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1.发明授权公开(公告)号：US08119984B2
公开(公告)日：2012-02-21
申请号：US12473570
申请日：2009-05-28
申请人： Jeffrey Shabanowitz , Philip D. Compton , Lee Earley , George C. Stafford, Jr. , Donald F. Hunt , Christopher Mullen
发明人： Jeffrey Shabanowitz , Philip D. Compton , Lee Earley , George C. Stafford, Jr. , Donald F. Hunt , Christopher Mullen
IPC分类号： H01J49/10
CPC分类号： H01J49/12 , H01J49/0072
摘要： A front-end reagent ion source for a mass spectrometer is disclosed. Reagent vapor is supplied to a reagent ionization volume located within a chamber of the mass spectrometer and maintained at a low vacuum pressure. Reagent ions are formed by interaction of the reagent vapor molecules with an electrical discharge (e.g., a glow discharge) within the ionization volume, and pass into the chamber of the mass spectrometer. At least one ion optical element located along the analyte ion path transports the reagent ions to successive chambers of the mass spectrometer. The reagent ions may be combined with the analyte ions to perform ion-ion studies such as electron transfer dissociation (ETD).
摘要翻译： 公开了用于质谱仪的前端试剂离子源。 将试剂蒸气供给到位于质谱仪室内的试剂电离体并保持在低真空压力下。 试剂离子通过试剂蒸气分子与离子化体积内的放电（例如，辉光放电）的相互作用而形成，并进入质谱仪的室。 沿着分析物离子路径定位的至少一个离子光学元件将试剂离子输送到质谱仪的连续室。 试剂离子可与分析物离子组合以进行离子离子研究，例如电子转移离解（ETD）。
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2.发明申请公开(公告)号：US20090294649A1
公开(公告)日：2009-12-03
申请号：US12473570
申请日：2009-05-28
申请人： Jeffrey Shabanowitz , Philip D. Compton , Lee Earley , George C. Stafford, JR. , Donald F. Hunt , Christopher Mullen
发明人： Jeffrey Shabanowitz , Philip D. Compton , Lee Earley , George C. Stafford, JR. , Donald F. Hunt , Christopher Mullen
CPC分类号： H01J49/12 , H01J49/0072
摘要： A front-end reagent ion source for a mass spectrometer is disclosed. Reagent vapor is supplied to a reagent ionization volume located within a chamber of the mass spectrometer and maintained at a low vacuum pressure. Reagent ions are formed by interaction of the reagent vapor molecules with an electrical discharge (e.g., a glow discharge) within the ionization volume, and pass into the chamber of the mass spectrometer. At least one ion optical element located along the analyte ion path transports the reagent ions to successive chambers of the mass spectrometer. The reagent ions may be combined with the analyte ions to perform ion-ion studies such as electron transfer dissociation (ETD).
摘要翻译： 公开了用于质谱仪的前端试剂离子源。 将试剂蒸气供给到位于质谱仪室内的试剂电离体并保持在低真空压力下。 试剂离子通过试剂蒸气分子与离子化体积内的放电（例如，辉光放电）的相互作用而形成，并进入质谱仪的室。 沿着分析物离子路径定位的至少一个离子光学元件将试剂离子输送到质谱仪的连续室。 试剂离子可与分析物离子组合以进行离子离子研究，例如电子转移离解（ETD）。
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公开(公告)号：US20120149125A1
公开(公告)日：2012-06-14
申请号：US12966956
申请日：2010-12-13
CPC分类号： H01J49/0072 , H01J49/12 , Y10T436/24
摘要： A method of providing reagent ions to a mass spectrometer comprises delivering a reagent species to a reagent ionization volume via a passageway at a flow rate. Using previously acquired information, an injection time duration is calculated for injecting reagent ions that are formed in the reagent ionization volume into a reaction region of the mass spectrometer. A determination is made as to whether the calculated injection time duration is within a specified range of injection time duration values. When it is determined that the calculated injection time duration falls outside of the specified range of injection time duration values, the flow rate at which the reagent species is delivered to the ionization volume is adjusted.
