C07K14/47 , C07K14/82 , C12N9/12 , C12N15/10 , C12N15/113 , C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6886 , C07H21/00 , C07K14/4746 , C07K14/82 , C12N9/1252 , C12N15/10 , C12N15/113 , C12Q1/682 , C12Q1/6823 , C12Q1/683 , C12Q1/689 , C12Q2537/149 , C12Q2525/301 , C12Q2521/319
摘要： The present invention relates to means for cleaving a nucleic acid cleavage structure in a site-specific manner. Enzymes, including 5′ nucleases and 3′ exonucleases, are used to detect and identify nucleic acids derived from microorganisms. Methods are provided which allow for the detection and identification of bacterial and viral pathogens in a sample.
摘要翻译： 本发明涉及以位点特异性方式切割核酸切割结构的方法。 酶包括5'核酸酶和3'核酸外切酶，用于检测和鉴定衍生自微生物的核酸。 提供了允许在样品中检测和鉴定细菌和病毒病原体的方法。
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公开(公告)号：US20060183109A1
公开(公告)日：2006-08-17
申请号：US11198675
申请日：2005-08-05
申请人： James Dahlberg , Mary Brow , Victor Lyamichev
发明人： James Dahlberg , Mary Brow , Victor Lyamichev
CPC分类号： C12N9/1252 , C12Q1/682 , C12Q1/6846 , C12Q2537/149 , C12Q2525/301 , C12Q2521/319
摘要： The present invention relates to means for cleaving a nucleic acid cleavage structure in a site-specific manner. Enzymes, including 5′ nucleases and 3′ exonucleases, are used to detect and identify nucleic acids derived from microorganisms. Methods are provided which allow for the detection and identification of bacterial and viral pathogens in a sample.
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公开(公告)号：US20060110750A1
公开(公告)日：2006-05-25
申请号：US11222565
申请日：2005-09-09
申请人： James Prudent , Jeff Hall , Victor Lyamichev , Mary Brow , James Dahlberg
发明人： James Prudent , Jeff Hall , Victor Lyamichev , Mary Brow , James Dahlberg
CPC分类号： C12N9/22 , C12Q1/6823 , C12Q1/6827 , C12Q1/683 , Y10S435/81 , Y10S435/822 , C12Q2565/525 , C12Q2561/109 , C12Q2525/301 , C12Q2563/149
摘要： The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
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公开(公告)号：US20060040299A1
公开(公告)日：2006-02-23
申请号：US11198657
申请日：2005-08-05
申请人： James Dahlberg , Mary Ann Brow , Victor Lyamichev
发明人： James Dahlberg , Mary Ann Brow , Victor Lyamichev
CPC分类号： C12N9/1252 , C12Q1/682 , C12Q1/6846 , C12Q2537/149 , C12Q2525/301 , C12Q2521/319
摘要： The present invention relates to means for cleaving a nucleic acid cleavage structure in a site-specific manner. Enzymes, including 5′ nucleases and 3′ exonucleases, are used to detect and identify nucleic acids derived from microorganisms. Methods are provided which allow for the detection and identification of bacterial and viral pathogens in a sample.
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公开(公告)号：US20060035257A1
公开(公告)日：2006-02-16
申请号：US11198794
申请日：2005-08-05
申请人： James Dahlberg , Mary Brow , Victor Lyamichev
发明人： James Dahlberg , Mary Brow , Victor Lyamichev
CPC分类号： C12N9/1252 , C12Q1/682 , C12Q1/6846 , C12Q2537/149 , C12Q2525/301 , C12Q2521/319
摘要： The present invention relates to means for cleaving a nucleic acid cleavage structure in a site-specific manner. Enzymes, including 5′ nucleases and 3′ exonucleases, are used to detect and identify nucleic acids derived from microorganisms. Methods are provided which allow for the detection and identification of bacterial and viral pathogens in a sample.
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公开(公告)号：US20060035256A1
公开(公告)日：2006-02-16
申请号：US11198746
申请日：2005-08-05
申请人： James Dahlberg , Mary Ann Brow , Victor Lyamichev
发明人： James Dahlberg , Mary Ann Brow , Victor Lyamichev
CPC分类号： C12N9/1252 , C12Q1/682 , C12Q1/6846 , C12Q2537/149 , C12Q2525/301 , C12Q2521/319
摘要： The present invention relates to means for cleaving a nucleic acid cleavage structure in a site-specific manner. Enzymes, including 5′ nucleases and 3′ exonucleases, are used to detect and identify nucleic acids derived from microorganisms. Methods are provided which allow for the detection and identification of bacterial and viral pathogens in a sample.
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公开(公告)号：US20070003942A1
公开(公告)日：2007-01-04
申请号：US11183077
申请日：2005-07-15
申请人： James Prudent , Jeff Hall , Victor Lyamichev , Mary Ann Brow , James Dahlberg
发明人： James Prudent , Jeff Hall , Victor Lyamichev , Mary Ann Brow , James Dahlberg
CPC分类号： C12N9/22 , C12Q1/6823 , C12Q1/6827 , C12Q1/683 , Y10S435/81 , Y10S435/822 , C12Q2565/525 , C12Q2561/109 , C12Q2525/301 , C12Q2563/149
摘要： The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
摘要翻译： 本发明涉及核酸序列的检测和表征以及核酸序列的变化的方法。 本发明还涉及在靶序列上形成核酸切割结构并以位点特异性方式切割核酸切割结构的方法。 使用各种酶的结构特异性核酸酶活性来切割靶依赖性切割结构，从而指示特异性核酸序列的存在或其特定变体。
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