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    Compounds Useful as Inhibitors of ATR Kinase
    3.
    发明申请
    Compounds Useful as Inhibitors of ATR Kinase 失效
    可用作ATR激酶抑制剂的化合物

    公开(公告)号：US20130089624A1

    公开(公告)日：2013-04-11

    申请号：US13631730

    申请日：2012-09-28

    申请人： Jean-Damien Charrier ,  Stephen Clinton Young ,  Christopher John Davis ,  John Studley

    发明人： Jean-Damien Charrier ,  Stephen Clinton Young ,  Christopher John Davis ,  John Studley

    IPC分类号： C07D413/14 ,  A61K33/24 ,  C07D267/10 ,  C07D413/10 ,  C07D413/04 ,  A61K31/5377 ,  C07D265/30

    CPC分类号： A61K31/5377 ,  A61K33/24 ,  C07D265/30 ,  C07D267/10 ,  C07D401/04 ,  C07D413/04 ,  C07D413/10 ,  C07D413/14

    摘要： The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I: wherein the variables are as defined herein.Additionally, the present invention also relates to novel processes for the production of various morpoholine based intermediates.

    摘要翻译： 本发明涉及可用作ATR蛋白激酶抑制剂的化合物。 本发明还涉及包含本发明化合物的药学上可接受的组合物; 使用本发明化合物治疗各种疾病，病症和病症的方法; 制备本发明化合物的方法; 用于制备本发明化合物的中间体; 以及在体外应用中使用化合物的方法，如生物和病理现象中激酶的研究; 由这种激酶介导的细胞内信号转导途径的研究; 和新型激酶抑制剂的比较评估。 本发明的化合物具有式I：其中变量如本文所定义。 此外，本发明还涉及用于生产各种基于morpoholine的中间体的新方法。

    Swivel Wheel Mounting For A Scooter
    10.
    发明申请
    Swivel Wheel Mounting For A Scooter 审中-公开
    旋转轮安装用于踏板车

    公开(公告)号：US20140312588A1

    公开(公告)日：2014-10-23

    申请号：US14365485

    申请日：2012-12-13

    申请人： Christopher John DAVIS

    发明人： Christopher John Davis

    IPC分类号： B60B30/00 ,  B62L1/04

    CPC分类号： B60B30/00 ,  B60B33/0039 ,  B60B33/0049 ,  B60B33/0071 ,  B60B2200/47 ,  B60B2900/531 ,  B60Y2200/126 ,  B62K3/002

    摘要： Scooters typically have a fixed rear wheel and a rotating front wheel on a length forming a handle. Such scooters are not always able to be used to perform tricks and stunts because they have a fixed rear wheel that can inhibit this. In particular many children and adults wish to drift the rear wheel, or have it at oblique angle to the scooter's direction of movement. The present invention provides a scooter wheel mounting capable of forming in use a two wheeled scooter, wherein the rear wheel being provided on a rotatable seat.

    摘要翻译： 滑板车通常具有固定的后轮和在形成手柄的长度上的旋转前轮。 这样的踏板车并不总是能够用来执行技巧和特技，因为它们具有可以抑制这种的固定后轮。 特别是许多儿童和成年人希望漂移后轮，或者与滑行车的运动方向倾斜。 本发明提供一种能够在使用中形成二轮摩托车的踏板车轮安装件，其中后轮设置在可旋转的座椅上。