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公开(公告)号:US09839685B2
公开(公告)日:2017-12-12
申请号:US11786855
申请日:2007-04-13
申请人: James R. Baker, Jr. , Anna Bielinska , Andrzej Myc
发明人: James R. Baker, Jr. , Anna Bielinska , Andrzej Myc
CPC分类号: A61K39/21 , A61K31/00 , A61K39/12 , A61K39/39 , A61K2039/541 , A61K2039/543 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , A61K2039/55572 , C07K14/005 , C12N2740/16122 , C12N2740/16134
摘要: The present invention relates to methods and compositions for the stimulation of immune responses. Specifically, the present invention provides methods of inducing an immune response to human immunodeficiency virus (HIV) in a subject (e.g., a human subject) and compositions useful in such methods (e.g., a nanoemulsion comprising HIV or antigenic portion thereof).
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公开(公告)号:US10138279B2
公开(公告)日:2018-11-27
申请号:US11786861
申请日:2007-04-13
申请人: James R. Baker, Jr. , Anna Bielinska , Andrzej Myc
发明人: James R. Baker, Jr. , Anna Bielinska , Andrzej Myc
摘要: The present invention relates to methods and compositions for stimulating an immune response. Specifically, the present invention provides methods of inducing an immune response to bacteria of the genus Bacillus (e.g., Bacillus anthracis) in a subject (e.g., a human subject) and compositions useful in such methods (e.g., a nanoemulsion comprising Bacillus anthracis or an immunogenic portion thereof). Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination) and research applications.
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公开(公告)号:US20150266933A1
公开(公告)日:2015-09-24
申请号:US11786861
申请日:2007-04-13
申请人: James R. Baker, JR. , Anna Bielinska , Andrzej Myc
发明人: James R. Baker, JR. , Anna Bielinska , Andrzej Myc
IPC分类号: C07K14/32
CPC分类号: C07K14/32 , A61K39/07 , A61K2039/543 , A61K2039/55561 , A61K2039/55566 , A61K2039/55572 , A61K2039/57 , A61K2039/575
摘要: The present invention relates to methods and compositions for stimulating an immune response. Specifically, the present invention provides methods of inducing an immune response to bacteria of the genus Bacillus (e.g., Bacillus anthracis) in a subject (e.g., a human subject) and compositions useful in such methods (e.g., a nanoemulsion comprising Bacillus anthracis or an immunogenic portion thereof). Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination) and research applications.
摘要翻译: 本发明涉及用于刺激免疫应答的方法和组合物。 具体地,本发明提供了在受试者(例如,人类受试者)中诱导针对芽孢杆菌属(例如,炭疽杆菌)的细菌的免疫应答的方法和可用于这些方法的组合物(例如,包含炭疽芽孢杆菌或 其免疫原性部分)。 本发明的组合物和方法尤其可用于临床(例如治疗和预防性药物(例如,疫苗接种)和研究应用)。
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公开(公告)号:US20090068225A1
公开(公告)日:2009-03-12
申请号:US12191688
申请日:2008-08-14
申请人: James R. Baker, JR. , Anna Bielinska , Andrzej Myc
发明人: James R. Baker, JR. , Anna Bielinska , Andrzej Myc
IPC分类号: A61K39/275 , A61P37/04
CPC分类号: A61K39/285 , A61K39/12 , A61K2039/5252 , A61K2039/55566 , C12N2710/24134
摘要: The present invention relates to methods and compositions for stimulating an immune response. Specifically, the present invention provides methods of inducing an immune response to an orthopox virus (e.g., vaccinia virus) in a subject (e.g., a human subject) and compositions useful in such methods (e.g., a nanoemulsion comprising vaccinia virus). Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination) and research applications.
摘要翻译: 本发明涉及用于刺激免疫应答的方法和组合物。 具体而言,本发明提供了在受试者(例如,人类受试者)中诱导针对正痘病毒(例如痘苗病毒)的免疫应答的方法和用于此类方法(例如,包含痘苗病毒的纳米乳剂)的组合物。 本发明的组合物和方法尤其可用于临床(例如治疗和预防性药物(例如,疫苗接种)和研究应用)。
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5.
公开(公告)号:US20080026988A1
公开(公告)日:2008-01-31
申请号:US11786855
申请日:2007-04-13
申请人: James Baker , Anna Bielinska , Andrzej Myc
发明人: James Baker , Anna Bielinska , Andrzej Myc
CPC分类号: A61K39/21 , A61K31/00 , A61K39/12 , A61K39/39 , A61K2039/541 , A61K2039/543 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , A61K2039/55572 , C07K14/005 , C12N2740/16122 , C12N2740/16134
摘要: The present invention relates to methods and compositions for the stimulation of immune responses. Specifically, the present invention provides methods of inducing an immune response to human immunodeficiency virus (HIV) in a subject (e.g., a human subject) and compositions useful in such methods (e.g., a nanoemulsion comprising HIV or antigenic portion thereof).
