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公开(公告)号:US08075622B2
公开(公告)日:2011-12-13
申请号:US12004647
申请日:2007-12-21
申请人: James E. Van Hoeck , Troy McDonald , Bradley J. Coates , Regis W. Haid, Jr. , Stephen E. Heim , Kevin Foley , Eugene C. Eckstein
发明人: James E. Van Hoeck , Troy McDonald , Bradley J. Coates , Regis W. Haid, Jr. , Stephen E. Heim , Kevin Foley , Eugene C. Eckstein
IPC分类号: A61F2/44
CPC分类号: A61F2/442 , A61F2/30724 , A61F2/30767 , A61F2/4455 , A61F2/4611 , A61F2002/2817 , A61F2002/2835 , A61F2002/30062 , A61F2002/30112 , A61F2002/30153 , A61F2002/30187 , A61F2002/30261 , A61F2002/30271 , A61F2002/30677 , A61F2002/3092 , A61F2002/30929 , A61F2002/4475 , A61F2002/4623 , A61F2002/4627 , A61F2210/0004 , A61F2230/0004 , A61F2230/0019 , A61F2230/0034 , A61F2230/0082 , A61F2310/00161 , A61F2310/00293 , A61F2310/00491 , A61F2310/00544 , A61F2310/00796 , A61L31/024 , A61L31/026 , A61L31/044 , A61L31/047 , A61L31/048 , A61L31/06 , A61L2430/38 , Y10S606/907 , Y10S606/908
摘要: One embodiment of a hollow spinal spacer (10) includes a curved anterior wall (11) having opposite ends (12, 13), a posterior wall (15) having opposite ends (16, 17), two lateral walls (20, 21), each integrally connected between the opposite ends (12, 13, 16, 17) of the anterior (11) and posterior (15) walls to define a chamber (30). The walls (11, 15, 20, 21) include a superior face (35) and an inferior face (40). The superior face (35) defines a first opening (36) in communication with the chamber (30) and includes a first vertebral engaging surface (37). The inferior face (40) defines a second opening (41) in communication with the chamber (30) and includes a second vertebral engaging surface (42).
摘要翻译: 空心脊椎间隔件(10)的一个实施例包括具有相对端(12,13)的弯曲前壁(11),具有相对端(16,17)的后壁(15),两个侧壁(20,21) ,每个整体连接在前(11)和后(15)壁的相对端(12,13,16,17)之间,以限定室(30)。 壁(11,15,20,21)包括上表面(35)和下表面(40)。 上表面(35)限定与腔室(30)连通的第一开口(36)并且包括第一椎骨接合表面(37)。 下表面(40)限定与腔室(30)连通的第二开口(41)并且包括第二椎骨接合表面(42)。
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公开(公告)号:US06423095B1
公开(公告)日:2002-07-23
申请号:US08603676
申请日:1996-02-20
申请人: James E. Van Hoeck , Troy McDonald , Bradley J. Coates , Regis W. Haid, Jr. , Stephen E. Heim , Kevin Foley , Eugene C. Eckstein
发明人: James E. Van Hoeck , Troy McDonald , Bradley J. Coates , Regis W. Haid, Jr. , Stephen E. Heim , Kevin Foley , Eugene C. Eckstein
IPC分类号: A61F244
CPC分类号: A61F2/442 , A61F2/30724 , A61F2/30767 , A61F2/4455 , A61F2/4611 , A61F2002/2817 , A61F2002/2835 , A61F2002/30062 , A61F2002/30112 , A61F2002/30153 , A61F2002/30187 , A61F2002/30261 , A61F2002/30271 , A61F2002/30677 , A61F2002/3092 , A61F2002/30929 , A61F2002/4475 , A61F2002/4623 , A61F2002/4627 , A61F2210/0004 , A61F2230/0004 , A61F2230/0019 , A61F2230/0034 , A61F2230/0082 , A61F2310/00161 , A61F2310/00293 , A61F2310/00491 , A61F2310/00544 , A61F2310/00796 , A61L31/024 , A61L31/026 , A61L31/044 , A61L31/047 , A61L31/048 , A61L31/06 , A61L2430/38 , Y10S606/907 , Y10S606/908
