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31 条记录 (耗时 0.039 秒)

    Compounds Useful as Inhibitors of ATR Kinase
    1.
    发明申请
    Compounds Useful as Inhibitors of ATR Kinase 失效
    可用作ATR激酶抑制剂的化合物

    公开(公告)号：US20130089624A1

    公开(公告)日：2013-04-11

    申请号：US13631730

    申请日：2012-09-28

    申请人： Jean-Damien Charrier ,  Stephen Clinton Young ,  Christopher John Davis ,  John Studley

    发明人： Jean-Damien Charrier ,  Stephen Clinton Young ,  Christopher John Davis ,  John Studley

    IPC分类号： C07D413/14 ,  A61K33/24 ,  C07D267/10 ,  C07D413/10 ,  C07D413/04 ,  A61K31/5377 ,  C07D265/30

    CPC分类号： A61K31/5377 ,  A61K33/24 ,  C07D265/30 ,  C07D267/10 ,  C07D401/04 ,  C07D413/04 ,  C07D413/10 ,  C07D413/14

    摘要： The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I: wherein the variables are as defined herein.Additionally, the present invention also relates to novel processes for the production of various morpoholine based intermediates.

    摘要翻译： 本发明涉及可用作ATR蛋白激酶抑制剂的化合物。 本发明还涉及包含本发明化合物的药学上可接受的组合物; 使用本发明化合物治疗各种疾病，病症和病症的方法; 制备本发明化合物的方法; 用于制备本发明化合物的中间体; 以及在体外应用中使用化合物的方法，如生物和病理现象中激酶的研究; 由这种激酶介导的细胞内信号转导途径的研究; 和新型激酶抑制剂的比较评估。 本发明的化合物具有式I：其中变量如本文所定义。 此外，本发明还涉及用于生产各种基于morpoholine的中间体的新方法。

    Pyrrolo[2,3-B]pyrazines useful as inhibitors of ATR kinase
    4.
    发明授权
    Pyrrolo[2,3-B]pyrazines useful as inhibitors of ATR kinase 有权
    吡咯并[2,3-B]吡嗪可用作ATR激酶的抑制剂

    公开(公告)号：US08822469B2

    公开(公告)日：2014-09-02

    申请号：US13531461

    申请日：2012-06-22

    申请人： Somhairle MacCormick ,  Pierre-Henri Storck ,  Michael Paul Mortimore ,  Jean-Damien Charrier ,  Ronald Knegtel ,  Stephen Clinton Young ,  Joanne Pinder ,  Steven John Durrant

    发明人： Somhairle MacCormick ,  Pierre-Henri Storck ,  Michael Paul Mortimore ,  Jean-Damien Charrier ,  Ronald Knegtel ,  Stephen Clinton Young ,  Joanne Pinder ,  Steven John Durrant

    IPC分类号： A61K31/4985 ,  C07D241/36

    CPC分类号： C07D487/04

    摘要： The present invention relates to pyrrolopyrazines compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I: wherein the variables are as defined herein.

    摘要翻译： 本发明涉及可用作ATR蛋白激酶抑制剂的吡咯并吡嗪化合物。 本发明还涉及包含本发明化合物的药学上可接受的组合物; 使用本发明化合物治疗各种疾病，病症和病症的方法; 制备本发明化合物的方法; 用于制备本发明化合物的中间体; 以及在体外应用中使用化合物的方法，如生物和病理现象中激酶的研究; 由这种激酶介导的细胞内信号转导途径的研究; 和新型激酶抑制剂的比较评估。 本发明的化合物具有式I：其中变量如本文所定义。