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    Resistive heating system and apparatus for improving blood flow in the heart
    1.
    发明授权
    Resistive heating system and apparatus for improving blood flow in the heart 失效
    用于改善心脏血流量的电阻加热系统和装置

    公开(公告)号：US06176856B1

    公开(公告)日：2001-01-23

    申请号：US09215110

    申请日：1998-12-18

    申请人： Jennifer Jandak ,  Michael J. Rosinko ,  Michael J. Horzewski ,  Alexander Khairkhahan

    发明人： Jennifer Jandak ,  Michael J. Rosinko ,  Michael J. Horzewski ,  Alexander Khairkhahan

    IPC分类号： A61B1804

    CPC分类号： A61B18/04 ,  A61B2017/00247 ,  A61B2018/00392

    摘要： A catheter system with an outer catheter body defining at least one lumen and an inner catheter body defining at least one lumen with proximal and distal portions. An introducer is coupled to the distal portion of the inner catheter body. The introducer has a tissue piercing distal end. A resistive heater element is positioned in the introducer. The outer catheter is introduced into a patient's vasculature. The inner catheter is then introduced through the lumen of the outer catheter to a selected heart site. The tissue piercing distal end of the introducer is then advanced into an interior of the heart at the selected heart site. Energy is delivered to the selected heart site from the resistive heater element to create a blood conducting pathway and/or stimulate angiogenesis. In an alternative embodiment, a heart treatment apparatus includes a handpiece with a proximal and a distal end and an elongated member defining at least one lumen coupled to the handpiece distal end. The elongated member has a distal end and an introducer coupled to the distal end. The introducer has a tissue piercing distal end. A resistive heater element is positioned in the introducer. The tissue piercing distal end is introduced through a port in the chest wall into a chest cavity and through an epicardial surface of the heart wall to a selected site within the heart. Energy is delivered to the selected heart site from the resistive heater element to create a blood conducting pathway and/or stimulate angiogenesis.

    摘要翻译： 具有限定至少一个内腔的外导管主体的导管系统和限定具有近端部分和远端部分的至少一个内腔的内导管主体。 引导器联接到内导管主体的远端部分。 导引器具有组织穿刺远端。 电阻加热器元件位于导引器中。 将外导管引入患者的脉管系统。 然后将内导管通过外导管的内腔引入选定的心脏部位。 然后导引器的组织穿刺远端在选定的心脏部位进入心脏的内部。 能量从电阻加热器元件输送到选定的心脏部位以产生血液传导途径和/或刺激血管发生。 在替代实施例中，心脏治疗装置包括具有近端和远端的手持件和限定连接到手持件远端的至少一个腔的细长构件。 细长构件具有远端和连接到远端的导引器。 导引器具有组织穿刺远端。 电阻加热器元件位于导引器中。 组织穿刺的远端通过胸壁中的口引入胸腔并通过心脏壁的心外膜表面到心脏内的选定位置。 能量从电阻加热器元件输送到选定的心脏部位以产生血液传导途径和/或刺激血管发生。

    Method for improving blood flow in the heart
    2.
    发明授权
    Method for improving blood flow in the heart 失效
    改善心脏血流量的方法

    公开(公告)号：US6123084A

    公开(公告)日：2000-09-26

    申请号：US216283

    申请日：1998-12-18

    申请人： Jennifer Jandak ,  Michael J. Rosinko ,  Michael Horzewski ,  Alexander Khairkhahan

    发明人： Jennifer Jandak ,  Michael J. Rosinko ,  Michael Horzewski ,  Alexander Khairkhahan

    IPC分类号： A61B18/08 ,  A61B19/00

    CPC分类号： A61B18/08 ,  A61B2017/003 ,  A61B2018/00392 ,  A61B2018/00738 ,  A61B2018/1475

    摘要： A method for improving blood flow in the heart provides a catheter system with an outer catheter defining at least one lumen and an inner catheter defining at least one lumen with proximal and distal portions. An introducer is coupled to the distal portion of the inner catheter. The introducer has a tissue piercing distal end. A resistive heater element is positioned in the introducer. The catheter system is introduced into a patient's vasculature. The inner catheter is then introduced through the a lumen of the outer catheter to a selected heart site. The tissue piercing distal end of the introducer is then advanced into an interior of the heart at the selected heart site. Energy is delivered to the selected heart site from the resistive heater element to create a blood conducting pathway and/or stimulate angiogenesis. In an alternative embodiment, a heart treatment apparatus is provided that includes a handpiece with a proximal and a distal end and an elongated member defining at least one lumen coupled to the handpiece distal end. The elongated member has a distal end and an introducer coupled to the distal end. The introducer has a tissue piercing distal end. A resistive heater element is positioned in the introducer. The tissue piercing distal end is introduced through a port in the chest wall into a chest cavity and through an epicardial surface of the heart wall to a selected site within the heart. Energy is delivered to the selected heart site from the resistive heater element to create a blood conducting pathway and/or stimulate angiogenesis.

