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    Opioid receptor ligands and methods for their preparation
    1.
    发明授权
    Opioid receptor ligands and methods for their preparation 有权
    阿片受体配体及其制备方法

    公开(公告)号：US07728001B2

    公开(公告)日：2010-06-01

    申请号：US11224706

    申请日：2005-09-12

    Applicant: Thomas Prisinzano ,  Richard Brian Rothman

    Inventor： Thomas Prisinzano ,  Richard Brian Rothman

    IPC: A61K31/38 ,  C07D335/08 ,  C07D311/78

    CPC classification number: C07D417/04 ,  C07D311/92 ,  C07D405/04 ,  C07D405/14 ,  C07D407/04 ,  C07D413/04 ,  C07F7/1804

    Abstract: The invention provides novel compounds of formula I: that are opioid receptor ligands. The invention also provides pharmaceutical compositions comprising such compounds as well as methods for treating diseases associated with opioid receptor function by administering such compounds to a mammal in need of treatment. The invention also provides an improved method for isolating intermediate materials useful for obtaining compounds of formula I.

    Abstract translation: 本发明提供新的式I化合物：它们是阿片受体配体。 本发明还提供了包含这些化合物的药物组合物以及通过将这些化合物施用于需要治疗的哺乳动物来治疗与阿片受体功能相关的疾病的方法。 本发明还提供了用于分离用于获得式I化合物的中间体的改进方法。

    Activated checkpoint therapy and methods of use thereof
    4.
    发明申请
    Activated checkpoint therapy and methods of use thereof 审中-公开
    活化检查点治疗及其使用方法

    公开(公告)号：US20050054018A1

    公开(公告)日：2005-03-10

    申请号：US10886750

    申请日：2004-07-08

    Applicant: Chiang Li

    Inventor： Chiang Li

    IPC: C12Q1/02 ,  A61K31/352 ,  A61K31/38 ,  A61K31/382 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P35/00 ,  C07D311/92 ,  C07D335/08 ,  C12N15/85 ,  C12Q1/68 ,  G01N33/574

    CPC classification number: G01N33/57484 ,  A61K31/38

    Abstract: Disclosed herein are novel methods and compositions for Activated Checkpoint Therapy™. Also disclosed are methods of treating cancer and apoptosis-associated disorders using cell cycle checkpoint activation modulators. The invention further discloses methods for screening for cell cycle checkpoint activation modulators and the cell cycle checkpoint activation modulators identified by those screening methods.

    Abstract translation: 本文公开了用于活化检查点治疗（TM）的新颖方法和组合物。 还公开了使用细胞周期检查点激活调节剂治疗癌症和凋亡相关疾病的方法。 本发明进一步公开了筛选细胞周期检查点激活调节剂的方法和通过这些筛选方法鉴定的细胞周期检查点激活调节剂。

    Oxime ester photoinitiators
    9.
    发明授权
    Oxime ester photoinitiators 有权
    肟酯光引发剂

    公开(公告)号：US08349548B2

    公开(公告)日：2013-01-08

    申请号：US12598601

    申请日：2008-04-28

    Applicant: Akira Matsumoto ,  Junichi Tanabe ,  Hisatoshi Kura ,  Masaki Ohwa

    Inventor： Akira Matsumoto ,  Junichi Tanabe ,  Hisatoshi Kura ,  Masaki Ohwa

    IPC: G03F7/20 ,  C07D209/88 ,  C07D335/08 ,  B32B27/18 ,  C09K3/00 ,  C08F2/46 ,  G02B5/20

    CPC classification number: C07D401/12 ,  B33Y70/00 ,  C07D417/06 ,  C08F2/50 ,  G03F7/031 ,  Y10T428/31855

    Abstract: Compounds of the formula (I), wherein A1 is formula (II); A2 is formula (III); A3 is formula (IV); A4 is formula (V); w, x, y and z independently of each other are an integer from 0-4, provided that the sum of x+y+z is an integer from 2-4, corresponding to the valency of Q; M1, M2, M3 and M4 for example are a direct bond, CO or O; Y for example is a direct bond or S; Q is a (x+y)-valent linking group; R1 is for example hydrogen, C1-C20alkyl or phenyl or naphthyl; R2 and R″2 for example are is hydrogen or C1-C20alkyl; R3, R4, R′3, R′4, R″3 and R″4 for example are hydrogen, halogen, phenyl, or C1-C20alkyl; and R24 is for example a direct bond; exhibit an unexpectedly good performance in photopolymerization reactions.

    Abstract translation: 式（I）化合物，其中A1为式（II）; A2是式（III）; A3是式（IV）; A4是公式（V）; w，x，y和z彼此独立地是0-4的整数，条件是x + y + z的和是2-4的整数，对应于Q的化合价; M1，M2，M3和M4例如是直接键，CO或O; Y例如是直接债券或S; Q是（x + y）价的连接基团; R1是例如氢，C1-C20烷基或苯基或萘基; R2和R“2例如是氢或C1-C20烷基; R 3，R 4，R'3，R'4，R“3和R”4例如是氢，卤素，苯基或C 1 -C 20烷基; 并且R 24例如是直接键; 在光聚合反应中表现出出人意料的良好性能。

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