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1.发明申请Methods for treating retinoid responsive disorders using selective inhibitors of CYP26A and CYP26B 失效使用CYP26A和CYP26B的选择性抑制剂治疗类视黄醇应答障碍的方法公开(公告)号：US20050187298A1
公开(公告)日：2005-08-25
申请号：US11010953
申请日：2004-12-13
申请人： Jayasree Vasudevan , Rong Yang , Liming Wang , Xiaoxia Liu , Kwok-Yin Tsang , Ling Li , Janet Takeuchi , Thong Vu , Richard Beard , Smita Bhat , Roshantha Chandraratna
发明人： Jayasree Vasudevan , Rong Yang , Liming Wang , Xiaoxia Liu , Kwok-Yin Tsang , Ling Li , Janet Takeuchi , Thong Vu , Richard Beard , Smita Bhat , Roshantha Chandraratna
IPC分类号： A61K31/19 , A61K31/192 , A61K31/35 , A61K31/38
CPC分类号： A61K31/19 , A61K31/192 , A61K31/35 , A61K31/38
摘要： The invention provides methods for treating an individual having a retinoid responsive disorder. In one embodiment, a method involves administering to the individual an effective amount of a selective CYP26B inhibitor, the selective CYP26B inhibitor having at least 10-fold selectivity for CYP26B relative to CYP26A. In another embodiment, a method involves administering to the individual an effective amount of a selective CYP26A inhibitor, the selective CYP26A inhibitor having a chemical formula set forth in the specification. The invention further provides screening methods for identifying a selective CYP26A inhibitor or selective CYP26B inhibitor.
摘要翻译： 本发明提供了治疗患有类视黄醇反应性障碍的个体的方法。 在一个实施方案中，一种方法涉及向个体施用有效量的选择性CYP26B抑制剂，所述选择性CYP26B抑制剂相对于CYP26A对CYP26B具有至少10倍的选择性。 在另一个实施方案中，一种方法包括向个体施用有效量的选择性CYP26A抑制剂，该选择性CYP26A抑制剂具有说明书中阐述的化学式。 本发明还提供用于鉴定选择性CYP26A抑制剂或选择性CYP26B抑制剂的筛选方法。
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2.发明授权Methods for treating retinoid responsive disorders using selective inhibitors of CYP26A and CYP26B 失效使用CYP26A和CYP26B的选择性抑制剂治疗类视黄醇应答障碍的方法公开(公告)号：US07468391B2
公开(公告)日：2008-12-23
申请号：US11010953
申请日：2004-12-13
申请人： Jayasree Vasudevan , Rong Yang , Liming Wang , Xiaoxia Liu , Kwok-Yin Tsang , Ling Li , Janet Takeuchi , Thong Vu , Richard Beard , Smita Bhat , Roshantha A. Chandraratna
发明人： Jayasree Vasudevan , Rong Yang , Liming Wang , Xiaoxia Liu , Kwok-Yin Tsang , Ling Li , Janet Takeuchi , Thong Vu , Richard Beard , Smita Bhat , Roshantha A. Chandraratna
IPC分类号： A01N31/00 , A61K9/00 , A61K31/415 , A61K9/20 , A61K9/48
CPC分类号： A61K31/19 , A61K31/192 , A61K31/35 , A61K31/38
摘要： The invention provides methods for treating an individual having a retinoid responsive disorder. In one embodiment, a method involves administering to the individual an effective amount of a selective CYP26B inhibitor, the selective CYP26B inhibitor having at least 10-fold selectivity for CYP26B relative to CYP26A. In another embodiment, a method involves administering to the individual an effective amount of a selective CYP26A inhibitor, the selective CYP26A inhibitor having a chemical formula set forth in the specification. The invention further provides screening methods for identifying a selective CYP26A inhibitor or selective CYP26B inhibitor.
