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公开(公告)号：US07067131B2
公开(公告)日：2006-06-27
申请号：US10330530
申请日：2002-12-26
申请人： Jean Gudas , Larry L. Green , Menashe Bar-Eli
发明人： Jean Gudas , Larry L. Green , Menashe Bar-Eli
IPC分类号： A61K39/395 , C07K16/00 , C12P21/00 , C12P21/04 , C12P21/08
CPC分类号： C07K16/2896 , A61K47/6803 , A61K47/6819 , A61K47/6865 , A61K51/1066 , A61K2039/505 , C07H21/04 , C07K2317/21
摘要： The present invention relates generally to the generation and characterization of anti-MUC18 monoclonal antibodies. The invention further relates to the use of such anti-MUC18 antibodies in the diagnosis and treatment of disorders associated with increased activity of MUC18, in particular, tumors, such as melanomas.
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公开(公告)号：US08278424B2
公开(公告)日：2012-10-02
申请号：US13094730
申请日：2011-04-26
申请人： Jean Gudas , Aya Jakobovits , Xiao-chi Jia , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Hui Shao , Pia M. Challita-Eid , Arthur B. Raitano
发明人： Jean Gudas , Aya Jakobovits , Xiao-chi Jia , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Hui Shao , Pia M. Challita-Eid , Arthur B. Raitano
IPC分类号： C07K16/00 , C12P21/08 , C07K16/30 , G01N33/53 , G01N33/567 , G01N33/574 , C07H21/02 , C07H21/04
CPC分类号： C07K14/4748 , A61K39/0011 , A61K51/1051 , A61K51/1054 , A61K51/1057 , A61K51/106 , A61K51/1072 , A61K2039/53 , C07K14/705 , C07K16/30 , C07K16/3069 , C07K2317/73 , G01N33/566 , G01N33/57415 , Y02A50/466
摘要： Antibodies and molecules derived therefrom that bind to novel PSCA protein, and variants thereof, are described wherein PSCA exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, PSCA provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The PSCA gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with PSCA can be used in active or passive immunization.
摘要翻译： 其中PSCA在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，PSCA提供诊断，预后， 癌症的预防和/或治疗靶标。 PSCA基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与PSCA反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US08206932B2
公开(公告)日：2012-06-26
申请号：US12413435
申请日：2009-03-27
申请人： Jean Gudas , Aya Jakobovits , Xiao-chi Jia , Robert Kendall Morrison , Pia M. Challita-Eid , Arthur B. Raitano
发明人： Jean Gudas , Aya Jakobovits , Xiao-chi Jia , Robert Kendall Morrison , Pia M. Challita-Eid , Arthur B. Raitano
IPC分类号： G01N33/53 , G01N33/567 , G01N33/574 , C12P21/08
CPC分类号： G01N33/57492 , A61K39/0011 , A61K47/6869 , A61K49/0002 , A61K51/1051 , A61K51/1054 , A61K51/1057 , A61K51/106 , A61K51/1072 , A61K2039/505 , A61K2039/53 , C07K14/4748 , C07K14/705 , C07K16/30 , C07K16/3069 , C07K2317/21 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/77 , G01N33/566 , G01N33/57415 , G01N33/57434 , G01N33/57484 , G01N2500/04
摘要： Antibodies and molecules derived therefrom that bind to novel PSCA protein, and variants thereof, are described wherein PSCA exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, PSCA provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The PSCA gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with PSCA can be used in active or passive immunization.
