公开(公告)号：US09131885B2

公开(公告)日：2015-09-15

申请号：US12829318

申请日：2010-07-01

Applicant: Peter C. Simpson ,  Robert Boock ,  Paul V. Neale ,  Sebastian Bohm ,  Matthew Wightlin ,  Jack Pryor ,  Jason Mitchell ,  Jeff Jackson ,  Kaushik Patel ,  Antonio C. Llevares

Inventor： Peter C. Simpson ,  Robert Boock ,  Paul V. Neale ,  Sebastian Bohm ,  Matthew Wightlin ,  Jack Pryor ,  Jason Mitchell ,  Jeff Jackson ,  Kaushik Patel ,  Antonio C. Llevares

IPC: A61B5/05 ,  A61B5/1473 ,  A61B5/145 ,  A61B5/1486 ,  B05C3/10

CPC classification number: A61B5/1473 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14865 ,  A61B2560/0223 ,  A61B2562/0209 ,  A61B2562/043 ,  A61B2562/125 ,  B05C3/10

Abstract: Analyte sensors and methods of manufacturing same are provided, including analyte sensors comprising multi-axis flexibility. For example, a multi-electrode sensor system 800 comprising two working electrodes and at least one reference/counter electrode is provided. The sensor system 800 comprises first and second elongated bodies E1, E2, each formed of a conductive core or of a core with a conductive layer deposited thereon, insulating layer 810 that separates the conductive layer 820 from the elongated body, a membrane layer deposited on top of the elongated bodies E1, E2, and working electrodes 802′, 802″ formed by removing portions of the conductive layer 820 and the insulating layer 810, thereby exposing electroactive surface of the elongated bodies E1, E2.

Abstract translation: 提供分析物传感器及其制造方法，包括包含多轴灵活性的分析物传感器。 例如，提供了包括两个工作电极和至少一个参考/对电极的多电极传感器系统800。 传感器系统800包括第一和第二细长体E1，E2，每个由导电芯或具有沉积在其上的导电层的芯构成，绝缘层810将导电层820与细长主体分隔开;膜层沉积在 通过去除导电层820和绝缘层810的部分而形成的细长体E1，E2和工作电极802'，802“的顶部，从而暴露细长体E1，E2的电活性表面。

公开(公告)号：US20120078071A1

公开(公告)日：2012-03-29

申请号：US13247856

申请日：2011-09-28

Applicant: Sebastian Bohm ,  Mark Dervaes ,  Eric Johnson ,  Apurv Ullas Kamath ,  Shawn Larvenz ,  Jacob S. Leach ,  Phong Lieu ,  Aarthi Mahalingam ,  Tom Miller ,  Paul V. Neale ,  Jack Pryor ,  Thomas A. Peyser ,  Daiting Rong ,  Kenneth San Vicente ,  Mohammad Ali Shariati ,  Peter C. Simpson ,  Matthew Wightlin

Inventor： Sebastian Bohm ,  Mark Dervaes ,  Eric Johnson ,  Apurv Ullas Kamath ,  Shawn Larvenz ,  Jacob S. Leach ,  Phong Lieu ,  Aarthi Mahalingam ,  Tom Miller ,  Paul V. Neale ,  Jack Pryor ,  Thomas A. Peyser ,  Daiting Rong ,  Kenneth San Vicente ,  Mohammad Ali Shariati ,  Peter C. Simpson ,  Matthew Wightlin

IPC: A61B5/145

CPC classification number: A61B5/14532 ,  A61B5/14507 ,  A61B5/1451 ,  A61B2560/0209 ,  A61B2560/0214 ,  A61B2562/02 ,  G06F1/3203

Abstract: Systems and methods for processing, transmitting, and displaying data received from a continuous analyte (e.g., glucose) sensor are provided. A sensor system can comprise a sensor electronics module that includes power saving features, e.g., a low power measurement circuit that can be switched between a measurement mode and a low power mode, wherein charging circuitry continues to apply power to electrodes of a sensor during the low power mode. The sensor electronics module can be switched between a low power storage mode and a higher power operational mode via a switch, e.g., a reed switch or optical switch. A validation routine can be implemented to ensure an interrupt signal sent from the switch is valid. The sensor can be physically connected to the sensor electronics module in direct wireless communication with a plurality of different display devices.

