公开(公告)号：US08437449B2

公开(公告)日：2013-05-07

申请号：US11189431

申请日：2005-07-25

申请人： James K. Riley ,  Eric Meier ,  J. Nelson Wright ,  Steven C. Dimmer ,  Timothy P. Mate

发明人： James K. Riley ,  Eric Meier ,  J. Nelson Wright ,  Steven C. Dimmer ,  Timothy P. Mate

IPC分类号： A61N5/10 ,  A61B5/00

CPC分类号： A61N5/1038 ,  A61N5/103 ,  A61N5/1048

摘要： A facility for facilitating custom radiation treatment planning is described. During a distinguished radiation treatment session for a patient, the facility collects data indicating positioning of a predefined treatment site of the patient relative to a target treatment location throughout the distinguished radiation treatment session. The facility associates the collected positioning data with data describing one or more other aspects of the distinguished radiation treatment session. The facility provides the associated data to a treatment planning facility to determine a treatment plan for future radiation treatment sessions for the patient.

摘要翻译： 描述了一种便于定制辐射治疗计划的设施。 在针对患者的不同的辐射治疗期间，设施收集指示患者相对于目标治疗位置在整个识别的辐射治疗期间的定位的数据。 该设施将收集的定位数据与描述不同的辐射治疗会话的一个或多个其他方面的数据相关联。 该设施将相关数据提供给治疗计划设施，以确定患者将来的放射治疗期间的治疗计划。

公开(公告)号：US09616248B2

公开(公告)日：2017-04-11

申请号：US13559518

申请日：2012-07-26

申请人： Eric Meier ,  Timothy P. Mate ,  J. Nelson Wright ,  Steven C. Dimmer ,  Lynn M. Purdy

发明人： Eric Meier ,  Timothy P. Mate ,  J. Nelson Wright ,  Steven C. Dimmer ,  Lynn M. Purdy

IPC分类号： A61B5/05 ,  A61N5/10

CPC分类号： A61N5/1039 ,  A61N5/1049 ,  A61N5/1067 ,  A61N5/107 ,  A61N2005/1051

摘要： An integrated radiation therapy process comprises acquiring first objective target data related to a parameter of a target within a patient by periodically locating a marker positioned within the patient using a localization modality. This method continues with obtaining second objective target data related to the parameter of the target by periodically locating the marker. The first objective target data can be acquired in a first area that is apart from a second area which contains a radiation delivery device for producing an ionizing radiation beam for treating the patient. The localization modality can be the same in both the first and second areas. In other embodiments, the first objective target data can be acquired using a first localization modality that uses a first energy type to identify the marker and the second objective target data can be obtained using a second localization modality that uses a second energy.

公开(公告)号：US10195464B2

公开(公告)日：2019-02-05

申请号：US11165843

申请日：2005-06-24

申请人： Edward J. Vertatschitsch ,  Steven C. Dimmer ,  Timothy P. Mate ,  Eric Meier ,  Keith Seiler ,  J. Nelson Wright

发明人： Edward J. Vertatschitsch ,  Steven C. Dimmer ,  Timothy P. Mate ,  Eric Meier ,  Keith Seiler ,  J. Nelson Wright

IPC分类号： A61B5/05 ,  A61N5/10 ,  A61B34/30 ,  A61B34/00 ,  A61B90/00

摘要： Systems and methods for treating a lung of a patient. One embodiment of a method comprises positioning a leadless marker in the lung of the patient relative to the target, and collecting position data of the marker. This method further comprises determining the location of the marker in an external reference frame outside of the patient based on the collected position data, and providing an objective output in the external reference frame that is responsive to movement of the marker. The objective output is provided at a frequency (i.e., periodicity) that results in a clinically acceptable tracking error. In addition, the objective output can also be provided at least substantially contemporaneously with collecting the position data used to determine the location of the marker.