摘要: One embodiment of a hollow spinal spacer (10) includes a curved anterior wall (11) having opposite ends (12, 13), a posterior wall (15) having opposite ends (16, 17), two lateral walls (20, 21), each integrally connected between the opposite ends (12, 13, 16, 17) of the anterior (11) and posterior (15) walls to define a chamber (30). The walls (11, 15, 20, 21) include a superior face (35) and an inferior face (40). The superior face (35) defines a first opening (36) in communication with the chamber (30) and includes a first vertebral engaging surface (37). The inferior face (40) defines a second opening (41) in communication with the chamber (30) and includes a second vertebral engaging surface (42). In one embodiment, a lateral wing projects from an external surface of each of the lateral walls. In another embodiment, the anterior wall defines an anterior superior surface and an anterior inferior surface. The anterior superior surface has a concave shape defining a first radius which is configured to correspond to the anterior shape of an inferior vertebral endplate. The anterior inferior surface has a convex shape defining a second radius which is configured to correspond to the anterior shape of a superior vertebral endplate. In other embodiments, the lateral walls define a convex lateral superior surface and a convex lateral inferior surface. Each of the lateral surfaces define a radius configured to correspond to the shape of a vertebral endplate.
摘要翻译: 空心脊椎间隔件(10)的一个实施例包括具有相对端(12,13)的弯曲前壁(11),具有相对端(16,17)的后壁(15),两个侧壁(20,21) ,每个整体连接在前(11)和后(15)壁的相对端(12,13,16,17)之间,以限定室(30)。 壁(11,15,20,21)包括上表面(35)和下表面(40)。 上表面(35)限定与腔室(30)连通的第一开口(36)并且包括第一椎骨接合表面(37)。 下表面(40)限定与腔室(30)连通的第二开口(41),并且包括第二椎骨接合表面(42)。在一个实施例中,侧翼从每个侧壁的外表面突出 。 在另一个实施例中,前壁限定前上表面和前下表面。 前上表面具有限定第一半径的凹形,其构造成对应于下椎骨终板的前形状。 前下表面具有限定第二半径的凸形形状,其被配置为对应于上椎骨终板的前形状。 在其他实施例中,侧壁限定凸的侧向上表面和凸的侧向下表面。 每个侧表面限定了被配置为对应于椎体终板的形状的半径。
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公开(公告)号:US07311734B2
公开(公告)日:2007-12-25
申请号:US10775546
申请日:2004-02-10
申请人: James E. Van Hoeck , Troy McDonald , Bradley J. Coates , Regis W. Haid, Jr. , Stephen E. Heim , Kevin Foley , Eugene C. Eckstein
发明人: James E. Van Hoeck , Troy McDonald , Bradley J. Coates , Regis W. Haid, Jr. , Stephen E. Heim , Kevin Foley , Eugene C. Eckstein
CPC分类号: A61F2/442 , A61F2/30724 , A61F2/30767 , A61F2/4455 , A61F2/4611 , A61F2002/2817 , A61F2002/2835 , A61F2002/30062 , A61F2002/30112 , A61F2002/30153 , A61F2002/30187 , A61F2002/30261 , A61F2002/30271 , A61F2002/30677 , A61F2002/3092 , A61F2002/30929 , A61F2002/4475 , A61F2002/4623 , A61F2002/4627 , A61F2210/0004 , A61F2230/0004 , A61F2230/0019 , A61F2230/0034 , A61F2230/0082 , A61F2310/00161 , A61F2310/00293 , A61F2310/00491 , A61F2310/00544 , A61F2310/00796 , A61L31/024 , A61L31/026 , A61L31/044 , A61L31/047 , A61L31/048 , A61L31/06 , A61L2430/38 , Y10S606/907 , Y10S606/908
摘要: One embodiment of a hollow spinal spacer (10) includes a curved anterior wall (11) having opposite ends (12, 13), a posterior wall (15) having opposite ends (16, 17), two lateral walls (20, 21), each integrally connected between the opposite ends (12, 13, 16, 17) of the anterior (11) and posterior (15) walls to define a chamber (30). The walls (11, 15, 20, 21) include a superior face (35) and an inferior face (40). The superior face (35) defines a first opening (36) in communication with the chamber (30) and includes a first vertebral engaging surface (37). The inferior face (40) defines a second opening (41) in communication with the chamber (30) and includes a second vertebral engaging surface (42).
