公开(公告)号：US20220095968A1

公开(公告)日：2022-03-31

申请号：US17545711

申请日：2021-12-08

申请人： Liang Wang ,  Shwetha Edla ,  Ghazaleh R. Esmaili ,  Hossein Mohammadiarani ,  Sebastian Bohm ,  Rui Ma ,  Minglian Shi ,  Anna Harley-Trochimczyk

发明人： Liang Wang ,  Shwetha Edla ,  Ghazaleh R. Esmaili ,  Hossein Mohammadiarani ,  Sebastian Bohm ,  Rui Ma ,  Minglian Shi ,  Anna Harley-Trochimczyk

IPC分类号： A61B5/145 ,  A61B5/01 ,  A61B5/1468

摘要： Various examples are directed to systems and methods for generating an estimated analyte value. An analyte sensor system may access a first sensor signal from an in vivo analyte sensor and a first temperature signal from the ex vivo temperature sensor. The analyte sensor system may generate a first analyte sensor temperature based at least in part on the first temperature signal and generate a first estimated analyte value based at least in part on the first sensor signal and the first temperature-compensated sensitivity.

公开(公告)号：US09131885B2

公开(公告)日：2015-09-15

申请号：US12829318

申请日：2010-07-01

申请人： Peter C. Simpson ,  Robert Boock ,  Paul V. Neale ,  Sebastian Bohm ,  Matthew Wightlin ,  Jack Pryor ,  Jason Mitchell ,  Jeff Jackson ,  Kaushik Patel ,  Antonio C. Llevares

发明人： Peter C. Simpson ,  Robert Boock ,  Paul V. Neale ,  Sebastian Bohm ,  Matthew Wightlin ,  Jack Pryor ,  Jason Mitchell ,  Jeff Jackson ,  Kaushik Patel ,  Antonio C. Llevares

IPC分类号： A61B5/05 ,  A61B5/1473 ,  A61B5/145 ,  A61B5/1486 ,  B05C3/10

CPC分类号： A61B5/1473 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14865 ,  A61B2560/0223 ,  A61B2562/0209 ,  A61B2562/043 ,  A61B2562/125 ,  B05C3/10

摘要： Analyte sensors and methods of manufacturing same are provided, including analyte sensors comprising multi-axis flexibility. For example, a multi-electrode sensor system 800 comprising two working electrodes and at least one reference/counter electrode is provided. The sensor system 800 comprises first and second elongated bodies E1, E2, each formed of a conductive core or of a core with a conductive layer deposited thereon, insulating layer 810 that separates the conductive layer 820 from the elongated body, a membrane layer deposited on top of the elongated bodies E1, E2, and working electrodes 802′, 802″ formed by removing portions of the conductive layer 820 and the insulating layer 810, thereby exposing electroactive surface of the elongated bodies E1, E2.

摘要翻译： 提供分析物传感器及其制造方法，包括包含多轴灵活性的分析物传感器。 例如，提供了包括两个工作电极和至少一个参考/对电极的多电极传感器系统800。 传感器系统800包括第一和第二细长体E1，E2，每个由导电芯或具有沉积在其上的导电层的芯构成，绝缘层810将导电层820与细长主体分隔开;膜层沉积在 通过去除导电层820和绝缘层810的部分而形成的细长体E1，E2和工作电极802'，802“的顶部，从而暴露细长体E1，E2的电活性表面。

公开(公告)号：US20100133151A1

公开(公告)日：2010-06-03

申请号：US12537802

申请日：2009-08-07

申请人： Sebastian Bohm ,  John R. Gilbert ,  Manish Deshpande

发明人： Sebastian Bohm ,  John R. Gilbert ,  Manish Deshpande

IPC分类号： B03B5/00

CPC分类号： B03B5/00 ,  B01L3/5027 ,  B07C5/34 ,  F15C5/00 ,  F16K99/0001 ,  F16K99/0028 ,  F16K99/0046 ,  F16K99/0048 ,  F16K99/0061 ,  F16K2099/0084 ,  G01N15/14 ,  G01N2015/149 ,  Y10S209/906 ,  Y10S209/932

摘要： A method and apparatus for sorting particles moving through a closed channel system of capillary size comprises a bubble valve for selectively generating a pressure pulse to separate a particle having a predetermined characteristic from a stream of particles. The particle sorting system may further include a buffer for absorbing the pressure pulse. The particle sorting system may include a plurality of closely coupled sorting modules which are combined to further increase the sorting rate. The particle sorting system may comprise a multi-stage sorting device for serially sorting streams of particles, in order to decrease the error rate.

