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    Metering technique for lateral flow assay devices
    2.
    发明授权
    Metering technique for lateral flow assay devices 有权
    侧流测定装置的计量技术

    公开(公告)号：US07790471B2

    公开(公告)日：2010-09-07

    申请号：US11867788

    申请日：2007-10-05

    申请人： James M. Takeuchi ,  Xuedong Song ,  Kaiyuan Yang ,  Ning Wei ,  Shawn R. Feaster

    发明人： James M. Takeuchi ,  Xuedong Song ,  Kaiyuan Yang ,  Ning Wei ,  Shawn R. Feaster

    IPC分类号： G01N21/00 ,  G01N15/06 ,  G01N33/53 ,  G01N31/00 ,  G01N33/566 ,  G01N33/543 ,  B01L3/00 ,  B01L3/02 ,  C12Q1/00 ,  C12M1/34 ,  C12M1/36 ,  C12M3/00

    CPC分类号： G01N33/558 ,  Y10S436/825 ,  Y10T436/107497 ,  Y10T436/108331 ,  Y10T436/25375 ,  Y10T436/25625

    摘要： A diagnostic method and associated test kit for detecting an analyte residing in a test sample is provided. A sample membrane is utilized having a collection region and a detection region, the collection region having a known saturation volume for the intended test sample. A barrier is defined between the collection region and the detection region. The collection region is saturated with the test sample having a volume of less than about 100 microliters so that a known volume of the test sample is contained in the collection region. The barrier is removed from between the collection region and detection region of the membrane and a diluent is supplied to the collection region of the membrane to facilitate flow of the test sample from the collection region to the detection region of the membrane.

    摘要翻译： 提供了用于检测驻留在测试样品中的分析物的诊断方法和相关测试试剂盒。 使用具有收集区域和检测区域的样品膜，所述收集区域具有用于预期测试样品的已知饱和体积。 在收集区域和检测区域之间限定屏障。 收集区域用体积小于约100微升的测试样品饱和，使得已知体积的测试样品被包含在收集区域中。 从收集区域和膜的检测区域之间移除屏障，并且将稀释剂供应到膜的收集区域，以促进测试样品从收集区域流到膜的检测区域。

    LATERAL-FLOW POROUS MEMBRANE ASSAY WITH FLOW RATE CONTROL
    3.
    发明申请
    LATERAL-FLOW POROUS MEMBRANE ASSAY WITH FLOW RATE CONTROL 审中-公开
    具有流量控制的侧向流动多孔膜测定

    公开(公告)号：US20100159599A1

    公开(公告)日：2010-06-24

    申请号：US12338636

    申请日：2008-12-18

    申请人： Xuedong Song ,  Shawn R. Feaster ,  James M. Takeuchi ,  Kaiyuan Yang

    发明人： Xuedong Song ,  Shawn R. Feaster ,  James M. Takeuchi ,  Kaiyuan Yang

    IPC分类号： G01N33/18 ,  G01N33/48 ,  A61F13/534 ,  G01N33/53

    CPC分类号： A61F13/42 ,  G01N33/54386 ,  G01N33/558 ,  Y10T428/18

    摘要： Various modifications to a porous substrate, such as employed in lateral flow assay devices, to regulate or modify the flow rate and/or flow path pattern of a fluid through the porous substrate is described. The lateral flow assay device has a porous substrate matrix in fluid communication with a flow-rate control zone having a number of flow-rate control devices arranged as features in or on a substrate surface or laminates thereof in a body. The flow-rate control devices may include: a density gradient, porosity gradient, ion affinity gradient, micro-channels, and combinations thereof.

    摘要翻译： 描述了多孔基底的各种修改，例如用于横向流动测定装置，以调节或改变通过多孔基底的流体的流速和/或流动路径图案。 侧流测定装置具有与流量控制区流体连通的多孔基质基质，该流速控制区具有多个流速控制装置，该流量控制装置作为特征置于基体表面中或基体表面上或层叠体上。 流量控制装置可以包括：密度梯度，孔隙度梯度，离子亲和梯度，微通道及其组合。

    Meter strip and method for lateral flow assay devices
    6.
    发明授权
    Meter strip and method for lateral flow assay devices 有权
    用于侧流测定装置的仪表条和方法