Abstract translation: 提供了用于处理，传输和显示从连续分析物（例如，葡萄糖）传感器接收的数据的系统和方法。 传感器系统可以包括传感器电子模块，其包括省电功能，例如可以在测量模式和低功率模式之间切换的低功率测量电路，其中充电电路在该期间继续向传感器的电极施加功率 低功耗模式。 传感器电子模块可以通过诸如簧片开关或光开关的开关在低功率存储模式和较高功率操作模式之间切换。 可以实现验证程序，以确保从交换机发送的中断信号有效。 传感器可以与多个不同的显示设备直接无线通信，物理地连接到传感器电子模块。

公开(公告)号：US20050267158A1

公开(公告)日：2005-12-01

申请号：US11081708

申请日：2005-03-15

Applicant: Qiang Ye ,  Scott Zook ,  Michael Ouellette ,  Don Hettinger ,  Jayaram Srirangam ,  Robert Kania ,  Nabil Saeed ,  Matthew Wightlin ,  Mark Mitchell

Inventor： Qiang Ye ,  Scott Zook ,  Michael Ouellette ,  Don Hettinger ,  Jayaram Srirangam ,  Robert Kania ,  Nabil Saeed ,  Matthew Wightlin ,  Mark Mitchell

IPC: A61K31/4439 ,  C07D401/14 ,  C07D43/14

CPC classification number: C07D401/14

Abstract: The invention provides several polymorphic forms and an amorphous form of 2,5-Dimethyl-2H-pyrazole-3-carboxylic acid {2-fluoro-5-[3-((E)-2-pyridin-2-yl-vinyl)-1H-indazol-6-ylamino]-phenyl}-amide, pharmaceutical compositions containing such polymorphic or amorphous forms, and methods of using such pharmaceutical compositions to treat disease states mediated by protein kinases, such as cancer and other disease states associated with unwanted angiogenesis and/or cellular proliferation.

Abstract translation: 本发明提供了几种多晶型和无定形形式的2,5-二甲基-2H-吡唑-3-羧酸{2-氟-5- [3 - （（E）-2-吡啶-2-基 - 乙烯基） -1H-吲唑-6-基氨基] - 苯基} - 酰胺，含有这种多晶型或无定形形式的药物组合物，以及使用这种药物组合物治疗由蛋白激酶介导的疾病状态的方法，例如与不想要的 血管生成和/或细胞增殖。

公开(公告)号：US10231653B2

公开(公告)日：2019-03-19

申请号：US13247856

申请日：2011-09-28

Applicant: Sebastian Bohm ,  Mark Dervaes ,  Eric Johnson ,  Apurv Ullas Kamath ,  Shawn Larvenz ,  Jacob S. Leach ,  Phong Lieu ,  Aarthi Mahalingam ,  Tom Miller ,  Paul V. Neale ,  Jack Pryor ,  Thomas A. Peyser ,  Daiting Rong ,  Kenneth San Vicente ,  Mohammad Ali Shariati ,  Peter C. Simpson ,  Matthew Wightlin

Inventor： Sebastian Bohm ,  Mark Dervaes ,  Eric Johnson ,  Apurv Ullas Kamath ,  Shawn Larvenz ,  Jacob S. Leach ,  Phong Lieu ,  Aarthi Mahalingam ,  Tom Miller ,  Paul V. Neale ,  Jack Pryor ,  Thomas A. Peyser ,  Daiting Rong ,  Kenneth San Vicente ,  Mohammad Ali Shariati ,  Peter C. Simpson ,  Matthew Wightlin

IPC: G06F1/32 ,  A61B5/145 ,  G06F1/3203

Abstract: Systems and methods for processing, transmitting, and displaying data received from a continuous analyte (e.g., glucose) sensor are provided. A sensor system can comprise a sensor electronics module that includes power saving features, e.g., a low power measurement circuit that can be switched between a measurement mode and a low power mode, wherein charging circuitry continues to apply power to electrodes of a sensor during the low power mode. The sensor electronics module can be switched between a low power storage mode and a higher power operational mode via a switch, e.g., a reed switch or optical switch. A validation routine can be implemented to ensure an interrupt signal sent from the switch is valid. The sensor can be physically connected to the sensor electronics module in direct wireless communication with a plurality of different display devices.

