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公开(公告)号：US08980876B2
公开(公告)日：2015-03-17
申请号：US13283894
申请日：2011-10-28
IPC分类号： A01N55/02 , C07D213/89
CPC分类号： A01N37/02 , A01N37/10 , A01N37/18 , A01N37/36 , A01N43/40 , A01N43/54 , A01N59/00 , A61K8/27 , A61K8/44 , A61K8/4926 , A61K8/4933 , A61K31/555 , A61K33/30 , A61K38/482 , A61Q5/006 , C12N9/88 , C12Q1/18 , C12Q1/527 , C12Y304/21053 , C12Y402/01003 , A01N59/16
摘要： The present invention is directed to a method of inhibiting aconitase activity of fungal cells in an individual, the method comprising administering an inhibitor of aconitase activity to the fungal cell in an amount effective to inhibit activity of aconitase by said fungal cells.
摘要翻译： 本发明涉及一种抑制个体中真菌细胞的乌头酸酶活性的方法，所述方法包括以有效抑制所述真菌细胞的乌头酸酶活性的量向真菌细胞施用乌头酸酶活性抑制剂。
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2.发明申请公开(公告)号：US20130109664A1
公开(公告)日：2013-05-02
申请号：US13283890
申请日：2011-10-28
申请人： James Robert SCHWARTZ , Charles Winston Saunders , Robert Scott Youngquist , Casey Patrick Kelly , Jeffrey Kenneth Domsic , Robie Lynn Lucas , Jun Xu
发明人： James Robert SCHWARTZ , Charles Winston Saunders , Robert Scott Youngquist , Casey Patrick Kelly , Jeffrey Kenneth Domsic , Robie Lynn Lucas , Jun Xu
IPC分类号： A61K31/555 , A61P17/00
CPC分类号： A61K31/555
摘要： The present invention is directed to a personal care composition comprising an effective amount of a pyrithione or a polyvalent metal salt of a pyrithione; an effective amount of an iron chelator or a material which chelates iron; wherein the combination of the iron chelator and the pyrithione or a polyvalent metal salt of a pyrithione has a fractional inhibitor concentration of less than or equal to 1.
摘要翻译： 本发明涉及一种个人护理组合物，其包含有效量的吡啶硫酮或吡啶硫酮的多价金属盐; 有效量的铁螯合剂或螯合铁的材料; 其中所述铁螯合剂和所述吡啶硫酮或吡啶硫酮的多价金属盐的组合具有小于或等于1的分数抑制剂浓度。
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公开(公告)号：US20130108610A1
公开(公告)日：2013-05-02
申请号：US13283894
申请日：2011-10-28
IPC分类号： A61K38/48 , A61K33/00 , A61K33/40 , A61K31/513 , C12Q1/18 , A01N37/02 , A01N59/00 , A01N37/08 , A01N37/10 , A01N43/54 , A01N37/18 , C07C55/32 , C07C61/06 , C07C63/307 , C12N9/64 , C07D239/60 , A61P31/10 , A01P3/00 , A61P17/00 , C01B21/20 , C01B21/24 , C01B15/01 , C01B15/04 , A61K31/194
CPC分类号： A01N37/02 , A01N37/10 , A01N37/18 , A01N37/36 , A01N43/40 , A01N43/54 , A01N59/00 , A61K8/27 , A61K8/44 , A61K8/4926 , A61K8/4933 , A61K31/555 , A61K33/30 , A61K38/482 , A61Q5/006 , C12N9/88 , C12Q1/18 , C12Q1/527 , C12Y304/21053 , C12Y402/01003 , A01N59/16
摘要： The present invention is directed to a method of inhibiting aconitase activity of fungal cells in an individual, the method comprising administering an inhibitor of aconitase activity to the fungal cell in an amount effective to inhibit activity of aconitase by said fungal cells.