摘要翻译: 空心脊椎间隔件(10)的一个实施例包括具有相对端(12,13)的弯曲前壁(11),具有相对端(16,17)的后壁(15),两个侧壁(20,21) ,每个整体连接在前(11)和后(15)壁的相对端(12,13,16,17)之间,以限定室(30)。 壁(11,15,20,21)包括上表面(35)和下表面(40)。 上表面(35)限定与腔室(30)连通的第一开口(36)并且包括第一椎骨接合表面(37)。 下表面(40)限定与腔室(30)连通的第二开口(41)并且包括第二椎骨接合表面(42)。
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公开(公告)号:US06899735B2
公开(公告)日:2005-05-31
申请号:US10263115
申请日:2002-10-02
CPC分类号: A61F2/4455 , A61F2/08 , A61F2/28 , A61F2/44 , A61F2/4425 , A61F2002/2817 , A61F2002/30062 , A61F2002/30378 , A61F2002/30383 , A61F2002/304 , A61F2002/305 , A61F2002/30507 , A61F2002/30514 , A61F2002/30578 , A61F2002/30604 , A61F2002/30614 , A61F2002/30616 , A61F2002/30772 , A61F2002/443 , A61F2210/0004 , A61F2220/0025 , A61F2220/0033 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00179 , A61F2310/00359
摘要: A modular intervertebral prosthesis system includes first and second baseplates and an insert designed to mate to the baseplates. The baseplates include a mounting section and a intervertebral section extending away from the mounting section generally perpendicular thereto. The intervertebral section has at least one aperture passing therethrough. When installed, the insert is disposed between the intervertebral sections of the baseplates and faces the apertures. In this way, the insert is not insulated from the vertebral members, thereby allowing for osteoinduction, osteoconduction, and/or osteointegration, if desired. The insert may take the form of an articulating-type insert or a fusion-type insert, with the baseplates being operative with both types of inserts. After installation of the insert between the baseplates, the insert may be readily removed, at least initially.
摘要翻译: 模块化椎间假体系统包括第一和第二基板和设计成与底板相配合的插入件。 底板包括安装部分和从大致垂直于其的安装部分延伸的椎间部分。 椎间部分具有穿过其中的至少一个孔。 当安装时,插入件设置在基板的椎间部分之间并面向孔。 以这种方式,如果需要,插入件不与脊椎构件绝缘,从而允许骨诱导,骨诱导和/或骨整合。 插入件可以采用铰接型插入件或熔接型插入件的形式,底板可与两种类型的插入件一起使用。 在插入件在基板之间安装之后,至少可以容易地移除插入件。
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5.
公开(公告)号:US06755839B2
公开(公告)日:2004-06-29
申请号:US10175221
申请日:2002-06-19
IPC分类号: A61B1756
CPC分类号: A61B17/025 , A61B17/0206 , A61B17/1757 , A61B2017/0256 , A61B2090/034
摘要: A guide and method of using the guide for positioning within a patient between vertebral members for contouring each of the members. The guide comprises a first section and a second section. A first edge is positioned along an edge of the first section, and a second edge is positioned along an edge of the second section. One or more elongated rods extend through the sections. One or both of the sections are movable along the rods to adjust a spacing between the first edge and the second edge. When positioned within the patient, the first edge is aligned along a first vertebral member and the second edge is aligned along a second vertebral manner. A manner of locking the sections is included for preventing the sections from moving relative to each other once the first and second edges are aligned within the patient.
