-
1.发明申请SUBSTITUTED BENZOFURANS, BENZOTHIOPHENES, BENZOSELENOPHENES AND INDOLES AND THEIR USE AS TUBULIN POLYMERISATION INHIBITORS 有权替代苯唑酮，苯并噻唑，苯并噻吩和吲哚，以及其作为管状体聚合抑制剂的用途公开(公告)号：US20100004208A1
公开(公告)日：2010-01-07
申请号：US12162917
申请日：2007-02-02
申请人： Jason Hugh Chaplin , Gurmit Singh Gill , Damian Wojciech Grobelny , Bernard Luke Flynn , Gabriel Kremmidiotis
发明人： Jason Hugh Chaplin , Gurmit Singh Gill , Damian Wojciech Grobelny , Bernard Luke Flynn , Gabriel Kremmidiotis
IPC分类号： A61K31/343 , C07D307/78 , C07D307/82 , C07D405/12 , A61K31/443 , A61K31/496 , A61K31/665 , A61P35/00
CPC分类号： A61K31/343 , A61K31/381 , A61K31/404 , A61K31/41 , A61K31/4178 , A61K31/443 , A61K31/496 , A61K31/665 , A61K39/3955 , A61K45/06 , A61K51/00 , C07D209/12 , C07D307/80 , C07D307/81 , C07D307/82 , C07D307/83 , C07D307/84 , C07D307/85 , C07D307/86 , C07D333/56 , C07D405/06 , C07D405/12 , C07D407/06 , C07D407/12 , C07F9/65517 , C07K16/22
摘要： The present invention relates generally to substituted benzofurans, benzothiophenes, and indoles and their use as tubulin polymerisation inhibitors.
摘要翻译： 本发明一般涉及取代的苯并呋喃，苯并噻吩和吲哚及其作为微管蛋白聚合抑制剂的用途。
-
2.发明授权Substituted benzofurans, benzothiophenes, benzoselenophenes and indoles and their use as tubulin polymerisation inhibitors 有权取代的苯并呋喃，苯并噻吩，苯并硒吩和吲哚及其作为微管蛋白聚合抑制剂的用途公开(公告)号：US08716335B2
公开(公告)日：2014-05-06
申请号：US13461213
申请日：2012-05-01
申请人： Jason Hugh Chaplin , Gurmit Singh Gill , Damian Wojciech Grobelny , Bernard Luke Flynn , Gabriel Kremmidiotis
发明人： Jason Hugh Chaplin , Gurmit Singh Gill , Damian Wojciech Grobelny , Bernard Luke Flynn , Gabriel Kremmidiotis
IPC分类号： A61K31/343 , C07D307/80
CPC分类号： A61K31/343 , A61K31/381 , A61K31/404 , A61K31/41 , A61K31/4178 , A61K31/443 , A61K31/496 , A61K31/665 , A61K39/3955 , A61K45/06 , A61K51/00 , C07D209/12 , C07D307/80 , C07D307/81 , C07D307/82 , C07D307/83 , C07D307/84 , C07D307/85 , C07D307/86 , C07D333/56 , C07D405/06 , C07D405/12 , C07D407/06 , C07D407/12 , C07F9/65517 , C07K16/22
摘要： The present invention relates generally to substituted benzofurans, benzothiophenes, and indoles and their use as tubulin polymerization inhibitors.
摘要翻译： 本发明一般涉及取代的苯并呋喃，苯并噻吩和吲哚及其作为微管蛋白聚合抑制剂的用途。
-
3.发明授权Substituted benzofurans, benzothiophenes, benzoselenophenes and indoles and their use as tubulin polymerisation inhibitors 有权取代的苯并呋喃，苯并噻吩，苯并硒吩和吲哚及其作为微管蛋白聚合抑制剂的用途公开(公告)号：US08198466B2
公开(公告)日：2012-06-12
申请号：US12162917
申请日：2007-02-02
申请人： Jason Hugh Chaplin , Gurmit Singh Gill , Damian Wojciech Grobelny , Bernard Luke Flynn , Gabriel Kremmidiotis
发明人： Jason Hugh Chaplin , Gurmit Singh Gill , Damian Wojciech Grobelny , Bernard Luke Flynn , Gabriel Kremmidiotis
IPC分类号： C07D307/80
CPC分类号： A61K31/343 , A61K31/381 , A61K31/404 , A61K31/41 , A61K31/4178 , A61K31/443 , A61K31/496 , A61K31/665 , A61K39/3955 , A61K45/06 , A61K51/00 , C07D209/12 , C07D307/80 , C07D307/81 , C07D307/82 , C07D307/83 , C07D307/84 , C07D307/85 , C07D307/86 , C07D333/56 , C07D405/06 , C07D405/12 , C07D407/06 , C07D407/12 , C07F9/65517 , C07K16/22
摘要： The present invention relates generally to substituted benzofurans, benzothiophenes, and indoles and their use as tubulin polymerization inhibitors.