摘要翻译： 本发明涉及一种抑制个体中真菌细胞的乌头酸酶活性的方法，所述方法包括以有效抑制所述真菌细胞的乌头酸酶活性的量向真菌细胞施用乌头酸酶活性抑制剂。
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公开(公告)号：US10072293B2
公开(公告)日：2018-09-11
申请号：US13437072
申请日：2012-04-02
申请人： Kevin John Mills , Robert Lloyd Binder , Robert Scott Youngquist , Jun Xu , Ping Hu , Makio Tamura
发明人： Kevin John Mills , Robert Lloyd Binder , Robert Scott Youngquist , Jun Xu , Ping Hu , Makio Tamura
IPC分类号： G01N33/48 , C12Q1/6883
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/148 , C12Q2600/158
摘要： Methods and systems for determining functional relationships between a skin-active agent and a skin condition of interest, and methods and systems for identifying cosmetic agents effective for treatment of dandruff, as well as the use of agents identified by such methods and systems for the preparation of cosmetic compositions, personal care products, or both are provided. Methods for developing in vitro models of skin disease and models for specific skin diseases are also provided.
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5.发明申请Systems and Methods for Identifying Cosmetic Agents for Skin Care Compositions 审中-公开用于鉴定护肤组合物的化妆品的系统和方法公开(公告)号：US20120283112A1
公开(公告)日：2012-11-08
申请号：US13402102
申请日：2012-02-22
申请人： Robert Lloyd Binder , Robert Scott Youngquist , Jun Xu , Kenton Duane Juhlin , Rosemarie Osborne , Scott Michael Hartman
发明人： Robert Lloyd Binder , Robert Scott Youngquist , Jun Xu , Kenton Duane Juhlin , Rosemarie Osborne , Scott Michael Hartman
CPC分类号： C12Q1/6883 , C12Q2600/148 , C12Q2600/158 , G16B20/00 , G16B25/00 , G16B50/00
摘要： Provided are methods and systems for determining functional relationships between a cosmetic agent and a skin tissue condition of interest. Also provided are methods and systems for identifying cosmetic agents that affect a skin aging tissue condition, as well as the use of agents identified by such methods and systems for the preparation of cosmetic compositions, personal care products, or both.
摘要翻译： 提供了用于确定化妆品和感兴趣的皮肤组织状况之间的功能关系的方法和系统。 还提供了用于鉴定影响皮肤老化组织状况的化妆品的方法和系统，以及用于制备化妆品组合物，个人护理产品或这两者的这些方法和系统鉴定的药剂的使用。
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6.发明授权公开(公告)号：US08618086B2
公开(公告)日：2013-12-31
申请号：US12138733
申请日：2008-06-13
IPC分类号： A61K31/165 , A61K31/21 , A61K31/33 , A61K31/425 , A61K31/54 , A61K8/00 , A61K8/18
CPC分类号： A61Q7/00 , A61K8/365 , A61K8/46 , A61K31/5575
摘要： A method for treating hair loss in mammals uses compositions containing prostaglandin F analogs. The compositions can be applied topically to the skin. The compositions can arrest hair loss, reverse hair loss, and promote hair growth.
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7.发明申请COMPOSITIONS AND METHODS FOR TREATING HAIR LOSS USING C16-C20 AROMATIC TETRAHYDRO PROSTAGLANDINS 有权使用C16-C20芳族四氢叶酸治疗头发损失的组合物和方法公开(公告)号：US20080241078A1
公开(公告)日：2008-10-02
申请号：US12138733
申请日：2008-06-13
IPC分类号： A61K9/12 , A61K31/192 , A61P17/14
CPC分类号： A61Q7/00 , A61K8/365 , A61K8/46 , A61K31/5575
摘要： A method for treating hair loss in mammals uses compositions containing prostaglandin F analogs. The compositions can be applied topically to the skin. The compositions can arrest hair loss, reverse hair loss, and promote hair growth.
