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公开(公告)号：US07018984B1
公开(公告)日：2006-03-28
申请号：US08477895
申请日：1995-06-06
申请人： Jang H. Han , Richard R. Spaete , Byoung J. Yoo , Byung S. Suh , Mark J. Selby , Michael Houghton
发明人： Jang H. Han , Richard R. Spaete , Byoung J. Yoo , Byung S. Suh , Mark J. Selby , Michael Houghton
IPC分类号： A61K31/7105 , A61K31/711 , C07H21/02 , C07H21/04 , C12N15/63
CPC分类号： C12N15/85 , A61K45/06 , C12N2770/24211 , C12N2770/24222 , C12N2840/105 , C12N2840/203
摘要： Embodiments of the present invention feature methods and compositions for controlling the translation of viral peptides and proteins from viral nucleic acid, with particular applications to pestivirus and HCV. The methods and compositions feature control elements of the 5′UT region of the viral genome.
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公开(公告)号：US5922857A
公开(公告)日：1999-07-13
申请号：US440209
申请日：1995-05-12
申请人： Jang H. Han , Richard R. Spaete , Byoung J. Yoo , Byung S. Suh , Mark J. Selby , Michael Houghton
发明人： Jang H. Han , Richard R. Spaete , Byoung J. Yoo , Byung S. Suh , Mark J. Selby , Michael Houghton
CPC分类号： C12N15/85 , A61K45/06 , C12N2770/24211 , C12N2770/24222 , C12N2840/105 , C12N2840/203
摘要： Embodiments of the present invention feature methods and compositions for controlling the translation of viral peptides and proteins from viral nucleic acid, with particular applications to pestiviras and HCV. The methods and compositions feature control elements of the 5'UT region of the viral genome.
摘要翻译： 本发明的实施方案特征在于用于控制来自病毒核酸的病毒肽和蛋白质的翻译的方法和组合物，具体应用于瘟病毒和HCV。 该方法和组合物特征在于病毒基因组的5'UT区域的控制元件。
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公开(公告)号：US6057093A
公开(公告)日：2000-05-02
申请号：US439996
申请日：1995-05-12
申请人： Jang H. Han , Richard R. Spaete , Byoung J. Yoo , Byung S. Suh , Mark J. Selby , Michael Houghton
发明人： Jang H. Han , Richard R. Spaete , Byoung J. Yoo , Byung S. Suh , Mark J. Selby , Michael Houghton
CPC分类号： C12N15/85 , A61K45/06 , C12N2770/24211 , C12N2770/24222 , C12N2840/105 , C12N2840/203
摘要： Embodiments of the present invention feature methods and compositions for controlling the translation of viral peptides and proteins from viral nucleic acid, with particular applications to pestivirus and HCV. The methods and compositions feature control elements of the 5'UT region of the viral genome.
摘要翻译： 本发明的实施方案的特征在于用于控制来自病毒核酸的病毒肽和蛋白质的翻译的方法和组合物，具体应用于瘟病毒和HCV。 该方法和组合物特征在于病毒基因组的5'UT区域的控制元件。
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公开(公告)号：US07943743B2
公开(公告)日：2011-05-17
申请号：US11917727
申请日：2006-06-30
申请人： Alan J. Korman , Mark J. Selby , Changyu Wang , Mohan Srinivasan , David B. Passmore , Haichun Huang , Haibin Chen
发明人： Alan J. Korman , Mark J. Selby , Changyu Wang , Mohan Srinivasan , David B. Passmore , Haichun Huang , Haibin Chen
IPC分类号： C07K16/00
CPC分类号： C07K16/2827 , A61K45/06 , A61K47/6817 , A61K47/6825 , A61K47/6849 , A61K2039/505 , C07K16/28 , C07K16/2803 , C07K16/2818 , C07K2317/21 , C07K2317/41 , C07K2317/56 , C07K2317/567 , C07K2317/732 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/77 , C07K2317/92 , Y02A50/386 , Y02A50/403 , Y02A50/407 , Y02A50/41 , Y02A50/412 , Y02A50/466
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to PD-L1 with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The disclosure also provides methods for detecting PD-L1, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PD-L1 antibodies.