摘要翻译: 本发明涉及用于刺激免疫应答的方法和组合物。 具体地,本发明提供了在受试者(例如人类受试者)中诱导对人类免疫缺陷病毒(HIV)的免疫应答的方法和用于这些方法(例如,包含HIV或其抗原部分的纳米乳剂)的组合物。
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公开(公告)号:US20060257426A1
公开(公告)日:2006-11-16
申请号:US11403316
申请日:2006-04-13
申请人: James Baker , Anna Bielinska , Andrzej Myc
发明人: James Baker , Anna Bielinska , Andrzej Myc
IPC分类号: A61K39/12 , A61K39/21 , A61K39/275 , A61K39/07
CPC分类号: A61K39/39 , A01N25/04 , A61K9/0043 , A61K9/1075 , A61K39/07 , A61K2039/521 , A61K2039/55566 , C12N2760/16134 , Y02A50/394 , Y02A50/403 , Y02A50/469 , Y02A50/489
摘要: The present invention provides methods and compositions for the stimulation of immune responses. Specifically, the present invention provides methods and compositions for the use of nanoemulsion compounds as mucosal adjuvants to induce immunity against environmental pathogens. Accordingly, in some embodiments, the present invention provides nanoemulsion vaccines comprising a nanoemulsion and an inactivated pathogen or protein derived from the pathogen. The present invention thus provides improved vaccines against a variety of environmental and human-released pathogens.
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公开(公告)号:US20120141526A1
公开(公告)日:2012-06-07
申请号:US11929275
申请日:2007-10-30
申请人: James R. Baker , Anna Bielinska , Andrzej Myc
发明人: James R. Baker , Anna Bielinska , Andrzej Myc
IPC分类号: A61K39/21 , A61K39/12 , A61K39/02 , A61K39/07 , A61K39/145 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/16 , A61P31/18 , A61K39/00 , A61P37/04 , B82Y5/00
CPC分类号: A61K39/39 , A01N25/04 , A61K9/0043 , A61K9/1075 , A61K39/07 , A61K2039/521 , A61K2039/55566 , C12N2760/16134 , Y02A50/394 , Y02A50/403 , Y02A50/469 , Y02A50/489
摘要: The present invention provides methods and compositions for the stimulation of immune responses. Specifically, the present invention provides methods and compositions for the use of nanoemulsion compounds as mucosal adjuvants to induce immunity against environmental pathogens. Accordingly, in some embodiments, the present invention provides nanoemulsion vaccines comprising a nanoemulsion and an inactivated pathogen or protein derived from the pathogen. The present invention thus provides improved vaccines against a variety of environmental and human-released pathogens.
摘要翻译: 本发明提供了用于刺激免疫应答的方法和组合物。 具体地,本发明提供了使用纳米乳液化合物作为粘膜佐剂以诱导对环境病原体免疫的方法和组合物。 因此,在一些实施方案中,本发明提供了包含纳米乳剂和衍生自病原体的灭活病原体或蛋白质的纳米乳剂疫苗。 因此,本发明提供了针对各种环境和人释放的病原体的改进的疫苗。
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公开(公告)号:US20080181949A1
公开(公告)日:2008-07-31
申请号:US11929295
申请日:2007-10-30
申请人: James R. Baker , Anna Bielinska , Andrzej Myc
发明人: James R. Baker , Anna Bielinska , Andrzej Myc
CPC分类号: A61K39/39 , A01N25/04 , A61K9/0043 , A61K9/1075 , A61K39/07 , A61K2039/521 , A61K2039/55566 , C12N2760/16134 , Y02A50/394 , Y02A50/403 , Y02A50/469 , Y02A50/489
摘要: The present invention provides methods and compositions for the stimulation of immune responses. Specifically, the present invention provides methods and compositions for the use of nanoemulsion compounds as mucosal adjuvants to induce immunity against environmental pathogens. Accordingly, in some embodiments, the present invention provides nanoemulsion vaccines comprising a nanoemulsion and an inactivated pathogen or protein derived from the pathogen. The present invention thus provides improved vaccines against a variety of environmental and human-released pathogens.
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公开(公告)号:US20080038295A1
公开(公告)日:2008-02-14
申请号:US11786860
申请日:2007-04-13
申请人: James Baker , Anna Bielinska , Andrzej Myc
发明人: James Baker , Anna Bielinska , Andrzej Myc
IPC分类号: A61K39/275 , A61P31/00
CPC分类号: A61K39/285 , A61K39/12 , A61K2039/5252 , A61K2039/55566 , C12N2710/24134
摘要: The present invention relates to methods and compositions for stimulating an immune response. Specifically, the present invention provides methods of inducing an immune response to an orthopox virus (e.g., vaccinia virus) in a subject (e.g., a human subject) and compositions useful in such methods (e.g., a nanoemulsion comprising vaccinia virus). Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination) and research applications.
摘要翻译: 本发明涉及用于刺激免疫应答的方法和组合物。 具体而言,本发明提供了在受试者(例如,人类受试者)中诱导针对正痘病毒(例如痘苗病毒)的免疫应答的方法和用于此类方法(例如,包含痘苗病毒的纳米乳剂)的组合物。 本发明的组合物和方法尤其可用于临床(例如治疗和预防性药物(例如,疫苗接种)和研究应用)。
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