公开(公告)号：US20070213686A1

公开(公告)日：2007-09-13

申请号：US11347008

申请日：2006-02-03

申请人： Vandana Mathur ,  Craig Ball ,  Jeffrey Elkins ,  Harry Goodson ,  Samir Patel

发明人： Vandana Mathur ,  Craig Ball ,  Jeffrey Elkins ,  Harry Goodson ,  Samir Patel

IPC分类号： A61B19/00

CPC分类号： A61M5/1723 ,  A61B90/00 ,  A61B2017/22082 ,  A61M5/007 ,  A61M25/0068 ,  A61M2005/1403 ,  A61M2025/0037 ,  A61M2025/1045

摘要： An apparatus and method particularly useful in treatments and therapies directed at the kidneys such as the prevention of radiocontrast nephropathy (RCN) arising from diagnostic procedures using iodinated contrast materials. A series of treatment schemes are provided based upon local therapeutic agent delivery to the kidneys that can be used as a prophylactic treatment for patients undergoing interventional procedures that have been identified as being at an elevated risk for developing RCN as well as for low risk patients. The methods may include pre-exposure and post contrast exposure treatments alone or in combination with the local delivery of therapeutic agents to the kidneys. Among the agents identified for such treatments are normal saline and the vasodilators papaverine and fenoldopam mesylate and appropriate dosing is provided.

摘要翻译： 特别适用于针对肾脏的治疗和疗法的装置和方法，例如使用碘化造影剂的诊断程序引起的放射性对比肾病（RCN）的预防。 提供了一系列基于局部治疗剂递送到肾脏的治疗方案，其可用作对已经被鉴定为发展RCN和低风险患者的高风险的介入手术的患者的预防性治疗。 所述方法可以包括单独的暴露前曝光和造影后处理，或与治疗剂局部递送到肾脏的方法。 鉴定用于这种治疗的药剂是生理盐水，并且提供了血管扩张剂罂粟碱和甲磺酸芬诺多胺，并提供适当的给药。

公开(公告)号：US20060149350A1

公开(公告)日：2006-07-06

申请号：US11295735

申请日：2005-12-05

申请人： Samir Patel ,  Harry Goodson ,  Jeffrey Elkins ,  Craig Ball ,  Vandana Mathur

发明人： Samir Patel ,  Harry Goodson ,  Jeffrey Elkins ,  Craig Ball ,  Vandana Mathur

IPC分类号： A61F2/06

CPC分类号： A61F2/954 ,  A61B2017/00331 ,  A61B2017/22068 ,  A61B2017/22071 ,  A61F2/013 ,  A61F2/958 ,  A61F2002/065 ,  A61F2002/821 ,  A61F2002/9517 ,  A61F2002/9528 ,  A61M25/1002

摘要： Bifurcated delivery assemblies provide bilateral access to first and second branch lumens extending from a main body space or lumen in a patient. One or more interventional devices are combined with the delivery assemblies for delivery s into one or both of the branch lumens. Bilateral renal stenting or embolic protection procedures are performed using the combination delivery/interventional device assemblies. Fluids may also be injected or aspirated from the assemblies. A bifurcated catheter has a first fluid port located on one bifurcation branch, a second fluid port located on a second branch of the bifurcation, and a third fluid port positioned so as to be located within a vena cava when the first and second ports are positioned bilaterally within first and second renal veins.

摘要翻译： 分叉输送组件提供从患者的主体空间或内腔延伸的第一和第二分支腔的双向通路。 将一个或多个介入装置与输送组件组合以用于输送到分支腔中的一个或两个。 使用组合递送/介入装置组件进行双侧肾支架置入或栓塞保护程序。 流体也可以从组件注入或吸出。 分叉导管具有位于一个分叉分支上的第一流体端口，位于分叉的第二分支上的第二流体端口和位于第一和第二端口定位的位于腔静脉内的第三流体端口 在第一和第二肾静脉内双侧。

公开(公告)号：US20050197624A1

公开(公告)日：2005-09-08

申请号：US11073421

申请日：2005-03-04

申请人： Harry Goodson ,  Craig Ball ,  Jeffrey Elkins

发明人： Harry Goodson ,  Craig Ball ,  Jeffrey Elkins

IPC分类号： A61M25/00 ,  A61M25/06 ,  A61M29/00

CPC分类号： A61M25/0662 ,  A61M25/0032 ,  A61M25/007

摘要： A dual lumen introducer sheath provides access to at least one renal artery and at least one peripheral blood vessel of a patient. The introducer sheath includes a proximal hub comprising first and second ports, a first lumen, and a second lumen. The first lumen extends from the first port to a first distal aperture and has sufficient length such that when the first port is positioned outside the patient the first distal aperture is positionable in the abdominal aorta at or near origins of the patient's renal arteries. The second lumen extends from the second port to a second distal aperture, has a shorter length than the length of the first lumen, and is configured to allow passage of a catheter device through the second lumen and into or through an iliac artery contralateral to an insertion point of the introducer sheath into the patient.