公开(公告)号：US09682253B2

公开(公告)日：2017-06-20

申请号：US11190193

申请日：2005-07-25

申请人： Eric Meier ,  Timothy P. Mate ,  J. Nelson Wright ,  Steven C. Dimmer ,  Lynn M. Purdy

发明人： Eric Meier ,  Timothy P. Mate ,  J. Nelson Wright ,  Steven C. Dimmer ,  Lynn M. Purdy

IPC分类号： A61B5/05 ,  A61N5/10

CPC分类号： A61N5/1039 ,  A61N5/1049 ,  A61N5/1067 ,  A61N5/107 ,  A61N2005/1051

摘要： An integrated radiation therapy process comprises acquiring first objective target data related to a parameter of a target within a patient by periodically locating a marker positioned within the patient using a localization modality. This method continues with obtaining second objective target data related to the parameter of the target by periodically locating the marker. The first objective target data can be acquired in a first area that is apart from a second area which contains a radiation delivery device for producing an ionizing radiation beam for treating the patient. The localization modality can be the same in both the first and second areas. In other embodiments, the first objective target data can be acquired using a first localization modality that uses a first energy type to identify the marker and the second objective target data can be obtained using a second localization modality that uses a second energy type to identify the marker that is different than the first energy type.

公开(公告)号：US20130172657A1

公开(公告)日：2013-07-04

申请号：US13559518

申请日：2012-07-26

申请人： Eric Meier ,  Timothy P. Mate ,  J. Nelson Wright ,  Steven C. Dimmer ,  Lynn M. Purdy

发明人： Eric Meier ,  Timothy P. Mate ,  J. Nelson Wright ,  Steven C. Dimmer ,  Lynn M. Purdy

IPC分类号： A61N5/10

CPC分类号： A61N5/1039 ,  A61N5/1049 ,  A61N5/1067 ,  A61N5/107 ,  A61N2005/1051

摘要： An integrated radiation therapy process comprises acquiring first objective target data related to a parameter of a target within a patient by periodically locating a marker positioned within the patient using a localization modality. This method continues with obtaining second objective target data related to the parameter of the target by periodically locating the marker. The first objective target data can be acquired in a first area that is apart from a second area which contains a radiation delivery device for producing an ionizing radiation beam for treating the patient. The localization modality can be the same in both the first and second areas. In other embodiments, the first objective target data can be acquired using a first localization modality that uses a first energy type to identify the marker and the second objective target data can be obtained using a second localization modality that uses a second energy.

摘要翻译： 综合放射治疗过程包括通过使用定位模式周期性地定位位于患者内的标记来获取与患者内的目标参数有关的第一目标目标数据。 该方法继续通过周期性地定位标记来获得与目标参数相关的第二目标目标数据。 第一目标数据可以在离开包含用于产生用于治疗患者的电离辐射束的辐射递送装置的第二区域的第一区域中获取。 第一和第二区域的定位方式可以相同。 在其他实施例中，可以使用使用第一能量类型来识别标记的第一定位模态来获取第一目标数据，并且可以使用使用第二能量的第二定位模态来获得第二目标数据。

公开(公告)号：US08340742B2

公开(公告)日：2012-12-25

申请号：US11190196

申请日：2005-07-25

申请人： Eric Meier ,  Timothy P. Mate ,  J. Nelson Wright ,  Steven C. Dimmer ,  Lynn M. Purdy

发明人： Eric Meier ,  Timothy P. Mate ,  J. Nelson Wright ,  Steven C. Dimmer ,  Lynn M. Purdy

IPC分类号： A61B5/05

CPC分类号： A61N5/1039 ,  A61N5/1049 ,  A61N5/1067 ,  A61N5/107 ,  A61N2005/1051

摘要： An integrated radiation therapy process comprises acquiring first objective target data related to a parameter of a target within a patient by periodically locating a marker positioned within the patient using a localization modality. This method continues with obtaining second objective target data related to the parameter of the target by periodically locating the marker. The first objective target data can be acquired in a first area that is apart from a second area which contains a radiation delivery device for producing an ionizing radiation beam for treating the patient. The localization modality can be the same in both the first and second areas. In other embodiments, the first objective target data can be acquired using a first localization modality that uses a first energy type to identify the marker and the second objective target data can be obtained using a second localization modality that uses a second energy type to identify the marker that is different than the first energy type.

