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    Metering technique for lateral flow assay devices
    4.
    发明授权
    Metering technique for lateral flow assay devices 有权
    侧流测定装置的计量技术

    公开(公告)号：US07790471B2

    公开(公告)日：2010-09-07

    申请号：US11867788

    申请日：2007-10-05

    申请人： James M. Takeuchi ,  Xuedong Song ,  Kaiyuan Yang ,  Ning Wei ,  Shawn R. Feaster

    发明人： James M. Takeuchi ,  Xuedong Song ,  Kaiyuan Yang ,  Ning Wei ,  Shawn R. Feaster

    IPC分类号： G01N21/00 ,  G01N15/06 ,  G01N33/53 ,  G01N31/00 ,  G01N33/566 ,  G01N33/543 ,  B01L3/00 ,  B01L3/02 ,  C12Q1/00 ,  C12M1/34 ,  C12M1/36 ,  C12M3/00

    CPC分类号： G01N33/558 ,  Y10S436/825 ,  Y10T436/107497 ,  Y10T436/108331 ,  Y10T436/25375 ,  Y10T436/25625

    摘要： A diagnostic method and associated test kit for detecting an analyte residing in a test sample is provided. A sample membrane is utilized having a collection region and a detection region, the collection region having a known saturation volume for the intended test sample. A barrier is defined between the collection region and the detection region. The collection region is saturated with the test sample having a volume of less than about 100 microliters so that a known volume of the test sample is contained in the collection region. The barrier is removed from between the collection region and detection region of the membrane and a diluent is supplied to the collection region of the membrane to facilitate flow of the test sample from the collection region to the detection region of the membrane.

    摘要翻译： 提供了用于检测驻留在测试样品中的分析物的诊断方法和相关测试试剂盒。 使用具有收集区域和检测区域的样品膜，所述收集区域具有用于预期测试样品的已知饱和体积。 在收集区域和检测区域之间限定屏障。 收集区域用体积小于约100微升的测试样品饱和，使得已知体积的测试样品被包含在收集区域中。 从收集区域和膜的检测区域之间移除屏障，并且将稀释剂供应到膜的收集区域，以促进测试样品从收集区域流到膜的检测区域。

    LATERAL-FLOW POROUS MEMBRANE ASSAY WITH FLOW RATE CONTROL
    5.
    发明申请
    LATERAL-FLOW POROUS MEMBRANE ASSAY WITH FLOW RATE CONTROL 审中-公开
    具有流量控制的侧向流动多孔膜测定

    公开(公告)号：US20100159599A1

    公开(公告)日：2010-06-24

    申请号：US12338636

    申请日：2008-12-18

    申请人： Xuedong Song ,  Shawn R. Feaster ,  James M. Takeuchi ,  Kaiyuan Yang

    发明人： Xuedong Song ,  Shawn R. Feaster ,  James M. Takeuchi ,  Kaiyuan Yang

    IPC分类号： G01N33/18 ,  G01N33/48 ,  A61F13/534 ,  G01N33/53

    CPC分类号： A61F13/42 ,  G01N33/54386 ,  G01N33/558 ,  Y10T428/18

    摘要： Various modifications to a porous substrate, such as employed in lateral flow assay devices, to regulate or modify the flow rate and/or flow path pattern of a fluid through the porous substrate is described. The lateral flow assay device has a porous substrate matrix in fluid communication with a flow-rate control zone having a number of flow-rate control devices arranged as features in or on a substrate surface or laminates thereof in a body. The flow-rate control devices may include: a density gradient, porosity gradient, ion affinity gradient, micro-channels, and combinations thereof.

    摘要翻译： 描述了多孔基底的各种修改，例如用于横向流动测定装置，以调节或改变通过多孔基底的流体的流速和/或流动路径图案。 侧流测定装置具有与流量控制区流体连通的多孔基质基质，该流速控制区具有多个流速控制装置，该流量控制装置作为特征置于基体表面中或基体表面上或层叠体上。 流量控制装置可以包括：密度梯度，孔隙度梯度，离子亲和梯度，微通道及其组合。

    QUALITY-CONTROL AND ALIGNMENT ELEMENT FOR ASSAY SUBSTRATES
    6.
    发明申请
    QUALITY-CONTROL AND ALIGNMENT ELEMENT FOR ASSAY SUBSTRATES 审中-公开
    质量控制和对准基准元件

    公开(公告)号：US20100204056A1

    公开(公告)日：2010-08-12

    申请号：US12641990

    申请日：2009-12-18

    申请人： James M. Takeuchi ,  Shawn R. Feaster

    发明人： James M. Takeuchi ,  Shawn R. Feaster

    IPC分类号： C40B30/04 ,  C40B50/14 ,  C40B40/10 ,  C40B40/12

    CPC分类号： G01N33/543 ,  B01J2219/00378 ,  B01J2219/00608 ,  B01J2219/00693

    摘要： A method for fabricating and assessing the quality of printing on substrates used for chemical or biological array testing, and method for ascertaining relative consistency of the deposit reproducibility is described. Generally, the method involves: providing a substrate, providing a solution mixture of a capture moiety and a colorant; depositing an amount of said solution mixture onto said substrate, monitoring the substrate such that the visible indicator colorant manifests in a co-extensive fashion as with the capture moiety on the substrate. In another aspect, the invention relates to a sensor or assay device comprising a physical complex of a number of capture agents and an amount of colorants adhere to least a part of a surface of a substrate.