摘要翻译： 本公开提供分离的单克隆抗体，特别是以高亲和力特异性结合PD-L1的人单克隆抗体。 还提供了编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本公开还提供了使用抗PD-L1抗体检测PD-L1的方法以及用于治疗各种疾病（包括癌症和感染性疾病）的方法。
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5.发明申请Human Monoclonal Antibodies To Programmed Death 1(PD-1) And Methods For Treating Cancer Using Anti-PD-1 Antibodies Alone or in Combination with Other Immunotherapeutics 有权使用单独或与其他免疫治疗组合的抗PD-1抗体治疗癌症的人单克隆抗体编程死亡1（PD-1）和方法公开(公告)号：US20090217401A1
公开(公告)日：2009-08-27
申请号：US11913217
申请日：2006-05-02
申请人： Alan J. Korman , Mohan Srinivasan , Changyu Wang , Mark J. Selby , Bing Chen , Josephine M. Cardarelli
发明人： Alan J. Korman , Mohan Srinivasan , Changyu Wang , Mark J. Selby , Bing Chen , Josephine M. Cardarelli
IPC分类号： A01K67/027 , A61K39/395 , C07H21/00 , C12N15/74 , C12N5/10 , C12N5/16 , C07K16/18 , A61P35/00
CPC分类号： A61K39/39558 , A61K39/00 , A61K39/3955 , A61K47/6849 , A61K51/10 , A61K2039/505 , A61K2039/507 , C07K16/18 , C07K16/28 , C07K16/2803 , C07K16/2818 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PD-1 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PD-1, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PD-1 antibodies. The present invention further provides methods for using a combination immunotherapy, such as the combination of anti-CTLA-4 and anti-PD-1 antibodies, to treat hyperproliferative disease, such as cancer. The invention also provides methods for altering adverse events related to treatment with such antibodies individually.
摘要翻译： 本发明提供以高亲和力特异性结合PD-1的分离的单克隆抗体，特别是人单克隆抗体。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供用于检测PD-1的方法，以及使用抗PD-1抗体治疗各种疾病（包括癌症和感染性疾病）的方法。 本发明还提供了使用组合免疫治疗如抗CTLA-4和抗-PD-1抗体的组合来治疗过度增殖性疾病如癌症的方法。 本发明还提供用于改变与用这种抗体单独治疗相关的不良事件的方法。
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公开(公告)号：US08779105B2
公开(公告)日：2014-07-15
申请号：US13210137
申请日：2011-08-15
申请人： Alan J. Korman , Mohan Srinivasan , Changyu Wang , Mark J. Selby , Bing Chen , Josephine M. Cardarelli , Haichun Huang
发明人： Alan J. Korman , Mohan Srinivasan , Changyu Wang , Mark J. Selby , Bing Chen , Josephine M. Cardarelli , Haichun Huang
CPC分类号： A61K39/39558 , A61K39/00 , A61K39/3955 , A61K47/6849 , A61K51/10 , A61K2039/505 , A61K2039/507 , C07K16/18 , C07K16/28 , C07K16/2803 , C07K16/2818 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PD-1 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PD-1, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PD-1 antibodies. The present invention further provides methods for using a combination immunotherapy, such as the combination of anti-CTLA-4 and anti-PD-1 antibodies, to treat hyperproliferative disease, such as cancer. The invention also provides methods for altering adverse events related to treatment with such antibodies individually.
摘要翻译： 本发明提供以高亲和力特异性结合PD-1的分离的单克隆抗体，特别是人单克隆抗体。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供用于检测PD-1的方法，以及使用抗PD-1抗体治疗各种疾病（包括癌症和感染性疾病）的方法。 本发明还提供了使用组合免疫治疗如抗CTLA-4和抗-PD-1抗体的组合来治疗过度增殖性疾病如癌症的方法。 本发明还提供用于改变与用这种抗体单独治疗相关的不良事件的方法。
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7.发明授权Human monoclonal antibodies to programmed death 1 (PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics 有权程序性死亡1（PD-1）的人单克隆抗体和单独使用抗PD-1抗体或与其他免疫治疗剂组合治疗癌症的方法公开(公告)号：US08008449B2
公开(公告)日：2011-08-30
申请号：US11913217
申请日：2006-05-02
申请人： Alan J. Korman , Mohan Srinivasan , Changyu Wang , Mark J. Selby , Bingliana Chen , Josephine M. Cardarelli
发明人： Alan J. Korman , Mohan Srinivasan , Changyu Wang , Mark J. Selby , Bingliana Chen , Josephine M. Cardarelli
IPC分类号： C07K16/28
CPC分类号： A61K39/39558 , A61K39/00 , A61K39/3955 , A61K47/6849 , A61K51/10 , A61K2039/505 , A61K2039/507 , C07K16/18 , C07K16/28 , C07K16/2803 , C07K16/2818 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PD-1 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PD-1, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PD-1 antibodies. The present invention further provides methods for using a combination immunotherapy, such as the combination of anti-CTLA-4 and anti-PD-1 antibodies, to treat hyperproliferative disease, such as cancer. The invention also provides methods for altering adverse events related to treatment with such antibodies individually.