摘要翻译： 向质谱仪提供试剂离子的方法包括以流速通过通道将试剂物质递送到试剂离子化体积。 使用先前获得的信息，计算将试剂离子化体积中形成的试剂离子注入质谱仪的反应区域的注射持续时间。 确定所计算的喷射持续时间是否在喷射持续时间值的指定范围内。 当确定计算出的注射持续时间超出注射持续时间值的指定范围时，调节将试剂物质输送到离子化体积的流量。
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公开(公告)号：US08058611B2
公开(公告)日：2011-11-15
申请号：US12565598
申请日：2009-09-23
IPC分类号： H01J49/26
CPC分类号： H01J49/0445
摘要： A system for preventing backflow as part of an ion source arrangement is introduced. Such a system incorporates a novel continuous flow guide within a source, such as an API ion source. In the spray direction, the cross-sectional area that defines the first portion of the internal volume initially decreases in a convergent-like manner and thereafter increases in a divergent-like manner towards the exit opening of the source housing. Such a flow guide has been designed as an integral part of an ion source housing to provide for an optimal unidirectional flow past a sampling orifice of a mass spectrometer inlet. Accordingly, the novel design of the present invention prevents recirculation and thus minimizes carryover, chemical noise, and source turbulence and as an added benefit, enables a user to easily clean such a system during maintenance.
摘要翻译： 引入了用于防止作为离子源装置的一部分的回流的系统。 这样的系统在源内包含新颖的连续流动引导件，例如API离子源。 在喷射方向上，限定内部容积的第一部分的横截面面积首先以收敛方式减小，然后以发散方式朝向源壳体的出口开口增加。 这种流动引导件已被设计为离子源壳体的组成部分，以提供通过质谱仪入口的采样孔的最佳单向流动。 因此，本发明的新颖设计防止再循环，从而使携带，化学噪声和源湍流最小化，并且作为附加的益处，使得用户能够在维护期间容易地清洁这样的系统。
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公开(公告)号：US20060161788A1
公开(公告)日：2006-07-20
申请号：US11264626
申请日：2005-11-01
申请人： Ken Turpin , Christopher Mullen , Paul Kroker
发明人： Ken Turpin , Christopher Mullen , Paul Kroker
IPC分类号： H04K1/00
CPC分类号： G01J3/513 , G01J3/0294 , G01J3/46 , G01J3/463 , G01J3/465 , G01J3/51 , G06K9/00577 , G06K9/4652 , G07D7/1205 , G07D7/205
摘要： A system for authenticating sampled objects including a database, a plurality of spectrum measuring devices, and a plurality of computers. The database stores a plurality of reference patterns measured from known reference objects. Each of the spectrum measuring devices measures a region of respective sampled objects so as to produce spectral content information identifying the sampled objects. The spectral content information includes information indicative of colors inside the visible spectrum of the human eye. The computers have access to spatial analysis software. The computer receives the spectral content information identifying the sampled object and provides the spectral content information to the spatial analysis software to generate a unique measured pattern. The spatial analysis software compares the unique measured pattern with the reference patterns stored in the database, and outputs signals indicative of matches between the unique measured pattern with the reference pattern within a tolerance level whereby the colors of the regions of the sampled objects are utilized to authenticate the sampled objects.
摘要翻译： 一种用于对包括数据库，多个频谱测量装置和多个计算机的采样对象进行认证的系统。 数据库存储从已知参考对象测量的多个参考图案。 每个频谱测量装置测量各个采样对象的区域，以便产生标识采样对象的频谱内容信息。 光谱内容信息包括指示人眼可见光谱内的颜色的信息。 电脑可以访问空间分析软件。 计算机接收标识采样对象的频谱内容信息，并将该频谱内容信息提供给空间分析软件以产生唯一的测量模式。 空间分析软件将唯一的测量模式与存储在数据库中的参考模式进行比较，并将指示唯一测量模式与参考模式之间的匹配的信号输出在公差水平内，由此将采样对象的区域的颜色用于 验证采样对象。
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公开(公告)号：US09159542B2
公开(公告)日：2015-10-13
申请号：US13399791
申请日：2012-02-17
CPC分类号： H01J49/147 , H01J27/26 , H01J49/0027 , H01J49/16 , H01J2237/06308
摘要： An ion source apparatus for a mass spectrometer comprises a refractory metal filament operable to provide a flow of electrons by thermionic emission; an electrical current source electrically coupled to the filament for heating the filament; a vacuum chamber enclosing the filament; an ionization volume within the vacuum chamber capable of receiving the flow of electrons; a source of an oxygen-providing gas or gases; a restrictive fluidic coupling to the source of oxygen-providing gas or gases; and a gas conduit fluidically coupled to the restrictive fluidic coupling, the restrictive fluidic coupling and conduit operable to provide a flow of the oxygen-providing gas or gases into the vacuum chamber so as to maintain a partial pressure of said gas or gases within the vacuum chamber that is sufficiently high so as to inhibit the otherwise formation of a carbonaceous growth on the filament in the presence of a gaseous carbon-containing material.