摘要翻译： 综合放射治疗过程包括通过使用定位模式周期性地定位位于患者内的标记来获取与患者内的目标参数有关的第一目标目标数据。 该方法继续通过周期性地定位标记来获得与目标参数相关的第二目标目标数据。 第一目标数据可以在离开包含用于产生用于治疗患者的电离辐射束的辐射递送装置的第二区域的第一区域中获取。 第一和第二区域的定位方式可以相同。 在其他实施例中，可以使用使用第一能量类型来识别标记的第一定位模态来获取第一目标目标数据，并且可以使用第二定位模式来获得第二目标数据，第二定位模式使用第二能量类型来识别 不同于第一种能量类型的标记。

公开(公告)号：US08244330B2

公开(公告)日：2012-08-14

申请号：US11190195

申请日：2005-07-25

申请人： Eric Meier ,  Timothy P. Mate ,  J. Nelson Wright ,  Steven C. Dimmer ,  Lynn M. Purdy

发明人： Eric Meier ,  Timothy P. Mate ,  J. Nelson Wright ,  Steven C. Dimmer ,  Lynn M. Purdy

IPC分类号： A61B5/05

CPC分类号： A61N5/1039 ,  A61N5/1049 ,  A61N5/1067 ,  A61N5/107 ,  A61N2005/1051

摘要： An integrated radiation therapy process comprises acquiring first objective target data related to a parameter of a target within a patient by periodically locating a marker positioned within the patient using a localization modality. This method continues with obtaining second objective target data related to the parameter of the target by periodically locating the marker. The first objective target data can be acquired in a first area that is apart from a second area which contains a radiation delivery device for producing an ionizing radiation beam for treating the patient. The localization modality can be the same in both the first and second areas. In other embodiments, the first objective target data can be acquired using a first localization modality that uses a first energy type to identify the marker and the second objective target data can be obtained using a second localization modality that uses a second energy type to identify the marker that is different than the first energy type.

公开(公告)号：US20090209852A1

公开(公告)日：2009-08-20

申请号：US11817383

申请日：2006-03-02

申请人： Timothy P. Mate ,  Steven C. Dimmer ,  Laurence J. Newell ,  J. Nelson Wright

发明人： Timothy P. Mate ,  Steven C. Dimmer ,  Laurence J. Newell ,  J. Nelson Wright

IPC分类号： A61N5/00 ,  A61B19/00

CPC分类号： A61B90/16 ,  A61B34/20 ,  A61B34/25 ,  A61B90/14 ,  A61B90/39 ,  A61B2034/2051 ,  A61B2090/101 ,  A61B2090/363 ,  A61B2090/374 ,  A61B2090/3975 ,  A61B2090/3995

摘要： Systems and methods for locating and tracking a target, i.e., measuring the position and/or rotation of a target during setup and treatment of a patient in guided radiation therapy applications for the head and neck. One embodiment is directed toward a device having a body and markers, such as excitable transponders and/or radiographic fiducials, fixable in or on the body for localizing the body. For example, the body can be a mouthpiece body having a channel configured to receive a patient's teeth such that the mouthpiece is repeatedly and consistently placed in the same relative position in the patient when the patient bites down on the mouthpiece. The transponders can be alternating magnetic transponders and the fiducials can be gold seeds. Other embodiments include a device having a two-piece body, a first piece of the body having excitable transponders and a second piece of the body having radiographic fiducials.

摘要翻译： 用于定位和跟踪目标的系统和方法，即在用于头颈部的引导放射治疗应用中，在患者的建立和治疗期间测量目标的位置和/或旋转。 一个实施例涉及具有身体和标记的装置，例如可固定在身体中或身体上的可兴奋的应答器和/或射线照相基准体，用于使身体定位。 例如，身体可以是具有通道的接口管体，该通道被配置为接收患者的牙齿，使得当患者咬在嘴件上时，接口管被重复且一致地放置在患者的相同相对位置。 应答器可以是交替磁转发器，基准可以是金种子。 其他实施例包括具有两件式主体的装置，具有可兴奋的应答器的本体的第一部分和具有放射照相基准的本体的第二部分。

