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公开(公告)号：US20050158716A1
公开(公告)日：2005-07-21
申请号：US10409594
申请日：2003-04-08
申请人： James Dahlberg , Mary Brow , Victor Lyamichev
发明人： James Dahlberg , Mary Brow , Victor Lyamichev
IPC分类号： C07H21/00 , C07K14/47 , C07K14/82 , C12N9/12 , C12N15/10 , C12N15/113 , C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6886 , C07H21/00 , C07K14/4746 , C07K14/82 , C12N9/1252 , C12N15/10 , C12N15/113 , C12Q1/682 , C12Q1/6823 , C12Q1/683 , C12Q1/689 , C12Q2537/149 , C12Q2525/301 , C12Q2521/319
摘要： The present invention relates to means for cleaving a nucleic acid cleavage structure in a site-specific manner. Enzymes, including 5′ nucleases and 3′ exonucleases, are used to detect and identify nucleic acids derived from microorganisms. Methods are provided which allow for the detection and identification of bacterial and viral pathogens in a sample.
摘要翻译： 本发明涉及以位点特异性方式切割核酸切割结构的方法。 酶包括5'核酸酶和3'核酸外切酶，用于检测和鉴定衍生自微生物的核酸。 提供了允许在样品中检测和鉴定细菌和病毒病原体的方法。
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公开(公告)号：US20060183109A1
公开(公告)日：2006-08-17
申请号：US11198675
申请日：2005-08-05
申请人： James Dahlberg , Mary Brow , Victor Lyamichev
发明人： James Dahlberg , Mary Brow , Victor Lyamichev
CPC分类号： C12N9/1252 , C12Q1/682 , C12Q1/6846 , C12Q2537/149 , C12Q2525/301 , C12Q2521/319
摘要： The present invention relates to means for cleaving a nucleic acid cleavage structure in a site-specific manner. Enzymes, including 5′ nucleases and 3′ exonucleases, are used to detect and identify nucleic acids derived from microorganisms. Methods are provided which allow for the detection and identification of bacterial and viral pathogens in a sample.
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公开(公告)号：US20070065815A1
公开(公告)日：2007-03-22
申请号：US11515854
申请日：2006-09-05
申请人： Fang Dong , Victor Lyamichev , James Prudent , Lance Fors , Bruce Neri , Mary Brow , Todd Anderson , James Dahlberg
发明人： Fang Dong , Victor Lyamichev , James Prudent , Lance Fors , Bruce Neri , Mary Brow , Todd Anderson , James Dahlberg
CPC分类号： C12Q1/6832 , C12Q1/701 , C12Q2565/133 , C12Q2521/301
摘要： The present invention relates to methods and compositions for analyzing nucleic acids. In particular, the present invention provides methods and compositions for the detection and characterization of nucleic acid sequences and sequence changes. The methods of the present invention permit the detection and/or identification of genetic polymorphism such as those associated with human disease and permit the identification of pathogens (e.g., viral and bacterial strain identification).
摘要翻译： 本发明涉及用于分析核酸的方法和组合物。 特别地，本发明提供了用于检测和表征核酸序列和序列变化的方法和组合物。 本发明的方法允许检测和/或鉴定遗传多态性，例如与人类疾病相关的遗传多态性，并允许鉴定病原体（例如病毒和细菌菌株鉴定）。
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公开(公告)号：US20060110750A1
公开(公告)日：2006-05-25
申请号：US11222565
申请日：2005-09-09
申请人： James Prudent , Jeff Hall , Victor Lyamichev , Mary Brow , James Dahlberg
发明人： James Prudent , Jeff Hall , Victor Lyamichev , Mary Brow , James Dahlberg
CPC分类号： C12N9/22 , C12Q1/6823 , C12Q1/6827 , C12Q1/683 , Y10S435/81 , Y10S435/822 , C12Q2565/525 , C12Q2561/109 , C12Q2525/301 , C12Q2563/149
摘要： The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
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公开(公告)号：US20060035257A1
公开(公告)日：2006-02-16
申请号：US11198794
申请日：2005-08-05
申请人： James Dahlberg , Mary Brow , Victor Lyamichev
发明人： James Dahlberg , Mary Brow , Victor Lyamichev
CPC分类号： C12N9/1252 , C12Q1/682 , C12Q1/6846 , C12Q2537/149 , C12Q2525/301 , C12Q2521/319
摘要： The present invention relates to means for cleaving a nucleic acid cleavage structure in a site-specific manner. Enzymes, including 5′ nucleases and 3′ exonucleases, are used to detect and identify nucleic acids derived from microorganisms. Methods are provided which allow for the detection and identification of bacterial and viral pathogens in a sample.
