利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

175 条记录 (耗时 0.058 秒)

    Protein kinase inhibitors
    1.
    发明授权
    Protein kinase inhibitors 有权
    蛋白激酶抑制剂

    公开(公告)号：US08618106B2

    公开(公告)日：2013-12-31

    申请号：US13593674

    申请日：2012-08-24

    申请人： Jean-Damien Charrier ,  Steve Durrant

    发明人： Jean-Damien Charrier ,  Steve Durrant

    IPC分类号： C07D475/12 ,  A61K31/519

    CPC分类号： C07D487/04

    摘要： In one aspect, the invention provides compounds of Formula I or pharmaceutically acceptable salts thereof. In another aspect, the invention provides methods for treatment of diseases or disorders mediated by a protein kinase, comprising administering a therapeutically effective amount of a compound of this invention.

    摘要翻译： 一方面，本发明提供式I化合物或其药学上可接受的盐。 另一方面，本发明提供了治疗由蛋白激酶介导的疾病或病症的方法，其包括施用治疗有效量的本发明化合物。

    Compounds Useful as Inhibitors of ATR Kinase
    6.
    发明申请
    Compounds Useful as Inhibitors of ATR Kinase 失效
    可用作ATR激酶抑制剂的化合物

    公开(公告)号：US20130089624A1

    公开(公告)日：2013-04-11

    申请号：US13631730

    申请日：2012-09-28

    申请人： Jean-Damien Charrier ,  Stephen Clinton Young ,  Christopher John Davis ,  John Studley

    发明人： Jean-Damien Charrier ,  Stephen Clinton Young ,  Christopher John Davis ,  John Studley

    IPC分类号： C07D413/14 ,  A61K33/24 ,  C07D267/10 ,  C07D413/10 ,  C07D413/04 ,  A61K31/5377 ,  C07D265/30

    CPC分类号： A61K31/5377 ,  A61K33/24 ,  C07D265/30 ,  C07D267/10 ,  C07D401/04 ,  C07D413/04 ,  C07D413/10 ,  C07D413/14

    摘要： The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I: wherein the variables are as defined herein.Additionally, the present invention also relates to novel processes for the production of various morpoholine based intermediates.

    摘要翻译： 本发明涉及可用作ATR蛋白激酶抑制剂的化合物。 本发明还涉及包含本发明化合物的药学上可接受的组合物; 使用本发明化合物治疗各种疾病，病症和病症的方法; 制备本发明化合物的方法; 用于制备本发明化合物的中间体; 以及在体外应用中使用化合物的方法，如生物和病理现象中激酶的研究; 由这种激酶介导的细胞内信号转导途径的研究; 和新型激酶抑制剂的比较评估。 本发明的化合物具有式I：其中变量如本文所定义。 此外，本发明还涉及用于生产各种基于morpoholine的中间体的新方法。