公开(公告)号：US07785797B2

公开(公告)日：2010-08-31

申请号：US12544182

申请日：2009-08-19

申请人： Jay Wohlgemuth ,  Kirk E. Fry ,  Robert Woodward ,  Ngoc Ly ,  James Prentice ,  Macdonald Morris ,  Steven Rosenberg

发明人： Jay Wohlgemuth ,  Kirk E. Fry ,  Robert Woodward ,  Ngoc Ly ,  James Prentice ,  Macdonald Morris ,  Steven Rosenberg

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q1/6881 ,  C12Q1/6888 ,  C12Q2600/158 ,  G01N33/564 ,  G01N33/6863 ,  G01N2800/245

摘要： Methods of diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection and kits or systems containing the same are also described.

公开(公告)号：US5959098A

公开(公告)日：1999-09-28

申请号：US634053

申请日：1996-04-17

申请人： Martin Goldberg ,  Martin Diggelman ,  Earl Hubbell ,  Glenn McGall ,  Nam Quoc Ngo ,  Macdonald Morris ,  Mel Yamamoto ,  Jennifer Tan ,  Richard P. Rava

发明人： Martin Goldberg ,  Martin Diggelman ,  Earl Hubbell ,  Glenn McGall ,  Nam Quoc Ngo ,  Macdonald Morris ,  Mel Yamamoto ,  Jennifer Tan ,  Richard P. Rava

IPC分类号： C12N15/09 ,  B01J19/00 ,  C07B61/00 ,  C07H21/00 ,  C07K1/00 ,  C07K1/04 ,  C12Q1/68 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14 ,  G01N33/53 ,  G01N37/00 ,  C08G63/48 ,  G01N33/543

CPC分类号： C07K1/047 ,  B01J19/0046 ,  B82Y30/00 ,  C07H21/00 ,  B01J2219/00432 ,  B01J2219/00527 ,  B01J2219/00529 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00608 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00711 ,  B01J2219/00722 ,  B01J2219/00725 ,  C07B2200/11 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14 ,  Y02P20/55 ,  Y10S436/809

摘要： The present invention provides novel processes for the large scale preparation of arrays of polymer sequences wherein each array includes a plurality of different, positionally distinct polymer sequences having known monomer sequences. The methods of the invention combine high throughput process steps with high resolution photolithographic techniques in the manufacture of polymer arrays.