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公开(公告)号：US07364551B2
公开(公告)日：2008-04-29
申请号：US10492953
申请日：2002-11-08
申请人： Jeffrey R. Allen , Paul E. Cranley , Kristine L. Danowski , James A. McIntyre , Reed A. Schick , Larry Sun , Bettina M. Rosner
发明人： Jeffrey R. Allen , Paul E. Cranley , Kristine L. Danowski , James A. McIntyre , Reed A. Schick , Larry Sun , Bettina M. Rosner
IPC分类号： A61B5/08
CPC分类号： A61B5/411 , A61B5/0002 , A61B5/083 , A61B10/00 , A61B2010/0009 , C12P7/04 , C12P7/28
摘要： The subject invention provides a hand-held medical apparatus (10) for detecting a predetermined component of user breath and producing a breath-component signal over a measurement time. Such breath-component signal may be correlated to a user fat metabolism indicator.
摘要翻译： 本发明提供一种用于检测用户呼吸的预定成分并在测量时间产生呼吸分量信号的手持式医疗装置（10）。 这样的呼吸分量信号可以与用户脂肪代谢指示符相关。
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公开(公告)号：US07794994B2
公开(公告)日：2010-09-14
申请号：US10494923
申请日：2002-11-08
申请人： Paul E. Cranley , Jeffrey R. Allen , Kristine L. Danowski , James A. McIntyre , Theodore E. Miller, Jr. , Bettina M. Rosner , Alan D. Strickland , Venkiteswaran Subramanian , Larry Sun
发明人： Paul E. Cranley , Jeffrey R. Allen , Kristine L. Danowski , James A. McIntyre , Theodore E. Miller, Jr. , Bettina M. Rosner , Alan D. Strickland , Venkiteswaran Subramanian , Larry Sun
CPC分类号： C12N9/0006 , C12P7/04 , C12P7/28 , C12Q1/005
摘要： Described are enzyme systems specific for acetone and methods of using these enzyme systems to detect acetone in biological or environmental samples. Biosensors containing these enzyme systems are disclosed, in which detection of acetone may be achieved by linking electrochemical, photometric, or other detection means to one or more acetone-specific enzyme reactions or pathways. Methods of using such acetone-specific biosensors include subject management of weight loss, disease detection, and bioavailability monitoring of therapeutics.
摘要翻译： 描述了丙酮特有的酶系统和使用这些酶系统检测生物或环境样品中的丙酮的方法。 公开了含有这些酶系统的生物传感器，其中可以通过将电化学，光度或其它检测手段与一种或多种丙酮特异性酶反应或途径连接来实现丙酮的检测。 使用这种丙酮特异性生物传感器的方法包括体重减轻，疾病检测和治疗剂的生物利用度监测的受试者管理。
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公开(公告)号：US20080004542A1
公开(公告)日：2008-01-03
申请号：US11781784
申请日：2007-07-23
申请人： Jeffrey Allen , Paul Cranley , Kristine Danowski , James McIntyre , Reed Shick , Bettina Rosner , Larry Sun
发明人： Jeffrey Allen , Paul Cranley , Kristine Danowski , James McIntyre , Reed Shick , Bettina Rosner , Larry Sun
IPC分类号： A61B5/00
CPC分类号： A61B5/411 , A61B5/0002 , A61B5/083 , A61B10/00 , A61B2010/0009 , C12P7/04 , C12P7/28
摘要： A medical apparatus (10) for detecting a predetermined component of breath and producing a breath-component signal over a measurement time. Such breath-component signal may be related to a fat metabolism indicator.