公开(公告)号：US20080197024A1

公开(公告)日：2008-08-21

申请号：US12055078

申请日：2008-03-25

Applicant: Peter C. Simpson ,  Apurv Ullas Kamath ,  Jacob S. Leach ,  Mark Brister ,  Vance Swanson ,  Curtis Hanson ,  Jack Pryor ,  Matthew Wightlin ,  Sean Saint ,  John Nolting

Inventor： Peter C. Simpson ,  Apurv Ullas Kamath ,  Jacob S. Leach ,  Mark Brister ,  Vance Swanson ,  Curtis Hanson ,  Jack Pryor ,  Matthew Wightlin ,  Sean Saint ,  John Nolting

IPC: G01N33/50

CPC classification number: A61B5/14865 ,  A61B5/145 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14542 ,  A61B5/14546 ,  A61B5/1495 ,  A61B5/412 ,  A61B5/6848 ,  A61B5/6849 ,  A61B2560/0223 ,  A61M5/14 ,  A61M5/16804 ,  A61M5/1723 ,  A61M2005/14296 ,  A61M2230/201 ,  C12Q1/001 ,  C12Q1/006 ,  G06F19/3468 ,  G16H40/40 ,  Y02A90/26

Abstract: Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system.

公开(公告)号：US20070235331A1

公开(公告)日：2007-10-11

申请号：US11750907

申请日：2007-05-18

Applicant: Peter Simpson ,  Robert Boock ,  James Petisce ,  Mark Brister ,  Monica Rixman ,  Kum Ming Woo ,  Lisa Nguyen ,  Seth Brunner ,  Arthur Chee ,  Melissa Nicholas ,  Matthew Wightlin ,  Jack Pryor ,  Dubravka Markovic

Inventor： Peter Simpson ,  Robert Boock ,  James Petisce ,  Mark Brister ,  Monica Rixman ,  Kum Ming Woo ,  Lisa Nguyen ,  Seth Brunner ,  Arthur Chee ,  Melissa Nicholas ,  Matthew Wightlin ,  Jack Pryor ,  Dubravka Markovic

IPC: G01N27/26

CPC classification number: A61B5/00 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/14735 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/6848 ,  A61B5/7203

Abstract: Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.

Abstract translation: 提供涉及具有基本上不受非恒定噪声影响的信噪比的传感器的系统和方法用于主机中的连续分析物测量。 在一些实施例中，连续分析物测量系统被配置为完全，经皮，血管内或体外植入。

公开(公告)号：US09237864B2

公开(公告)日：2016-01-19

申请号：US12829306

申请日：2010-07-01

Applicant: Peter C. Simpson ,  Robert Boock ,  Paul V. Neale ,  Sebastian Bohm ,  Matthew Wightlin ,  Jack Pryor ,  Jason Mitchell ,  Jeff Jackson ,  Kaushik Patel ,  Antonio C. Llevares

Inventor： Peter C. Simpson ,  Robert Boock ,  Paul V. Neale ,  Sebastian Bohm ,  Matthew Wightlin ,  Jack Pryor ,  Jason Mitchell ,  Jeff Jackson ,  Kaushik Patel ,  Antonio C. Llevares

IPC: A61B5/00 ,  A61B5/1473 ,  A61B5/145 ,  A61B5/1486 ,  B05C3/10

CPC classification number: A61B5/1473 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14865 ,  A61B2560/0223 ,  A61B2562/0209 ,  A61B2562/043 ,  A61B2562/125 ,  B05C3/10

Abstract: Analyte sensors and methods of manufacturing same are provided, including analyte sensors comprising multi-axis flexibility. For example, a multi-electrode sensor system 800 comprising two working electrodes and at least one reference/counter electrode is provided. The sensor system 800 comprises first and second elongated bodies E1, E2, each formed of a conductive core or of a core with a conductive layer deposited thereon, insulating layer 810 that separates the conductive layer 820 from the elongated body, a membrane layer deposited on top of the elongated bodies E1, E2, and working electrodes 802′, 802″ formed by removing portions of the conductive layer 820 and the insulating layer 810, thereby exposing electroactive surface of the elongated bodies E1, E2.