摘要翻译： 用于分选移动通过毛细管尺寸的封闭通道系统的颗粒的方法和装置包括气泡阀，用于选择性地产生压力脉冲以将具有预定特征的颗粒与颗粒流分离。 颗粒分选系统还可以包括用于吸收压力脉冲的缓冲器。 颗粒分选系统可以包括多个紧密耦合的分类模块，其被组合以进一步提高排序率。 颗粒分选系统可以包括用于串行排列颗粒流的多级分选装置，以便降低误差率。

公开(公告)号：US07665303B2

公开(公告)日：2010-02-23

申请号：US11095636

申请日：2005-03-30

申请人： Sebastian Bohm ,  Alan W. McNeilage

发明人： Sebastian Bohm ,  Alan W. McNeilage

IPC分类号： F01K1/00

CPC分类号： B01L3/502784 ,  B01L2200/0605 ,  B01L2200/0673 ,  B01L2200/143 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/0442 ,  B01L2400/0487 ,  B01L2400/0694 ,  G01N27/3271 ,  G01N35/1095

摘要： The invention described is a method of segregating a bolus of fluid using a pneumatic actuator in a fluid handling circuit. The described invention further includes a method of segregating a bolus of fluid using a pneumatic actuator in a fluid handling circuit wherein the method includes the step of injecting an air pocket into the fluid stream to create the bolus. In addition, the described invention includes a method of measuring the analyte concentration in a bolus of fluid using a pneumatic actuator in a fluid handling circuit. The described invention further includes a method of measuring the analyte concentration in a bolus of fluid using a pneumatic actuator in a fluid handling circuit wherein the method includes the step of injecting an air pocket into the fluid stream to create the bolus.

摘要翻译： 本发明描述了一种在流体处理电路中使用气动致动器分离流体的方法。 所描述的发明还包括在流体处理电路中使用气动致动器分离流体的方法，其中所述方法包括将空气袋注入流体流以产生推注的步骤。 此外，所描述的发明包括使用流体处理电路中的气动致动器测量流体中的分析物浓度的方法。 所描述的发明还包括使用流体处理电路中的气动致动器来测量流体中的分析物浓度的方法，其中所述方法包括将空气袋注入流体流中以产生推注的步骤。

公开(公告)号：US07654127B2

公开(公告)日：2010-02-02

申请号：US11614211

申请日：2006-12-21

申请人： Peter Krulevitch ,  Mingqi Zhao ,  Sebastian Bohm ,  Deon Anex ,  Michael Gearhart

发明人： Peter Krulevitch ,  Mingqi Zhao ,  Sebastian Bohm ,  Deon Anex ,  Michael Gearhart

IPC分类号： G01F25/00 ,  G01N19/00

CPC分类号： A61M5/14526 ,  A61M5/14244 ,  A61M5/14566 ,  A61M5/16831 ,  A61M2005/14513 ,  A61M2205/3317

摘要： The present application is directed to systems and methods associated with infusion pumps, which can optionally utilize an electrokinetic driving mechanism. Infusion pumps, including electrokinetically-driven pumps, are discussed, along with schemes for controlling their operation. As well, systems and methods of detecting malfunctions in infusion pumps are discussed. Any number of malfunctions can be detected including the presence of occlusions and/or leaks. In some instances, a measurement associated with some aspect of electrokinetic phenomena (e.g., an electrode measurement such as voltage or current) is compared with one or more sample values, the comparison allowing an indication of pump malfunction to be determined. A variety of such measurements and comparison techniques are discussed in the present disclosure.