公开(公告)号：US20090216113A1

公开(公告)日：2009-08-27

申请号：US12159554

申请日：2006-11-17

申请人： Eric Meier ,  Steven C. Dimmer ,  J. Nelson Wright ,  Rich Edelson

发明人： Eric Meier ,  Steven C. Dimmer ,  J. Nelson Wright ,  Rich Edelson

IPC分类号： A61B5/05

CPC分类号： A61B17/32 ,  A61B5/0002 ,  A61B5/062 ,  A61B5/4504 ,  A61B5/686 ,  A61B17/15 ,  A61B17/155 ,  A61B17/157 ,  A61B17/17 ,  A61B17/1757 ,  A61B90/39 ,  A61B2017/320052 ,  A61B2090/3958 ,  A61B2090/3966 ,  A61B2090/3975 ,  A61B2090/3991 ,  A61F2/32 ,  A61F2/38 ,  A61F2/441 ,  A61F2002/3067 ,  A61F2250/0002 ,  G06F19/00

摘要： Electromagnetic transponders as markers are used to localize and guide orthopedic procedures including: knee replacement, hip replacement, shoulder replacement, damaged bone reconstruction, and spine surgery, and more particularly, to guide orthopedic surgical navigation and alignment techniques and instruments. For example, the marker could further be used in any number of guides or templates that attach to the bony anatomy, such as a surgical guide, cutting guide, cutting jig, resection block and/or resurfacing guide. Further, the marker could be incorporated into an existing intramedullary guide rod for a femur and an extramedullary guide rod for a tibia in a knee replacement surgery; or into an external surgical guide system, or the marker could eliminate the need for an external template altogether. According to yet another anticipated use of the tracking system, the marker could be used in conjunction with or replace an optical alignment system.

摘要翻译： 电磁转发器作为标记用于定位和引导矫形手术，包括：膝关节置换，髋关节置换，肩关节置换，骨重建受损和脊柱手术，更具体地，指导骨科手术导航和对准技术和手段。 例如，标记可以进一步用于附着于骨骼解剖结构的任何数量的引导件或模板中，例如手术引导件，切割引导件，切割夹具，切除块和/或表面置换引导件。 此外，标记可以结合到膝关节置换手术中用于股骨的现有髓内导杆和用于胫骨的髓外导杆; 或进入外部手术引导系统，或者标记可以完全消除对外部模板的需要。 根据跟踪系统的另一预期使用，标记可以与光学对准系统结合使用或替代光学对准系统。

公开(公告)号：US08239005B2

公开(公告)日：2012-08-07

申请号：US12684639

申请日：2010-01-08

申请人： J. Nelson Wright ,  Steven C. Dimmer

发明人： J. Nelson Wright ,  Steven C. Dimmer

IPC分类号： A61B5/05

CPC分类号： A61B5/06 ,  A61B5/055 ,  A61B6/12 ,  A61B8/0833 ,  A61B34/20 ,  A61B34/25 ,  A61B90/36 ,  A61B90/39 ,  A61B2034/2051 ,  A61B2034/252 ,  A61B2090/3908 ,  A61B2090/3954 ,  A61B2090/3958 ,  A61B2090/3995 ,  A61N5/1049 ,  A61N5/1067 ,  A61N5/107 ,  A61N2005/1051

摘要： Systems and methods for tracking targets in real time for radiation therapy and other applications. In one embodiment, a method includes collecting position information of a marker implanted within a patient at a site relative to the target at a time tn, and providing an objective output indicative of the location of the target based on the position information collected at time tn. The objective output is provided to a memory device, user interface, and/or radiation delivery machine within 1 ms to 2 seconds of the time tn when the position information was collected. This embodiment of the method can further include providing the objective output at a periodicity of 10-200 ms during at least a portion of a treatment procedure. For example, the method can further include generating a beam of ionizing radiation and directing the beam to a machine isocenter, and continuously repeating the collecting procedure and the providing procedure every 10-200 ms while irradiating the patient with the ionizing radiation beam.

摘要翻译： 用于实时跟踪靶向放射治疗和其他应用的系统和方法。 在一个实施例中，一种方法包括在时刻tn收集在相对于目标的位置处植入在患者体内的标记的位置信息，并且基于在时间tn收集的位置信息提供指示目标位置的客观输出 。 当收集位置信息时，在时间tn的1秒至2秒内，将目标输出提供给存储装置，用户界面和/或辐射递送机。 该方法的该实施例还可以包括在至少一部分治疗过程期间以10-200ms的周期提供目标输出。 例如，该方法可以进一步包括产生电离辐射束并将光束引导到机器等角点，并且在每隔10-200毫秒同时持续地重复采集过程和提供过程，同时用电离辐射束照射患者。