摘要翻译： 用于质谱仪的离子源装置包括可操作以通过热离子发射提供电子流的难熔金属细丝; 与灯丝电耦合以加热灯丝的电流源; 封闭灯丝的真空室; 能够接收电子流的真空室内的电离体积; 供氧气体或气体的来源; 与供氧气体或气体源的限制性流体耦合; 以及气体导管，其流体地联接到所述限制性流体耦合，所述限制性流体耦合和导管可操作以将所述供氧气体或所述气体的流提供到所述真空室中，以便将所述气体或气体的分压保持在所述真空中 室，其足够高以便在气态含碳材料存在下抑制另外在细丝上形成碳质生长。
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7.发明授权公开(公告)号：US07915580B2
公开(公告)日：2011-03-29
申请号：US12252013
申请日：2008-10-15
申请人： Maurizio A. Splendore , Eloy R. Wouters , Michael W. Senko , Paul R. Atherton , Jean Jacques Dunyach , Christopher Mullen
发明人： Maurizio A. Splendore , Eloy R. Wouters , Michael W. Senko , Paul R. Atherton , Jean Jacques Dunyach , Christopher Mullen
IPC分类号： H01J49/06
CPC分类号： H01J49/0404 , H01J49/066
摘要： A device for improved transportation and focusing of ions in a low vacuum or atmospheric-pressure region of a mass spectrometer is constructed from one or more electro-dynamic or electrostatic focusing lenses that is/are coupled to the first electrode of a stacked ring ion guide (SRIG) to which oscillatory (e.g., radio-frequency) voltages are applied. Such configurations as disclosed herein, minimizes deleterious field effects and/or repositioning problems of desired ion transfer instruments that utilize such stacked ring ion guides by generally configuring the outlet end of the ion transfer device to a desired position within the electro-dynamic or electro-static focusing lens(es).
摘要翻译： 用于改善离子在质谱仪的低真空或大气压力区域中的运输和聚焦的装置由一个或多个电动或静电聚焦透镜构成，所述电动或静电聚焦透镜被耦合到堆叠环离子导向件的第一电极 （SRIG），施加振荡（例如，射频）电压。 通过将离子转移装置的出口端大致配置到电动态或电动式离子转移装置中的期望位置，使这种堆叠的环形离子引导件的所需离子传递装置的有害场效应和/或重新定位问题最小化， 静态聚焦透镜。
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8.发明申请公开(公告)号：US20100090104A1
公开(公告)日：2010-04-15
申请号：US12252013
申请日：2008-10-15
申请人： Maurizio A. Splendore , Eloy R. Wouters , Michael W. Senko , Paul R. Atherton , Jean Jacques Dunyach , Christopher Mullen
发明人： Maurizio A. Splendore , Eloy R. Wouters , Michael W. Senko , Paul R. Atherton , Jean Jacques Dunyach , Christopher Mullen
IPC分类号： B01D59/46
CPC分类号： H01J49/0404 , H01J49/066
摘要： A device for improved transportation and focusing of ions in a low vacuum or atmospheric-pressure region of a mass spectrometer is constructed from one or more electro-dynamic or electrostatic focusing lenses that is/are coupled to the first electrode of a stacked ring ion guide (SRIG) to which oscillatory (e.g., radio-frequency) voltages are applied. Such configurations as disclosed herein, minimizes deleterious field effects and/or repositioning problems of desired ion transfer instruments that utilize such stacked ring ion guides by generally configuring the outlet end of the ion transfer device to a desired position within the electro-dynamic or electro-static focusing lens(es).
摘要翻译： 用于改善离子在质谱仪的低真空或大气压力区域中的运输和聚焦的装置由一个或多个电动或静电聚焦透镜构成，所述电动或静电聚焦透镜被耦合到堆叠环离子导向件的第一电极 （SRIG），施加振荡（例如，射频）电压。 通过将离子转移装置的出口端大致配置到电动态或电动式离子转移装置中的期望位置，使这种堆叠的环形离子引导件的所需离子传递装置的有害场效应和/或重新定位问题最小化， 静态聚焦透镜。
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