摘要翻译: 一种使用该引导件在椎体构件之间定位患者之间以用于轮廓化每个构件的引导和方法。 引导件包括第一部分和第二部分。 第一边缘沿着第一部分的边缘定位,并且第二边缘沿着第二部分的边缘定位。 一个或多个细长的杆延伸穿过这些部分。 这些部分中的一个或两个可沿杆移动以调节第一边缘和第二边缘之间的间隔。 当定位在患者体内时,第一边缘沿着第一椎骨构件对准,并且第二边缘沿着第二椎体方式对齐。 包括锁定部分的方式,一旦第一和第二边缘在患者体内对准,就防止这些部分相对于彼此移动。
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公开(公告)号:US20080109083A1
公开(公告)日:2008-05-08
申请号:US12004647
申请日:2007-12-21
申请人: James Van Hoeck , Troy McDonald , Bradley Coates , Regis Haid , Stephen Heim , Kevin Foley , Eugene Eckstein
发明人: James Van Hoeck , Troy McDonald , Bradley Coates , Regis Haid , Stephen Heim , Kevin Foley , Eugene Eckstein
IPC分类号: A61F2/44
CPC分类号: A61F2/442 , A61F2/30724 , A61F2/30767 , A61F2/4455 , A61F2/4611 , A61F2002/2817 , A61F2002/2835 , A61F2002/30062 , A61F2002/30112 , A61F2002/30153 , A61F2002/30187 , A61F2002/30261 , A61F2002/30271 , A61F2002/30677 , A61F2002/3092 , A61F2002/30929 , A61F2002/4475 , A61F2002/4623 , A61F2002/4627 , A61F2210/0004 , A61F2230/0004 , A61F2230/0019 , A61F2230/0034 , A61F2230/0082 , A61F2310/00161 , A61F2310/00293 , A61F2310/00491 , A61F2310/00544 , A61F2310/00796 , A61L31/024 , A61L31/026 , A61L31/044 , A61L31/047 , A61L31/048 , A61L31/06 , A61L2430/38 , Y10S606/907 , Y10S606/908
摘要: One embodiment of a hollow spinal spacer (10) includes a curved anterior wall (11) having opposite ends (12, 13), a posterior wall (15) having opposite ends (16, 17), two lateral walls (20, 21), each integrally connected between the opposite ends (12, 13, 16, 17) of the anterior (11) and posterior (15) walls to define a chamber (30). The walls (11, 15, 20, 21) include a superior face (35) and an inferior face (40). The superior face (35) defines a first opening (36) in communication with the chamber (30) and includes a first vertebral engaging surface (37). The inferior face (40) defines a second opening (41) in communication with the chamber (30) and includes a second vertebral engaging surface (42).
摘要翻译: 空心脊椎间隔件(10)的一个实施例包括具有相对端(12,13)的弯曲前壁(11),具有相对端(16,17)的后壁(15),两个侧壁(20,21) ,每个整体连接在前(11)和后(15)壁的相对端(12,13,16,17)之间,以限定室(30)。 壁(11,15,20,21)包括上表面(35)和下表面(40)。 上表面(35)限定与腔室(30)连通的第一开口(36)并且包括第一椎骨接合表面(37)。 下表面(40)限定与腔室(30)连通的第二开口(41)并且包括第二椎骨接合表面(42)。
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公开(公告)号:US20140094436A1
公开(公告)日:2014-04-03
申请号:US14103420
申请日:2013-12-11
申请人: Weiwen Ying , Zhenjian Du , Kevin Foley
发明人: Weiwen Ying , Zhenjian Du , Kevin Foley
IPC分类号: C07D233/84 , C07F9/6506 , C07D233/88 , C07D403/10
CPC分类号: A61K31/4164 , A61K31/4178 , A61K31/4184 , A61K31/428 , A61K31/4709 , A61K31/52 , A61K31/5377 , A61K31/675 , C07D233/70 , C07D233/84 , C07D233/88 , C07D403/02 , C07D403/04 , C07D403/10 , C07F9/6506
摘要: Compounds of formula (I), pharmaceutical compositions comprising compounds of formula (I) and methods of inhibiting Hsp90 in a cell, treating or preventing a proliferation disorder in a mammal and treating cancer in a mammal comprising administering a compound of formula (I) to a patient or a cell. Variable R5 is an optionally substituted heteroaryl; an optionally substituted 6 to 14-membered aryl; a bicyclic 9-member heterocycle optionally substituted at any substitutable nitrogen or carbon atoms; or a substituent R18, defined herein. Ring A is an aryl or a heteroaryl optionally further substituted with one or more substituents in addition to R3. Substituent R3 is defined herein.