摘要翻译： 其中PSCA在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，PSCA提供诊断，预后， 癌症的预防和/或治疗靶标。 PSCA基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与PSCA反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US20120078028A1
公开(公告)日：2012-03-29
申请号：US13249111
申请日：2011-09-29
申请人： Daulet SATPAYEV , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Jean Gudas , Aya Jakobovits , Michael Torgov , Zili An
发明人： Daulet SATPAYEV , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Jean Gudas , Aya Jakobovits , Michael Torgov , Zili An
IPC分类号： A61N5/00 , A61K39/395 , A61P35/00 , C07K16/28
CPC分类号： A61K47/6851 , A61K47/6801 , A61K47/6803 , A61K47/6811 , A61K47/6855 , A61K47/6857 , A61K47/6859 , A61K47/6861 , A61K47/6889 , A61K2039/505 , A61N5/1001 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K2317/14 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/92
摘要： Antibody drug conjugates (ADC's) that bind to 191P4D12 protein and variants thereof are described herein. 191P4D12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
摘要翻译： 本文描述了结合191P4D12蛋白及其变体的抗体药物偶联物（ADC）。 191P4D12在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，本发明的ADC提供了用于治疗癌症的治疗组合物。
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公开(公告)号：US07595379B2
公开(公告)日：2009-09-29
申请号：US11131648
申请日：2005-05-17
申请人： Jean Gudas , Aya Jakobovits , Xiao-Chi Jia , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Hui Shao , Pia M. Challita-Eid , Arthur B. Raitano
发明人： Jean Gudas , Aya Jakobovits , Xiao-Chi Jia , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Hui Shao , Pia M. Challita-Eid , Arthur B. Raitano
CPC分类号： A61K39/0011 , A61K51/1051 , A61K51/1054 , A61K51/1057 , A61K51/106 , A61K51/1072 , A61K2039/505 , A61K2039/53 , A61K2039/545 , C07K14/4748 , C07K14/705 , C07K16/30 , C07K16/3069 , C07K2317/34 , C07K2317/73 , C07K2317/734 , C07K2317/77 , G01N33/566 , G01N33/57415 , G01N33/57434 , G01N33/57492 , G01N2500/04
摘要： Antibodies and molecules derived therefrom that bind to novel PSCA protein, and variants thereof, are described wherein PSCA exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, PSCA provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The PSCA gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with PSCA can be used in active or passive immunization.
摘要翻译： 其中PSCA在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，PSCA提供诊断，预后， 癌症的预防和/或治疗靶标。 PSCA基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与PSCA反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US20050208039A1
公开(公告)日：2005-09-22
申请号：US10776773
申请日：2004-02-10
申请人： Aya Jakobovits , Robert Morrison , Arthur Raitano , Pia Challita-Eid , Juan Perez-Villar , Karen Morrison , Mary Faris , Wangmao Ge , Jean Gudas , Steven Kanner
发明人： Aya Jakobovits , Robert Morrison , Arthur Raitano , Pia Challita-Eid , Juan Perez-Villar , Karen Morrison , Mary Faris , Wangmao Ge , Jean Gudas , Steven Kanner
CPC分类号： C07K16/18 , A61K38/00 , A61K47/646 , A61K47/6813 , A61K51/1093 , C07K14/47 , C07K16/30 , C07K16/3038 , C07K2317/54 , C07K2317/55 , C07K2317/622 , G01N33/57484 , Y10T436/25
摘要： A novel gene (designated 158P1D7) and its encoded protein are described. While 158P1D7 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers including set forth in Table 1. Consequently, 158P1D7 provides a diagnostic and/or therapeutic target for cancers. The 158P1D7 gene or fragment thereof, or its encoded protein or a fragment thereof, can be used to elicit an immune response.