    摘要翻译： 描述了用于制造和评估用于化学或生物阵列测试的衬底上的印刷质量的方法，以及用于确定沉积重现性的相对一致性的方法。 通常，该方法包括：提供底物，提供捕获部分和着色剂的溶液混合物; 将一定量的所述溶液混合物沉积到所述基底上，监测所述基底，使得所述可见指示剂着色剂以与所述基底上的捕获部分相同的方式显示。 在另一方面，本发明涉及包含许多捕获剂的物理复合物和一定数量的着色剂粘附至基底表面的至少一部分的传感器或测定装置。

    HYDRATION/DEHYDRATION SENSOR
    8.
    发明申请
    HYDRATION/DEHYDRATION SENSOR 审中-公开
    水力/脱水传感器

    公开(公告)号：US20100159611A1

    公开(公告)日：2010-06-24

    申请号：US12338673

    申请日：2008-12-18

    申请人： Xuedong Song ,  James M. Takeuchi

    发明人： Xuedong Song ,  James M. Takeuchi

    IPC分类号： G01N33/84 ,  G01N31/22

    CPC分类号： G01N33/84 ,  A61B10/007 ,  B01L3/5023 ,  B01L3/502746 ,  B01L2300/0825 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2300/0887 ,  G01N31/22 ,  G01N33/558

    摘要： A fluidic assay device or test format that can regulate or control the sample flow rate and modulate the manifestation of test results to reduce or eliminate errors is described. The assay device has a substrate with a flow-rate control zone that regulates the amount of time needed for development and appearance of a visual signal in the observation-feedback zone until the color transition in the detection zone reaches color stability. The present invention also describes absorbent articles incorporating such an assay device and methods of monitoring dehydration or testing ion strength of a urine sample using such a test format.

    摘要翻译： 描述了可以调节或控制样品流速并调节测试结果的表现以减少或消除误差的流体测定装置或测试格式。 测定装置具有流动速率控制区的基板，其调节观察反馈区域中的显影所需的时间量和视觉信号的出现直到检测区域中的颜色转变达到颜色稳定性。 本发明还描述了结合这种测定装置的吸收制品以及使用这种测试形式监测尿样的脱水或测试离子强度的方法。

    Three-dimensional vertical hydration/dehydration sensor
    9.
    发明申请
    Three-dimensional vertical hydration/dehydration sensor 审中-公开
    三维垂直水化/脱水传感器

    公开(公告)号：US20100145294A1

    公开(公告)日：2010-06-10

    申请号：US12315693

    申请日：2008-12-05

    申请人： Xuedong Song ,  James M. Takeuchi

    发明人： Xuedong Song ,  James M. Takeuchi

    IPC分类号： G01N33/50 ,  A61F13/42 ,  G01N33/53

    CPC分类号： G01N33/558 ,  A61F13/42 ,  B01L3/5023 ,  B01L3/502746 ,  B01L2300/0874 ,  B01L2300/165 ,  B01L2400/0406 ,  G01N31/22

    摘要： A three-dimensional fluidic assay device or sensor is described. The sensor has a porous substrate with a first face or plane defined along x-y coordinate axes, and a second face remote in a z-direction from the first face. The first face contains a sample deposition zone and the second face has at least one detection zone, such that when a fluid sample is deposited in the sample deposition zone, fluid is transported by means of capillary action along the z-direction to the detection zone and manifests a signal development. An absorbent article, such as a diaper or feminine hygiene product, having such a three-dimensional sensor integrated across the thickness of the absorbent article, from an inner layer to an outer layer, is also described.

    摘要翻译： 描述了三维流体测定装置或传感器。 传感器具有多孔基底，其具有沿x-y坐标轴限定的第一面或平面，以及从第一面向z方向远离的第二面。 第一面包含样品沉积区，并且第二面具有至少一个检测区，使得当流体样品沉积在样品沉积区中时，流体通过毛细管作用沿着z方向传送到检测区 并表现出信号发展。 还描述了一种诸如尿布或女性卫生产品的吸收制品，其具有从内层到外层跨过吸收性物品的厚度集成的这种三维传感器。