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公开(公告)号：US20190071435A1
公开(公告)日：2019-03-07
申请号：US16180612
申请日：2018-11-05
发明人： Zhihua Sui , Chaozhong Cai , Xuqing Zhang
IPC分类号： C07D417/12 , C07D275/00 , C07D333/32 , C07D417/04 , C07D333/16 , C07D275/03 , C07D275/02 , C07D409/04
摘要： Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR120 receptor. Such compounds are represented by Formula (I) and Formula (II) as follows: wherein Y, R1, G, and Q are defined herein; and wherein R11, R21, R41, RB1 and G1, are defined herein.
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公开(公告)号：US20170029381A1
公开(公告)日：2017-02-02
申请号：US15303746
申请日：2015-04-14
发明人： Xuqing Zhang , Mark J. Wall , Zhihua Sui
IPC分类号： C07D235/02 , C07D491/052 , C07D401/12 , C07D405/04 , C07D417/12 , C07D403/12
CPC分类号： C07D235/02 , A61K31/12 , A61K31/4184 , A61K31/4188 , A61K31/423 , A61K31/427 , A61K31/5377 , A61K45/06 , C07D401/12 , C07D403/12 , C07D405/04 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/052
摘要： The present invention comprises compounds of Formula (I). wherein: R1, R2, R3, R4, R5, R6, R7, R8, X, Z1 and Z2 are defined in the specification.
摘要翻译： 本发明包括式（I）的化合物。 其中：在说明书中定义了R1，R2，R3，R4，R5，R6，R7，R8，X，Z1和Z2。
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公开(公告)号：US10590083B2
公开(公告)日：2020-03-17
申请号：US16059072
申请日：2018-08-09
发明人： Xuqing Zhang , Mark J. Macielag
IPC分类号： C07D213/64 , C07D401/14 , A61P3/10 , C07D413/14 , C07D413/06
摘要： The present invention is directed to pyridin-2-one derivatives, pharmaceutical compositions containing them and their use as antagonists of the EP3 receptor, for the treatment of for example, impaired oral glucose tolerance, elevated fasting glucose, Type II Diabetes Mellitus, Syndrome X (also known as Metabolic Syndrome) and related disorders and complications thereof.
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公开(公告)号：US20190047961A1
公开(公告)日：2019-02-14
申请号：US16059075
申请日：2018-08-09
发明人： Xuqing Zhang , Mark J. Macielag
IPC分类号： C07D213/64 , C07D413/04 , C07D417/04 , A61P3/10
CPC分类号： C07D213/64 , A61P3/10 , C07D413/04 , C07D417/04
摘要： The present invention is directed to pyridin-2-one derivatives, pharmaceutical compositions containing them and their use as antagonists of the EP3 receptor, for the treatment of for example, impaired oral glucose tolerance, elevated fasting glucose, Type II Diabetes Mellitus, Syndrome X (also known as Metabolic Syndrome) and related disorders and complications thereof.
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公开(公告)号：US10077241B2
公开(公告)日：2018-09-18
申请号：US15303746
申请日：2015-04-14
发明人： Xuqing Zhang , Mark J. Wall , Zhihua Sui
IPC分类号： C07D405/04 , C07D413/04 , C07D235/02 , C07D403/12 , A61K31/12 , A61K31/4184 , A61K31/4188 , A61K31/423 , A61K31/427 , A61K31/5377 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/052 , A61K45/06 , C07D401/12
CPC分类号： C07D235/02 , A61K31/12 , A61K31/4184 , A61K31/4188 , A61K31/423 , A61K31/427 , A61K31/5377 , A61K45/06 , C07D401/12 , C07D403/12 , C07D405/04 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/052
摘要： The present invention comprises compounds of Formula (I). wherein: R1, R2, R3, R4, R5, R6, R7, R8, X, Z1 and Z2 are defined in the specification.