摘要翻译： 双腔引导器护套提供对患者的至少一个肾动脉和至少一个外周血管的通路。 导引鞘包括近端毂，其包括第一和第二端口，第一腔和第二腔。 第一腔从第一端口延伸到第一远端孔并且具有足够的长度，使得当第一端口位于患者外部时，第一远端孔可定位在患者肾动脉起点处或其附近的腹主动脉中。 所述第二腔从所述第二端口延伸到第二远端孔，具有比所述第一腔的长度更短的长度，并且构造成允许导管装置通过所述第二腔并进入或穿过对侧的髂动脉 导引鞘的插入点进入患者。

公开(公告)号：US20070167913A1

公开(公告)日：2007-07-19

申请号：US11548565

申请日：2006-10-11

申请人： Jeffrey Elkins ,  Harry Goodson ,  Craig Ball ,  Aurelio Valencia ,  Samir Patel ,  Neema Hekmat

发明人： Jeffrey Elkins ,  Harry Goodson ,  Craig Ball ,  Aurelio Valencia ,  Samir Patel ,  Neema Hekmat

IPC分类号： A61M5/178 ,  A61F2/06 ,  A61M31/00

CPC分类号： A61M25/0662 ,  A61F2/07 ,  A61F2002/065 ,  A61M25/0668 ,  A61M2025/0024 ,  A61M2025/0183 ,  A61M2025/0188 ,  A61M2025/0681

摘要： A system for delivering a renal treatment and a peripheral treatment includes a renal catheter, a peripheral catheter, and an introducer sheath having first and second lumens. The first lumen is configured to receive the renal catheter and is sized to extend from a patient insertion site to a femoral or iliac artery location near or distal to a patient aortic branch. The second lumen is configured to receive the peripheral catheter and is sized to extend from the patient insertion site to an opposite femoral or iliac artery location near or distal to the patient aortic branch. A method of delivering a renal treatment and a peripheral treatment includes positioning an introducer sheath in an iliac artery, advancing a renal catheter and a peripheral catheter through the introducer sheath, where the renal catheter is separated from the peripheral catheter within the introducer sheath by a flap.

摘要翻译： 用于递送肾脏治疗和外周治疗的系统包括肾导管，外周导管和具有第一和第二腔的导引鞘。 第一管腔被配置为接纳肾导管，其尺寸设计成从患者插入位置延伸到患者主动脉分支附近或远侧的股骨或髂动脉位置。 第二管腔构造成接收外周导管，其尺寸设计成从患者插入位置延伸到患者主动脉分支附近或远侧的相对的股骨或髂动脉位置。 递送肾脏治疗和周边治疗的方法包括将引导器鞘定位在髂动脉中，使肾导管和外周导管穿过导引鞘，其中肾导管与导引鞘内的周围导管分开一个 皮瓣

公开(公告)号：US20060036218A1

公开(公告)日：2006-02-16

申请号：US11084738

申请日：2005-03-16

申请人： Harry Goodson ,  Jeffrey Elkins ,  Samir Patel ,  Aurelio Valencia ,  Ricardo Aboytes ,  Craig Ball ,  Randy Kesten ,  Andrew Kramer ,  Sam Payne ,  Sophia Pesotchinsky ,  Michael Rosenthal

发明人： Harry Goodson ,  Jeffrey Elkins ,  Samir Patel ,  Aurelio Valencia ,  Ricardo Aboytes ,  Craig Ball ,  Randy Kesten ,  Andrew Kramer ,  Sam Payne ,  Sophia Pesotchinsky ,  Michael Rosenthal

IPC分类号： A61M25/00

CPC分类号： A61M25/04 ,  A61M25/0029 ,  A61M25/0054 ,  A61M25/0147 ,  A61M25/0152 ,  A61M29/02 ,  A61M39/06 ,  A61M2025/0008 ,  A61M2025/0034 ,  A61M2025/0037 ,  A61M2025/0161 ,  A61M2025/0188 ,  A61M2025/1004 ,  A61M2025/1047 ,  A61M2025/1052

摘要： Two renal delivery members have two distal ports that are adapted to be positioned within two renal arteries via their corresponding renal ostia at unique locations along an abdominal aortic wall. A proximal coupler assembly is outside the body and is coupled to deliver material to the two distal ports for bi-lateral renal therapy. One or both of the delivery members may be self-cannulating into the corresponding renal ostium, or may be controllably steered into the respective ostium. Non-occlusive anchors may be coupled with one or both of the delivery members at anchoring positions in the renal artery or abdominal aorta to secure the renal delivery member within the renal artery. Renal-active fluid agents are coupled to the bi-lateral delivery system. Another renal therapy system cannulates a renal vein from the vena cava and controls a retrograde delivery of agents to the respective kidney.