摘要翻译： 本发明提供了治疗患有类视黄醇反应性障碍的个体的方法。 在一个实施方案中，一种方法涉及向个体施用有效量的选择性CYP26B抑制剂，所述选择性CYP26B抑制剂相对于CYP26A对CYP26B具有至少10倍的选择性。 在另一个实施方案中，一种方法包括向个体施用有效量的选择性CYP26A抑制剂，该选择性CYP26A抑制剂具有说明书中阐述的化学式。 本发明还提供用于鉴定选择性CYP26A抑制剂或选择性CYP26B抑制剂的筛选方法。
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3.发明申请Compounds having selective cytochrome P450RAI-1 or selective cytochrome P450RAI-2 inhibitory activity and methods of obtaining the same 失效具有选择性细胞色素P450RAI-1或选择性细胞色素P450RAI-2抑制活性的化合物及其获得方法公开(公告)号：US20080004455A1
公开(公告)日：2008-01-03
申请号：US11728313
申请日：2007-03-23
申请人： Jayasree Vasudevan , Liming Wang , Xiaoxia Liu , Kwok Tsang , Ling Li , Janet Takeuchi , Thong Vu , Richard Beard , Smita Bhat , Vidyasagar Vuligonda , Roshantha Chandraratna
发明人： Jayasree Vasudevan , Liming Wang , Xiaoxia Liu , Kwok Tsang , Ling Li , Janet Takeuchi , Thong Vu , Richard Beard , Smita Bhat , Vidyasagar Vuligonda , Roshantha Chandraratna
IPC分类号： C07D311/96 , C07C229/44 , C07C63/331 , C07D311/04
CPC分类号： C07C69/73 , C07C57/42 , C07C59/64 , C07C59/86 , C07C69/753 , C07C69/76 , C07C229/34 , C07C229/38 , C07C229/46 , C07C229/50 , C07C275/42 , C07C2601/02 , C07C2602/10 , C07D311/58 , C07D311/64 , C07D311/96
摘要： Compounds of formulas 1 through 17 provided in the specification specifically or selectively inhibit either the cytochrome P450RAI-1 enzyme or the cytochrome P450RAI-2 enzyme.
摘要翻译： 在说明书中提供的式1至17的化合物具体地或选择性地抑制细胞色素P450RAI-1酶或细胞色素P450RAI-2酶。
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4.发明申请Compounds having selective cytochrome P450RAI-1 or selective cytochrome P450RAI-2 inhibitory activity and methods of obtaining the same 失效具有选择性细胞色素P450RAI-1或选择性细胞色素P450RAI-2抑制活性的化合物及其获得方法公开(公告)号：US20050176689A1
公开(公告)日：2005-08-11
申请号：US11014460
申请日：2004-12-16
申请人： Jayasree Vasudevan , Liming Wang , Xiaoxia Liu , Kwok Tsang , Ling Li , Janet Takeuchi , Thong Vu , Richard Beard , Smita Bhat , Vidyasagar Vuligonda , Roshantha Chandraratna
发明人： Jayasree Vasudevan , Liming Wang , Xiaoxia Liu , Kwok Tsang , Ling Li , Janet Takeuchi , Thong Vu , Richard Beard , Smita Bhat , Vidyasagar Vuligonda , Roshantha Chandraratna
IPC分类号： C07C57/42 , C07C59/64 , C07C59/86 , C07C69/18 , C07C69/73 , C07C69/753 , C07C69/76 , C07C229/34 , C07C229/38 , C07C229/46 , C07C229/50 , C07C275/42 , C07D311/58 , C07D311/64 , C07D311/96 , A61K31/655 , A61K31/4747 , A61K31/497 , A61K31/502 , A61K31/506
CPC分类号： C07C69/73 , C07C57/42 , C07C59/64 , C07C59/86 , C07C69/753 , C07C69/76 , C07C229/34 , C07C229/38 , C07C229/46 , C07C229/50 , C07C275/42 , C07C2601/02 , C07C2602/10 , C07D311/58 , C07D311/64 , C07D311/96
摘要： Compounds of formulas 1 through 17 provided in the specification specifically or selectively inhibit either the cytochrome P450RAI-1 enzyme or the cytochrome P450RAI-2 enzyme.