摘要翻译: 式(I)化合物,包含式(I)化合物的药物组合物和抑制细胞中Hsp90的方法,治疗或预防哺乳动物中的增殖病症并治疗哺乳动物的癌症,其包括给予式(I)化合物至 患者或细胞。 变量R5是任选取代的杂芳基; 任选取代的6至14元芳基; 任选在任何可取代的氮或碳原子上取代的双环9元杂环; 或本文定义的取代基R18。 环A是除了R3之外任选进一步被一个或多个取代基取代的芳基或杂芳基。 取代基R 3在本文中定义。
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公开(公告)号:US20130218740A1
公开(公告)日:2013-08-22
申请号:US13614758
申请日:2012-09-13
申请人: Howard W. Lutnick , Kevin Foley , Philip Marber , Bill Rice , Andrew Fishkind
发明人: Howard W. Lutnick , Kevin Foley , Philip Marber , Bill Rice , Andrew Fishkind
IPC分类号: G06Q40/04
摘要: A trading platform and trading method that allows access to additional pools of liquidity is described. Other embodiments are also described.
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公开(公告)号:US20130097065A1
公开(公告)日:2013-04-18
申请号:US13613862
申请日:2012-09-13
申请人: Howard W. Lutnick , Mark Miller , Dean P. Alderucci , Bill Rice , Kevin Foley , Andrew Fishkind , Philip Marber , Brian Gay
发明人: Howard W. Lutnick , Mark Miller , Dean P. Alderucci , Bill Rice , Kevin Foley , Andrew Fishkind , Philip Marber , Brian Gay
IPC分类号: G06Q40/04
摘要: An electronic trading marketplace (ETM) communicates with interfacing modules interfacing directly with order management systems (OMS's) at trading institutions. The interfacing modules automatically transmit orders from the OMS databases to the ETM and update the OMS databases in response to orders executed at the ETM. Traders can communicate with the ETM to anonymously negotiate trades of securities.
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公开(公告)号:US08269017B2
公开(公告)日:2012-09-18
申请号:US12883883
申请日:2010-09-16
申请人: Lijun Sun , Christopher Borella , Hao Li , Jun Jiang , Shoujun Chen , Keizo Koya , Takayo Inoue , Zhenjian Du , Kevin Foley , Yaming Wu , Mei Zhang , Weiwen Ying
发明人: Lijun Sun , Christopher Borella , Hao Li , Jun Jiang , Shoujun Chen , Keizo Koya , Takayo Inoue , Zhenjian Du , Kevin Foley , Yaming Wu , Mei Zhang , Weiwen Ying
IPC分类号: C07D261/02 , A61K31/42
CPC分类号: C07D413/14 , A61K31/42 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/675 , A61K45/06 , C07D261/08 , C07D413/04 , C07D413/10 , C07F9/653
摘要: The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.
摘要翻译: 本发明涉及结构式(I)的化合物或其药学上可接受的盐,溶剂化物,包合物和前药,其中R a,R b和R 2在本文中定义。 这些化合物抑制微管蛋白聚合和/或靶向脉管系统,并且可用于治疗增殖性疾病如癌症。
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