摘要翻译： 两个肾递送部件具有两个远端端口，其适于通过其腹主动脉壁的独特位置处经由其相应的肾口位于两个肾动脉内。 近端联接器组件在身体外部并且联接以将材料递送到两个远端端口用于双侧肾疗法。 递送部件中的一个或两个可以是自插管到相应的肾口中，或者可以被可控制地引导到相应的口中。 非闭塞性锚固件可以与肾动脉或腹主动脉中的锚定位置处的一个或两个递送构件联接，以将肾递送构件固定在肾动脉内。 肾活性流体剂联接到双向递送系统。 另一种肾脏治疗系统将来自腔静脉的肾静脉插管并控制向相应肾脏逆行递送药剂。

公开(公告)号：US20050245892A1

公开(公告)日：2005-11-03

申请号：US11084295

申请日：2005-03-18

申请人： Jeffrey Elkins ,  Harry Goodson ,  Mark Maguire ,  Aurelio Valencia ,  Samir Patel

发明人： Jeffrey Elkins ,  Harry Goodson ,  Mark Maguire ,  Aurelio Valencia ,  Samir Patel

IPC分类号： A61M25/00 ,  A61M25/01 ,  A61M25/06 ,  A61M31/00

CPC分类号： A61M25/0043 ,  A61M25/0662 ,  A61M39/06

摘要： An introducer system delivers therapy locally to a renal system in a patient. A proximal coupler assembly is coupled to an introducer sheath that delivers multiple devices simultaneously into a location within an abdominal aorta associated with first and second renal artery ostia. The coupler assembly has a network of branch lumens arranged to allow for smooth slideable engagement of multiple coupled devices without substantial interference therebetween. A first branch lumen typically introduces a percutaneous translumenal interventional device such as an angiography or guiding catheter into the introducer sheath and is substantially aligned with a longitudinal axis of the sheath. One or more other branch lumen are off-axis from the longitudinal axis by about 30 degrees or less and introduce components of a bilateral renal delivery assembly into the introducer sheath in conjunction with the other device. Novel insertion devices are provided to coordinate the coupling of the multiple devices.

摘要翻译： 导引器系统将局部给予患者的肾系统治疗。 近端联接器组件联接到导引器鞘，其将多个装置同时输送到与第一和第二肾动脉口相关联的腹主动脉内的位置。 耦合器组件具有布置成允许多个耦合器件的平滑可滑动接合而没有实质干涉的分支腔的网络。 第一分支腔通常将经皮腔内介入装置（例如血管造影或引导导管）引入导引器鞘并且基本上与护套的纵向轴线对准。 一个或多个其它分支腔从纵向轴线偏离约30度或更小，并且将双侧肾递送组件的组件与另一装置一起引入导引鞘中。 提供了新的插入装置来协调多个装置的耦合。

公开(公告)号：US20070287967A1

公开(公告)日：2007-12-13

申请号：US11758417

申请日：2007-06-05

申请人： Neema Hekmat ,  Harry Goodson ,  Aurelio Valencia ,  Jeffrey Elkins

发明人： Neema Hekmat ,  Harry Goodson ,  Aurelio Valencia ,  Jeffrey Elkins

IPC分类号： A61M25/00

CPC分类号： A61M25/0068 ,  A61M25/0028 ,  A61M25/0029 ,  A61M25/0071 ,  A61M25/0074 ,  A61M25/0075 ,  A61M25/008 ,  A61M25/02 ,  A61M2025/0034 ,  A61M2025/0037 ,  A61M2025/0073 ,  A61M2025/024 ,  A61M2025/1045

摘要： Renal infusion systems include an infusion catheter having a bifurcated distal end with a first branch and second branch, the branches being biased to deploy laterally when unconstrained. Systems also include a delivery sheath having a lumen which receives the infusion catheter and constrains the first branch and second branch. A distal opening of the delivery sheath is formed asymmetrically to allow one of the first and second branches to open laterally while the other of the branches remains constrained. Methods of using renal infusion systems are also provided.