摘要翻译： 本发明一般涉及取代的苯并呋喃，苯并噻吩和吲哚及其作为微管蛋白聚合抑制剂的用途。
-
公开(公告)号：US08278290B2
公开(公告)日：2012-10-02
申请号：US11816209
申请日：2006-02-14
IPC分类号： A61K31/38 , A61K31/675 , A01N57/00 , C07D405/00
CPC分类号： C07D403/04 , C07D307/80 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07F9/65517 , C07F9/65586
摘要： The present invention relates to compounds of general formula (I) as tublin polymerization inhibitors and methods for preparing such compounds.
摘要翻译： 本发明涉及作为都柏林聚合抑制剂的通式（I）化合物及其制备方法。
-
公开(公告)号：US08202513B2
公开(公告)日：2012-06-19
申请号：US12681763
申请日：2008-10-03
申请人： Bernard Luke Flynn , Jonathan Bayldon Baell , Jason Hugh Chaplin , Gurmit Singh Gill , Damian Wojciech Grobelny , Andrew John Harvey , Jorgen Alvar Mould , Dharam Paul
发明人： Bernard Luke Flynn , Jonathan Bayldon Baell , Jason Hugh Chaplin , Gurmit Singh Gill , Damian Wojciech Grobelny , Andrew John Harvey , Jorgen Alvar Mould , Dharam Paul
IPC分类号： A61K38/21 , A61K31/138 , A61K31/4402 , A61K31/5375 , A61K31/4453 , A61K31/40 , A61K31/4965 , A61K31/54 , A61K31/4174 , A61K31/4196 , A61K31/397 , A61K31/198 , A61K39/395 , C07C215/64 , A61P29/00 , A61P3/10 , A61P25/28 , C07D213/54 , C07D265/30 , C07D211/34 , C07D211/74 , C07D207/08 , C07D241/18 , C07D279/12 , C07D233/60 , C07D249/08 , C07D205/04
CPC分类号： C07C217/22 , C07C49/84 , C07C2601/08 , C07D205/04 , C07D205/08 , C07D207/10 , C07D211/38 , C07D211/46 , C07D211/74 , C07D213/30 , C07D233/60 , C07D241/18 , C07D249/08 , C07D265/30 , C07D295/088
摘要： The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.
摘要翻译： 本发明涉及可用于调节细胞中钾通道活性的化合物，特别是在T细胞中发现的Kv1.3通道的活性。 本发明还涉及这些化合物在治疗或预防自身免疫性和炎性疾病，包括多发性硬化症中的用途，含有这些化合物的药物组合物及其制备方法。
-
公开(公告)号：US20100292190A1
公开(公告)日：2010-11-18
申请号：US11816209
申请日：2006-02-14
IPC分类号： A61K31/675 , A61K31/67 , A61K31/665 , A61K31/496 , A61K31/443 , A61K31/4192 , A61K31/427 , A61K31/424 , A61K31/422 , A61K31/41 , A61K31/4196 , A61K31/4178 , A61K31/4155 , A61K31/4025 , A61K31/381 , A61K31/343 , C07D405/04 , C07F9/09 , C07D417/04 , C07D498/14 , C07D413/04 , C07D403/04 , C07D409/04 , C07D407/04 , A61P29/00 , A61P35/00 , A61P17/06
CPC分类号： C07D403/04 , C07D307/80 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07F9/65517 , C07F9/65586
摘要： The present invention relates to compounds of general formula (I) as tublin polymerisation inhibitors and methods for preparing such compounds.