    摘要翻译： 用于改善心脏中的血液流动的方法提供了一种具有限定至少一个内腔的外导管和限定具有近端和远端部分的至少一个内腔的内导管的导管系统。 引导器联接到内导管的远端部分。 导引器具有组织穿刺远端。 电阻加热器元件位于导引器中。 将导管系统引入患者的脉管系统。 然后将内导管通过外导管的内腔引入选定的心脏部位。 然后导引器的组织穿刺远端在选定的心脏部位进入心脏的内部。 能量从电阻加热器元件输送到选定的心脏部位以产生血液传导途径和/或刺激血管发生。 在替代实施例中，提供了一种心脏治疗装置，其包括具有近端和远端的手持件以及限定连接到手持件远端的至少一个腔的细长构件。 细长构件具有远端和连接到远端的导引器。 导引器具有组织穿刺远端。 电阻加热器元件位于导引器中。 组织穿刺的远端通过胸壁中的口引入胸腔并通过心脏壁的心外膜表面到心脏内的选定位置。 能量从电阻加热器元件输送到选定的心脏部位以产生血液传导途径和/或刺激血管发生。

    Delivery catheter systems and methods
    5.
    发明授权
    Delivery catheter systems and methods 有权

    公开(公告)号：US08615310B2

    公开(公告)日：2013-12-24

    申请号：US13324781

    申请日：2011-12-13

    申请人： Alexander Khairkhahan ,  Alan Klenk

    发明人： Alexander Khairkhahan ,  Alan Klenk

    IPC分类号： A61N1/05

    CPC分类号： A61M25/0074 ,  A61N1/057 ,  A61N1/0573 ,  A61N1/362 ,  A61N1/3756 ,  A61N2001/058

    摘要： A delivery system for implanting a leadless cardiac pacemaker into a patient is provided. The cardiac pacemaker can include a docking or delivery feature having a through-hole disposed on or near a proximal end of the pacemaker for attachment to the delivery system. In some embodiments, the delivery catheter can include first and second tethers configured to engage the delivery feature of the pacemaker. The tethers, when partially aligned, can have a cross-sectional diameter larger than the through-hole of the delivery feature, and when un-aligned, can have a cross-sectional diameter smaller than the through-hole of the delivery feature. Methods of delivering the leadless cardiac pacemaker with the delivery system are also provided.

    System for improving cardiac function by sealing a partitioning membrane within a ventricle
    6.
    发明授权
    System for improving cardiac function by sealing a partitioning membrane within a ventricle 有权
    通过密封心室内的分隔膜来改善心脏功能的系统

    公开(公告)号：US08388672B2

    公开(公告)日：2013-03-05

    申请号：US12422144

    申请日：2009-04-10

    申请人： Alexander Khairkhahan ,  Serjan D. Nikolic ,  Hugh R. Sharkey

    发明人： Alexander Khairkhahan ,  Serjan D. Nikolic ,  Hugh R. Sharkey

    IPC分类号： A61F2/06 ,  A61M29/08

    CPC分类号： A61F2/2487 ,  A61B17/0057 ,  A61B17/12022 ,  A61B17/12122 ,  A61B17/1214 ,  A61B17/12172 ,  A61B17/12195 ,  A61B2017/00243 ,  A61B2017/00557 ,  A61B2017/00575 ,  A61B2017/00579 ,  A61B2017/00592 ,  A61B2017/00597 ,  A61B2017/00601 ,  A61B2017/00615 ,  A61B2017/00632 ,  A61B2017/00867 ,  A61B2017/0649 ,  A61B2017/12095

    摘要： Partitioning devices that may be secured and sealed within a heart chamber for separating a patient's heart chamber into a productive portion and a non-productive portion are described herein. The partitioning devices described herein may include a reinforced membrane with outwardly biased members. The reinforced membrane may have a central hub with a distally extending support stem with a plurality of feet which extend radially from a centerline axis and preferably have ends that are aligned in a common plane. These devices may be secured within the heart chamber by sealing them to the wall of the heart chamber, for example, by inflating an inflatable element on the periphery of the device. The non-productive portion may be filled with a material, including occlusive materials. Sealing and/or filling the non-productive portion formed by the devices described herein may help prevent leakage from the non-productive region. Also described herein are systems including these devices and methods of using them, which may be suitable for treating patients with heart disease, particularly congestive heart failure.