摘要翻译： 一种用于检测预定呼吸成分并在测量时间产生呼吸分量信号的医疗装置（10）。 这种呼吸分量信号可能与脂肪代谢指示剂有关。
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公开(公告)号：US20060289640A1
公开(公告)日：2006-12-28
申请号：US11436917
申请日：2006-05-18
申请人： Peter Mercure , Kristine Danowski , Larry Sun , Robert Haley , Douglas White , Michelle Pressler , Susan Babinec , Flor Castillo , Jahne Simon , Paul Cranley , Malcolm Warren , Diedre Strand , Bettina Rosner , Robert Fletcher , Christopher Jones , Thomas Kalantar , Mark Bernius , W. McDougall , Mark Felix
发明人： Peter Mercure , Kristine Danowski , Larry Sun , Robert Haley , Douglas White , Michelle Pressler , Susan Babinec , Flor Castillo , Jahne Simon , Paul Cranley , Malcolm Warren , Diedre Strand , Bettina Rosner , Robert Fletcher , Christopher Jones , Thomas Kalantar , Mark Bernius , W. McDougall , Mark Felix
CPC分类号： G06K19/04 , A01K11/007 , A61B5/4833 , A61J3/007 , A61J3/071 , A61J2200/30 , A61K9/0009 , A61K9/2072 , A61K9/4808 , G06K7/0008 , G06K7/10079 , G06K19/07327 , G06K19/07336 , G06K19/07345 , G06K19/07749 , H01Q1/2208 , H01Q1/273 , H01Q1/362 , H01Q7/00 , H01Q11/08
摘要： A device useful for oral drug delivery device consisting of: (a) a capsule, tablet or pill designed to disperse in the gastrointestinal system; (b) an RFID tag positioned in the capsule, tablet or pill, the RFID tag comprising an antenna; (c) an object selected from the group consisting of a magnet, a ferromagnetic object, a ferrite object and an electromagnetic shielding object positioned within, over or adjacent the antenna of the RFID tag to alter the antenna characteristics of the RFID tag so that if the RFID tag is interrogated before the capsule, tablet or pill disperses in the gastrointestinal system, the response of the RFID tag is sufficiently altered or attenuated to determine that the capsule, tablet or pill has not dispersed in the gastrointestinal system and so that if the RFID tag is interrogated after the capsule, tablet or pill has dispersed in the gastrointestinal system, the object separates from the RFID tag so that the response of the RFID tag is sufficiently detectable to determine that the capsule, tablet or pill has dispersed in the gastrointestinal system. Alternatively, a switch can be used to signal ingestion of the device, and change the response of the device. In another embodiment, the instant invention is a device useful for oral drug delivery, consisting of: (a) a capsule, tablet or pill designed to disperse in the gastrointestinal system; (b) a first non-anti-collision RFID tag positioned in the capsule; (c) a second non-anti-collision RFID tag positioned in the capsule, so that if the RFID tags are interrogated by an RFID reader before the capsule, tablet or pill disperses in the gastrointestinal system, the response of the RFID tags collide and so that after the dispersible material of the capsule has dispersed in the gastrointestinal system thereby allowing the first and second non-anti-collision tags to separate from each other, then the response of the RFID tags is sufficiently different from each other to determine that the capsule has dispersed in the gastrointestinal system
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公开(公告)号：US20050084921A1
公开(公告)日：2005-04-21
申请号：US10494923
申请日：2004-05-05
申请人： Paul Cranley , Jeffrey Allen , Kristine Danowski , James McIntyre , Theodore Miller Jr , Bettina Rosner , Alan Strickland , Venkiteswaran Subramanian , Larry Sun
发明人： Paul Cranley , Jeffrey Allen , Kristine Danowski , James McIntyre , Theodore Miller Jr , Bettina Rosner , Alan Strickland , Venkiteswaran Subramanian , Larry Sun
CPC分类号： C12N9/0006 , C12P7/04 , C12P7/28 , C12Q1/005
摘要： Described are enzyme systems specific for acetone and methods of using these enzyme systems to detect acetone in biological or environmental samples. Biosensors containing these enzyme systems are disclosed, in which detection of acetone may be achieved by linking electrochemical, photometric, or other detection means to one or more acetone-specific enzyme reactions or pathways. Methods of using such acetone-specific biosensors include subject management of weight loss, disease detection, and bioavailability monitoring of therapeutics.
摘要翻译： 描述了丙酮特有的酶系统和使用这些酶系统检测生物或环境样品中的丙酮的方法。 公开了含有这些酶系统的生物传感器，其中可以通过将电化学，光度或其它检测手段与一种或多种丙酮特异性酶反应或途径连接来实现丙酮的检测。 使用这种丙酮特异性生物传感器的方法包括体重减轻，疾病检测和治疗剂的生物利用度监测的受试者管理。
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