    公开(公告)号：US07838258B2

    公开(公告)日：2010-11-23

    申请号：US12570713

    申请日：2009-09-30

    申请人： Kaiyuan Yang ,  Shawn R. Feaster ,  Ning Wei ,  Rosann M. Kaylor ,  Chibueze O. Chidebelu-Eze

    发明人： Kaiyuan Yang ,  Shawn R. Feaster ,  Ning Wei ,  Rosann M. Kaylor ,  Chibueze O. Chidebelu-Eze

    IPC分类号： G01N33/53 ,  G01N33/543

    CPC分类号： G01N33/54366 ,  B01L3/5023 ,  B01L2200/027 ,  B01L2300/0681 ,  B01L2300/0825 ,  B01L2300/0867 ,  B01L2400/0406 ,  B01L2400/0683 ,  G01N33/558 ,  Y10S436/825 ,  Y10T436/107497 ,  Y10T436/108331

    摘要： A diagnostic method and associated test kit for detecting an analyte residing in a test sample is provided. The kit includes a housing, and a membrane disposed within the housing having a detection region and a collection region. A blood sample meter is provided having a first end for absorption of a blood sample, a filtering section adjacent to the first end that filters red blood cell components from the blood sample, and a storage section adjacent to the filtering section that receives plasma or serum from the filtering section. An opening in the housing is sized for insertion of the sample meter into the housing such that the storage section of the sample meter is disposed in fluid communication with the collection region of the membrane. The plasma or serum is transferred from the storage section of the sample meter to the collection region of the membrane for subsequent migration to the detection region.

    摘要翻译： 提供了用于检测驻留在测试样品中的分析物的诊断方法和相关测试试剂盒。 套件包括壳体和设置在壳体内的膜，其具有检测区域和收集区域。 提供血样计，其具有用于吸收血液样本的第一端，与第一端相邻的过滤部分，其从血液样品中过滤红细胞成分，以及与过滤部相邻的存储部，其接收血浆或血清 从过滤部分。 壳体中的开口的尺寸适于将样品计量器插入壳体中，使得样品计量器的存储部分设置成与膜的收集区域流体连通。 将血浆或血清从样品计量器的储存部分转移到膜的收集区域，以便随后迁移到检测区域。

    Meter Strip and Method for Lateral Flow Assay Devices
    7.
    发明申请
    Meter Strip and Method for Lateral Flow Assay Devices 有权
    流量测定装置的流量计和方法

    公开(公告)号：US20100015658A1

    公开(公告)日：2010-01-21

    申请号：US12570713

    申请日：2009-09-30

    申请人： Kaiyuan Yang ,  Shawn R. Feaster ,  Ning Wei ,  Rosann M. Kaylor ,  Chibueze O. Chidebelu-Eze

    发明人： Kaiyuan Yang ,  Shawn R. Feaster ,  Ning Wei ,  Rosann M. Kaylor ,  Chibueze O. Chidebelu-Eze

    IPC分类号： C12Q1/02

    CPC分类号： G01N33/54366 ,  B01L3/5023 ,  B01L2200/027 ,  B01L2300/0681 ,  B01L2300/0825 ,  B01L2300/0867 ,  B01L2400/0406 ,  B01L2400/0683 ,  G01N33/558 ,  Y10S436/825 ,  Y10T436/107497 ,  Y10T436/108331

    摘要： A diagnostic method and associated test kit for detecting an analyte residing in a test sample is provided. The kit includes a housing, and a membrane disposed within the housing having a detection region and a collection region. A blood sample meter is provided having a first end for absorption of a blood sample, a filtering section adjacent to the first end that filters red blood cell components from the blood sample, and a storage section adjacent to the filtering section that receives plasma or serum from the filtering section. An opening in the housing is sized for insertion of the sample meter into the housing such that the storage section of the sample meter is disposed in fluid communication with the collection region of the membrane. The plasma or serum is transferred from the storage section of the sample meter to the collection region of the membrane for subsequent migration to the detection region.