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公开(公告)号：US08637642B2
公开(公告)日：2014-01-28
申请号：US13249111
申请日：2011-09-29
申请人： Daulet Satpayev , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Jean Gudas , Aya Jakobovits , Michael Torgov , Zili An
发明人： Daulet Satpayev , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Jean Gudas , Aya Jakobovits , Michael Torgov , Zili An
CPC分类号： A61K47/6851 , A61K47/6801 , A61K47/6803 , A61K47/6811 , A61K47/6855 , A61K47/6857 , A61K47/6859 , A61K47/6861 , A61K47/6889 , A61K2039/505 , A61N5/1001 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K2317/14 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/92
摘要： Antibody drug conjugates (ADC's) that bind to 191P4D12 protein and variants thereof are described herein. 191P4D12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
摘要翻译： 本文描述了结合191P4D12蛋白及其变体的抗体药物偶联物（ADC）。 191P4D12在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，本发明的ADC提供了用于治疗癌症的治疗组合物。
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公开(公告)号：US08350009B2
公开(公告)日：2013-01-08
申请号：US12757935
申请日：2010-04-09
申请人： Aya Jakobovits , Steven B. Kanner , Pia M. Challita-Eid , Juan J. Perez-Villar , Daulet Satpaev , Arthur B. Raitano , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Xiao-chi Jia , Jean Gudas
发明人： Aya Jakobovits , Steven B. Kanner , Pia M. Challita-Eid , Juan J. Perez-Villar , Daulet Satpaev , Arthur B. Raitano , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Xiao-chi Jia , Jean Gudas
CPC分类号： C07K16/30 , A61K2039/505 , C07K2317/24 , C07K2317/73 , C07K2317/732
摘要： Antibodies and molecules derived therefrom that bind to 161P2F10B protein and variants thereof, are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 161P2F10B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 161P2F10B gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 161P2F10B can be used in active or passive immunization.
摘要翻译： 其中161P2F10B在正常成人组织中表现出组织特异性表达，并且在表I所示的癌症中异常表达。因此，161P2F10B提供诊断，预后，预防和 /或癌症治疗靶标。 161P2F10B基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与161P2F10B反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US08236310B2
公开(公告)日：2012-08-07
申请号：US12881461
申请日：2010-09-14
申请人： Aya Jakobovits , Steven B. Kanner , Pia M. Challita-Eid , Juan J. Perez-Villar , Daulet Satpaev , Arthur B. Raitano , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Xiao-chi Jia , Jean Gudas
发明人： Aya Jakobovits , Steven B. Kanner , Pia M. Challita-Eid , Juan J. Perez-Villar , Daulet Satpaev , Arthur B. Raitano , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Xiao-chi Jia , Jean Gudas
IPC分类号： A61K39/395 , G01N33/574 , C07K16/30
CPC分类号： C07K16/30 , A61K2039/505 , C07K2317/24 , C07K2317/73
摘要： Antibodies and molecules derived therefrom that bind to 161P2F10B protein and variants thereof, are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 161P2F10B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 161P2F10B gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 161P2F10B can be used in active or passive immunization.
摘要翻译： 其中161P2F10B在正常成人组织中表现出组织特异性表达，并且在表I所示的癌症中异常表达。因此，161P2F10B提供诊断，预后，预防和 /或癌症治疗靶标。 161P2F10B基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与161P2F10B反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US08013128B2
公开(公告)日：2011-09-06
申请号：US12397992
申请日：2009-03-04
申请人： Jean Gudas , Aya Jakobovits , Xiao-chi Jia , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Hui Shao , Pia M. Challita-Eid , Arthur B. Raitano
发明人： Jean Gudas , Aya Jakobovits , Xiao-chi Jia , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Hui Shao , Pia M. Challita-Eid , Arthur B. Raitano
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , A61K39/00
CPC分类号： A61K39/0011 , A61K51/1051 , A61K51/1054 , A61K51/1057 , A61K51/106 , A61K51/1072 , A61K2039/505 , A61K2039/53 , A61K2039/545 , C07K14/4748 , C07K14/705 , C07K16/30 , C07K16/3069 , C07K2317/34 , C07K2317/73 , C07K2317/734 , C07K2317/77 , G01N33/566 , G01N33/57415 , G01N33/57434 , G01N33/57492 , G01N2500/04
摘要： Antibodies and molecules derived therefrom that bind to novel PSCA protein, and variants thereof, are described wherein PSCA exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, PSCA provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The PSCA gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with PSCA can be used in active or passive immunization.
摘要翻译： 其中PSCA在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，PSCA提供诊断，预后， 癌症的预防和/或治疗靶标。 PSCA基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与PSCA反应的抗体或T细胞可用于主动或被动免疫。
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