摘要翻译： 在说明书中提供的式1至17的化合物具体地或选择性地抑制细胞色素P450RAI-1酶或细胞色素P450RAI-2酶。
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5.发明授权Compounds having selective cytochrome P450RAI-1 or selective cytochrome P450RAI-2 inhibitory activity and methods of obtaining the same 失效具有选择性细胞色素P450RAI-1或选择性细胞色素P450RAI-2抑制活性的化合物及其获得方法公开(公告)号：US07226951B2
公开(公告)日：2007-06-05
申请号：US11014460
申请日：2004-12-16
申请人： Jayasree Vasudevan , Liming Wang , Xiaoxia Liu , Kwok Yin Tsang , Ling Li , Janet A. Takeuchi , Thong Vu , Richard Beard , Smita Bhat , Vidyasagar Vuligonda , Roshantha A. Chandraratna
发明人： Jayasree Vasudevan , Liming Wang , Xiaoxia Liu , Kwok Yin Tsang , Ling Li , Janet A. Takeuchi , Thong Vu , Richard Beard , Smita Bhat , Vidyasagar Vuligonda , Roshantha A. Chandraratna
IPC分类号： A61K31/135 , C07C62/00 , C07C69/52 , C07C211/16
CPC分类号： C07C69/73 , C07C57/42 , C07C59/64 , C07C59/86 , C07C69/753 , C07C69/76 , C07C229/34 , C07C229/38 , C07C229/46 , C07C229/50 , C07C275/42 , C07C2601/02 , C07C2602/10 , C07D311/58 , C07D311/64 , C07D311/96
摘要： Compounds of formulas 1 through 17 provided in the specification specifically or selectively inhibit either the cytochrome P450RAI-1 enzyme or the cytochrome P450RAI-2 enzyme.
摘要翻译： 在说明书中提供的式1至17的化合物具体地或选择性地抑制细胞色素P450RAI-1酶或细胞色素P450RAI-2酶。
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6.发明授权Compounds having selective cytochrome P450RAI-1 or selective cytochrome P450RAI-2 inhibitory activity and methods of obtaining the same 失效具有选择性细胞色素P450RAI-1或选择性细胞色素P450RAI-2抑制活性的化合物及其获得方法公开(公告)号：US07638648B2
公开(公告)日：2009-12-29
申请号：US11728313
申请日：2007-03-23
申请人： Jayasree Vasudevan , Liming Wang , Xiaoxia Liu , Kwok Yin Tsang , Ling Li , Janet A. Takeuchi , Thong Vu , Richard Beard , Smita Bhat , Vidyasagar Vuligonda , Roshantha A. Chandraratna
发明人： Jayasree Vasudevan , Liming Wang , Xiaoxia Liu , Kwok Yin Tsang , Ling Li , Janet A. Takeuchi , Thong Vu , Richard Beard , Smita Bhat , Vidyasagar Vuligonda , Roshantha A. Chandraratna
IPC分类号： C07D265/06 , C07D263/02 , C07D277/02 , C07D213/02 , C07D333/04 , C07D307/34 , C07C229/34
CPC分类号： C07C69/73 , C07C57/42 , C07C59/64 , C07C59/86 , C07C69/753 , C07C69/76 , C07C229/34 , C07C229/38 , C07C229/46 , C07C229/50 , C07C275/42 , C07C2601/02 , C07C2602/10 , C07D311/58 , C07D311/64 , C07D311/96
摘要： Compounds of formulas 1 through 17 provided in the specification specifically or selectively inhibit either the cytochrome P450RAI-1 enzyme or the cytochrome P450RAI-2 enzyme.
摘要翻译： 本说明书中提供的式1至17的化合物具体地或选择性地抑制细胞色素P450RAI-1酶或细胞色素P450RAI-2酶。
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公开(公告)号：US08481010B2
公开(公告)日：2013-07-09
申请号：US12127769
申请日：2008-05-27
申请人： Douglas D. Schoon , James Duff , Thong Vu , Andry Hong , Daniel Moore
发明人： Douglas D. Schoon , James Duff , Thong Vu , Andry Hong , Daniel Moore
IPC分类号： A61K8/18
CPC分类号： C08L71/02 , A61K8/37 , A61K8/41 , A61Q3/02 , C08F290/06 , C08G2650/50 , C08L2205/05 , C09D133/10 , C08L2666/04 , C08L2666/20
摘要： The present invention relates generally to the field of primers and adhesion promoters. More specifically, the primer of the present invention is comprised of one or more multi-carbonylated methacrylates. In a preferred embodiment, a non-ketone polar solvent is also employed. The resulting composition eliminates primer related discoloration of artificial nail enhancements, eliminates the potential for corrosion of skin and nails, and eliminates risk of chemical burn injury, while providing stronger adhesion than currently available primers.