公开(公告)号：US08423114B2

公开(公告)日：2013-04-16

申请号：US11865572

申请日：2007-10-01

Applicant: Peter C. Simpson ,  Mark Brister ,  Matthew Wightlin ,  Jack Pryor

Inventor： Peter C. Simpson ,  Mark Brister ,  Matthew Wightlin ,  Jack Pryor

IPC: A61B5/00 ,  A61B5/05

CPC classification number: A61B5/14532 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/6849 ,  C12Q1/006

Abstract: Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure additional analyte or non-analyte related signal. Such measurements may provide a background and/or sensitivity measurement(s) for use in processing sensor data and may be used to trigger events such as digital filtering of data or suspending display of data.

Abstract translation: 本文公开了用于连续分析物传感器（例如连续葡萄糖传感器）的系统和方法。 一个这样的系统利用第一和第二工作电极来测量附加分析物或非分析物相关信号。 这样的测量可以提供用于处理传感器数据的背景和/或灵敏度测量，并且可以用于触发诸如数据的数字滤波或暂停显示数据的事件。

公开(公告)号：US20110024307A1

公开(公告)日：2011-02-03

申请号：US12829264

申请日：2010-07-01

Applicant: Peter C. Simpson ,  Robert Boock ,  Apurv Ullas Kamath ,  Matthew Wightlin ,  Michael J. Estes

Inventor： Peter C. Simpson ,  Robert Boock ,  Apurv Ullas Kamath ,  Matthew Wightlin ,  Michael J. Estes

IPC: G01N27/26 ,  G01N33/50 ,  G01N27/416

Abstract: Devices and methods are provided for continuous measurement of an analyte concentration. The device can include a sensor having a plurality of sensor elements, each having at least one characteristic that is different from other sensor(s) of the device. In some embodiments, the plurality of sensor elements are each tuned to measure a different range of analyte concentration, thereby providing the device with the capability of achieving a substantially consistent level of measurement accuracy across a physiologically relevant range. In other embodiments, the device includes a plurality of sensor elements each tuned to measure during different time periods after insertion or implantation, thereby providing the sensor with the capability to continuously and accurately measure analyte concentrations across a wide range of time periods. For example, a sensor system 180 is provided having a first working electrode 150 comprising a first sensor element 102 and a second working electrode 160 comprising a second sensor element 104, and a reference electrode 108 for providing a reference value for measuring the working electrode potential of the sensor elements 102, 104.

Abstract translation: 提供了用于连续测量分析物浓度的装置和方法。 该装置可以包括具有多个传感器元件的传感器，每个传感器元件具有与装置的其它传感器不同的至少一个特性。 在一些实施例中，多个传感器元件各自被调谐以测量分析物浓度的不同范围，从而为器件提供在生理学相关范围内实现基本一致的测量精度水平的能力。 在其他实施例中，该装置包括多个传感器元件，每个传感器元件在插入或植入之后的不同时间期间被调整以测量，从而为传感器提供在宽范围的时间段内连续且精确地测量分析物浓度的能力。 例如，传感器系统180被提供有具有包括第一传感器元件102的第一工作电极150和包括第二传感器元件104的第二工作电极160以及用于提供用于测量工作电极电位的参考值的参考电极108 的传感器元件102,104。

公开(公告)号：US20100076283A1

公开(公告)日：2010-03-25

申请号：US12562011

申请日：2009-09-17

Applicant: Peter C. Simpson ,  Robert J. Boock ,  Matthew Wightlin ,  Mark Shults

Inventor： Peter C. Simpson ,  Robert J. Boock ,  Matthew Wightlin ,  Mark Shults

IPC: A61B5/1473

CPC classification number: A61B5/1473 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14865 ,  A61B5/6848 ,  A61B2562/028

Abstract: Systems and methods of use involving sensors having a particle-containing domain are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.

Abstract translation: 提供涉及具有含颗粒结构域的传感器的系统和使用方法用于在主机中连续分析物测量。 在一些实施例中，连续分析物测量系统被配置为完全，经皮，血管内或体外植入。