    摘要翻译： 提供了用于检测驻留在测试样品中的分析物的诊断方法和相关测试试剂盒。 套件包括壳体和设置在壳体内的膜，其具有检测区域和收集区域。 提供血样计，其具有用于吸收血液样本的第一端，与第一端相邻的过滤部分，其从血液样品中过滤红细胞成分，以及与过滤部相邻的存储部，其接收血浆或血清 从过滤部分。 壳体中的开口的尺寸适于将样品计量器插入壳体中，使得样品计量器的存储部分设置成与膜的收集区域流体连通。 将血浆或血清从样品计量器的储存部分转移到膜的收集区域，以便随后迁移到检测区域。

    Metering Technique for Lateral Flow Assay Devices
    9.
    发明申请
    Metering Technique for Lateral Flow Assay Devices 有权
    侧流测试装置的计量技术

    公开(公告)号：US20080026484A1

    公开(公告)日：2008-01-31

    申请号：US11867788

    申请日：2007-10-05

    申请人： James Takeuchi ,  Xuedong Song ,  Kaiyuan Yang ,  Ning Wei ,  Shawn Feaster

    发明人： James Takeuchi ,  Xuedong Song ,  Kaiyuan Yang ,  Ning Wei ,  Shawn Feaster

    IPC分类号： G01N1/28 ,  G01N1/38

    CPC分类号： G01N33/558 ,  Y10S436/825 ,  Y10T436/107497 ,  Y10T436/108331 ,  Y10T436/25375 ,  Y10T436/25625

    摘要： A diagnostic method and associated test kit for detecting an analyte residing in a test sample is provided. A sample membrane is utilized having a collection region and a detection region, the collection region having a known saturation volume for the intended test sample. A barrier is defined between the collection region and the detection region. The collection region is saturated with the test sample having a volume of less than about 100 microliters so that a known volume of the test sample is contained in the collection region. The barrier is removed from between the collection region and detection region of the membrane and a diluent is supplied to the collection region of the membrane to facilitate flow of the test sample from the collection region to the detection region of the membrane.

    摘要翻译： 提供了用于检测驻留在测试样品中的分析物的诊断方法和相关测试试剂盒。 使用具有收集区域和检测区域的样品膜，所述收集区域具有用于预期测试样品的已知饱和体积。 在收集区域和检测区域之间限定屏障。 收集区域用体积小于约100微升的测试样品饱和，使得已知体积的测试样品被包含在收集区域中。 从收集区域和膜的检测区域之间移除屏障，并且将稀释剂供应到膜的收集区域，以促进测试样品从收集区域流到膜的检测区域。

    Metering technique for lateral flow assay devices
    10.
    发明申请
    Metering technique for lateral flow assay devices 有权
    侧流测定装置的计量技术

    公开(公告)号：US20070134811A1

    公开(公告)日：2007-06-14

    申请号：US11301631

    申请日：2005-12-13

    申请人： James Takeuchi ,  Xuedong Song ,  Kaiyuan Yang ,  Ning Wei ,  Shawn Feaster

    发明人： James Takeuchi ,  Xuedong Song ,  Kaiyuan Yang ,  Ning Wei ,  Shawn Feaster

    IPC分类号： G01N33/558

    CPC分类号： G01N33/558 ,  Y10S436/825 ,  Y10T436/107497 ,  Y10T436/108331 ,  Y10T436/25375 ,  Y10T436/25625

    摘要： A diagnostic method and associated test kit for detecting an analyte residing in a test sample is provided. A sample membrane is utilized having a collection region and a detection region, the collection region having a known saturation volume for the intended test sample. A barrier is defined between the collection region and the detection region. The collection region is saturated with the test sample having a volume of less than about 100 microliters so that a known volume of the test sample is contained in the collection region. The barrier is removed from between the collection region and detection region of the membrane and a diluent is supplied to the collection region of the membrane to facilitate flow of the test sample from the collection region to the detection region of the membrane.

    摘要翻译： 提供了用于检测驻留在测试样品中的分析物的诊断方法和相关测试试剂盒。 使用具有收集区域和检测区域的样品膜，所述收集区域具有用于预期测试样品的已知饱和体积。 在收集区域和检测区域之间限定屏障。 收集区域用体积小于约100微升的测试样品饱和，使得已知体积的测试样品被包含在收集区域中。 从收集区域和膜的检测区域之间移除屏障，并且将稀释剂供应到膜的收集区域，以促进测试样品从收集区域流到膜的检测区域。