摘要翻译： 本申请涉及与输注泵相关联的系统和方法，其可以可选地使用电动驱动机构。 讨论了输液泵，包括电动泵，以及控制其操作的方案。 此外，还讨论了检测输液泵故障的系统和方法。 可以检测到任何数量的故障，包括堵塞和/或泄漏的存在。 在一些情况下，将与动电现象的一些方面（例如电极测量例如电压或电流）相关联的测量与一个或多个样本值进行比较，该比较允许确定泵故障的指示。 在本公开中讨论了各种这样的测量和比较技术。

公开(公告)号：US20090139577A1

公开(公告)日：2009-06-04

申请号：US12363850

申请日：2009-02-02

申请人： Sebastian Bohm

发明人： Sebastian Bohm

IPC分类号： F17D1/00

CPC分类号： F04B19/24 ,  F04B43/06 ,  F04B53/10 ,  F04B53/1077 ,  Y10T137/0379

摘要： The present invention is directed to methods for controlling the flow of fluid and, more particularly, to a method of using triggerable passive valves to control the flow of fluid. In one embodiment of the present invention a method of using triggerable passive valves to control the flow of fluid is described wherein fluid is moved through a passive valve by providing pneumatic pressure between the passive valve and a flow restrictor, the pneumatic pressure exerted causing the pressure exerted by the fluid on the passive valve to exceed the burst pressure of the passive valve.

摘要翻译： 本发明涉及用于控制流体流动的方法，更具体地，涉及一种使用可触发的被动阀来控制流体流动的方法。 在本发明的一个实施例中，描述了使用可触发的被动阀来控制流体流动的方法，其中通过在被动阀和限流器之间提供气动压力将流体移动通过被动阀，引起压力的气压 由被动阀上的流体施加以超过被动阀的爆破压力。

公开(公告)号：US20070062250A1

公开(公告)日：2007-03-22

申请号：US11532691

申请日：2006-09-18

申请人： Peter Krulevitch ,  Sebastian Bohm ,  Mingqi Zhao ,  Deon Anex

发明人： Peter Krulevitch ,  Sebastian Bohm ,  Mingqi Zhao ,  Deon Anex

IPC分类号： G01F25/00

CPC分类号： A61M5/14244 ,  A61M5/14248 ,  A61M5/1452 ,  A61M5/16831 ,  A61M5/172 ,  A61M2005/14513 ,  A61M2205/3317 ,  A61M2205/3389

摘要： Systems and methods of detecting occlusions and fluid-loss conditions (e.g., disconnects and/or leakages) in an infusion pump are discussed. For example, electrokinetic infusion pumps may develop an occlusion in the fluid flow path, which can disrupt control of fluid dispersed from the pump. As well, an infusion set disconnect can also result in a fluid-loss that can be disruptive. Such disruptions can be troublesome to systems that control the infusion pump, such as closed loop controllers. Accordingly, systems and methods described herein can be used to detect such occlusions and fluid-loss conditions during infusion pump operation. For example, a position sensor can be used to monitor fluid flow from the infusion pump, with the measurement being compared with an expected value to detect an occlusion or fluid-loss condition. Other algorithms for utilizing the position sensor are also described.

摘要翻译： 讨论了检测输液泵中的闭塞和流体损失状况（例如断开和/或泄漏）的系统和方法。 例如，电动输液泵可能在流体流动路径中产生阻塞，这可能破坏从泵分散的流体的控制。 同样，输液器断开也可能导致流体损失，这可能是破坏性的。 对于控制输液泵的系统，例如闭环控制器，这种中断可能是麻烦的。 因此，本文所述的系统和方法可用于在输注泵操作期间检测这种闭塞和流体损失状况。 例如，位置传感器可用于监测来自输注泵的流体流动，其中测量值与预期值进行比较以检测堵塞或流体损失状况。 还描述了用于利用位置传感器的其它算法。

公开(公告)号：US20070044851A1

公开(公告)日：2007-03-01

申请号：US11591213

申请日：2006-11-01

申请人： John Gilbert ,  Bernard Bunner ,  Sebastian Bohm ,  Manish Deshpande

发明人： John Gilbert ,  Bernard Bunner ,  Sebastian Bohm ,  Manish Deshpande

IPC分类号： F16K27/00

CPC分类号： F16K99/0001 ,  F15C5/00 ,  F16K99/0005 ,  F16K99/0007 ,  F16K99/0009 ,  F16K99/0015 ,  F16K99/0046 ,  F16K99/0048 ,  F16K2099/0069 ,  F16K2099/0071 ,  F16K2099/0074 ,  F16K2099/0076 ,  F16K2099/008 ,  F16K2099/0084 ,  G05D7/0694 ,  Y10T29/49412 ,  Y10T137/87314