摘要翻译： 本发明一般涉及引物和粘附促进剂领域。 更具体地，本发明的引物由一种或多种多羰基化甲基丙烯酸酯组成。 在优选的实施方案中，也使用非酮极性溶剂。 所得组合物消除了人造指甲增强的引物相关变色，消除了皮肤和指甲腐蚀的可能性，并且消除了化学性烧伤的风险，同时提供了比目前可用的底漆更强的附着力。
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8.发明申请DIHYDRONAPHTHALENE AND NAPHTHALENE DERIVATIVES AS N-FORMYL PEPTIDE RECEPTOR LIKE-1 (FPRL-1) RECEPTOR MODULATORS 有权作为N-甲基肽受体样-1（FPRL-1）受体调节剂的二氢萘和萘衍生物公开(公告)号：US20120238628A1
公开(公告)日：2012-09-20
申请号：US13409228
申请日：2012-03-01
申请人： Vidyasagar Vuligonda , Richard L. Beard , Thong Vu , John E. Donello , Veena Viswanath , Michael E. Garst
发明人： Vidyasagar Vuligonda , Richard L. Beard , Thong Vu , John E. Donello , Veena Viswanath , Michael E. Garst
IPC分类号： A61K31/196 , A61P27/02 , A61P35/00 , A61P35/04 , A61P29/00 , A61P11/00 , A61P31/18 , A61P9/00 , A61P25/00 , A61P11/06 , A61P37/08 , A61P19/04 , A61P17/06 , A61P25/28 , A61P19/02 , A61P31/00 , A61P1/00 , A61P9/10 , A61P17/00 , A61P17/10 , A61P17/12 , A61P17/14 , A61P17/08 , C07C229/46
CPC分类号： C07C235/84 , C07C233/59 , C07C235/82 , C07C2602/10
摘要： The present invention relates to novel dihydronaphthalene and naphthalene derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of the N-formyl peptide receptor like-1 (FPRL-1) receptor.
摘要翻译： 本发明涉及新型二氢萘和萘衍生物，其制备方法，含有它们的药物组合物及其作为N-甲酰基肽受体1（FPRL-1）受体调节剂的药物的用途。
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公开(公告)号：US20110274633A1
公开(公告)日：2011-11-10
申请号：US13042436
申请日：2011-03-07
申请人： Thong Vu , Chad CONGER , Diane Marie LARSEN , David VALIA
发明人： Thong Vu , Chad CONGER , Diane Marie LARSEN , David VALIA
CPC分类号： A61K8/8135 , A61K8/46 , A61K8/731 , A61K8/8147 , A61K8/8152 , A61K8/86 , A61K8/87 , A61K2800/20 , A61K2800/40 , A61Q3/02 , C09D4/06 , C09D101/14 , C09D133/10 , C09D133/14 , C08F220/00
摘要： The present disclosure relates generally to compositions for natural and artificial nail coatings, and particularly, but not by way of limitation, to polymerizable compositions that provide improved adhesion-promoting and improved solvent-susceptibility.
摘要翻译： 本公开一般涉及用于天然和人造指甲涂层的组合物，特别是但不限于提供改进的粘附促进和改善的溶剂敏感性的可聚合组合物。
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公开(公告)号：US08541482B2
公开(公告)日：2013-09-24
申请号：US12573640
申请日：2009-10-05
申请人： Thong Vu , Douglas D. Schoon
发明人： Thong Vu , Douglas D. Schoon
CPC分类号： A61Q3/02 , A45D31/00 , A61K8/39 , A61K8/731 , A61K8/87 , A61K8/91 , A61K2800/81 , A61K2800/95 , C08F251/02
摘要： The present disclosure relates generally to compositions for nail coatings, and particularly, but not by way of limitation, to polymerizable compositions. The disclosure further relates to methods of making a polymerizable, protective and scratch resistant topcoat layer that can be easily removed.
摘要翻译： 本公开一般涉及用于指甲涂层的组合物，特别是但不限于可聚合组合物。 本公开还涉及制备可以容易地去除的可聚合的，保护和耐划伤的顶涂层的方法。
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