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公开(公告)号：US09434688B2
公开(公告)日：2016-09-06
申请号：US14277429
申请日：2014-05-14
发明人： James C Lanter , Zhihua Sui , James J Fiordeliso , Weiqin Jiang , Xuqing Zhang
IPC分类号： C07D209/12 , C07D209/08 , C07D209/30 , A61K31/407 , A61K31/5025 , A61K31/519 , A61K31/4985 , C07D401/04 , C07D405/04 , C07D409/04 , C07D487/04
CPC分类号： C07D209/12 , A61K31/407 , A61K31/4985 , A61K31/5025 , A61K31/519 , C07D209/08 , C07D209/30 , C07D401/04 , C07D405/04 , C07D409/04 , C07D487/04
摘要： The present invention is directed to novel indole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.
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7.发明申请公开(公告)号：US20140336170A1
公开(公告)日：2014-11-13
申请号：US14338816
申请日：2014-07-23
发明人： Xuqing Zhang , Marta C. Abad , Alan C. Gibbs , Gee-Hong Kuo , Fengbin Song , Zhihua Sui
IPC分类号： C07D491/08 , C07D231/56 , C07D401/12 , C07D403/12
CPC分类号： C07D491/08 , C07D231/56 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D471/04 , C07D487/04 , C07D487/10
摘要： The present invention is directed to substituted indazole compounds, pharmaceutical compositions of these compounds and methods of use thereof. The compounds of the present invention are ketohexokinase (KHK) inhibitors, useful for treating or ameliorating a KHK mediated metabolic disorders and/or diseases such as obesity, Type II diabetes mellitus and Metabolic Syndrome X.
摘要翻译： 本发明涉及取代的吲唑化合物，这些化合物的药物组合物及其使用方法。 本发明的化合物是用于治疗或改善KHK介导的代谢紊乱和/或疾病如肥胖，II型糖尿病和代谢综合征X的酮基己糖激酶（KHK）抑制剂。
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公开(公告)号：US10118922B2
公开(公告)日：2018-11-06
申请号：US14200108
申请日：2014-03-07
发明人： Zhihua Sui , Chaozhong Cai , Xuqing Zhang
IPC分类号： C07D417/12 , C07D275/02 , C07D275/03 , C07D333/16 , C07D409/04 , C07D417/04 , C07D333/32 , C07D275/00
摘要： Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR120 receptor. Such compounds are represented by Formula (I) and Formula (II) as follows: wherein Y, R1, G, and Q are defined herein; and wherein R11, R21, R41, RB1 and G1, are defined herein.
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公开(公告)号：US09771375B2
公开(公告)日：2017-09-26
申请号：US14338816
申请日：2014-07-23
发明人： Xuqing Zhang , Marta C Abad , Alan C. Gibbs , Gee-Hong Kuo , Fengbin Song , Zhihua Sui , Lawrence C. Kuo
IPC分类号： C07D487/04 , A61K31/519 , A61P3/10 , A61P3/04 , A61P3/06 , C07D471/04 , C07D491/08 , C07D231/56 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D487/10 , A61K31/437
CPC分类号： C07D491/08 , C07D231/56 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D471/04 , C07D487/04 , C07D487/10
摘要： The present invention is directed to substituted indazole compounds, pharmaceutical compositions of these compounds and methods of use thereof. The compounds of the present invention are ketohexokinase (KHK) inhibitors, useful for treating or ameliorating a KHK mediated metabolic disorders and/or diseases such as obesity, Type II diabetes mellitus and Metabolic Syndrome X. In some embodiments, the substituted indazole compounds are of formula I, wherein R1-R3, Q, X, Y, Z, a, and b are defined herein.
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10.发明申请NOVEL INDOLE DERIVATIVES AS SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) 审中-公开作为选择性受体调节剂（SARMS）的新型吲哚衍生物公开(公告)号：US20140249197A1
公开(公告)日：2014-09-04
申请号：US14277429
申请日：2014-05-14
发明人： James C. Lanter , Zhihua Sui , James J. Fiordeliso , Weiqin Jiang , Xuqing Zhang
IPC分类号： C07D209/12 , C07D209/08 , C07D405/04
CPC分类号： C07D209/12 , A61K31/407 , A61K31/4985 , A61K31/5025 , A61K31/519 , C07D209/08 , C07D209/30 , C07D401/04 , C07D405/04 , C07D409/04 , C07D487/04
摘要： The present invention is directed to novel indole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.
摘要翻译： 本发明涉及新的吲哚衍生物，含有它们的药物组合物及其用于治疗由雄激素受体调节的病症和状况。
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