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公开(公告)号：US20060177835A1
公开(公告)日：2006-08-10
申请号：US11183078
申请日：2005-07-15
申请人： James Prudent , Jeff Hall , Victor Lyamichev , Mary Brow , James Dahlberg
发明人： James Prudent , Jeff Hall , Victor Lyamichev , Mary Brow , James Dahlberg
CPC分类号： C12N9/22 , C12Q1/6823 , C12Q1/6827 , C12Q1/683 , Y10S435/81 , Y10S435/822 , C12Q2565/525 , C12Q2561/109 , C12Q2525/301 , C12Q2563/149
摘要： The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
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公开(公告)号：US20060068383A1
公开(公告)日：2006-03-30
申请号：US09941095
申请日：2001-08-28
申请人： James Dahlberg , Mary Brow , Victor Lyamichev
发明人： James Dahlberg , Mary Brow , Victor Lyamichev
CPC分类号： C12N15/113 , C07H21/00 , C07K14/4746 , C07K14/82 , C12N9/1252 , C12N15/10 , C12Q1/68 , C12Q1/682 , C12Q1/6823 , C12Q1/6827 , C12Q1/683 , C12Q1/6853 , C12Q1/686 , C12Q1/689 , C12Q1/705 , Y10T436/143333 , C12Q2537/149 , C12Q2525/301 , C12Q2521/319
摘要： The present invention relates to means for cleaving a nucleic acid cleavage structure in a site-specific manner. Enzymes, including 5′ nucleases and 3′ exonucleases, are used to detect and identify nucleic acids derived from microorganisms. Methods are provided which allow for the detection and identification of bacterial and viral pathogens in a sample.
摘要翻译： 本发明涉及以位点特异性方式切割核酸切割结构的方法。 酶包括5'核酸酶和3'核酸外切酶，用于检测和鉴定衍生自微生物的核酸。 提供了允许在样品中检测和鉴定细菌和病毒病原体的方法。
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公开(公告)号：US20060040294A1
公开(公告)日：2006-02-23
申请号：US11183211
申请日：2005-07-15
申请人： James Prudent , Jeff Hall , Victor Lyamichev , Mary Brow , James Dahlberg
发明人： James Prudent , Jeff Hall , Victor Lyamichev , Mary Brow , James Dahlberg
CPC分类号： C12N9/22 , C12Q1/6823 , C12Q1/6827 , C12Q1/683 , Y10S435/81 , Y10S435/822 , C12Q2565/525 , C12Q2561/109 , C12Q2525/301 , C12Q2563/149
摘要： The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
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公开(公告)号：US20050181435A1
公开(公告)日：2005-08-18
申请号：US11103943
申请日：2005-04-12
申请人： James Prudent , Jeff Hall , Victor Lyamichev , Mary Brow , James Dahlberg
发明人： James Prudent , Jeff Hall , Victor Lyamichev , Mary Brow , James Dahlberg
IPC分类号： G01N33/50 , C12N1/21 , C12N9/12 , C12N9/16 , C12N9/22 , C12N15/09 , C12Q1/68 , G01N33/566 , C07H21/04
CPC分类号： C12N9/22 , C12Q1/6823 , C12Q1/6827 , C12Q1/683 , Y10S435/81 , Y10S435/822 , C12Q2565/525 , C12Q2561/109 , C12Q2525/301 , C12Q2563/149
摘要： The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
摘要翻译： 本发明涉及核酸序列的检测和表征以及核酸序列的变化的方法。 本发明还涉及在靶序列上形成核酸切割结构并以位点特异性方式切割核酸切割结构的方法。 使用各种酶的结构特异性核酸酶活性来切割靶依赖性切割结构，从而指示特异性核酸序列的存在或其特定变体。
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公开(公告)号：US20050003432A1
公开(公告)日：2005-01-06
申请号：US10897793
申请日：2004-07-23
申请人： Jeff Hall , Victor Lyamichev , Andrea Mast , Mary Brow , Robert Kwiatkowski , Stephanie Vavra
发明人： Jeff Hall , Victor Lyamichev , Andrea Mast , Mary Brow , Robert Kwiatkowski , Stephanie Vavra
CPC分类号： C12N9/1252 , C12N9/22 , C12Q1/6823 , C12Q1/683 , C12Q1/701 , C12Q1/703 , C12Q1/706 , Y10S435/81 , C12Q2561/109
摘要： The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof. The present invention further relates to methods and devices for the separation of nucleic acid molecules based on charge. The present invention also provides methods for the detection of non-target cleavage products via the formation of a complete and activated protein binding region. The invention further provides sensitive and specific methods for the detection of nucleic acid from various viruses in a sample.
摘要翻译： 本发明涉及核酸序列的检测和表征以及核酸序列的变化的方法。 本发明还涉及在靶序列上形成核酸切割结构并以位点特异性方式切割核酸切割结构的方法。 使用各种酶的结构特异性核酸酶活性来切割靶依赖性切割结构，从而指示特异性核酸序列的存在或其特定变体。 本发明还涉及基于电荷分离核酸分子的方法和装置。 本发明还提供了通过形成完整和活化的蛋白质结合区域来检测非靶切割产物的方法。 本发明还提供用于检测样品中各种病毒的核酸的敏感和具体方法。
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