摘要： A latching microregulator for regulating liquid flow on micro-scale levels comprises a substrate having an inlet port and an outlet port, a valve element defining a valve chamber for opening and closing the inlet port, and an actuator assembly for actuating the valve element. The valve chamber is configured to contain a volume of fluid, and the inlet port and the outlet port are in fluid communication with the valve chamber to provide a liquid flow path through the chamber. The actuator assembly comprises a cantilever beam for moving the valve element between an open position and a closed position, an actuator, such as a piezoelectric element, for moving the cantilever beam, and a latch, such as a permanent magnet, for securing the cantilever beam in the closed position. A flow regulation system comprises a plurality of fluid channels of varied flow conductance and a plurality of latching microregulators for selectively blocking or allowing flow through each of the fluid channels.

公开(公告)号：US20050092658A1

公开(公告)日：2005-05-05

申请号：US10940143

申请日：2004-09-13

申请人： Sebastian Bohm ,  John Gilbert ,  Manish Deshpande

发明人： Sebastian Bohm ,  John Gilbert ,  Manish Deshpande

IPC分类号： B01L3/00 ,  B07C5/34 ,  F15C5/00 ,  F16K99/00 ,  G01N15/14 ,  B03B5/30

CPC分类号： B03B5/00 ,  B01L3/5027 ,  B07C5/34 ,  F15C5/00 ,  F16K99/0001 ,  F16K99/0028 ,  F16K99/0046 ,  F16K99/0048 ,  F16K99/0061 ,  F16K2099/0084 ,  G01N15/14 ,  G01N2015/149 ,  Y10S209/906 ,  Y10S209/932

摘要： A method and apparatus for sorting particles moving through a closed channel system of capillary size comprises a bubble valve for selectively generating a pressure pulse to separate a particle having a predetermined characteristic from a stream of particles. The particle sorting system may further include a buffer for absorbing the pressure pulse. The particle sorting system may include a plurality of closely coupled sorting modules which are combined to further increase the sorting rate. The particle sorting system may comprise a multi-stage sorting device for serially sorting streams of particles, in order to decrease the error rate.

公开(公告)号：US10231653B2

公开(公告)日：2019-03-19

申请号：US13247856

申请日：2011-09-28

申请人： Sebastian Bohm ,  Mark Dervaes ,  Eric Johnson ,  Apurv Ullas Kamath ,  Shawn Larvenz ,  Jacob S. Leach ,  Phong Lieu ,  Aarthi Mahalingam ,  Tom Miller ,  Paul V. Neale ,  Jack Pryor ,  Thomas A. Peyser ,  Daiting Rong ,  Kenneth San Vicente ,  Mohammad Ali Shariati ,  Peter C. Simpson ,  Matthew Wightlin

发明人： Sebastian Bohm ,  Mark Dervaes ,  Eric Johnson ,  Apurv Ullas Kamath ,  Shawn Larvenz ,  Jacob S. Leach ,  Phong Lieu ,  Aarthi Mahalingam ,  Tom Miller ,  Paul V. Neale ,  Jack Pryor ,  Thomas A. Peyser ,  Daiting Rong ,  Kenneth San Vicente ,  Mohammad Ali Shariati ,  Peter C. Simpson ,  Matthew Wightlin

IPC分类号： G06F1/32 ,  A61B5/145 ,  G06F1/3203

摘要： Systems and methods for processing, transmitting, and displaying data received from a continuous analyte (e.g., glucose) sensor are provided. A sensor system can comprise a sensor electronics module that includes power saving features, e.g., a low power measurement circuit that can be switched between a measurement mode and a low power mode, wherein charging circuitry continues to apply power to electrodes of a sensor during the low power mode. The sensor electronics module can be switched between a low power storage mode and a higher power operational mode via a switch, e.g., a reed switch or optical switch. A validation routine can be implemented to ensure an interrupt signal sent from the switch is valid. The sensor can be physically connected to the sensor electronics module in direct wireless communication with a plurality of different display devices.