    摘要翻译： 本文描述了可以在心室内固定和密封以将患者的心室分离成生产部分和非生产性部分的分隔装置。 本文所述的分隔装置可以包括具有向外偏置构件的增强膜。 增强膜可以具有中心毂，其具有远端延伸的支撑杆，其具有从中心线轴线径向延伸的多个脚，并且优选地具有在公共平面中对准的端部。 这些装置可以通过将它们密封到心室的壁来固定在心脏腔室内，例如通过使装置的周边上的可充气元件膨胀。 非生产性部分可以填充材料，包括封闭材料。 密封和/或填充由本文所述的装置形成的非生产性部分可以有助于防止从非生产性区域泄漏。 本文还描述了包括这些装置和使用它们的方法的系统，其可适用于治疗心脏病患者，特别是充血性心力衰竭。

    Inflatable ventricular partitioning device
    8.
    发明授权
    Inflatable ventricular partitioning device 有权
    充气式心室分配装置

    公开(公告)号：US07976455B2

    公开(公告)日：2011-07-12

    申请号：US12181282

    申请日：2008-07-28

    申请人： Alexander Khairkhahan

    发明人： Alexander Khairkhahan

    IPC分类号： A61F2/00 ,  A61F2/02

    CPC分类号： A61F2/2487

    摘要： This invention is directed to a device and method of using the device for partitioning a patient's heart chamber into a productive portion and a non-productive portion. The device is particularly suitable for treating patients with congestive heart failure. The device has an inflatable partitioning element which separates the productive and non-productive portions of the heart chamber and in some embodiments also has a supporting element, which may also be inflatable, extending between the inflatable partitioning element and the wall of the non-productive portion of the patient's heart chamber. The supporting element may have a non-traumatic distal end to engage the ventricular wall or a tissue penetrating anchoring element to secure the device to the patient's heart wall.

    摘要翻译： 本发明涉及一种使用该装置将患者的心室分成生产部分和非生产性部分的装置和方法。 该装置特别适用于治疗充血性心力衰竭患者。 该装置具有可分离心室的生产性和非生产性部分的可充气的分隔元件，并且在一些实施例中还具有支撑元件，该支撑元件也可以是可充气的，该可支撑元件在可膨胀的分隔元件和非生产性的壁之间延伸 患者心室的一部分。 支撑元件可以具有非创伤性远端以接合心室壁或组织穿透锚固元件以将装置固定到患者的心脏壁。

    APPARATUS AND METHODS FOR CLOT DISSOLUTION
    9.
    发明申请
    APPARATUS AND METHODS FOR CLOT DISSOLUTION 有权
    装置解决方案的装置和方法

    公开(公告)号：US20110046542A1

    公开(公告)日：2011-02-24

    申请号：US12816347

    申请日：2010-06-15

    申请人： Michael A. Evans ,  Denise Demarias ,  Dino De Cicco ,  Kelvin Ning ,  Alexander Khairkhahan ,  Tyler Jon Strang

    发明人： Michael A. Evans ,  Denise Demarias ,  Dino De Cicco ,  Kelvin Ning ,  Alexander Khairkhahan ,  Tyler Jon Strang

    IPC分类号： A61B17/22 ,  A61M25/00 ,  A61M25/10 ,  A61M25/09

    CPC分类号： A61M25/0021 ,  A61B17/22 ,  A61B17/320725 ,  A61B17/320758 ,  A61B2017/22067 ,  A61B2017/22084 ,  A61M25/007 ,  A61M25/0105

    摘要： Clot disruption and dissolution are achieved using a catheter having the ability to infuse a thrombolytic agent, aspirate clot and fluid, and allow passage of a guidewire. Optionally, the catheter may also include a mechanical agitator for further disrupt clot in the presence of the thrombolytic agent. A flow resistor in the catheter provides for infusion and/or aspiration to be concentrated primarily at a clot treatment area in a blood vessel while also providing optional infusion and/or aspiration distal to the treatment area. In some embodiments, infusion, aspiration and guidewire passage occur through a common lumen. The thrombolytic agent, such as tPA, streptokinase, or urokinase, is directly released into the clot at the point where the agitator is engaging the clot. In this way, the thrombolytic activity of the agent is enhanced and the dissolution of the clot is improved.

    摘要翻译： 使用具有注入溶栓剂，抽吸凝块和流体并允许导丝通过的能力的导管实现凝块破裂和溶解。 任选地，导管还可以包括用于在溶栓剂存在下进一步破坏凝块的机械搅拌器。 导管中的流阻器提供输注和/或抽吸主要集中在血管中的凝块治疗区域，同时还提供可选的输液和/或远离治疗区域的抽吸。 在一些实施例中，输注，抽吸和导丝通过共同内腔。 血栓溶解剂如tPA，链激酶或尿激酶在搅拌器与凝块接合的位置处直接释放到凝块中。 以这种方式，药剂的溶栓活性增强，并且凝块的溶解得到改善。