摘要翻译： 肾输液系统包括具有分叉远端的输注导管，其具有第一分支和第二分支，所述分支被偏置以在无约束时横向展开。 系统还包括具有接收输注导管并限制第一分支和第二分支的内腔的输送鞘。 输送护套的远端开口不对称地形成，以允许第一和第二分支中的一个横向打开，而另一个分支保持约束。 还提供了使用肾输注系统的方法。

公开(公告)号：US20060069323A1

公开(公告)日：2006-03-30

申请号：US11233562

申请日：2005-09-22

申请人： Jeffrey Elkins ,  Harry Goodson ,  Aurelio Valencia ,  Richard Aboytes ,  Samir Patel

发明人： Jeffrey Elkins ,  Harry Goodson ,  Aurelio Valencia ,  Richard Aboytes ,  Samir Patel

IPC分类号： A61M25/00

CPC分类号： A61M25/0172 ,  A61M25/01 ,  A61M25/0105 ,  A61M25/0662 ,  A61M25/09

摘要： A system and method is provided that is adapted to allow for rapid cannulation of a guidewire into a branch lumen extending from a main lumen in a body of a patient, and in particular into two renal arteries extending from an abdominal aorta wall. A dual lumen catheter shaft delivers first and second pre-shaped guidewires to the location of the renal arteries in the aorta, such that the first and second pre-shaped guidewires self-cannulate within the renal arteries. Additional guidewires and/or interventional devices may be incorporated into the system and method for use with the catheter shaft, or over the two pre-shaped guidewires, to meet a particular need for a particular patient or intended procedure.

摘要翻译： 提供了一种系统和方法，其适于允许将导丝快速插入到从患者体内的主腔延伸的分支腔中，特别是从腹主动脉壁延伸的两个肾动脉中。 双腔导管轴将第一和第二预形状导丝导管到主动脉中肾动脉的位置，使得第一和第二预成形导丝在肾动脉内自我插管。 额外的导线和/或介入装置可以并入用于导管轴或两个预成形导丝线上的系统和方法，以满足特定患者或预期程序的特定需要。

公开(公告)号：US20050267010A1

公开(公告)日：2005-12-01

申请号：US11129101

申请日：2005-05-13

申请人： Harry Goodson ,  Samir Patel ,  Craig Ball ,  Jeffrey Elkins

发明人： Harry Goodson ,  Samir Patel ,  Craig Ball ,  Jeffrey Elkins

IPC分类号： A61K38/17 ,  A61K38/22 ,  A61M25/00 ,  A61M25/04

CPC分类号： A61M25/0041 ,  A61K38/2242 ,  A61M25/0054 ,  A61M25/04 ,  A61M2025/0681 ,  A61M2210/1085

摘要： The invention relates to systems and methods for local renal delivery of agents to subjects that are at risk for congestive heart failure and other conditions. The invention encompasses devices for renal drug delivery and methods of use.

摘要翻译： 本发明涉及用于将局部肾递送给患有充血性心力衰竭和其他病症风险的受试者的系统和方法。 本发明包括用于肾药物递送的装置和使用方法。

公开(公告)号：US20050245882A1

公开(公告)日：2005-11-03

申请号：US11084434

申请日：2005-03-18

申请人： Jeffrey Elkins ,  Aurelio Valencia ,  Samir Patel ,  Ricardo Aboytes ,  Harry Goodson ,  Craig Ball

发明人： Jeffrey Elkins ,  Aurelio Valencia ,  Samir Patel ,  Ricardo Aboytes ,  Harry Goodson ,  Craig Ball

IPC分类号： A61M20060101 ,  A61M5/31 ,  A61M25/00 ,  A61M37/00

CPC分类号： A61M25/0068 ,  A61M25/00 ,  A61M25/0041 ,  A61M25/007 ,  A61M25/0071 ,  A61M25/0074 ,  A61M25/0075 ,  A61M25/0082 ,  A61M39/06 ,  A61M2025/0073 ,  A61M2025/105

摘要： A renal flow system injects a volume of fluid agent into a location within an abdominal aorta in a manner that flows bi-laterally into each of two renal arteries via their respectively spaced ostia along the abdominal aorta wall. A local injection assembly includes two injection members, each having an injection port that couples to a source of fluid agent externally of the patient. The injection ports may be positioned with an outer region of blood flow along the abdominal aorta wall perfusing the two renal arteries. A flow isolation assembly may isolate flow of the injected agent within the outer region and into the renals. The injection members are delivered to the location in a first radially collapsed condition, and bifurcate across the aorta to inject into the spaced renal ostia. A delivery catheter for upstream interventions is used as a chassis to deliver a bilateral local renal injection assembly to the location within the abdominal aorta.

摘要翻译： 肾流系统以一定的方式将一定体积的流体药剂注入腹主动脉内的一个位置，这两种方式通过沿着腹主动脉壁的分别间隔开的两个肾动脉双向流入两个肾动脉。 局部注射组件包括两个注射构件，每个注射构件具有连接到病人外部的流体剂源的注射口。 注射口可以沿着灌注两个肾动脉的腹主动脉壁的外侧血流区域定位。 流动隔离组件可以隔离外部区域内的注射药剂流入肾脏。 注射构件在第一径向折叠状态下被输送到该位置，并且跨越主动脉分叉以注入间隔开的肾口。 用于上游干预的输送导管用作底架以将双侧局部肾注射组件递送至腹主动脉内的位置。