摘要翻译： 用于治疗哺乳动物脱发的方法使用含有前列腺素F类似物的组合物。 组合物可以局部施用于皮肤。 组合物可以阻止脱发，逆转脱发，并促进毛发生长。
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公开(公告)号：US20120157478A1
公开(公告)日：2012-06-21
申请号：US13328176
申请日：2011-12-16
申请人： Thomas Larry DAWSON, JR. , Robert Scott Youngquist , Jeanette Anthea Richards , Sancai Xie , Mary Jane Combs
发明人： Thomas Larry DAWSON, JR. , Robert Scott Youngquist , Jeanette Anthea Richards , Sancai Xie , Mary Jane Combs
摘要： Hair care compositions and methods that can increase the appearance of healthier hair by increasing the appearance of thicker and fuller hair, longer hair, and/or delayed emergence of gray hair. Such compositions can be applied to any areas where healthier hair appearance is desired, such as the scalp or face.
摘要翻译： 护发组合物和方法可以通过增加更厚和更丰满的头发，更长的头发和/或延迟出现灰白色头发的外观来增加更健康的头发的外观。 这样的组合物可以应用于需要更健康的头发外观的任何区域，例如头皮或脸部。
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9.发明授权Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins 有权使用C16-C20芳族四氢前列腺素治疗脱发的组合物和方法公开(公告)号：US07407987B2
公开(公告)日：2008-08-05
申请号：US11565297
申请日：2006-11-30
IPC分类号： A61K31/215 , A61K31/33 , A61K31/38 , A61K31/41
CPC分类号： A61Q7/00 , A61K8/365 , A61K8/46 , A61K31/5575
摘要： A method for treating hair loss in mammals uses compositions containing prostaglandin F analogs. The compositions can be applied topically to the skin. The compositions can arrest hair loss, reverse hair loss, and promote hair growth.
摘要翻译： 用于治疗哺乳动物脱发的方法使用含有前列腺素F类似物的组合物。 组合物可以局部施用于皮肤。 组合物可以阻止脱发，逆转脱发，并促进毛发生长。
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公开(公告)号：US06646005B1
公开(公告)日：2003-11-11
申请号：US09980351
申请日：2002-02-21
IPC分类号： A61K3150
CPC分类号： A61Q7/00 , A61K8/46 , A61K8/4953
摘要： Methods for treating hair loss using a composition including a compound having the following structure and pharmaceutically acceptable salts, hydrates, and biohydrolyzable amides, esters, and imides thereof are provided. R1 is —(CH2)n(CHNR7R8)mC(O)R9, wherein n is an integer from 1 to 3, and m is an integer from 0 to 1. R3 and R5each, independently, is chlorine, bromine, iodine and —CH3. R7 and R8 each, independently, is hydrogen or C1 to C4 alkyl. R9 is hydroxy, C1 to C4 alkoxy and —NR7R8. R31 is a hydrogen, chlorine, bromine, iodine, C1 to C4 alkyl, C4 to C6 cycloalklyl, C1 to C4 haloalkyl, C4 to C6 halocycloalkyl, or CH(R10)Ar. Ar is 5-hydroxypyrid-2-yl, 6-hydroxypyrid-3-yl, 6-hydroxypyridazin-3-yl, 6-methioxypyridazin-3-yl N-oxide or 6-hydroxypyridazin-3-yl N-oxide. R10 is hydrogen or C1 to C4 alkyl. R41 is hydroxy or C1 to C4 alkoxy.
摘要翻译： 提供了使用包含具有以下结构的化合物和药学上可接受的盐，水合物和生物可水解的酰胺，酯和酰亚胺的组合物来治疗脱发的方法。 R 1为 - （CH 2）n（CHNR 7 R 8）m C（O）R 9，其中n为1至3的整数，m为0至1的整数。R 3和R 5各自独立地为氯，溴，碘和 - CH3。 R 7和R 8各自独立地是氢或C 1至C 4烷基。 R9是羟基，C1-C4烷氧基和-NR7R8。 R31是氢，氯，溴，碘，C1至C4烷基，C4至C6环烷基，C1至C4卤代烷基，C4至C6卤代环烷基或CH（R10）Ar。 Ar是5-羟基吡啶-2-基，6-羟基吡啶-3-基，6-羟基哒嗪-3-基，6-甲氧基哒嗪-3-基N-氧化物或6-羟基哒嗪-3-基N-氧化物。 R 10是氢或C 1至C 4烷基。 R41是羟基或C1-C4烷氧基。
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