摘要翻译： 本发明涉及作为都柏林聚合抑制剂的通式（I）化合物及其制备方法。
-
公开(公告)号：US08557982B2
公开(公告)日：2013-10-15
申请号：US13584046
申请日：2012-08-13
IPC分类号： C07D265/26 , C07D498/00 , C07D405/00 , A61K31/38
CPC分类号： C07D403/04 , C07D307/80 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07F9/65517 , C07F9/65586
摘要： The present invention relates to compounds of general formula (I) as tublin polymerization inhibitors and methods for preparing such compounds.
摘要翻译： 本发明涉及作为都柏林聚合抑制剂的通式（I）化合物及其制备方法。
-
公开(公告)号：US20120309768A1
公开(公告)日：2012-12-06
申请号：US13584046
申请日：2012-08-13
IPC分类号： A61K31/4155 , A61K31/443 , A61K31/381 , A61K31/422 , A61K31/4192 , A61K31/4025 , A61K31/4178 , A61K31/4196 , A61K31/427 , A61K31/496 , A61K31/41 , A61P35/00 , A61P35/02 , A61P29/00 , A61K31/343
CPC分类号： C07D403/04 , C07D307/80 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07F9/65517 , C07F9/65586
摘要： The present invention relates to compounds of general formula (I) as tublin polymerisation inhibitors and methods for preparing such compounds.
摘要翻译： 本发明涉及作为都柏林聚合抑制剂的通式（I）化合物及其制备方法。
-
公开(公告)号：US08507539B2
公开(公告)日：2013-08-13
申请号：US12997864
申请日：2009-06-12
申请人： Andrew John Harvey , Bernard Luke Flynn , Jorgen Alvar Mould , Dharam Paul , Gurmit Singh Gill , Justin Anthony Ripper , Rachel Christine Cooke , Julia Stephanie Crossman , Jonathan Bayldon Baell , Nathan Wayne Kuchel , Rajinder Singh
发明人： Andrew John Harvey , Bernard Luke Flynn , Jorgen Alvar Mould , Dharam Paul , Gurmit Singh Gill , Justin Anthony Ripper , Rachel Christine Cooke , Julia Stephanie Crossman , Jonathan Bayldon Baell , Nathan Wayne Kuchel , Rajinder Singh
IPC分类号： A61K31/423 , C07D263/54
CPC分类号： C07D263/56 , C07D413/12
摘要： The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.
摘要翻译： 本发明涉及可用于调节细胞中钾通道活性的化合物，特别是在T细胞中发现的Kv1.3通道的活性。 本发明还涉及这些化合物在治疗或预防自身免疫性和炎性疾病，包括多发性硬化症中的用途，含有这些化合物的药物组合物及其制备方法。
-
公开(公告)号：US20110166130A1
公开(公告)日：2011-07-07
申请号：US12997864
申请日：2009-06-12
申请人： Andrew John Harvey , Bernard Luke Flynn , Jorgen Alvar Mould , Dharam Paul , Gurmit Singh Gill , Justin Anthony Ripper , Rachel Christine Cooke , Julia Stephanie Crossman , Jonathan Bayldon Baell , Nathan Wayne Kuchel , Rajinder Singh
发明人： Andrew John Harvey , Bernard Luke Flynn , Jorgen Alvar Mould , Dharam Paul , Gurmit Singh Gill , Justin Anthony Ripper , Rachel Christine Cooke , Julia Stephanie Crossman , Jonathan Bayldon Baell , Nathan Wayne Kuchel , Rajinder Singh
IPC分类号： A61K31/54 , C07D413/12 , C07D263/54 , C07D417/12 , A61K31/5377 , A61K31/4439 , A61K31/421 , C12N5/0783 , A61P37/02
CPC分类号： C07D263/56 , C07D413/12
摘要： The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.
摘要翻译： 本发明涉及可用于调节细胞中钾通道活性的化合物，特别是在T细胞中发现的Kv1.3通道的活性。 本发明还涉及这些化合物在治疗或预防自身免疫性和炎性疾病，包括多发性硬化症中的用途，含有这些化合物的药物组合物及其制备方法。
-
-
-
-
-
-
-
-
-
搜索结果
10 条记录 (耗时 0.033 秒)