摘要翻译： 本发明提供以高亲和力特异性结合PD-1的分离的单克隆抗体，特别是人单克隆抗体。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供用于检测PD-1的方法，以及使用抗PD-1抗体治疗各种疾病（包括癌症和感染性疾病）的方法。 本发明还提供了使用组合免疫治疗如抗CTLA-4和抗-PD-1抗体的组合来治疗过度增殖性疾病如癌症的方法。 本发明还提供用于改变与用这种抗体单独治疗相关的不良事件的方法。
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公开(公告)号：US06436666B1
公开(公告)日：2002-08-20
申请号：US08997055
申请日：1997-10-17
IPC分类号： C12P2106
CPC分类号： C07K14/005 , C12N2770/24222 , C12Q1/025 , C12Q1/37 , G01N2333/18 , G01N2500/00
摘要： A polypeptide containing an anchor region, a protease recognition site, and a detectable signal region can be produced recombinantly and directly attached to a solid support. The polypeptide is useful for screening protease regulators, especially protease inhibitors.
摘要翻译： 包含锚定区，蛋白酶识别位点和可检测信号区的多肽可以重组并直接连接到固体支持物上。 该多肽可用于筛选蛋白酶调节剂，特别是蛋白酶抑制剂。
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公开(公告)号：US08609816B2
公开(公告)日：2013-12-17
申请号：US12092866
申请日：2006-12-08
申请人： Alan J. Korman , Mark J. Selby , Li-Sheng Lu , Alison Witte , Haichun Huang
发明人： Alan J. Korman , Mark J. Selby , Li-Sheng Lu , Alison Witte , Haichun Huang
CPC分类号： C07K16/2827 , A61K47/6849 , A61K51/1027 , A61K2039/505 , C07H21/00 , C07K16/30 , C07K16/3015 , C07K2317/14 , C07K2317/21 , C07K2317/40 , C07K2317/41 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/77 , C07K2317/92 , C07K2319/55 , C12N15/00 , C12N15/09 , C12N15/62
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to O8E with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for treating cancer.
摘要翻译： 本公开提供分离的单克隆抗体，特别是以高亲和力特异性结合O8E的人单克隆抗体。 还提供了编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本公开的抗体的药物组合物。 本公开还提供了治疗癌症的方法。
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10.发明授权Nucleic acids encoding monoclonal antibodies to programmed death ligand 1 (PD-L1) 有权编码程序性死亡配体1（PD-L1）的单克隆抗体的核酸公开(公告)号：US08383796B2
公开(公告)日：2013-02-26
申请号：US13091936
申请日：2011-04-21
申请人： Alan J. Korman , Mark J. Selby , Changyu Wang , Mohan Srinivasan , David B. Passmore , Haichun Huang , Haibin Chen
发明人： Alan J. Korman , Mark J. Selby , Changyu Wang , Mohan Srinivasan , David B. Passmore , Haichun Huang , Haibin Chen
IPC分类号： C07H21/04
CPC分类号： C07K16/2827 , A61K45/06 , A61K47/6817 , A61K47/6825 , A61K47/6849 , A61K2039/505 , C07K16/28 , C07K16/2803 , C07K16/2818 , C07K2317/21 , C07K2317/41 , C07K2317/56 , C07K2317/567 , C07K2317/732 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/77 , C07K2317/92 , Y02A50/386 , Y02A50/403 , Y02A50/407 , Y02A50/41 , Y02A50/412 , Y02A50/466
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to PD-L1 with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The disclosure also provides methods for detecting PD-L1, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PD-L1 antibodies.
摘要翻译： 本公开提供分离的单克隆抗体，特别是以高亲和力特异性结合PD-L1的人单克隆抗体。 还提供了编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本公开还提供了使用抗PD-L1抗体检测PD-L1的方法以及用于治疗各种疾病（包括癌症和感染性疾病）的方法。
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